α-synuclein sequesters Dnmt1 from the nucleus: A novel mechanism for epigenetic alterations in Lewy body diseases

Journal of Biological Chemistry

Volumn 286, Issue 11, 2011, Pages 9031-9037

  Desplats, Paula ^a   Spencer, Brian ^a   Coffee, Elizabeth ^a   Patel, Pruthul ^a   Michael, Sarah ^a   Patrick, Christina ^a   Adame, Anthony ^a   Rockenstein, Edward ^a   Masliah, Eliezer ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT BRAIN; BRAIN SAMPLE; CPG ISLANDS; DNA METHYLATION; EPIGENETIC ALTERATIONS; EPIGENETIC MODIFICATION; HYPOMETHYLATION; LEWY BODIES; MOUSE BRAIN; NEURONAL CELL CULTURE; OVER-EXPRESSION; PARKINSON DISEASE; SUBCELLULAR LOCALIZATIONS; SYNUCLEIN; TRANSGENIC MICE;

ALKYLATION; ANIMAL CELL CULTURE; BRAIN MODELS; CELL CULTURE; DISEASES; DNA; GENE EXPRESSION; METHYLATION; PARKS;

NUCLEIC ACIDS;

ALPHA SYNUCLEIN; DNA METHYLTRANSFERASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CPG ISLAND; CYTOPLASM; DIFFUSE LEWY BODY DISEASE; DNA METHYLATION; EPIGENETICS; FEMALE; FRONTAL CORTEX; GENE; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; OLIGOMERIZATION; PARKINSON DISEASE; PRIORITY JOURNAL; PRKAR2A GENE; PROTEIN AGGREGATION; SEPW1 GENE; SNCA GENE;

ADULT; ALPHA-SYNUCLEIN; ANIMALS; BRAIN; CPG ISLANDS; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIIALPHA SUBUNIT; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; LEWY BODY DISEASE; MICE; MICE, KNOCKOUT; SELENOPROTEIN W;

MUS MUSCULUS;

EID: 79953178935     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C110.212589     Document Type: Article

References (22)

1. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Nature 388, 839-840
2. Takeda, A., Mallory, M., Sundsmo, M., Honer, W., Hansen, L., and Masliah, E. (1998) Am. J. Pathol. 152, 367-372
3. Burn, D. J. (2006) Curr. Opin. Neurol. 19, 572-579
4. Levy, O. A., Malagelada, C., and Greene, L. A. (2009) Apoptosis 14, 478-500
5. Simunovic, F., Yi, M., Wang, Y., Macey, L., Brown, L. T., Krichevsky, A. M., Andersen, S. L., Stephens, R. M., Benes, F. M., and Sonntag, K. C. (2009) Brain 132, 1795-1809
6. Yacoubian, T. A., Cantuti-Castelvetri, I., Bouzou, B., Asteris, G., McLean, P. J., Hyman, B. T., and Standaert, D. G. (2008) Neurobiol. Dis. 29, 515-528
7. Day, J. J., and Sweatt, J. D. (2010) Nat. Neurosci. 13, 1319-1323
8. Urdinguio, R. G., Sanchez-Mut, J. V., and Esteller, M. (2009) Lancet Neurol. 8, 1056-1072
9. Jowaed, A., Schmitt, I., Kaut, O., and Wüllner, U. (2010) J. Neurosci. 30, 6355-6359
10. Matsumoto, L., Takuma, H., Tamaoka, A., Kurisaki, H., Date, H., Tsuji, S., and Iwata, A. (2010) PLoS One 5, e15522
11. Rockenstein, E., Mallory, M., Hashimoto, M., Song, D., Shults, C. W., Lang, I., and Masliah, E. (2002) J. Neurosci. Res. 68, 568-578
12. Spencer, B., Potkar, R., Trejo, M., Rockenstein, E., Patrick, C., Gindi, R., Adame, A., Wyss-Coray, T., and Masliah, E. (2009) J. Neurosci. 29, 13578-13588
13. Tiscornia, G., Singer, O., and Verma, I. M. (2006) Nat. Protoc. 1, 241-245
14. Crews, L., Mizuno, H, Desplats, P., Rockenstein, E., Adame, A., Patrick, C., Winner, B., Winkler, J., and Masliah, E. (2008) J. Neurosci. 28, 4250-4260
15. Desplats, P. A., Lambert, J. R., and Thomas, E. A. (2008) Neurobiol. Dis. 31, 298-308
16. Liu, L., van Groen, T., Kadish, I., and Tollefsbol, T. O. (2009) Neurobiol. Aging 30, 549-560
17. Stamper, C., Siegel, A., Liang, W. S., Pearson, J. V., Stephan, D. A., Shill, H., Connor, D., Caviness, J. N., Sabbagh, M., Beach, T. G., Adler, C. H., and Dunckley, T. (2008) Mov. Disord. 23, 1588-1595
18. George, J. M. (2002) Genome Biol. 3, REVIEWS3002
19. Miller, C. A., Gavin, C. F., White, J. A., Parrish, R. R., Honasoge, A., Yancey, C. R., Rivera, I. M., Rubio, M. D., Rumbaugh, G., and Sweatt, J. D. (2010) Nat. Neurosci. 13, 664-666
20. Christensen, B. C., Houseman, E. A., Marsit, C. J., Zheng, S., Wrensch, M. R., Wiemels, J. L., Nelson, H. H., Karagas, M. R., Padbury, J. F., Bueno, R., Sugarbaker, D. J., Yeh, R. F., Wiencke, J. K., and Kelsey, K. T. (2009) PLoS Genet. 5, e1000602
21. Hernandez, D. G., Nalls, M. A., Gibbs, J. R., Arepalli, S., van der Brug, M., Chong, S., Moore, M., Longo, D. L., Cookson, M. R., Traynor, B. J., and Singleton, A. B. (2011). Hum. Mol. Genet., in press
22. Siegmund, K. D., Connor, C. M., Campan, M., Long, T. I., Weisenberger, D. J., Biniszkiewicz, D., Jaenisch, R., Laird, P. W., and Akbarian, S. (2007) PLoS One 2, e895