메뉴 건너뛰기




Volumn 5, Issue DEC, 2013, Pages

DNA methylation, a hand behind neurodegenerative diseases

Author keywords

Alzheimer's disease; Amyotrophic lateral sclerosis; DNA methylation; Huntington's disease; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; BETA SECRETASE 1; CYTOSINE; GLUTAMATE TRANSPORTER; GLYCOGEN SYNTHASE KINASE 3BETA; METHYL GROUP; PROTEIN; PSEN1 PROTEIN; RIBOSOME DNA; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84895817996     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2013.00085     Document Type: Review
Times cited : (131)

References (149)
  • 1
    • 84857782880 scopus 로고    scopus 로고
    • Epigenetic programming of neurodegenerative diseases by an adverse environment
    • doi: 10.1016/j.brainres.2012.01.038
    • Babenko, O., Kovalchuk, I., and Metz, G. A. (2012). Epigenetic programming of neurodegenerative diseases by an adverse environment. Brain Res. 1444, 96-111. doi: 10.1016/j.brainres.2012.01.038.
    • (2012) Brain Res. , vol.1444 , pp. 96-111
    • Babenko, O.1    Kovalchuk, I.2    Metz, G.A.3
  • 2
    • 84859412462 scopus 로고    scopus 로고
    • Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex
    • doi: 10.3233/JAD-2012-111223
    • Bakulski, K. M., Dolinoy, D. C., Sartor, M. A., Paulson, H. L., Konen, J. R., Lieberman, A. P., et al. (2012). Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex. J. Alzheimers Dis. 29, 571-588. doi: 10.3233/JAD-2012-111223.
    • (2012) J. Alzheimers Dis. , vol.29 , pp. 571-588
    • Bakulski, K.M.1    Dolinoy, D.C.2    Sartor, M.A.3    Paulson, H.L.4    Konen, J.R.5    Lieberman, A.P.6
  • 3
    • 69449086451 scopus 로고    scopus 로고
    • DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain
    • doi: 10.1097/NEN.0b013e3181af2e46
    • Barrachina, M., and Ferrer, I. (2009). DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. J. Neuropathol. Exp. Neurol. 68, 880-891. doi: 10.1097/NEN.0b013e3181af2e46.
    • (2009) J. Neuropathol. Exp. Neurol. , vol.68 , pp. 880-891
    • Barrachina, M.1    Ferrer, I.2
  • 4
    • 12844273354 scopus 로고    scopus 로고
    • The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain
    • doi: 10.1523/JNEUROSCI.4335-04.2005
    • Basha, M. R., Wei, W., Bakheet, S. A., Benitez, N., Siddiqi, H. K., Ge, Y. W., et al. (2005). The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain. J. Neurosci. 25, 823-829. doi: 10.1523/JNEUROSCI.4335-04.2005.
    • (2005) J. Neurosci. , vol.25 , pp. 823-829
    • Basha, M.R.1    Wei, W.2    Bakheet, S.A.3    Benitez, N.4    Siddiqi, H.K.5    Ge, Y.W.6
  • 5
    • 0028009935 scopus 로고
    • Enzymatic amplification of synthetic oligodeoxyribonucleotides: implication for triplet repeat expansions in the human genome
    • doi: 10.1002/humu.1380030104
    • Behnkrappa, A., and Doerfler, W. (1994). Enzymatic amplification of synthetic oligodeoxyribonucleotides: implication for triplet repeat expansions in the human genome. Human Mutat. 3, 19-24. doi: 10.1002/humu.1380030104.
    • (1994) Human Mutat. , vol.3 , pp. 19-24
    • Behnkrappa, A.1    Doerfler, W.2
  • 6
    • 58049200720 scopus 로고    scopus 로고
    • Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease
    • doi: 10.1038/sj.mp.4002089
    • Bensemain, F., Hot, D., Ferreira, S., Dumont, J., Bombois, S., Maurage, C. A., et al. (2009). Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease. Mol. Psychiatr. 14, 106-116. doi: 10.1038/sj.mp.4002089.
    • (2009) Mol. Psychiatr. , vol.14 , pp. 106-116
    • Bensemain, F.1    Hot, D.2    Ferreira, S.3    Dumont, J.4    Bombois, S.5    Maurage, C.A.6
  • 7
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • doi: 10.1093/hmg/9.16.2395
    • Bestor, T. H. (2000). The DNA methyltransferases of mammals. Hum. Mol. Genet. 9, 2395-2402. doi: 10.1093/hmg/9.16.2395.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 8
    • 80052933429 scopus 로고    scopus 로고
    • DNA demethylation dynamics
    • doi: 10.1016/j.cell.2011.08.042
    • Bhutani, N., Burns, D. M., and Blau, H. M. (2011). DNA demethylation dynamics. Cell 146, 866-872. doi: 10.1016/j.cell.2011.08.042.
    • (2011) Cell , vol.146 , pp. 866-872
    • Bhutani, N.1    Burns, D.M.2    Blau, H.M.3
  • 9
    • 84455193330 scopus 로고    scopus 로고
    • Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer's disease
    • doi: 10.3233/JAD-2011-111013
    • Bihaqi, S. W., Huang, H., Wu, J., and Zawia, N. H. (2011). Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer's disease. J. Alzheimers Dis. 27, 819-833. doi: 10.3233/JAD-2011-111013.
    • (2011) J. Alzheimers Dis. , vol.27 , pp. 819-833
    • Bihaqi, S.W.1    Huang, H.2    Wu, J.3    Zawia, N.H.4
  • 10
    • 84861174335 scopus 로고    scopus 로고
    • Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro
    • Bihaqi, S. W., and Zawia, N. H. (2012). Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro. Curr. Alzheimer Res. 9, 555-562.
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 555-562
    • Bihaqi, S.W.1    Zawia, N.H.2
  • 11
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • doi: 10.1101/gad.947102
    • Bird, A. (2002). DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6-21. doi: 10.1101/gad.947102.
    • (2002) Genes Dev. , vol.16 , pp. 6-21
    • Bird, A.1
  • 13
  • 14
    • 13844250333 scopus 로고    scopus 로고
    • DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism
    • doi: 10.1097/00001756-200502080-00020
    • Bonsch, D., Lenz, B., Kornhuber, J., and Bleich, S. (2005). DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism. Neuroreport 16, 167-170. doi: 10.1097/00001756-200502080-00020.
    • (2005) Neuroreport , vol.16 , pp. 167-170
    • Bonsch, D.1    Lenz, B.2    Kornhuber, J.3    Bleich, S.4
  • 15
    • 0035936643 scopus 로고    scopus 로고
    • Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD
    • doi: 10.1212/WNL.56.2.281
    • Brattstrom, L. (2001). Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD. Neurology 56, 281. doi: 10.1212/WNL.56.2.281.
    • (2001) Neurology , vol.56 , pp. 281
    • Brattstrom, L.1
  • 16
    • 78649381716 scopus 로고    scopus 로고
    • A DNA methylation study of the amyloid precursor protein gene in several brain regions from patients with familial Alzheimer disease
    • doi: 10.3109/01677063.2010.503978
    • Brohede, J., Rinde, M., Winblad, B., and Graff, C. (2010). A DNA methylation study of the amyloid precursor protein gene in several brain regions from patients with familial Alzheimer disease. J. Neurogenet. 24, 179-181. doi: 10.3109/01677063.2010.503978.
    • (2010) J. Neurogenet. , vol.24 , pp. 179-181
    • Brohede, J.1    Rinde, M.2    Winblad, B.3    Graff, C.4
  • 17
    • 84855762409 scopus 로고    scopus 로고
    • DNA methylation of the 5'-untranslated region at +298 and +351 represses BACE1 expression in mouse BV-2 microglial cells
    • doi: 10.1016/j.bbrc.2011.11.123
    • Byun, C. J., Seo, J., Jo, S. A., Park, Y. J., Klug, M., Rehli, M., et al. (2012). DNA methylation of the 5'-untranslated region at +298 and +351 represses BACE1 expression in mouse BV-2 microglial cells. Biochem. Biophys. Res. Commun. 417, 387-392. doi: 10.1016/j.bbrc.2011.11.123.
    • (2012) Biochem. Biophys. Res. Commun. , vol.417 , pp. 387-392
    • Byun, C.J.1    Seo, J.2    Jo, S.A.3    Park, Y.J.4    Klug, M.5    Rehli, M.6
  • 18
    • 80051524687 scopus 로고    scopus 로고
    • Study of methylation levels of parkin gene promoter in Parkinson's disease patients
    • doi: 10.3109/00207454.2011.580866
    • Cai, M., Tian, J., Zhao, G. H., Luo, W., and Zhang, B. R. (2011). Study of methylation levels of parkin gene promoter in Parkinson's disease patients. Int. J. Neurosci. 121, 497-502. doi: 10.3109/00207454.2011.580866.
    • (2011) Int. J. Neurosci. , vol.121 , pp. 497-502
    • Cai, M.1    Tian, J.2    Zhao, G.H.3    Luo, W.4    Zhang, B.R.5
  • 19
    • 77949580716 scopus 로고    scopus 로고
    • Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson's disease
    • doi: 10.1111/j.1468-1331.2009.02848.x
    • Cai, Y., Liu, S., Sothern, R. B., Xu, S., and Chan, P. (2010). Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson's disease. Eur. J. Neurol. 17, 550-554. doi: 10.1111/j.1468-1331.2009.02848.x.
    • (2010) Eur. J. Neurol. , vol.17 , pp. 550-554
    • Cai, Y.1    Liu, S.2    Sothern, R.B.3    Xu, S.4    Chan, P.5
  • 20
    • 84862994335 scopus 로고    scopus 로고
    • Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus
    • doi: 10.3233/RNN-2012-110223
    • Chen, H., Dzitoyeva, S., and Manev, H. (2012). Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus. Restor. Neurol. Neurosci. 30, 237-245. doi: 10.3233/RNN-2012-110223.
    • (2012) Restor. Neurol. Neurosci. , vol.30 , pp. 237-245
    • Chen, H.1    Dzitoyeva, S.2    Manev, H.3
  • 21
    • 56949102195 scopus 로고    scopus 로고
    • The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells
    • doi: 10.1016/j.bbrc.2008.10.173
    • Chen, K. L., Wang, S. S., Yang, Y. Y., Yuan, R. Y., Chen, R. M., and Hu, C. J. (2009). The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells. Biochem. Biophys. Res. Commun. 378, 57-61. doi: 10.1016/j.bbrc.2008.10.173.
    • (2009) Biochem. Biophys. Res. Commun. , vol.378 , pp. 57-61
    • Chen, K.L.1    Wang, S.S.2    Yang, Y.Y.3    Yuan, R.Y.4    Chen, R.M.5    Hu, C.J.6
  • 22
    • 81255143014 scopus 로고    scopus 로고
    • Epigenetic regulation of motor neuron cell death through DNA methylation
    • doi: 10.1523/JNEUROSCI.1639-11.2011
    • Chestnut, B. A., Chang, Q., Price, A., Lesuisse, C., Wong, M., and Martin, L. J. (2011). Epigenetic regulation of motor neuron cell death through DNA methylation. J. Neurosci. 31, 16619-16636. doi: 10.1523/JNEUROSCI.1639-11.2011.
    • (2011) J. Neurosci. , vol.31 , pp. 16619-16636
    • Chestnut, B.A.1    Chang, Q.2    Price, A.3    Lesuisse, C.4    Wong, M.5    Martin, L.J.6
  • 23
    • 84878944565 scopus 로고    scopus 로고
    • Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
    • doi: 10.1016/j.neurobiolaging.2013.02.021
    • Chouliaras, L., Mastroeni, D., Delvaux, E., Grover, A., Kenis, G., Hof, P. R., et al. (2013). Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients. Neurobiol. Aging 34, 2091-2099. doi: 10.1016/j.neurobiolaging.2013.02.021.
    • (2013) Neurobiol. Aging , vol.34 , pp. 2091-2099
    • Chouliaras, L.1    Mastroeni, D.2    Delvaux, E.3    Grover, A.4    Kenis, G.5    Hof, P.R.6
  • 24
    • 77952515576 scopus 로고    scopus 로고
    • An overview of APP processing enzymes and products
    • doi: 10.1007/s12017-009-8104-z
    • Chow, V. W., Mattson, M. P., Wong, P. C., and Gleichmann, M. (2010). An overview of APP processing enzymes and products. Neuromol. Med. 12, 1-12. doi: 10.1007/s12017-009-8104-z.
    • (2010) Neuromol. Med. , vol.12 , pp. 1-12
    • Chow, V.W.1    Mattson, M.P.2    Wong, P.C.3    Gleichmann, M.4
  • 25
    • 0031597388 scopus 로고    scopus 로고
    • Folate, vitamin B-12, and serum total homocysteine levels in confirmed Alzheimer disease Arch
    • doi: 10.1001/archneur.55.11.1449
    • Clarke, R., Smith, A. D., Jobst, K. A., Refsum, H., Sutton, L., and Ueland, P. M. (1998). Folate, vitamin B-12, and serum total homocysteine levels in confirmed Alzheimer disease Arch. Neurol. 55, 1449-1455. doi: 10.1001/archneur.55.11.1449.
    • (1998) Neurol. , vol.55 , pp. 1449-1455
    • Clarke, R.1    Smith, A.D.2    Jobst, K.A.3    Refsum, H.4    Sutton, L.5    Ueland, P.M.6
  • 26
    • 77958580776 scopus 로고    scopus 로고
    • DNA methylation and memory formation
    • doi: 10.1038/nn.2666
    • Day, J. J., and Sweatt, J. D. (2010). DNA methylation and memory formation. Nat. Neurosci. 13, 1319-1323. doi: 10.1038/nn.2666.
    • (2010) Nat. Neurosci. , vol.13 , pp. 1319-1323
    • Day, J.J.1    Sweatt, J.D.2
  • 27
    • 84855878253 scopus 로고    scopus 로고
    • Next-Generation sequencing reveals regional differences of the alpha-synuclein methylation state independent of Lewy body disease Neuromol
    • doi: 10.1007/s12017-011-8163-9
    • de Boni, L., Tierling, S., Roeber, S., Walter, J., Giese, A., and Kretzschmar, H. A. (2011). Next-Generation sequencing reveals regional differences of the alpha-synuclein methylation state independent of Lewy body disease Neuromol. Med. 13, 310-320. doi: 10.1007/s12017-011-8163-9.
    • (2011) Med. , vol.13 , pp. 310-320
    • de Boni, L.1    Tierling, S.2    Roeber, S.3    Walter, J.4    Giese, A.5    Kretzschmar, H.A.6
  • 28
    • 80052435603 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: an update
    • doi: 10.1097/WCO.0b013e32834916a9
    • de Carvalho, M., and Swash, M. (2011). Amyotrophic lateral sclerosis: an update. Curr. Opin. Neurol. 24, 497-503. doi: 10.1097/WCO.0b013e32834916a9.
    • (2011) Curr. Opin. Neurol. , vol.24 , pp. 497-503
    • de Carvalho, M.1    Swash, M.2
  • 29
    • 33745919520 scopus 로고    scopus 로고
    • Epidemiology of Parkinson's disease
    • doi: 10.1016/S1474-4422(06)70471-9
    • de Lau, L. M. L., and Breteler, M. M. B. (2006). Epidemiology of Parkinson's disease. Lancet Neurol. 5, 525-535. doi: 10.1016/S1474-4422(06)70471-9.
    • (2006) Lancet Neurol. , vol.5 , pp. 525-535
    • de Lau, L.M.L.1    Breteler, M.M.B.2
  • 30
    • 79953178935 scopus 로고    scopus 로고
    • Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases
    • doi: 10.1074/jbc. C110.212589
    • Desplats, P., Spencer, B., Coffee, E., Patel, P., Michael, S., Patrick, C., et al. (2011). Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J. Biol. Chem. 286, 9031-9037. doi: 10.1074/jbc. C110.212589.
    • (2011) J. Biol. Chem. , vol.286 , pp. 9031-9037
    • Desplats, P.1    Spencer, B.2    Coffee, E.3    Patel, P.4    Michael, S.5    Patrick, C.6
  • 31
    • 27144494994 scopus 로고    scopus 로고
    • Ribosome dysfunction is an early event in Alzheimer's disease
    • doi: 10.1523/JNEUROSCI.3040-05.2005
    • Ding, Q., Markesbery, W. R., Chen, Q., Li, F., and Keller, J. N. (2005). Ribosome dysfunction is an early event in Alzheimer's disease. J. Neurosci. 25, 9171-9175. doi: 10.1523/JNEUROSCI.3040-05.2005.
    • (2005) J. Neurosci. , vol.25 , pp. 9171-9175
    • Ding, Q.1    Markesbery, W.R.2    Chen, Q.3    Li, F.4    Keller, J.N.5
  • 32
    • 0036572179 scopus 로고    scopus 로고
    • De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation
    • doi: 10.1016/S0378-1119(02)00469-9
    • Dodge, J. E., Ramsahoye, B. H., Wo, Z. G., Okano, M., and Li, E. (2002). De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation. Gene 289, 41-48. doi: 10.1016/S0378-1119(02)00469-9.
    • (2002) Gene , vol.289 , pp. 41-48
    • Dodge, J.E.1    Ramsahoye, B.H.2    Wo, Z.G.3    Okano, M.4    Li, E.5
  • 33
    • 0036270262 scopus 로고    scopus 로고
    • Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic, neurons in models of Parkinson's disease
    • doi: 10.1046/j.0022-3042.2001.00676.x
    • Duan, W., Ladenheim, B., Cutler, R. G., Kruman, I. I., Cadet, J. L., and Mattson, M. P. (2002). Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic, neurons in models of Parkinson's disease. J. Neurochem. 80, 101-110. doi: 10.1046/j.0022-3042.2001.00676.x.
    • (2002) J. Neurochem. , vol.80 , pp. 101-110
    • Duan, W.1    Ladenheim, B.2    Cutler, R.G.3    Kruman, I.I.4    Cadet, J.L.5    Mattson, M.P.6
  • 34
    • 77954224132 scopus 로고    scopus 로고
    • Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns
    • doi: 10.1101/gr.101535.109
    • Edwards, J. R., O'Donnell, A. H., Rollins, R. A., Peckham, H. E., Lee, C., Milekic, M. H., et al. (2010). Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns. Genome Res. 20, 972-980. doi: 10.1101/gr.101535.109.
    • (2010) Genome Res. , vol.20 , pp. 972-980
    • Edwards, J.R.1    O'Donnell, A.H.2    Rollins, R.A.3    Peckham, H.E.4    Lee, C.5    Milekic, M.H.6
  • 35
    • 0026536403 scopus 로고
    • Inverse relationship between age at onset of huntington disease and paternal age suggests involvement of genetic imprinting
    • Farrer, L. A., Cupples, L. A., Kiely, D. K., Conneally, P. M., and Myers, R. H. (1992). Inverse relationship between age at onset of huntington disease and paternal age suggests involvement of genetic imprinting. Am. J. Hum. Genet. 50, 528-535.
    • (1992) Am. J. Hum. Genet. , vol.50 , pp. 528-535
    • Farrer, L.A.1    Cupples, L.A.2    Kiely, D.K.3    Conneally, P.M.4    Myers, R.H.5
  • 36
    • 33748298837 scopus 로고    scopus 로고
    • MBD family proteins: reading the epigenetic code
    • doi: 10.1242/jcs.03099
    • Fatemi, M., and Wade, P. A. (2006). MBD family proteins: reading the epigenetic code. J. Cell. Sci. 119, 3033-3037. doi: 10.1242/jcs.03099.
    • (2006) J. Cell. Sci. , vol.119 , pp. 3033-3037
    • Fatemi, M.1    Wade, P.A.2
  • 37
    • 80755163102 scopus 로고    scopus 로고
    • Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
    • doi: 10.1038/nrneurol.2011.152
    • Ferraiuolo, L., Kirby, J., Grierson, A. J., Sendtner, M., and Shaw, P. J. (2011). Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis. Nat. Rev. Neurol. 7, 616-630. doi: 10.1038/nrneurol.2011.152.
    • (2011) Nat. Rev. Neurol. , vol.7 , pp. 616-630
    • Ferraiuolo, L.1    Kirby, J.2    Grierson, A.J.3    Sendtner, M.4    Shaw, P.J.5
  • 38
    • 0034935016 scopus 로고    scopus 로고
    • CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus
    • doi: 10.1038/ng570
    • Filippova, G. N., Thienes, C. P., Penn, B. H., Cho, D. H., Hu, Y. J., Moore, J. M., et al. (2001). CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus. Nat. Genet. 28, 335-343. doi: 10.1038/ng570.
    • (2001) Nat. Genet. , vol.28 , pp. 335-343
    • Filippova, G.N.1    Thienes, C.P.2    Penn, B.H.3    Cho, D.H.4    Hu, Y.J.5    Moore, J.M.6
  • 39
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • doi: 10.1073/pnas.0500398102
    • Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., et al. (2005). Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. U.S.A. 102, 10604-10609. doi: 10.1073/pnas.0500398102.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 10604-10609
    • Fraga, M.F.1    Ballestar, E.2    Paz, M.F.3    Ropero, S.4    Setien, F.5    Ballestar, M.L.6
  • 40
    • 84870057718 scopus 로고    scopus 로고
    • SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's disease
    • doi: 10.1016/j.neuint.2012.07.014
    • Furuya, T. K., da Silva, P. N., Payao, S. L., Rasmussen, L. T., de Labio, R. W., Bertolucci, P. H., et al. (2012a). SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's disease. Neurochem. Int. 61, 973-975. doi: 10.1016/j.neuint.2012.07.014.
    • (2012) Neurochem. Int. , vol.61 , pp. 973-975
    • Furuya, T.K.1    da Silva, P.N.2    Payao, S.L.3    Rasmussen, L.T.4    de Labio, R.W.5    Bertolucci, P.H.6
  • 41
    • 84864777566 scopus 로고    scopus 로고
    • Analysis of SNAP25 mRNA expression and promoter DNA methylation in brain areas of Alzheimer's disease patients
    • doi: 10.1016/j.neuroscience.2012.06.035
    • Furuya, T. K., Silva, P. N., Payao, S. L., Bertolucci, P. H., Rasmussen, L. T., de Labio, R. W., et al. (2012b). Analysis of SNAP25 mRNA expression and promoter DNA methylation in brain areas of Alzheimer's disease patients. Neuroscience 220, 41-46. doi: 10.1016/j.neuroscience.2012.06.035.
    • (2012) Neuroscience , vol.220 , pp. 41-46
    • Furuya, T.K.1    Silva, P.N.2    Payao, S.L.3    Bertolucci, P.H.4    Rasmussen, L.T.5    de Labio, R.W.6
  • 42
    • 84861135122 scopus 로고    scopus 로고
    • PSEN1 promoter demethylation in hyperhomocysteinemic TgCRND8 mice is the culprit, not the consequence
    • Fuso, A., Cavallaro, R. A., Nicolia, V., and Scarpa, S. (2012a). PSEN1 promoter demethylation in hyperhomocysteinemic TgCRND8 mice is the culprit, not the consequence. Curr. Alzheimer Res. 9, 527-535.
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 527-535
    • Fuso, A.1    Cavallaro, R.A.2    Nicolia, V.3    Scarpa, S.4
  • 43
    • 84860368886 scopus 로고    scopus 로고
    • S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice
    • 1482.e1-1482.e16, doi: 10.1016/j.neurobiolaging.2011.12.013
    • Fuso, A., Nicolia, V., Ricceri, L., Cavallaro, R. A., Isopi, E., Mangia, F., et al. (2012b). S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice. Neurobiol. Aging 33, 1482.e1-1482.e16. doi: 10.1016/j.neurobiolaging.2011.12.013.
    • (2012) Neurobiol. Aging , vol.33
    • Fuso, A.1    Nicolia, V.2    Ricceri, L.3    Cavallaro, R.A.4    Isopi, E.5    Mangia, F.6
  • 44
    • 34447642134 scopus 로고    scopus 로고
    • γ-secretase is differentially modulated by alteration of homocysteine cycle in neuroblastoma and glioblastoma cells
    • Fuso, A., Cavallaroa, R. A., Zampellia, A., D'Anselmia, F., Piscopob, P., Confalonib, A., et al. (2007). γ-secretase is differentially modulated by alteration of homocysteine cycle in neuroblastoma and glioblastoma cells. J. Alzheimers Dis. 11, 275-290.
    • (2007) J. Alzheimers Dis. , vol.11 , pp. 275-290
    • Fuso, A.1    Cavallaroa, R.A.2    Zampellia, A.3    D'Anselmia, F.4    Piscopob, P.5    Confalonib, A.6
  • 45
    • 41249098662 scopus 로고    scopus 로고
    • B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice
    • doi: 10.1016/j.mcn.2007.12.018
    • Fuso, A., Nicolia, V., Cavallaro, R. A., Ricceri, L., D'Anselmi, F., Coluccia, P., et al. (2008). B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice. Mol. Cell. Neurosci. 37, 731-746. doi: 10.1016/j.mcn.2007.12.018.
    • (2008) Mol. Cell. Neurosci. , vol.37 , pp. 731-746
    • Fuso, A.1    Nicolia, V.2    Cavallaro, R.A.3    Ricceri, L.4    D'Anselmi, F.5    Coluccia, P.6
  • 46
    • 79951677959 scopus 로고    scopus 로고
    • DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models
    • doi: 10.1016/j.jnutbio.2010.01.010
    • Fuso, A., Nicolia, V., Cavallaro, R. A., and Scarpa, S. (2011a). DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models. J. Nutr. Biochem. 22, 242-251. doi: 10.1016/j.jnutbio.2010.01.010.
    • (2011) J. Nutr. Biochem. , vol.22 , pp. 242-251
    • Fuso, A.1    Nicolia, V.2    Cavallaro, R.A.3    Scarpa, S.4
  • 47
    • 78649872779 scopus 로고    scopus 로고
    • Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency
    • doi: 10.1016/j.neurobiolaging.2009.02.013
    • Fuso, A., Nicolia, V., Pasqualato, A., Fiorenza, M. T., Cavallaro, R. A., and Scarpa, S. (2011b). Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency. Neurobiol. Aging 32, 187-199. doi: 10.1016/j.neurobiolaging.2009.02.013.
    • (2011) Neurobiol. Aging , vol.32 , pp. 187-199
    • Fuso, A.1    Nicolia, V.2    Pasqualato, A.3    Fiorenza, M.T.4    Cavallaro, R.A.5    Scarpa, S.6
  • 48
    • 79958766232 scopus 로고    scopus 로고
    • One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?
    • doi: 10.1016/j.neurobiolaging.2011.01.012
    • Fuso, A., and Scarpa, S. (2011). One-carbon metabolism and Alzheimer's disease: is it all a methylation matter? Neurobiol. Aging 32, 1192-1195. doi: 10.1016/j.neurobiolaging.2011.01.012.
    • (2011) Neurobiol. Aging , vol.32 , pp. 1192-1195
    • Fuso, A.1    Scarpa, S.2
  • 49
    • 10644237168 scopus 로고    scopus 로고
    • S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production
    • doi: 10.1016/j.mcn.2004.09.007
    • Fuso, A., Seminara, L., Cavallaro, R. A., D'Anselmi, F., and Scarpa, S. (2005). S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol. Cell. Neurosci. 28, 195-204. doi: 10.1016/j.mcn.2004.09.007.
    • (2005) Mol. Cell. Neurosci. , vol.28 , pp. 195-204
    • Fuso, A.1    Seminara, L.2    Cavallaro, R.A.3    D'Anselmi, F.4    Scarpa, S.5
  • 50
    • 31144449613 scopus 로고    scopus 로고
    • Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2
    • doi: 10.1126/science.1120976
    • Goll, M. G., Kirpekar, F., Maggert, K. A., Yoder, J. A., Hsieh, C. L., Zhang, X., et al. (2006). Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science 311, 395-398. doi: 10.1126/science.1120976.
    • (2006) Science , vol.311 , pp. 395-398
    • Goll, M.G.1    Kirpekar, F.2    Maggert, K.A.3    Yoder, J.A.4    Hsieh, C.L.5    Zhang, X.6
  • 51
    • 9744253732 scopus 로고    scopus 로고
    • Genome-wide demethylation destabilizes CTG. CAG trinucleotide repeats in mammalian cells
    • doi: 10.1093/hmg/ddh317
    • Gorbunova, V., Seluanov, A., Mittelman, D., and Wilson, J. H. (2004). Genome-wide demethylation destabilizes CTG. CAG trinucleotide repeats in mammalian cells. Hum. Mol. Genet. 13, 2979-2989. doi: 10.1093/hmg/ddh317.
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 2979-2989
    • Gorbunova, V.1    Seluanov, A.2    Mittelman, D.3    Wilson, J.H.4
  • 52
    • 84872305918 scopus 로고    scopus 로고
    • Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: potential epigenetic mechanisms in gene transcription in Abeta production
    • doi: 10.1016/j.neurobiolaging.2012.10.013
    • Gu, X., Sun, J., Li, S., Wu, X., and Li, L. (2013). Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: potential epigenetic mechanisms in gene transcription in Abeta production. Neurobiol. Aging 34, 1069-1079. doi: 10.1016/j.neurobiolaging.2012.10.013.
    • (2013) Neurobiol. Aging , vol.34 , pp. 1069-1079
    • Gu, X.1    Sun, J.2    Li, S.3    Wu, X.4    Li, L.5
  • 53
    • 84155167262 scopus 로고    scopus 로고
    • Effect of vitamin E administration on the elevated oxygen stress and the telomeric and subtelomeric status in Alzheimer's disease
    • doi: 10.1159/000327821
    • Guan, J. Z., Guan, W. P., Maeda, T., and Makino, N. (2012). Effect of vitamin E administration on the elevated oxygen stress and the telomeric and subtelomeric status in Alzheimer's disease. Gerontology 58, 62-69. doi: 10.1159/000327821.
    • (2012) Gerontology , vol.58 , pp. 62-69
    • Guan, J.Z.1    Guan, W.P.2    Maeda, T.3    Makino, N.4
  • 54
    • 47049087917 scopus 로고    scopus 로고
    • A percentage analysis of the telomere length in Parkinson's disease patients
    • doi: 10.1093/gerona/63.5.467
    • Guan, J. Z., Maeda, T., Sugano, M., Oyama, J., Higuchi, Y., Suzuki, T., et al. (2008). A percentage analysis of the telomere length in Parkinson's disease patients. J. Gerontol. A Biol. Sci. Med. Sci. 63, 467-473. doi: 10.1093/gerona/63.5.467.
    • (2008) J. Gerontol. A Biol. Sci. Med. Sci. , vol.63 , pp. 467-473
    • Guan, J.Z.1    Maeda, T.2    Sugano, M.3    Oyama, J.4    Higuchi, Y.5    Suzuki, T.6
  • 55
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    • doi: 10.1016/j.cell.2011.03.022
    • Guo, J. U., Su, Y., Zhong, C., Ming, G. L., and Song, H. (2011a). Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145, 423-434. doi: 10.1016/j.cell.2011.03.022.
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 56
    • 84860409543 scopus 로고    scopus 로고
    • Epigenetic mechanisms of amyloid-beta production in anisomycin-treated SH-SY5Y cells
    • doi: 10.1016/j.neuroscience.2011.07.012
    • Guo, X., Wu, X., Ren, L., Liu, G., and Li, L. (2011b). Epigenetic mechanisms of amyloid-beta production in anisomycin-treated SH-SY5Y cells. Neuroscience 194, 272-281. doi: 10.1016/j.neuroscience.2011.07.012.
    • (2011) Neuroscience , vol.194 , pp. 272-281
    • Guo, X.1    Wu, X.2    Ren, L.3    Liu, G.4    Li, L.5
  • 57
    • 0035894537 scopus 로고    scopus 로고
    • Allele-specific non-CpG methylation of the Nf1 gene during early mouse development
    • doi: 10.1006/dbio.2001.0504
    • Haines, T. R., Rodenhiser, D. I., and Ainsworth, P. J. (2001). Allele-specific non-CpG methylation of the Nf1 gene during early mouse development. Dev. Biol. 240, 585-598. doi: 10.1006/dbio.2001.0504.
    • (2001) Dev. Biol. , vol.240 , pp. 585-598
    • Haines, T.R.1    Rodenhiser, D.I.2    Ainsworth, P.J.3
  • 58
    • 84885021247 scopus 로고    scopus 로고
    • Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues
    • doi: 10.1038/ng.2746
    • Hon, G. C., Rajagopal, N., Shen, Y., Mccleary, D. F., Yue, F., Dang, M. D., et al. (2013). Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues. Nat. Genet. 45, 1198-1206. doi: 10.1038/ng.2746.
    • (2013) Nat. Genet. , vol.45 , pp. 1198-1206
    • Hon, G.C.1    Rajagopal, N.2    Shen, Y.3    Mccleary, D.F.4    Yue, F.5    Dang, M.D.6
  • 59
    • 77958566429 scopus 로고    scopus 로고
    • Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors
    • doi: 10.1523/JNEUROSCI.2128-10.2010
    • Hood, S., Cassidy, P., Cossette, M. P., Weigl, Y., Verwey, M., Robinson, B., et al. (2010). Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors. J. Neurosci. 30, 14046-14058. doi: 10.1523/JNEUROSCI.2128-10.2010.
    • (2010) J. Neurosci. , vol.30 , pp. 14046-14058
    • Hood, S.1    Cassidy, P.2    Cossette, M.P.3    Weigl, Y.4    Verwey, M.5    Robinson, B.6
  • 60
    • 84866868744 scopus 로고    scopus 로고
    • Aging effects on DNA methylation modules in human brain and blood tissue
    • doi: 10.1186/gb-2012-13-10-r97
    • Horvath, S., Zhang, Y., Langfelder, P., Kahn, R. S., Boks, M. P., van Eijk, K., et al. (2012). Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol. 13:R97. doi: 10.1186/gb-2012-13-10-r97.
    • (2012) Genome Biol. , vol.13
    • Horvath, S.1    Zhang, Y.2    Langfelder, P.3    Kahn, R.S.4    Boks, M.P.5    van Eijk, K.6
  • 61
    • 84957846754 scopus 로고
    • The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography
    • Hotchkiss, R. D. (1948). The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography. J. Biol. Chem. 175, 315-332.
    • (1948) J. Biol. Chem. , vol.175 , pp. 315-332
    • Hotchkiss, R.D.1
  • 62
    • 78751644048 scopus 로고    scopus 로고
    • Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease
    • doi: 10.1038/nrn2967
    • Ittner, L. M., and Gotz, J. (2011). Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease. Nat. Rev. Neurosci. 12, 65-72. doi: 10.1038/nrn2967.
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 65-72
    • Ittner, L.M.1    Gotz, J.2
  • 63
    • 79955557706 scopus 로고    scopus 로고
    • Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons
    • doi: 10.1101/gr.112755.110
    • Iwamoto, K., Bundo, M., Ueda, J., Oldham, M. C., Ukai, W., Hashimoto, E., et al. (2011). Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Res. 21, 688-696. doi: 10.1101/gr.112755.110.
    • (2011) Genome Res. , vol.21 , pp. 688-696
    • Iwamoto, K.1    Bundo, M.2    Ueda, J.3    Oldham, M.C.4    Ukai, W.5    Hashimoto, E.6
  • 64
    • 0033621739 scopus 로고    scopus 로고
    • Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition
    • doi: 10.1038/77399
    • Iwata, N., Tsubuki, S., Takaki, Y., Watanabe, K., Sekiguchi, M., Hosoki, E., et al. (2000). Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat. Med. 6, 143-150. doi: 10.1038/77399.
    • (2000) Nat. Med. , vol.6 , pp. 143-150
    • Iwata, N.1    Tsubuki, S.2    Takaki, Y.3    Watanabe, K.4    Sekiguchi, M.5    Hosoki, E.6
  • 65
    • 44649197748 scopus 로고    scopus 로고
    • ApoE promotes the proteolytic degradation of Abeta
    • doi: 10.1016/j.neuron.2008.04.010
    • Jiang, Q., Lee, C. Y., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., et al. (2008). ApoE promotes the proteolytic degradation of Abeta. Neuron 58, 681-693. doi: 10.1016/j.neuron.2008.04.010.
    • (2008) Neuron , vol.58 , pp. 681-693
    • Jiang, Q.1    Lee, C.Y.2    Mandrekar, S.3    Wilkinson, B.4    Cramer, P.5    Zelcer, N.6
  • 66
    • 79951536222 scopus 로고    scopus 로고
    • alpha-Synuclein negatively regulates protein kinase Cdelta expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity
    • doi: 10.1523/JNEUROSCI.5634-10.2011
    • Jin, H., Kanthasamy, A., Ghosh, A., Yang, Y., Anantharam, V., and Kanthasamy, A. G. (2011). alpha-Synuclein negatively regulates protein kinase Cdelta expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J. Neurosci. 31, 2035-2051. doi: 10.1523/JNEUROSCI.5634-10.2011.
    • (2011) J. Neurosci. , vol.31 , pp. 2035-2051
    • Jin, H.1    Kanthasamy, A.2    Ghosh, A.3    Yang, Y.4    Anantharam, V.5    Kanthasamy, A.G.6
  • 67
    • 77951842993 scopus 로고    scopus 로고
    • Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains
    • doi: 10.1523/JNEUROSCI.6119-09.2010
    • Jowaed, A., Schmitt, I., Kaut, O., and Wullner, U. (2010). Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains. J. Neurosci. 30, 6355-6359. doi: 10.1523/JNEUROSCI.6119-09.2010.
    • (2010) J. Neurosci. , vol.30 , pp. 6355-6359
    • Jowaed, A.1    Schmitt, I.2    Kaut, O.3    Wullner, U.4
  • 68
    • 44649194410 scopus 로고    scopus 로고
    • CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma
    • doi: 10.1016/j.juro.2008.02.044
    • Kagara, I., Enokida, H., Kawakami, K., Matsuda, R., Toki, K., Nishimura, H., et al. (2008). CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma. J. Urology 180, 343-351. doi: 10.1016/j.juro.2008.02.044.
    • (2008) J. Urology , vol.180 , pp. 343-351
    • Kagara, I.1    Enokida, H.2    Kawakami, K.3    Matsuda, R.4    Toki, K.5    Nishimura, H.6
  • 69
    • 1342284214 scopus 로고    scopus 로고
    • DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia
    • doi: 10.1002/gps.1042
    • Kalbe, E., Kessler, J., Calabrese, P., Smith, R., Passmore, A. P., Brand, M., et al. (2004). DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia. Int. J. Geriatr. Psychiatry 19, 136-143. doi: 10.1002/gps.1042.
    • (2004) Int. J. Geriatr. Psychiatry , vol.19 , pp. 136-143
    • Kalbe, E.1    Kessler, J.2    Calabrese, P.3    Smith, R.4    Passmore, A.P.5    Brand, M.6
  • 70
    • 84861317766 scopus 로고    scopus 로고
    • Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1
    • doi: 10.1007/s10048-011-0308-3
    • Kaut, O., Schmitt, I., and Wullner, U. (2012). Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1. Neurogenetics 13, 87-91. doi: 10.1007/s10048-011-0308-3.
    • (2012) Neurogenetics , vol.13 , pp. 87-91
    • Kaut, O.1    Schmitt, I.2    Wullner, U.3
  • 71
    • 37649003389 scopus 로고    scopus 로고
    • Neuroglobin attenuates-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo
    • doi: 10.1073/pnas.0706167104
    • Khan, A. A., Mao, X. O., Banwait, S., Jin, K., and Greenberg, D. A. (2007). Neuroglobin attenuates-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo. Proc. Natl. Acad. Sci. U.S.A. 104, 19114-19119. doi: 10.1073/pnas.0706167104.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 19114-19119
    • Khan, A.A.1    Mao, X.O.2    Banwait, S.3    Jin, K.4    Greenberg, D.A.5
  • 72
    • 79952486262 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis
    • doi: 10.1016/S0140-6736(10)61156-7
    • Kiernan, M., Vucic, S., Cheah, B., Turner, M., Eisen, A., Hardiman, O., et al. (2011). Amyotrophic lateral sclerosis. Lancet 377, 942-955. doi: 10.1016/S0140-6736(10)61156-7.
    • (2011) Lancet , vol.377 , pp. 942-955
    • Kiernan, M.1    Vucic, S.2    Cheah, B.3    Turner, M.4    Eisen, A.5    Hardiman, O.6
  • 73
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of INK4/ARF in cancer and aging
    • doi: 10.1016/j.cell.2006.10.003
    • Kim, W. Y., and Sharpless, N. E. (2006). The regulation of INK4/ARF in cancer and aging. Cell 127, 265-275. doi: 10.1016/j.cell.2006.10.003.
    • (2006) Cell , vol.127 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2
  • 74
    • 84864589889 scopus 로고    scopus 로고
    • 5'-Aza-dC sensitizes paraquat toxic effects on PC12 cell
    • doi: 10.1016/j.neulet.2012.07.001
    • Kong, M., Ba, M., Liang, H., Ma, L., Yu, Q., Yu, T., et al. (2012). 5'-Aza-dC sensitizes paraquat toxic effects on PC12 cell. Neurosci. Lett. 524, 35-39. doi: 10.1016/j.neulet.2012.07.001.
    • (2012) Neurosci. Lett. , vol.524 , pp. 35-39
    • Kong, M.1    Ba, M.2    Liang, H.3    Ma, L.4    Yu, Q.5    Yu, T.6
  • 75
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • doi: 10.1126/science.1169786
    • Kriaucionis, S., and Heintz, N. (2009). The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324, 929-930. doi: 10.1126/science.1169786.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 76
    • 0028176821 scopus 로고
    • Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
    • doi: 10.1016/0014-5793(94)00387-4
    • Kurochkin, I. V., and Goto, S. (1994). Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett. 345, 33-37. doi: 10.1016/0014-5793(94)00387-4.
    • (1994) FEBS Lett. , vol.345 , pp. 33-37
    • Kurochkin, I.V.1    Goto, S.2
  • 77
    • 84855300158 scopus 로고    scopus 로고
    • Genomer-wide epigenetic regulation by early-life trauma
    • doi: 10.1001/archgenpsychiatry.2011.2287
    • Labonte, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I., et al. (2012). Genomer-wide epigenetic regulation by early-life trauma. Arch. Gen. Psychiatry 69, 722-731. doi: 10.1001/archgenpsychiatry.2011.2287.
    • (2012) Arch. Gen. Psychiatry , vol.69 , pp. 722-731
    • Labonte, B.1    Suderman, M.2    Maussion, G.3    Navaro, L.4    Yerko, V.5    Mahar, I.6
  • 78
    • 84860843024 scopus 로고    scopus 로고
    • Epigenetics DNA methylation in the core ataxin-2 gene promoter: novel physiological and pathological implications
    • doi: 10.1007/s00439-011-1101-y
    • Laffita-Mesa, J., Bauer, P., Kouri, V., Serrano, L., Roskams, J., Gotay, D., et al. (2012). Epigenetics DNA methylation in the core ataxin-2 gene promoter: novel physiological and pathological implications. Hum. Genet. 131, 625-638. doi: 10.1007/s00439-011-1101-y.
    • (2012) Hum. Genet. , vol.131 , pp. 625-638
    • Laffita-Mesa, J.1    Bauer, P.2    Kouri, V.3    Serrano, L.4    Roskams, J.5    Gotay, D.6
  • 79
    • 84863007261 scopus 로고    scopus 로고
    • The "LEARn" (latent early-life associated regulation) model: an epigenetic pathway linking metabolic and cognitive disorders
    • doi: 10.3233/JAD-2012-120373
    • Lahiri, D. K., and Maloney, B. (2012). The "LEARn" (latent early-life associated regulation) model: an epigenetic pathway linking metabolic and cognitive disorders. J. Alzheimers Dis. 30(Suppl. 2), S15-S30. doi: 10.3233/JAD-2012-120373.
    • (2012) J. Alzheimers Dis. , vol.30 , Issue.SUPPL. 2
    • Lahiri, D.K.1    Maloney, B.2
  • 80
    • 56049100240 scopus 로고    scopus 로고
    • Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model
    • doi: 10.1007/s10522-008-9162-6
    • Lahiri, D. K., Zawia, N. H., Greig, N. H., Sambamurti, K., and Maloney, B. (2008). Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model. Biogerontology 9, 375-379. doi: 10.1007/s10522-008-9162-6.
    • (2008) Biogerontology , vol.9 , pp. 375-379
    • Lahiri, D.K.1    Zawia, N.H.2    Greig, N.H.3    Sambamurti, K.4    Maloney, B.5
  • 81
    • 84865176096 scopus 로고    scopus 로고
    • ATXN2 and its neighbouring gene SH2B3 are associated with increased ALS risk in the Turkish population
    • doi: 10.1371/journal.pone.0042956
    • Lahut, S., Omur, O., Uyan, O., Agim, Z. S., Ozoguz, A., Parman, Y., et al. (2012). ATXN2 and its neighbouring gene SH2B3 are associated with increased ALS risk in the Turkish population. PLoS ONE 7:e42956. doi: 10.1371/journal.pone.0042956.
    • (2012) PLoS ONE , vol.7
    • Lahut, S.1    Omur, O.2    Uyan, O.3    Agim, Z.S.4    Ozoguz, A.5    Parman, Y.6
  • 82
    • 57149089871 scopus 로고    scopus 로고
    • CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination
    • doi: 10.1371/journal.pgen.1000257
    • Libby, R. T., Hagerman, K. A., Pineda, V. V., Lau, R., Cho, D. H., Baccam, S. L., et al. (2008). CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination. PLoS Genet. 4:e1000257. doi: 10.1371/journal.pgen.1000257.
    • (2008) PLoS Genet. , vol.4
    • Libby, R.T.1    Hagerman, K.A.2    Pineda, V.V.3    Lau, R.4    Cho, D.H.5    Baccam, S.L.6
  • 83
    • 84858623502 scopus 로고    scopus 로고
    • S-Adenosylhomocysteine enhances DNA damage through increased beta-amyloid formation and inhibition of the DNA-repair enzyme OGG1b in microglial BV-2 cells
    • doi: 10.1016/j.tox.2011.10.016
    • Lin, H. C., Song, T. Y., and Hu, M. L. (2011). S-Adenosylhomocysteine enhances DNA damage through increased beta-amyloid formation and inhibition of the DNA-repair enzyme OGG1b in microglial BV-2 cells. Toxicology 290, 342-349. doi: 10.1016/j.tox.2011.10.016.
    • (2011) Toxicology , vol.290 , pp. 342-349
    • Lin, H.C.1    Song, T.Y.2    Hu, M.L.3
  • 84
    • 84855333470 scopus 로고    scopus 로고
    • Promoter methylation analysis of seven clock genes in Parkinson's disease
    • doi: 10.1016/j.neulet.2011.12.007
    • Lin, Q., Ding, H., Zheng, Z., Gu, Z., Ma, J., Chen, L., et al. (2012). Promoter methylation analysis of seven clock genes in Parkinson's disease. Neurosci. Lett. 507, 147-150. doi: 10.1016/j.neulet.2011.12.007.
    • (2012) Neurosci. Lett. , vol.507 , pp. 147-150
    • Lin, Q.1    Ding, H.2    Zheng, Z.3    Gu, Z.4    Ma, J.5    Chen, L.6
  • 85
    • 84879663784 scopus 로고    scopus 로고
    • Global epigenomic reconfiguration during mammalian brain development
    • doi: 10.1126/science.1237905
    • Lister, R., Mukamel, E. A., Nery, J. R., Urich, M., Puddifoot, C. A., Johnson, N. D., et al. (2013). Global epigenomic reconfiguration during mammalian brain development. Science 341, 1237905. doi: 10.1126/science.1237905.
    • (2013) Science , vol.341 , pp. 1237905
    • Lister, R.1    Mukamel, E.A.2    Nery, J.R.3    Urich, M.4    Puddifoot, C.A.5    Johnson, N.D.6
  • 86
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • doi: 10.1038/nature08514
    • Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., et al. (2009). Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462, 315-322. doi: 10.1038/nature08514.
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1    Pelizzola, M.2    Dowen, R.H.3    Hawkins, R.D.4    Hon, G.5    Tonti-Filippini, J.6
  • 87
    • 41549090375 scopus 로고    scopus 로고
    • A pilot study for circadian gene disturbance in dementia patients
    • doi: 10.1016/j.neulet.2008.02.041
    • Liu, H. C., Hu, C. J., Tang, Y. C., and Chang, J. G. (2008). A pilot study for circadian gene disturbance in dementia patients. Neurosci. Lett. 435, 229-233. doi: 10.1016/j.neulet.2008.02.041.
    • (2008) Neurosci. Lett. , vol.435 , pp. 229-233
    • Liu, H.C.1    Hu, C.J.2    Tang, Y.C.3    Chang, J.G.4
  • 88
    • 68949123246 scopus 로고    scopus 로고
    • Aging-associated alteration of subtelomeric methylation in Parkinson's disease
    • doi: 10.1093/gerona/glp070
    • Maeda, T., Guan, J. Z., Oyama, J., Higuchi, Y., and Makino, N. (2009). Aging-associated alteration of subtelomeric methylation in Parkinson's disease. J. Gerontol. A Biol. Sci. Med. Sci. 64, 949-955. doi: 10.1093/gerona/glp070.
    • (2009) J. Gerontol. A Biol. Sci. Med. Sci. , vol.64 , pp. 949-955
    • Maeda, T.1    Guan, J.Z.2    Oyama, J.3    Higuchi, Y.4    Makino, N.5
  • 89
    • 78650179659 scopus 로고    scopus 로고
    • Epigenetic changes in Alzheimer's disease: decrements in DNA methylation
    • doi: 10.1016/j.neurobiolaging.2008.12.005
    • Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C., Coleman, P. D., and Rogers, J. (2010). Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol. Aging 31, 2025-2037. doi: 10.1016/j.neurobiolaging.2008.12.005.
    • (2010) Neurobiol. Aging , vol.31 , pp. 2025-2037
    • Mastroeni, D.1    Grover, A.2    Delvaux, E.3    Whiteside, C.4    Coleman, P.D.5    Rogers, J.6
  • 90
    • 79958769568 scopus 로고    scopus 로고
    • Epigenetic mechanisms in Alzheimer's disease
    • doi: 10.1016/j.neurobiolaging.2010.08.017
    • Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C., Coleman, P. D., and Rogers, J. (2011). Epigenetic mechanisms in Alzheimer's disease. Neurobiol. Aging 32, 1161-1180. doi: 10.1016/j.neurobiolaging.2010.08.017.
    • (2011) Neurobiol. Aging , vol.32 , pp. 1161-1180
    • Mastroeni, D.1    Grover, A.2    Delvaux, E.3    Whiteside, C.4    Coleman, P.D.5    Rogers, J.6
  • 91
    • 68949096744 scopus 로고    scopus 로고
    • Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
    • doi: 10.1371/journal.pone.0006617
    • Mastroeni, D., Mckee, A., Grover, A., Rogers, J., and Coleman, P. (2009). Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS ONE 4:e6617. doi: 10.1371/journal.pone.0006617.
    • (2009) PLoS ONE , vol.4
    • Mastroeni, D.1    Mckee, A.2    Grover, A.3    Rogers, J.4    Coleman, P.5
  • 92
    • 78649652766 scopus 로고    scopus 로고
    • CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease
    • doi: 10.1371/journal.pone.0015522
    • Matsumoto, L., Takuma, H., Tamaoka, A., Kurisaki, H., Date, H., Tsuji, S., et al. (2010). CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease. PLoS ONE 5:e15522. doi: 10.1371/journal.pone.0015522.
    • (2010) PLoS ONE , vol.5
    • Matsumoto, L.1    Takuma, H.2    Tamaoka, A.3    Kurisaki, H.4    Date, H.5    Tsuji, S.6
  • 93
    • 0034708767 scopus 로고    scopus 로고
    • Membrane association and protein conformation of alpha-synuclein in intact neurons-effect of Parkinson's disease-linked mutations
    • doi: 10.1074/jbc.275.12.8812
    • Mclean, P. J., Kawamata, H., Ribich, S., and Hyman, B. T. (2000). Membrane association and protein conformation of alpha-synuclein in intact neurons-effect of Parkinson's disease-linked mutations. J. Biol. Chem. 275, 8812-8816. doi: 10.1074/jbc.275.12.8812.
    • (2000) J. Biol. Chem. , vol.275 , pp. 8812-8816
    • Mclean, P.J.1    Kawamata, H.2    Ribich, S.3    Hyman, B.T.4
  • 94
    • 41649096261 scopus 로고    scopus 로고
    • DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity
    • doi: 10.1016/j.nlm.2007.07.016
    • Miller, C. A., Campbell, S. L., and Sweatt, J. D. (2008). DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity. Neurobiol. Learn. Mem. 89, 599-603. doi: 10.1016/j.nlm.2007.07.016.
    • (2008) Neurobiol. Learn. Mem. , vol.89 , pp. 599-603
    • Miller, C.A.1    Campbell, S.L.2    Sweatt, J.D.3
  • 95
    • 0028220787 scopus 로고
    • Vitamin B-6 deficiency vs. folate deficiency: comparison of responses to methionine loading in rats
    • Miller, J., Nadeau, M., Smith, D., and Selhub, J. (1994). Vitamin B-6 deficiency vs. folate deficiency: comparison of responses to methionine loading in rats. Am. J. Clin. Nutr. 59, 1033-1039.
    • (1994) Am. J. Clin. Nutr. , vol.59 , pp. 1033-1039
    • Miller, J.1    Nadeau, M.2    Smith, D.3    Selhub, J.4
  • 96
    • 78649666051 scopus 로고    scopus 로고
    • Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function
    • doi: 10.1074/jbc. M110.146258
    • Minagawa, H., Watanabe, A., Akatsu, H., Adachi, K., Ohtsuka, C., Terayama, Y., et al. (2010). Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function. J. Biol. Chem. 285, 38382-38388. doi: 10.1074/jbc. M110.146258.
    • (2010) J. Biol. Chem. , vol.285 , pp. 38382-38388
    • Minagawa, H.1    Watanabe, A.2    Akatsu, H.3    Adachi, K.4    Ohtsuka, C.5    Terayama, Y.6
  • 97
    • 0030582991 scopus 로고    scopus 로고
    • Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease
    • doi: 10.1016/0304-3940(96)12706-3
    • Mogi, M., Harada, M., Narabayashi, H., Inagaki, H., Minami, M., and Nagatsu, T. (1996). Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease. Neurosci. Lett. 211, 13-16. doi: 10.1016/0304-3940(96)12706-3.
    • (1996) Neurosci. Lett. , vol.211 , pp. 13-16
    • Mogi, M.1    Harada, M.2    Narabayashi, H.3    Inagaki, H.4    Minami, M.5    Nagatsu, T.6
  • 98
    • 33845387531 scopus 로고    scopus 로고
    • Are metallothionein genes silenced in ALS?
    • doi: 10.1016/j.toxlet.2006.11.003
    • Morahan, J. M., Yu, B., Trent, R. J., and Pamphlett, R. (2007). Are metallothionein genes silenced in ALS? Toxicol. Lett. 168, 83-87. doi: 10.1016/j.toxlet.2006.11.003.
    • (2007) Toxicol. Lett. , vol.168 , pp. 83-87
    • Morahan, J.M.1    Yu, B.2    Trent, R.J.3    Pamphlett, R.4
  • 99
    • 70450158919 scopus 로고    scopus 로고
    • A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis
    • doi: 10.3109/17482960802635397
    • Morahan, J. M., Yu, B., Trent, R. J., and Pamphlett, R. (2009). A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 10, 418-429. doi: 10.3109/17482960802635397.
    • (2009) Amyotroph Lateral Scler. , vol.10 , pp. 418-429
    • Morahan, J.M.1    Yu, B.2    Trent, R.J.3    Pamphlett, R.4
  • 100
    • 84873477433 scopus 로고    scopus 로고
    • Extensive changes in DNA methylation are associated with expression of mutant huntingtin
    • doi: 10.1073/pnas.1221292110
    • Ng, C. W., Yildirim, F., Yap, Y. S., Dalin, S., Matthews, B. J., Velez, P. J., et al. (2013). Extensive changes in DNA methylation are associated with expression of mutant huntingtin. Proc. Natl. Acad. Sci. U.S.A. 110, 2354-2359. doi: 10.1073/pnas.1221292110.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 2354-2359
    • Ng, C.W.1    Yildirim, F.2    Yap, Y.S.3    Dalin, S.4    Matthews, B.J.5    Velez, P.J.6
  • 101
    • 77149130504 scopus 로고    scopus 로고
    • B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A
    • doi: 10.3233/JAD-2010-1284
    • Nicolia, V., Fuso, A., Cavallaro, R. A., Di Luzio, A., and Scarpa, S. (2010). B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A. J. Alzheimers Dis. 19, 895-907. doi: 10.3233/JAD-2010-1284.
    • (2010) J. Alzheimers Dis. , vol.19 , pp. 895-907
    • Nicolia, V.1    Fuso, A.2    Cavallaro, R.A.3    Di Luzio, A.4    Scarpa, S.5
  • 102
    • 34247182685 scopus 로고    scopus 로고
    • An epigenetic analysis of SOD1 and VEGF in ALS
    • doi: 10.1080/17482960601149160
    • Oates, N., and Pamphlett, R. (2007). An epigenetic analysis of SOD1 and VEGF in ALS. Amyotroph. Lateral Scler. 8, 83-86. doi: 10.1080/17482960601149160.
    • (2007) Amyotroph. Lateral Scler. , vol.8 , pp. 83-86
    • Oates, N.1    Pamphlett, R.2
  • 103
    • 70349678703 scopus 로고    scopus 로고
    • Methylation status and neurodegenerative markers in Parkinson disease
    • doi: 10.1373/clinchem.2009.125021
    • Obeid, R., Schadt, A., Dillmann, U., Kostopoulos, P., Fassbender, K., and Herrmann, W. (2009). Methylation status and neurodegenerative markers in Parkinson disease. Clin. Chem. 55, 1852-1860. doi: 10.1373/clinchem.2009.125021.
    • (2009) Clin. Chem. , vol.55 , pp. 1852-1860
    • Obeid, R.1    Schadt, A.2    Dillmann, U.3    Kostopoulos, P.4    Fassbender, K.5    Herrmann, W.6
  • 104
    • 32544435097 scopus 로고    scopus 로고
    • The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments
    • doi: 10.1523/JNEUROSCI.4946-05.2006
    • Offe, K., Dodson, S. E., Shoemaker, J. T., Fritz, J. J., Gearing, M., Levey, A. I., et al. (2006). The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J. Neurosci. 26, 1596-1603. doi: 10.1523/JNEUROSCI.4946-05.2006.
    • (2006) J. Neurosci. , vol.26 , pp. 1596-1603
    • Offe, K.1    Dodson, S.E.2    Shoemaker, J.T.3    Fritz, J.J.4    Gearing, M.5    Levey, A.I.6
  • 105
    • 2942525889 scopus 로고    scopus 로고
    • Elevated plasma homocysteine level in patients with Parkinson disease
    • doi: 10.1001/archneur.61.6.865
    • O'Suilleabhain, P. E., Sung, V., Hernandez, C., Lacritz, L., Dewey, B. R., Bottiglieri, T., et al. (2004). Elevated plasma homocysteine level in patients with Parkinson disease. Arch. Neurol. 61, 865-868. doi: 10.1001/archneur.61.6.865.
    • (2004) Arch. Neurol. , vol.61 , pp. 865-868
    • O'Suilleabhain, P.E.1    Sung, V.2    Hernandez, C.3    Lacritz, L.4    Dewey, B.R.5    Bottiglieri, T.6
  • 106
    • 79960790803 scopus 로고    scopus 로고
    • Diet, nutrition and telomere length
    • doi: 10.1016/j.jnutbio.2010.12.001
    • Paul, L. (2011). Diet, nutrition and telomere length. J. Nutr. Biochem. 22, 895-901. doi: 10.1016/j.jnutbio.2010.12.001.
    • (2011) J. Nutr. Biochem. , vol.22 , pp. 895-901
    • Paul, L.1
  • 107
    • 67649961706 scopus 로고    scopus 로고
    • Telomere length in peripheral blood mononuclear cells is associated with folate status in men
    • doi: 10.3945/jn.109.104984
    • Paul, L., Cattaneo, M., D'Angelo, A., Sampietro, F., Fermo, I., Razzari, C., et al. (2009). Telomere length in peripheral blood mononuclear cells is associated with folate status in men. J. Nutr. 139, 1273-1278. doi: 10.3945/jn.109.104984.
    • (2009) J. Nutr. , vol.139 , pp. 1273-1278
    • Paul, L.1    Cattaneo, M.2    D'Angelo, A.3    Sampietro, F.4    Fermo, I.5    Razzari, C.6
  • 108
    • 0015298215 scopus 로고
    • Presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid
    • Penn, N. W., Suwalski, R., O'Riley, C., Bojanowski, K., and Yura, R. (1972). Presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem. J. 126, 781-790.
    • (1972) Biochem. J. , vol.126 , pp. 781-790
    • Penn, N.W.1    Suwalski, R.2    O'Riley, C.3    Bojanowski, K.4    Yura, R.5
  • 109
    • 56449115830 scopus 로고    scopus 로고
    • Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability
    • doi: 10.1016/j.nbd.2008.09.010
    • Pieper, H. C., Evert, B. O., Kaut, O., Riederer, P. F., Waha, A., and Wullner, U. (2008). Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability. Neurobiol. Dis. 32, 521-527. doi: 10.1016/j.nbd.2008.09.010.
    • (2008) Neurobiol. Dis. , vol.32 , pp. 521-527
    • Pieper, H.C.1    Evert, B.O.2    Kaut, O.3    Riederer, P.F.4    Waha, A.5    Wullner, U.6
  • 110
    • 79960688688 scopus 로고    scopus 로고
    • Epigenetic silencing of nucleolar rRNA genes in Alzheimer's disease
    • doi: 10.1371/journal.pone.0022585
    • Pietrzak, M., Rempala, G., Nelson, P. T., Zheng, J. J., and Hetman, M. (2011). Epigenetic silencing of nucleolar rRNA genes in Alzheimer's disease. PLoS ONE 6:e22585. doi: 10.1371/journal.pone.0022585.
    • (2011) PLoS ONE , vol.6
    • Pietrzak, M.1    Rempala, G.2    Nelson, P.T.3    Zheng, J.J.4    Hetman, M.5
  • 111
    • 79959851714 scopus 로고    scopus 로고
    • A two-stage meta-analysis identifies several new loci for Parkinson's disease
    • doi: 10.1371/journal.pgen.1002142
    • Plagnol, V., Nalls, M. A., Bras, J. M., Hernandez, D. G., Sharma, M., Sheerin, U. M., et al. (2011). A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet. 7:e1002142. doi: 10.1371/journal.pgen.1002142.
    • (2011) PLoS Genet. , vol.7
    • Plagnol, V.1    Nalls, M.A.2    Bras, J.M.3    Hernandez, D.G.4    Sharma, M.5    Sheerin, U.M.6
  • 112
    • 78650663065 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci
    • doi: 10.1074/jbc. M110.170704
    • Popkie, A. P., Zeidner, L. C., Albrecht, A. M., D'Ippolito, A., Eckardt, S., Newsom, D. E., et al. (2010). Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J. Biol. Chem. 285, 41337-41347. doi: 10.1074/jbc. M110.170704.
    • (2010) J. Biol. Chem. , vol.285 , pp. 41337-41347
    • Popkie, A.P.1    Zeidner, L.C.2    Albrecht, A.M.3    D'Ippolito, A.4    Eckardt, S.5    Newsom, D.E.6
  • 113
    • 0024710275 scopus 로고
    • Methylation at the Huntington disease-linked D4S95 locus
    • Pritchard, C. A., Cox, D. R., and Myers, R. M. (1989). Methylation at the Huntington disease-linked D4S95 locus. Am. J. Hum. Genet. 45, 335-336.
    • (1989) Am. J. Hum. Genet. , vol.45 , pp. 335-336
    • Pritchard, C.A.1    Cox, D.R.2    Myers, R.M.3
  • 114
    • 84863757162 scopus 로고    scopus 로고
    • Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients
    • doi: 10.1038/tp.2012.55
    • Rao, J. S., Keleshian, V. L., Klein, S., and Rapoport, S. I. (2012). Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Transl. Psychiatry 2:e132. doi: 10.1038/tp.2012.55.
    • (2012) Transl. Psychiatry , vol.2
    • Rao, J.S.1    Keleshian, V.L.2    Klein, S.3    Rapoport, S.I.4
  • 115
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • doi: 10.1126/science.1063443
    • Reik, W., Dean, W., and Walter, J. (2001). Epigenetic reprogramming in mammalian development. Science 293, 1089-1093. doi: 10.1126/science.1063443.
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 116
    • 0027461790 scopus 로고
    • Age at onset in Huntington's disease and methylation at D4S95
    • doi: 10.1136/jmg.30.3.185
    • Reik, W., Maher, E. R., Morrison, P. J., Harding, A. E., and Simpson, S. A. (1993). Age at onset in Huntington's disease and methylation at D4S95. J. Med. Genet. 30, 185-188. doi: 10.1136/jmg.30.3.185.
    • (1993) J. Med. Genet. , vol.30 , pp. 185-188
    • Reik, W.1    Maher, E.R.2    Morrison, P.J.3    Harding, A.E.4    Simpson, S.A.5
  • 117
    • 84859422631 scopus 로고    scopus 로고
    • No evidence for differential methylation of alpha-synuclein in leukocyte DNA of Parkinson's disease patients
    • doi: 10.1002/mds.24907
    • Richter, J., Appenzeller, S., Ammerpohl, O., Deuschl, G., Paschen, S., Brueggemann, N., et al. (2012). No evidence for differential methylation of alpha-synuclein in leukocyte DNA of Parkinson's disease patients. Movement Disord. 27, 590-591. doi: 10.1002/mds.24907.
    • (2012) Movement Disord. , vol.27 , pp. 590-591
    • Richter, J.1    Appenzeller, S.2    Ammerpohl, O.3    Deuschl, G.4    Paschen, S.5    Brueggemann, N.6
  • 118
    • 84875441083 scopus 로고    scopus 로고
    • The changing scene of amyotrophic lateral sclerosis
    • doi: 10.1038/nrn3430
    • Robberecht, W., and Philips, T. (2013). The changing scene of amyotrophic lateral sclerosis. Nat. Rev. Neurosci. 14, 248-264. doi: 10.1038/nrn3430.
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 248-264
    • Robberecht, W.1    Philips, T.2
  • 119
    • 0029263413 scopus 로고
    • Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease
    • 45-41
    • Roses, A. D., Saunders, A. M., Corder, E. H., Pericakvance, M. A., Han, S. H., Einstein, G., et al. (1995). Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease. Arzneimittelforschung 45-41, 413-417.
    • (1995) Arzneimittelforschung , pp. 413-417
    • Roses, A.D.1    Saunders, A.M.2    Corder, E.H.3    Pericakvance, M.A.4    Han, S.H.5    Einstein, G.6
  • 120
    • 0029030610 scopus 로고
    • Selective loss of glial glutamate transporter GLT-1 in amyotrophiclateral-sclerosis
    • doi: 10.1002/ana.410380114
    • Rothstein, J. D., Vankammen, M., Levey, A. I., Martin, L. J., and Kuncl, R. W. (1995). Selective loss of glial glutamate transporter GLT-1 in amyotrophiclateral-sclerosis. Ann. Neurol. 38, 73-84. doi: 10.1002/ana.410380114.
    • (1995) Ann. Neurol. , vol.38 , pp. 73-84
    • Rothstein, J.D.1    Vankammen, M.2    Levey, A.I.3    Martin, L.J.4    Kuncl, R.W.5
  • 121
    • 84855499458 scopus 로고    scopus 로고
    • Huntington's disease: molecular basis of neurodegeneration
    • doi: 10.1017/S1462399403006549
    • Rubinsztein, D. C., and Carmichael, J. (2004). Huntington's disease: molecular basis of neurodegeneration. Expert Rev. Mol. Med. 5, 1-21. doi: 10.1017/S1462399403006549.
    • (2004) Expert Rev. Mol. Med. , vol.5 , pp. 1-21
    • Rubinsztein, D.C.1    Carmichael, J.2
  • 122
    • 33747449599 scopus 로고    scopus 로고
    • Gene silencing through methylation: an epigenetic intervention on Alzheimer disease
    • Scarpa, S., Cavallaro, R. A., D'Anselmi, F., and Fuso, A. (2006). Gene silencing through methylation: an epigenetic intervention on Alzheimer disease. J. Alzheimers Dis. 9, 407-414.
    • (2006) J. Alzheimers Dis. , vol.9 , pp. 407-414
    • Scarpa, S.1    Cavallaro, R.A.2    D'Anselmi, F.3    Fuso, A.4
  • 123
    • 0037464488 scopus 로고    scopus 로고
    • Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?
    • doi: 10.1016/S0014-5793(03)00277-1
    • Scarpa, S., Fuso, A., D'Anselmi, F., and Cavallaro, R. A. (2003). Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease? FEBS Lett. 541, 145-148. doi: 10.1016/S0014-5793(03)00277-1.
    • (2003) FEBS Lett. , vol.541 , pp. 145-148
    • Scarpa, S.1    Fuso, A.2    D'Anselmi, F.3    Cavallaro, R.A.4
  • 124
    • 0037075257 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    • doi: 10.1056/NEJMoa011613
    • Seshadri, S., Beiser, A., Selhub, J., Jacques, P. F., Rosenberg, I. H., D'Agostino, R. B., et al. (2002). Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. New Engl. J. Med. 346, 476-483. doi: 10.1056/NEJMoa011613.
    • (2002) New Engl. J. Med. , vol.346 , pp. 476-483
    • Seshadri, S.1    Beiser, A.2    Selhub, J.3    Jacques, P.F.4    Rosenberg, I.H.5    D'Agostino, R.B.6
  • 125
    • 41149090082 scopus 로고    scopus 로고
    • DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
    • doi: 10.1371/journal.pone.0000895
    • Siegmund, K. D., Connor, C. M., Campan, M., Long, T. I., Weisenberger, D. J., Biniszkiewicz, D., et al. (2007). DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS ONE 2:e895. doi: 10.1371/journal.pone.0000895.
    • (2007) PLoS ONE , vol.2
    • Siegmund, K.D.1    Connor, C.M.2    Campan, M.3    Long, T.I.4    Weisenberger, D.J.5    Biniszkiewicz, D.6
  • 126
    • 84872452263 scopus 로고    scopus 로고
    • CNP and DPYSL2 mRNA expression and promoter methylation levels in brain of Alzheimer's disease patients
    • doi: 10.3233/JAD-2012-121192
    • Silva, P. N., Furuya, T. K., Sampaio Braga, I., Rasmussen, L. T., de Labio, R. W., Bertolucci, P. H., et al. (2013). CNP and DPYSL2 mRNA expression and promoter methylation levels in brain of Alzheimer's disease patients. J. Alzheimers Dis. 33, 349-355. doi: 10.3233/JAD-2012-121192.
    • (2013) J. Alzheimers Dis. , vol.33 , pp. 349-355
    • Silva, P.N.1    Furuya, T.K.2    Sampaio Braga, I.3    Rasmussen, L.T.4    de Labio, R.W.5    Bertolucci, P.H.6
  • 127
    • 44849107824 scopus 로고    scopus 로고
    • Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease
    • Silva, P. N. O., Gigek, C. O., Leal, M. F., Bertolucci, P. H. F., de Labio, R. W., Payao, S. L. M., et al. (2008). Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease. J. Alzheimers Dis. 13, 173-176.
    • (2008) J. Alzheimers Dis. , vol.13 , pp. 173-176
    • Silva, P.N.O.1    Gigek, C.O.2    Leal, M.F.3    Bertolucci, P.H.F.4    de Labio, R.W.5    Payao, S.L.M.6
  • 128
  • 129
    • 80555122780 scopus 로고    scopus 로고
    • Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell line
    • doi: 10.1016/j.bbrc.2011.09.136
    • Sung, H. Y., Choi, E. N., Ahn Jo, S., Oh, S., and Ahn, J. H. (2011). Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell line. Biochem. Biophys. Res. Commun. 414, 700-705. doi: 10.1016/j.bbrc.2011.09.136.
    • (2011) Biochem. Biophys. Res. Commun. , vol.414 , pp. 700-705
    • Sung, H.Y.1    Choi, E.N.2    Ahn Jo, S.3    Oh, S.4    Ahn, J.H.5
  • 130
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • doi: 10.1126/science.1170116
    • Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., et al. (2009). Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935. doi: 10.1126/science.1170116.
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3    Pastor, W.A.4    Bandukwala, H.5    Brudno, Y.6
  • 131
    • 84875354777 scopus 로고    scopus 로고
    • 2013 Alzheimer's disease facts and figures
    • doi: 10.1016/j.jalz.2013.02.003
    • Thies, W., Bleiler, L., and Assoc, A. S. (2013). 2013 Alzheimer's disease facts and figures. Alzheimers Dement. 9, 208-245. doi: 10.1016/j.jalz.2013.02.003.
    • (2013) Alzheimers Dement. , vol.9 , pp. 208-245
    • Thies, W.1    Bleiler, L.2    Assoc, A.S.3
  • 132
    • 84875046091 scopus 로고    scopus 로고
    • A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease
    • doi: 10.1016/j.ab.2013.01.035
    • Thomas, B., Matson, S., Chopra, V., Sun, L., Sharma, S., Hersch, S., et al. (2013). A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease. Anal. Biochem. 436, 112-120. doi: 10.1016/j.ab.2013.01.035.
    • (2013) Anal. Biochem. , vol.436 , pp. 112-120
    • Thomas, B.1    Matson, S.2    Chopra, V.3    Sun, L.4    Sharma, S.5    Hersch, S.6
  • 133
    • 79251644774 scopus 로고    scopus 로고
    • Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease
    • doi: 10.1371/journal.pone.0016266
    • Twine, N. A., Janitz, K., Wilkins, M. R., and Janitz, M. (2011). Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease. PLoS ONE 6:e16266. doi: 10.1371/journal.pone.0016266.
    • (2011) PLoS ONE , vol.6
    • Twine, N.A.1    Janitz, K.2    Wilkins, M.R.3    Janitz, M.4
  • 134
    • 70449725209 scopus 로고    scopus 로고
    • Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies
    • doi: 10.1016/S1474-4422(09)70262-5
    • Urdinguio, R. G., Sanchez-Mut, J. V., and Esteller, M. (2009). Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol. 8, 1056-1072. doi: 10.1016/S1474-4422(09)70262-5.
    • (2009) Lancet Neurol. , vol.8 , pp. 1056-1072
    • Urdinguio, R.G.1    Sanchez-Mut, J.V.2    Esteller, M.3
  • 135
    • 84861118285 scopus 로고    scopus 로고
    • The Role of 5-Hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies
    • van den Hove, D. L. A., Chouliaras, L., and Rutten, B. P. F. (2012). The Role of 5-Hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies. Curr. Alzheimer Res. 9, 545-549.
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 545-549
    • van den Hove, D.L.A.1    Chouliaras, L.2    Rutten, B.P.F.3
  • 136
    • 79951722994 scopus 로고    scopus 로고
    • Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ?4 allele
    • doi: 10.1016/S1474-4422(10)70306-9
    • van der Flier, W. M., Pijnenburg, Y.a. L., Fox, N. C., and Scheltens, P. (2011). Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ?4 allele. Lancet Neurol. 10, 280-288. doi: 10.1016/S1474-4422(10)70306-9.
    • (2011) Lancet Neurol. , vol.10 , pp. 280-288
    • van der Flier, W.M.1    Pijnenburg Y.a., L.2    Fox, N.C.3    Scheltens, P.4
  • 137
    • 84874546182 scopus 로고    scopus 로고
    • Epigenetic mechanisms in the development and maintenance of dopaminergic neurons
    • doi: 10.1242/dev.089359
    • van Heesbeen, H. J., Mesman, S., Veenvliet, J. V., and Smidt, M. P. (2013). Epigenetic mechanisms in the development and maintenance of dopaminergic neurons. Development 140, 1159-1169. doi: 10.1242/dev.089359.
    • (2013) Development , vol.140 , pp. 1159-1169
    • van Heesbeen, H.J.1    Mesman, S.2    Veenvliet, J.V.3    Smidt, M.P.4
  • 138
    • 84877744385 scopus 로고    scopus 로고
    • Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A(2A)R levels in Huntington's disease
    • doi: 10.1007/s12017-013-8219-0
    • Villar-Menendez, I., Blanch, M., Tyebji, S., Pereira-Veiga, T., Albasanz, J. L., Martin, M., et al. (2013). Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A(2A)R levels in Huntington's disease. Neuromol. Med. 15, 295-309. doi: 10.1007/s12017-013-8219-0.
    • (2013) Neuromol. Med. , vol.15 , pp. 295-309
    • Villar-Menendez, I.1    Blanch, M.2    Tyebji, S.3    Pereira-Veiga, T.4    Albasanz, J.L.5    Martin, M.6
  • 139
    • 77952711518 scopus 로고    scopus 로고
    • Allelic imbalance of expression and epigenetic regulation within the alpha-synuclein wild-type and p. Ala53Thr alleles in Parkinson disease
    • doi: 10.1002/humu.21248
    • Voutsinas, G. E., Stavrou, E. F., Karousos, G., Dasoula, A., Papachatzopoulou, A., Syrrou, M., et al. (2010). Allelic imbalance of expression and epigenetic regulation within the alpha-synuclein wild-type and p. Ala53Thr alleles in Parkinson disease. Hum. Mutat. 31, 685-691. doi: 10.1002/humu.21248.
    • (2010) Hum. Mutat. , vol.31 , pp. 685-691
    • Voutsinas, G.E.1    Stavrou, E.F.2    Karousos, G.3    Dasoula, A.4    Papachatzopoulou, A.5    Syrrou, M.6
  • 140
    • 33846225133 scopus 로고    scopus 로고
    • Huntington's disease
    • doi: 10.1016/S0140-6736(07)60111-1
    • Walker, F. O. (2007). Huntington's disease. Lancet 369, 218-228. doi: 10.1016/S0140-6736(07)60111-1.
    • (2007) Lancet , vol.369 , pp. 218-228
    • Walker, F.O.1
  • 141
    • 49949108971 scopus 로고    scopus 로고
    • Age-specific epigenetic drift in late-onset Alzheimer's disease
    • doi: 10.1371/journal.pone.0002698
    • Wang, S. C., Oelze, B., and Schumacher, A. (2008). Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS ONE 3:e2698. doi: 10.1371/journal.pone.0002698.
    • (2008) PLoS ONE , vol.3
    • Wang, S.C.1    Oelze, B.2    Schumacher, A.3
  • 142
    • 84874357192 scopus 로고    scopus 로고
    • A DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine, exacerbates neurotoxicity and upregulates Parkinson's disease-related genes in dopaminergic neurons
    • doi: 10.1111/cns.12059
    • Wang, Y., Wang, X., Li, R., Yang, Z. F., Wang, Y. Z., Gong, X. L., et al. (2013). A DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine, exacerbates neurotoxicity and upregulates Parkinson's disease-related genes in dopaminergic neurons. CNS Neurosci. Ther. 19, 183-190. doi: 10.1111/cns.12059.
    • (2013) CNS Neurosci. Ther. , vol.19 , pp. 183-190
    • Wang, Y.1    Wang, X.2    Li, R.3    Yang, Z.F.4    Wang, Y.Z.5    Gong, X.L.6
  • 143
    • 0023910824 scopus 로고
    • A highly polymorphic locus very tightly linked to the Huntington's disease gene
    • doi: 10.1038/332734a0
    • Wasmuth, J. J., Hewitt, J., Smith, B., Allard, D., Haines, J. L., Skarecky, D., et al. (1988). A highly polymorphic locus very tightly linked to the Huntington's disease gene. Nature 332, 734-736. doi: 10.1038/332734a0.
    • (1988) Nature , vol.332 , pp. 734-736
    • Wasmuth, J.J.1    Hewitt, J.2    Smith, B.3    Allard, D.4    Haines, J.L.5    Skarecky, D.6
  • 144
    • 38149024924 scopus 로고    scopus 로고
    • Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD
    • doi: 10.1523/JNEUROSCI.4405-07.2008
    • Wu, J., Basha, M. R., Brock, B., Cox, D. P., Cardozo-Pelaez, F., Mcpherson, C. A., et al. (2008). Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. J. Neurosci. 28, 3-9. doi: 10.1523/JNEUROSCI.4405-07.2008.
    • (2008) J. Neurosci. , vol.28 , pp. 3-9
    • Wu, J.1    Basha, M.R.2    Brock, B.3    Cox, D.P.4    Cardozo-Pelaez, F.5    Mcpherson, C.A.6
  • 145
    • 75849150180 scopus 로고    scopus 로고
    • Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1
    • doi: 10.1002/glia.20922
    • Yang, Y., Gozen, O., Vidensky, S., Robinson, M. B., and Rothstein, J. D. (2010). Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1. Glia 58, 277-286. doi: 10.1002/glia.20922.
    • (2010) Glia , vol.58 , pp. 277-286
    • Yang, Y.1    Gozen, O.2    Vidensky, S.3    Robinson, M.B.4    Rothstein, J.D.5
  • 146
    • 49649107454 scopus 로고    scopus 로고
    • Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors
    • doi: 10.1002/hep.22343
    • Yu, J., Tao, Q., Cheung, K. F., Jin, H., Poon, F. F., Wang, X., et al. (2008). Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors. Hepatology 48, 508-518. doi: 10.1002/hep.22343.
    • (2008) Hepatology , vol.48 , pp. 508-518
    • Yu, J.1    Tao, Q.2    Cheung, K.F.3    Jin, H.4    Poon, F.F.5    Wang, X.6
  • 147
    • 33847649977 scopus 로고    scopus 로고
    • Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody
    • doi: 10.1016/j.neuroscience.2006.12.028
    • Yu, S., Li, X., Liu, G., Han, J., Zhang, C., Li, Y., et al. (2007). Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody. Neuroscience 145, 539-555. doi: 10.1016/j.neuroscience.2006.12.028.
    • (2007) Neuroscience , vol.145 , pp. 539-555
    • Yu, S.1    Li, X.2    Liu, G.3    Han, J.4    Zhang, C.5    Li, Y.6
  • 148
    • 77951579326 scopus 로고    scopus 로고
    • Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice
    • doi: 10.1002/hipo.20658
    • Zajac, M. S., Pang, T. Y., Wong, N., Weinrich, B., Leang, L. S., Craig, J. M., et al. (2010). Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice. Hippocampus 20, 621-636. doi: 10.1002/hipo.20658.
    • (2010) Hippocampus , vol.20 , pp. 621-636
    • Zajac, M.S.1    Pang, T.Y.2    Wong, N.3    Weinrich, B.4    Leang, L.S.5    Craig, J.M.6
  • 149
    • 79957788312 scopus 로고    scopus 로고
    • Functional and sequence analysis of human neuroglobin gene promoter region
    • doi: 10.1016/j.bbagrm.2011.02.003
    • Zhang, W., Tian, Z., Sha, S., Cheng, L. Y. L., Philipsen, S., and Tan-Un, K.-C. (2011). Functional and sequence analysis of human neuroglobin gene promoter region. BBA 1809, 236-244. doi: 10.1016/j.bbagrm.2011.02.003.
    • (2011) BBA , vol.1809 , pp. 236-244
    • Zhang, W.1    Tian, Z.2    Sha, S.3    Cheng, L.Y.L.4    Philipsen, S.5    Tan-Un, K.-C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.