CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: A novel basis for mutational hot spot determination

PLoS Genetics

Volumn 4, Issue 11, 2008, Pages

  Libby, Randell T ^a   Hagerman, Katharine A ^b,c   Pineda, Victor V ^a   Lau, Rachel ^b   Cho, Diane H ^d   Baccam, Sandy L ^a   Axford, Michelle M ^b,c   Cleary, John D ^b,c   Moore, James M ^d   Sopher, Bryce L ^a   Tapscott, Stephen J ^a,d   Filippova, Galina N ^d   Pearson, Christopher E ^b,c   La Spada, Albert R ^a  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 7; CTCF PROTEIN; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG; ATAXIN-7; CCCTC BINDING FACTOR; CCCTC-BINDING FACTOR; DNA BINDING PROTEIN; NERVE PROTEIN; REPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; CPG ISLAND; DNA CONFORMATION; EPIGENETICS; GENOME IMPRINTING; GERM LINE; METHYLATION; MOUSE; MUTATION; NONHUMAN; REGULATORY MECHANISM; SOMATIC CELL; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT; ANIMAL; C3H MOUSE; C57BL MOUSE; DNA METHYLATION; FEMALE; GENETIC EPIGENESIS; GENETICS; GENOMIC INSTABILITY; HUMAN; MALE; METABOLISM; REGULATORY SEQUENCE; SPINOCEREBELLAR DEGENERATION;

MUS; MUS MUSCULUS;

ANIMALS; BINDING SITES; DNA METHYLATION; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; FEMALE; GENOMIC INSTABILITY; HUMANS; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; REPRESSOR PROTEINS; SPINOCEREBELLAR ATAXIAS; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 57149089871     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000257     Document Type: Article

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