메뉴 건너뛰기




Volumn 13, Issue 4, 2011, Pages 310-320

Next-generation sequencing reveals regional differences of the α-synuclein methylation state independent of Lewy body disease

Author keywords

Alpha synuclein; Epigenetics; Lewy body disease; Methylation

Indexed keywords

ADULT; AGED; ALPHA SYNUCLEIN GENE; AMPLICON; ARTICLE; BRAIN REGION; BRAIN STEM; CINGULATE GYRUS; CONTROLLED STUDY; CPG ISLAND; DIFFUSE LEWY BODY DISEASE; DNA METHYLATION; EPIGENETICS; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; INTRON; LIMBIC CORTEX; MALE; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PUTAMEN; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SUBSTANTIA NIGRA; TEMPORAL CORTEX;

EID: 84855878253     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-011-8163-9     Document Type: Article
Times cited : (55)

References (46)
  • 1
    • 44249113558 scopus 로고    scopus 로고
    • Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease
    • DOI 10.1016/j.parkreldis.2007.09.005, PII S1353802007002052
    • Alvira, D., Ferrer, I., Gutierrez-Cuesta, J., Garcia-Castro, B., Pallas, M., & Camins, A. (2008). Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease. Parkinsonism Related Disorder, 14(4), 309-313. doi:10.1016/j.parkreldis.2007.09.005. (Pubitemid 351726515)
    • (2008) Parkinsonism and Related Disorders , vol.14 , Issue.4 , pp. 309-313
    • Alvira, D.1    Ferrer, I.2    Gutierrez-Cuesta, J.3    Garcia-Castro, B.4    Pallas, M.5    Camins, A.6
  • 2
    • 77950188650 scopus 로고    scopus 로고
    • Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models
    • doi:10.1007/s12031-009-9325-1
    • Asikainen, S., Rudgalvyte, M., Heikkinen, L., Louhiranta, K., Lakso, M., Wong, G., et al. (2010). Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models. Journal of Molecular Neuroscience, 41(1), 210-218. doi:10.1007/s12031-009-9325-1.
    • (2010) Journal of Molecular Neuroscience , vol.41 , Issue.1 , pp. 210-218
    • Asikainen, S.1    Rudgalvyte, M.2    Heikkinen, L.3    Louhiranta, K.4    Lakso, M.5    Wong, G.6
  • 3
    • 64349091471 scopus 로고    scopus 로고
    • Targeted and genome-scale strategies reveal genebody methylation signatures in human cells
    • doi:10.1038/nbt.1533
    • Ball, M. P., Li, J. B., Gao, Y., Lee, J. H., LeProust, E. M., Park, I. H., et al. (2009). Targeted and genome-scale strategies reveal genebody methylation signatures in human cells. Natural Biotechnology, 27(4), 361-368. doi:10.1038/nbt.1533.
    • (2009) Natural Biotechnology , vol.27 , Issue.4 , pp. 361-368
    • Ball, M.P.1    Li, J.B.2    Gao, Y.3    Lee, J.H.4    Le Proust, E.M.5    Park, I.H.6
  • 4
    • 27744577751 scopus 로고    scopus 로고
    • BiQ Analyzer: Visualization and quality control for DNA methylation data from bisulfite sequencing
    • DOI 10.1093/bioinformatics/bti652
    • Bock, C., Reither, S., Mikeska, T., Paulsen, M., Walter, J., & Lengauer, T. (2005). BiQ analyzer: Visualization and quality control for DNA methylation data from bisulfite sequencing. Bioinformatics, 21(21), 4067-4068. doi:10.1093/bioinformatics/bti652. (Pubitemid 41631851)
    • (2005) Bioinformatics , vol.21 , Issue.21 , pp. 4067-4068
    • Bock, C.1    Reither, S.2    Mikeska, T.3    Paulsen, M.4    Walter, J.5    Lengauer, T.6
  • 5
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • DOI 10.1016/S0197-4580(02)00065-9, PII S0197458002000659
    • Braak, H., Del Tredici, K., Rub, U., de Vos, R. A., Jansen Steur, E. N., & Braak, E. (2003). Staging of brain pathology related to sporadic Parkinson's disease. Neurobiology of Aging, 24(2), 197-211. (Pubitemid 36007810)
    • (2003) Neurobiology of Aging , vol.24 , Issue.2 , pp. 197-211
    • Braak, H.1    Del Tredici, K.2    Rub, U.3    De Vos, R.A.I.4    Jansen Steur, E.N.H.5    Braak, E.6
  • 6
    • 0023007801 scopus 로고
    • Purification and biochemical characterization of the promoter-specific transcription factor, Sp1
    • Briggs, M. R., Kadonaga, J. T., Bell, S. P., & Tjian, R. (1986). Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science, 234(4772), 47-52. (Pubitemid 17171544)
    • (1986) Science , vol.234 , Issue.4772 , pp. 47-52
    • Briggs, M.R.1    Kadonaga, J.T.2    Bell, S.P.3    Tjian, R.4
  • 7
    • 42649083650 scopus 로고    scopus 로고
    • Single-molecule polymerase chain reaction reduces bias: Application to DNA methylation analysis by bisulfite sequencing
    • doi:10.1016/j.ab.2008.02.026
    • Chhibber, A., & Schroeder, B. G. (2008). Single-molecule polymerase chain reaction reduces bias: Application to DNA methylation analysis by bisulfite sequencing. Analytical Biochemistry, 377(1), 46-54. doi:10.1016/j.ab.2008.02.026.
    • (2008) Analytical Biochemistry , vol.377 , Issue.1 , pp. 46-54
    • Chhibber, A.1    Schroeder, B.G.2
  • 8
    • 0029086190 scopus 로고
    • Association of p107 with Sp1: Genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription
    • Datta, P. K., Raychaudhuri, P., & Bagchi, S. (1995). Association of p107 with Sp1: Genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription. Molecular and Cellular Biology, 15(10), 5444-5452.
    • (1995) Molecular and Cellular Biology , vol.15 , Issue.10 , pp. 5444-5452
    • Datta, P.K.1    Raychaudhuri, P.2    Bagchi, S.3
  • 9
    • 79953178935 scopus 로고    scopus 로고
    • Alpha-synuclein sequesters DNMT1 from the nucleus: A novel mechanism for epigenetic alterations in Lewy body diseases
    • doi:10.1074/jbc.C110.212589
    • Desplats, P., Spencer, B., Coffee, E., Patel, P., Michael, S., Patrick, C., et al. (2011). Alpha-synuclein sequesters DNMT1 from the nucleus: A novel mechanism for epigenetic alterations in Lewy body diseases. Journal of Biological Chemistry, 286(11), 9031-9037. doi:10.1074/jbc.C110.212589.
    • (2011) Journal of Biological Chemistry , vol.286 , Issue.11 , pp. 9031-9037
    • Desplats, P.1    Spencer, B.2    Coffee, E.3    Patel, P.4    Michael, S.5    Patrick, C.6
  • 10
    • 77951249562 scopus 로고    scopus 로고
    • Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153
    • doi:10.1074/jbc.M109.086827
    • Doxakis, E. (2010). Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153. Journal of Biological Chemistry, 285(17), 12726-12734. doi:10.1074/jbc.M109.086827.
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.17 , pp. 12726-12734
    • Doxakis, E.1
  • 11
    • 77954208049 scopus 로고    scopus 로고
    • Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation
    • doi:10.1091/mbc.E10-03-0200
    • Du, G., Liu, X., Chen, X., Song, M., Yan, Y., Jiao, R., et al. (2010). Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation. Molecular Biology Cell, 21(13), 2128-2137. doi:10.1091/mbc.E10-03-0200.
    • (2010) Molecular Biology Cell , vol.21 , Issue.13 , pp. 2128-2137
    • Du, G.1    Liu, X.2    Chen, X.3    Song, M.4    Yan, Y.5    Jiao, R.6
  • 12
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • DOI 10.1038/nrg2005, PII NRG2005
    • Esteller, M. (2007). Cancer epigenomics: DNA methylomes and histone-modification maps. Natural Review of Genetics, 8(4), 286-298. doi:10.1038/nrg2005. (Pubitemid 46439286)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.4 , pp. 286-298
    • Esteller, M.1
  • 13
    • 77957372037 scopus 로고    scopus 로고
    • Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues
    • Ghosh, S., Yates, A. J., Fruhwald, M. C., Miecznikowski, J. C., Plass, C., & Smiraglia, D. (2010). Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues. Epigenetics, 5(6), 527-538.
    • (2010) Epigenetics , vol.5 , Issue.6 , pp. 527-538
    • Ghosh, S.1    Yates, A.J.2    Fruhwald, M.C.3    Miecznikowski, J.C.4    Plass, C.5    Smiraglia, D.6
  • 14
    • 79955622702 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression in physiological and pathological brain processes
    • doi: 10.1152/physrev.00012.2010
    • Graff, J., Kim, D., Dobbin, M. M., & Tsai, L. H. (2011). Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiological Reviews, 91(2), 603-649. doi: 10.1152/physrev.00012.2010.
    • (2011) Physiological Reviews , vol.91 , Issue.2 , pp. 603-649
    • Graff, J.1    Kim, D.2    Dobbin, M.M.3    Tsai, L.H.4
  • 16
    • 4644236043 scopus 로고    scopus 로고
    • Causal relation between α-synuclein gene duplication and familial Parkinson's disease
    • DOI 10.1016/S0140-6736(04)17104-3, PII S0140673604171043
    • Ibanez, P., Bonnet, A. M., Debarges, B., Lohmann, E., Tison, F., Pollak, P., et al. (2004). Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet, 364(9440), 1169-1171. doi:10.1016/S0140- 6736(04)17104-3. (Pubitemid 39296605)
    • (2004) Lancet , vol.364 , Issue.9440 , pp. 1169-1171
    • Ibanez, P.1    Bonnet, A.-M.2    Debarges, B.3    Lohmann, E.4    Tison, F.5    Pollak, P.6    Agid, Y.7    Durr, A.8    Brice, P.A.9
  • 17
    • 67649586411 scopus 로고    scopus 로고
    • The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1
    • doi:10.1158/1541-7786. mcr-08-0359
    • Jenal, M., Trinh, E., Britschgi, C., Britschgi, A., Roh, V., Vorburger, S. A., et al. (2009). The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Molecular Cancer Research, 7(6), 916-922. doi:10.1158/1541-7786. mcr-08-0359.
    • (2009) Molecular Cancer Research , vol.7 , Issue.6 , pp. 916-922
    • Jenal, M.1    Trinh, E.2    Britschgi, C.3    Britschgi, A.4    Roh, V.5    Vorburger, S.A.6
  • 18
    • 79951536222 scopus 로고    scopus 로고
    • Alpha-synuclein negatively regulates protein kinase C delta expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity
    • doi: 10.1523/JNEUROSCI.5634-10.2011
    • Jin, H., Kanthasamy, A., Ghosh, A., Yang, Y., Anantharam, V., & Kanthasamy, A. G. (2011). Alpha-synuclein negatively regulates protein kinase C delta expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. Journal of Neuroscience, 31(6), 2035-2051. doi: 10.1523/JNEUROSCI.5634-10.2011.
    • (2011) Journal of Neuroscience , vol.31 , Issue.6 , pp. 2035-2051
    • Jin, H.1    Kanthasamy, A.2    Ghosh, A.3    Yang, Y.4    Anantharam, V.5    Kanthasamy, A.G.6
  • 19
    • 79960249232 scopus 로고    scopus 로고
    • Genomic mapping of 5-hydroxymethylcytosine in the human brain
    • doi:10.1093/nar/gkr120
    • Jin, S. G., Wu, X., Li, A. X., & Pfeifer, G. P. (2011). Genomic mapping of 5-hydroxymethylcytosine in the human brain. Nucleic Acids Research, 39(12), 5015-5024, doi:10.1093/nar/gkr120.
    • (2011) Nucleic Acids Research , vol.39 , Issue.12 , pp. 5015-5024
    • Jin, S.G.1    Wu, X.2    Li, A.X.3    Pfeifer, G.P.4
  • 20
    • 77951842993 scopus 로고    scopus 로고
    • Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains
    • doi:10.1523/JNEUROSCI.6119-09.2010
    • Jowaed, A., Schmitt, I., Kaut, O., & Wullner, U. (2010). Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains. Journal of Neuroscience, 30(18), 6355-6359. doi:10.1523/JNEUROSCI.6119-09.2010.
    • (2010) Journal of Neuroscience , vol.30 , Issue.18 , pp. 6355-6359
    • Jowaed, A.1    Schmitt, I.2    Kaut, O.3    Wullner, U.4
  • 23
    • 33749583553 scopus 로고    scopus 로고
    • α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
    • DOI 10.1093/hmg/ddl243
    • Kontopoulos, E., Parvin, J. D., & Feany, M. B. (2006). Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Human Molecular Genetics, 15(20), 3012-3023. doi:10.1093/hmg/ ddl243. (Pubitemid 44530705)
    • (2006) Human Molecular Genetics , vol.15 , Issue.20 , pp. 3012-3023
    • Kontopoulos, E.1    Parvin, J.D.2    Feany, M.B.3
  • 25
    • 79960012671 scopus 로고    scopus 로고
    • BiQ analyzer HT: Locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing
    • doi:10.1093/nar/gkr312
    • Lutsik, P., Feuerbach, L., Arand, J., Lengauer, T., Walter, J., & Bock, C. (2011). BiQ analyzer HT: Locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing. Nucleic Acids Research, 39(suppl 2), W551-W556. doi:10.1093/nar/gkr312.
    • (2011) Nucleic Acids Research , vol.39 , Issue.SUPPL. 2
    • Lutsik, P.1    Feuerbach, L.2    Arand, J.3    Lengauer, T.4    Walter, J.5    Bock, C.6
  • 27
    • 78649652766 scopus 로고    scopus 로고
    • CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease
    • doi:10.1371/journal.pone.0015522
    • Matsumoto, L., Takuma, H., Tamaoka, A., Kurisaki, H., Date, H., Tsuji, S., et al. (2010). CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease. PLoS One, 5(11), e15522, doi:10.1371/journal.pone.0015522.
    • (2010) PLoS One , vol.5 , Issue.11
    • Matsumoto, L.1    Takuma, H.2    Tamaoka, A.3    Kurisaki, H.4    Date, H.5    Tsuji, S.6
  • 29
    • 0027129389 scopus 로고
    • Transcriptional regulation. A closer look at E2F
    • doi:10.1038/358375a0
    • Nevins, J. R. (1992). Transcriptional regulation. A closer look at E2F. Nature, 358(6385), 375-376. doi:10.1038/358375a0.
    • (1992) Nature , vol.358 , Issue.6385 , pp. 375-376
    • Nevins, J.R.1
  • 31
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • doi: 10.1038/nbt.1685
    • Portela, A., & Esteller, M. (2010). Epigenetic modifications and human disease. Natural Biotechnology, 28(10), 1057-1068. doi: 10.1038/nbt.1685.
    • (2010) Natural Biotechnology , vol.28 , Issue.10 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 32
    • 79960560477 scopus 로고    scopus 로고
    • The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression
    • doi:10.1016/j.bbrc.2011.06.077
    • Robertson, J., Robertson, A. B., & Klungland, A. (2011). The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression. Biochemistry and Biophysics Research Community, 411(1), 40-43. doi:10.1016/j.bbrc.2011.06.077.
    • (2011) Biochemistry and Biophysics Research Community , vol.411 , Issue.1 , pp. 40-43
    • Robertson, J.1    Robertson, A.B.2    Klungland, A.3
  • 33
    • 70549084415 scopus 로고    scopus 로고
    • Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
    • doi:10.1038/ng.485
    • Satake, W., Nakabayashi, Y., Mizuta, I., Hirota, Y., Ito, C., Kubo, M., et al. (2009). Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Natural Genetics, 41(12), 1303-1307. doi:10.1038/ng.485.
    • (2009) Natural Genetics , vol.41 , Issue.12 , pp. 1303-1307
    • Satake, W.1    Nakabayashi, Y.2    Mizuta, I.3    Hirota, Y.4    Ito, C.5    Kubo, M.6
  • 34
    • 49449102642 scopus 로고    scopus 로고
    • GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein
    • doi:10.1073/pnas.0802437105
    • Scherzer, C. R., Grass, J. A., Liao, Z., Pepivani, I., Zheng, B., Eklund, A. C., et al. (2008). GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proceedings of Natural Academy of Science U S A, 105(31), 10907-10912, doi:10.1073/pnas.0802437105.
    • (2008) Proceedings of Natural Academy of Science u S A , vol.105 , Issue.31 , pp. 10907-10912
    • Scherzer, C.R.1    Grass, J.A.2    Liao, Z.3    Pepivani, I.4    Zheng, B.5    Eklund, A.C.6
  • 35
    • 33847736948 scopus 로고    scopus 로고
    • Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis
    • 50, 52 passim
    • Shen, L., Guo, Y., Chen, X., Ahmed, S., & Issa, J. P. (2007). Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis. Biotechniques, 42(1), 48, 50, 52 passim.
    • (2007) Biotechniques , vol.42 , Issue.1 , pp. 48
    • Shen, L.1    Guo, Y.2    Chen, X.3    Ahmed, S.4    Issa, J.P.5
  • 37
    • 70549088602 scopus 로고    scopus 로고
    • Genome-wide association study reveals genetic risk underlying Parkinson's disease
    • doi:10.1038/ng.487
    • Simon-Sanchez, J., Schulte, C., Bras, J. M., Sharma, M., Gibbs, J. R., Berg, D., et al. (2009). Genome-wide association study reveals genetic risk underlying Parkinson's disease. Natural Genetics, 41(12), 1308-1312. doi:10.1038/ng.487.
    • (2009) Natural Genetics , vol.41 , Issue.12 , pp. 1308-1312
    • Simon-Sanchez, J.1    Schulte, C.2    Bras, J.M.3    Sharma, M.4    Gibbs, J.R.5    Berg, D.6
  • 39
    • 78649383152 scopus 로고    scopus 로고
    • Cancer epigenetics
    • doi:10.3322/caac.20085
    • Taby, R., & Issa, J. P. (2010). Cancer epigenetics. CA: A Cancer Journal for Clinicians, 60(6), 376-392. doi:10.3322/caac.20085.
    • (2010) CA: A Cancer Journal for Clinicians , vol.60 , Issue.6 , pp. 376-392
    • Taby, R.1    Issa, J.P.2
  • 40
    • 34548734299 scopus 로고    scopus 로고
    • Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing
    • DOI 10.1158/0008-5472.CAN-07-1016
    • Taylor, K. H., Kramer, R. S., Davis, J. W., Guo, J., Duff, D. J., Xu, D., et al. (2007). Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing. Cancer Research, 67(18), 8511-8518. doi:10.1158/0008-5472.can-07-1016. (Pubitemid 47437425)
    • (2007) Cancer Research , vol.67 , Issue.18 , pp. 8511-8518
    • Taylor, K.H.1    Kramer, R.S.2    Davis, J.W.3    Guo, J.4    Duff, D.J.5    Xu, D.6    Caldwell, C.W.7    Shi, H.8
  • 41
    • 70449725209 scopus 로고    scopus 로고
    • Epigenetic mechanisms in neurological diseases: Genes, syndromes, and therapies
    • doi:10.1016/S1474-4422(09)70262-5
    • Urdinguio, R. G., Sanchez-Mut, J. V., & Esteller, M. (2009). Epigenetic mechanisms in neurological diseases: Genes, syndromes, and therapies. The Lancet Neurology, 8(11), 1056-1072. doi:10.1016/S1474-4422(09)70262-5.
    • (2009) The Lancet Neurology , vol.8 , Issue.11 , pp. 1056-1072
    • Urdinguio, R.G.1    Sanchez-Mut, J.V.2    Esteller, M.3
  • 42
    • 0036311202 scopus 로고    scopus 로고
    • Identification and resolution of artifacts in bisulfite sequencing
    • DOI 10.1016/S1046-2023(02)00060-9, PII S1046202302000609
    • Warnecke, P. M., Stirzaker, C., Song, J., Grunau, C., Melki, J. R., & Clark, S. J. (2002). Identification and resolution of artifacts in bisulfite sequencing. Methods, 27(2), 101-107. (Pubitemid 34757119)
    • (2002) Methods , vol.27 , Issue.2 , pp. 101-107
    • Warnecke, P.M.1    Stirzaker, C.2    Song, J.3    Grunau, C.4    Melki, J.R.5    Clark, S.J.6
  • 43
    • 69949106668 scopus 로고    scopus 로고
    • A new approach to primer design for the control of PCR bias in methylation studies
    • doi:10.1186/1756-0500-1-54
    • Wojdacz, T. K., Hansen, L. L., & Dobrovic, A. (2008). A new approach to primer design for the control of PCR bias in methylation studies. BMC Research Notes, 1, 54. doi:10.1186/1756-0500-1-54.
    • (2008) BMC Research Notes , vol.1 , pp. 54
    • Wojdacz, T.K.1    Hansen, L.L.2    Dobrovic, A.3
  • 44
    • 77956216039 scopus 로고    scopus 로고
    • Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices
    • doi:10.1371/journal.pone.0011357
    • Xin, Y., Chanrion, B., Liu, M. M., Galfalvy, H., Costa, R., Ilievski, B., et al. (2010). Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices. PLoS One, 5(6), e11357. doi:10.1371/journal.pone.0011357.
    • (2010) PLoS One , vol.5 , Issue.6
    • Xin, Y.1    Chanrion, B.2    Liu, M.M.3    Galfalvy, H.4    Costa, R.5    Ilievski, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.