Conjugated linoleic acid: An anticancer fatty acid found in milk and meat

Frontiers in Nutrition Research

Volumn , Issue , 2006, Pages 69-105

  Dhiman, T R ^a   Ure, A L ^a   Walters, J L ^a  

^a UTAH STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

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EID: 84895285541     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (235)

1. Ha, Y. L., Grimm, N. K., and Pariza, M. W. (1989). Newly recognized anticarcinogenic fatty acids: Identification and quantification in natural and processed cheeses. J. Agric. Food Chem., 37:75-81.
2. Ip, C., Chin, S. F., Scimeca, J. A., and Pariza, M. W. (1991). Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res., 51:6118-6124.
3. Ip, C., Singh, M., Thompson, H. J., and Scimeca, J. A. (1994). Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res., 54:1212-1215.
4. Ip, C., Scimeca, J. A., and Thompson, H. (1995). Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. Nutr. Cancer, 24:241-247.
5. Ip, C., Briggs, S. P., Haegele, A. D., Thompson, H. J., Storkson, J., and Scimeca, J. A. (1996). The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet. Carcinogenesis, 17:1045-1050.
6. Ip, C., and Scimeca, J. A. (1997). Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis. Nutr. Cancer, 27:131-135.
7. Cesano, A., Visonneau, S., Scimeca, J. A., Kritchevsky, D., and Santoli, D. (1998). Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. Anticancer Res., 18:1429-1434.
8. Banni, S., Angioni, E., Casu, V., Melis, M. P., Carta, G., Corongiu, F. P., Thompson, H., and Ip, C. (1999). Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid. Carcinogenesis, 20:1019-1024.
9. Aro, A., Männistö, S., Salminen, I., Ovaskainen, M. L., Kataja, V., and Uusitupa, M. (2000). Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. Nutr. Cancer, 38: 151-157.
10. Hubbard, N. E., Lim, D., Summers, L., and Erickson, K. L. (2000). Reduction of murine mammary tumor metastasis by conjugated linoleic acid. Cancer Lett., 150:93-100.
11. Park, H. S., Ryu, J. H., Ha, Y. L., and Park, J. H. Y. (2001). Dietary conjugated linoleic acid (CLA) induces apoptosis of colonic mucosa in 1,2-Dimethylhydrazine-treated rats: A possible mechanism of the anticarcinogenic effects by CLA. Br. J. Nutr., 86:549-555.
12. Ip, C., Dong, Y., Thompson, H. J., Bauman, D. E., and Ip, M. M. (2001). Control of rat mammary epithelium proliferation by conjugated linoleic acid. Nutr. Cancer, 39:233-238.
13. Majumder, B., Wahle, K. W. J., Moir, S., Schofield, A. C., Choe, S. N., Farquharson, A., Grant, I., and Heys., S. D. (2002). Conjugated linoleic acid (CLAs) regulate the expression of key apoptotic genes in human breast cancer cells. FASEB J., 16:1447-1449.
14. Palombo, J. D., Ganguly, A., Bistrian, B. R., and Menard, M. P. (2002). The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells. Cancer Lett., 177:163-172.
15. Durgam, V. R., and Fernandes, G. (1997). The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system. Cancer Lett., 116:121-130.
16. Thompson, H., Zhu, Z., Banni, S., Darcy, K., Loftus, T., and Ip, C. (1997). Morphological and biochemical status of the mammary gland as influenced by conjugated linoleic acid: implication for reduction in mammary cancer risk. Cancer Res., 57:5067-5072.
17. Visonneau, S., Cesano, A., Tepper, S. A., Scimeca, J. A., Santoli, D., and Kritchevsky, D. (1997). Conjugated linoleic acid suppresses the growth of human breast adenocarcinoma cells in SCID mice. Anticancer Res., 17:969-973.
18. Bougnoux P., Lavillonniere, F., Riboli, E., Chajes, V., Martin, J., and Lhuillery, C. (1999). Inverse relation between CLA in adipose breast tissue and risk of breast cancer: A case-control study in France, Health and Nutrition Section-3, S43. In: Proc. Am. Oil Chemist's Soc. Annual meeting, France.
19. Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., and Pariza, M. W. (1997). Effect of conjugated linoleic acid on body composition in mice. Lipids, 32:853-858.
20. Park, Y., Storkson, J. M., Albright, K. J., Liu, W., and Pariza, M. W. (1999). Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids, 34:235-241.
21. Park, Y., Albright, K. J., Storkson, J. M., Liu, W., Cook, M. E., and Pariza, M. W. (1999). Changes in body composition in mice during feeding withdrawal of conjugated linoleic acid, Lipids, 34:243-248.
22. Dunshea, F. R., Ostrowska, E., Muralitharan, M., Cross, R., Bauman, D. E., Pariza, M. W., and Skarie, C. (1998). Dietary conjugated linoleic acid decreases back fat in finisher gilts. J. Dairy Sci., 81 (Suppl. 1):131. (Abstr.)
23. West, D. B., Delany, J. P., Camet, P. M., Blohm, F., Truett, A. A., and Scimeca, J. (1998). Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am. J. Physiol. Regulatory Integrative Comp. Physiol., 275:R667-R672.
24. DeLany, J. P., Blohm, F., Truett, A. A., Scimeca, J. A., and West, D. B. (1999). Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am. J. Physiol. Regulatory Integrative Comp. Physiol., 276, R1172-R1179.
25. Kreider, R. B., Ferreira, M. P., Greenwood, M., Wilson, M., and Almada, A. L. (2002). Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. J. Strength Cond. Res., 16:325-334.
26. Cook, M. E., Miller, C. C., Park, Y., and Pariza, M. W. (1993). Immune modulation by altered nutrient metabolism: nutritional control of immune-induced growth depression. Poultry Sci., 72:1301-1305.
27. Miller, C. C., Park, Y., Pariza, M. W., and Cook, M. E. (1994). Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection. Biochem. Biophys. Res. Commun., 198:1107-1112.
28. Chew, B. P., Wong, T. S., Schultz, T. D., and Magnuson, N. S. (1997). Effects of conjugated dienoic derivatives of linoleic acid and ß-carotene in modulating lymphocyte and macrophage function. Anticancer Res., 17:1099-1106.
29. Wong, M. W., Chew, B. P., Wong, T. S., Hosick, H. L., Boylston, T. D., and Schultz, T. D. (1997). Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice. Anticancer Res., 17:987-993.
30. Hayek, M. G., Han, S. N., Wu, D., Watkin, B. A., Meydani, M., Dorsey, J. L., Smith, D. E., and Meydani, S. N. (1999). Dietary conjugated linoleic acid influences the immune response of young and old C57BL/6NCrlBR mice. J. Nutr., 129:32-38.
31. Whigham, L. D., Cook, E. B., Stahl, J. L., Saban, R., Bjorling, D. E., Pariza, M. W., and Cook, M. E. (2001). CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae. Am. J. Physiol. Regul. Regulatory Integrative Physiol., 280:R908-912.
32. Lee, K. N., Kritchevsky, D., and Pariza, M. W. (1994). Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis, 108:19-25.
33. Nicolosi, R. J., Rogers, E. J., Kritchevsky, D., Scimeca, J. A., and Huth, P. J. (1997). Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery, 22:266-277.
34. Houseknecht, K. L., Vanden Heuvel, J. P., Moya-Camarena, S. Y., Portocarrero, C. P., Peck, L. W., Nickel, K. P., and Belury, M. A. (1998). Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem. Biophy. Res. Comm., 244:678-682.
35. Kritchevsky, D., Tepper, S. A., Wright, S., Tso, P., and Czarnecki, S. K. (2000). Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits J. Am. Coll. Nutr., 19:472S-477S.
36. Kritchevsky, D., Tepper, S. A., Wright, S., and Czarnecki, S. K. (2002). Influence of graded levels of conjugated linoleic acid (CLA) on experimental atherosclerosis in rabbits. Nutr. Res., 22:1275-1279.
37. Chin, S. F., Liu, W., Storkson, J. M., Ha, Y. L., and Pariza, M. W. (1992). Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. J. Food. Comp. Anal., 5:185-197.
38. Kepler, C. R., and Tove, S. B. (1967). Biohydrogenation of unsaturated fatty acids: III. Purification and properties of a linoeate delta-12-cis, delta-11-trans-isomerase from Butyrivibrio fibrisolvens. J. Biol. Chem., 242:5686-5692.
39. Christie, W. W., Dobson, G., and Gunstone, F. D. (1997). Isomers of commercial samples of conjugated linoleic acid. J. Am. Oil Chem. Soc., 74:1231.
40. Sehat, N., Kramer, J. K. G, Mossoba, M. M., Yurawecz, M. P., Roach, J. A. G., Eulitz, K., Morehouse, K. M., and Ku, Y. (1998). Identification of conjugated linoleic acid isomers in cheese by gas chromatography, silver ion high performance liquid chromatography and mass spectral reconstructed ion profiles. Comparison of chromatographic elution sequences. Lipids, 33:963-971.
41. Parodi, P. W. (1977). Conjugated octadecadienoic acids of milk fat. J. Dairy Sci., 60:1550-1553.
42. Chin, S. F., Storkson, J. M., and Pariza, M. W. (1993). Conjugated dienoic derivatives of linoleic acid. A new class of food-derived anticarcinogens. In: Spanier, A. M., Okai, H., and Tamura. M. (Eds.). Food Flavor and Safety: Molecular Analysis and Design. pp 262-271. Washington, DC: American Chemical Society.
43. Kramer, J. K., Fellner, V., Dugan, M. E., Sauer, F. D., Mossoba, M. M., and Yurawecz, M. P. (1997). Evaluating acid and base catalysts in the methylation of milk and rumen fatty acids with special emphasis on the conjugated dienes and total trans fatty acids. Lipids, 32:1219-1228.
44. Sehat, N., Rickert, R., Mossoba, M. M., Kramer, J. K. G., Yurawecz, M. P., Roach, J. A., Adlof, R. O., Morehouse, K. M., Fritsche, J., Eulitz, K. D., Steinhart, H., and Ku, Y. (1999). Improved separation of conjugated fatty acid methyl esters by silver ion-high performance liquid chromatography. Lipids, 34:407-413.
45. Bauman, D. E., Barbano, D. M., Dwyer, D. A. (2000). Technical note: production of butter with enhanced conjugated linoleic acid for use in biomedical studies with animal models. J. Dairy Sci., 83:2422-2425.
46. Fritsche J., Fritsche, S., Solomon, M. B., Mossoba, M. M., Yurawecz, M. P., Morehouse, K., and Ku, Y. (2000). Quantitative determination of conjugated linoleic acid isomers in beef fat. Eur. J. Lipid Sci. Technol., 102:667-672.
47. Fritsche J. (1998). Conjugated linoleic acid isomers in food: physiological properties, analysis, contents and dietary intake. Lipid Technol. Newsletter, 4(6):115-119.
48. Bauman, D. E., Baumgard, L. H., Corl, B. A., and Griinari, J. M. (1999). Biosynthesis of conjugated linoleic acid in ruminants. Proc. Am. Soc. Anim. Sci., pp. 1-15.
49. Griinari, J. M., Corl, B. A., Lacy, S. H., Chouinard, P. Y., Nurmela, K. V. V., and Bauman, D. E. (2000). Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by delta (9)-destaurase. J. Nutr., 30:2285-2291.
50. Corl, B. A., Baumgard, L. H., Dwyer, D. A., Griinari, J. M., Phillips, B. S., and Bauman, D. E. (2001). The role of delta(9)-destaurase in the production of cis-9, trans-11 CLA. J. Nutr. Biochem., 12:622-630.
51. Dawson, R. M. C., Hemington, N., and Hazlewood, G. P. (1977). On the role of higher plant and microbial lipases in the ruminal hydrolysis of grass lipids. Br. J. Nutr., 38:225-232.
52. Demeyer, D. I., and Van Nevel, C. J. (1995). Transformations and effects of lipids in the rumen: three decades of research at Gent University. Arch. Anim. Nutr., 48:119-134.
53. Jenkins, T. C. (1993). Lipid metabolism in the rumen. J. Dairy Sci., 76:3851-3863.
54. Kemp, P., Lander, D. J., and Gunstone, F. D. (1984). The hydrogenation of some cisand trans-octadecenoic acids to stearic acid by a rumen Fusocillus sp, Br. J. Nutr., 52:165-170.
55. Kellens, M. J., Goderis, H. L., and Tobback, P. P. (1986). Biohydrogenation of unsaturated fatty acids by a mixed culture of rumen microorganisms. Biotech. Bioeng., 28:1268-1276.
56. Harfoot, C. G. and Hazlewood, G. P. (1988). Lipid metabolism in the rumen. In: Hobson, P. N. (Ed.). The Rumen Microbial Ecosystem, pp 285-321. New York: Elsevier Applied Science.
57. Jiang, J., Bjoerck, L., Fonden, R., and Emanuelson, M. (1996). Occurrence of conjugated cis-9, trans-11-Octadecadienoic acid in bovine milk: Effects of feed and dietary regimen. J. Dairy Sci., 79:438-445.
58. Griinari, J. M., and Bauman, D. E. (1999). Biosynthesis of conjugated linoleic acid and its incorporation into meat and milk in ruminants. In: Yurawecz, M. P., Mossoba, M. M., Kramer, J. K. G, Pariza, M. W., and Nelson, G. J. (eds.), Advances in Conjugated linoleic Acid Research, Volume 1, pp 180-220. Champaign, IL: AOCS Press.
59. Fellner, V., Sauer, F. D., and Kramer, J. K. G. (1995). Steady-states of linoleic acid biohydrogenation by ruminal bacteria in continuous culture. J. Dairy. Sci., 78:1815-1823.
60. Kemp, P., and Lander, D. J. (1984). Hydrogenation in vitro of a-linoleic acid to stearic acid by mixed cultures of pure strains of rumen bacteria. J. Gen. Microbiol., 130:527-533.
61. Leat, W. M. F., Kemp, P., Lysons, R. J., and Alexander, T. J. L. (1977). Fatty acid composition of depot fats from gnotobiotic lambs. J. Agri. Sci., 88:175-179.
62. Van Soest, P. J. (1994). Lipids. In: Van Soest, P. J. (Ed.). Nutritional Ecology of the Ruminant, 2nd ed., pp 325-336, Ithaca, NY: Cornell University Press.
63. Griinari, J. M., Dwyer, D. A., McGuire, M. A., Bauman, D. E., Palmquist, D. L., and Nurmela, K. V. V. (1998). Trans-octadecenoic acids and milk fat depression in lactating dairy cows. J. Dairy Sci., 81:1251-1261.
64. Yang, A. (1999). Delta (9) destaurase activity in bovine subcutaneous adipose tissue of different fatty acid composition. Lipids, 34:971-978.
65. Lock, A. L., and Garnsworthy, P. C. (2002). Independent effects of dietary linoleic acid and linolenic fatty acids on the conjugated acid content of cows' milk. Anim. Sci., 74:163-176.
66. Chang, J. H. P., Lunt, D. K. and Smith, S. B. (1992). Fatty acid composition and fatty acid elongase and stearoyl-CoA desaturase activities in tissues of steers fed high oleate sunflower seed. J. Nutr., 122:2074-2080.
67. Cameron, P. J., Rogers, M., Oman, J., May, S. G., Lunt, D. K. and Smith, S. B. (1994). Stearoyl coenzyme A desaturase enzyme activity and mRNA levels are not different in subcutaneous adipose tissue from Angus and American Wagyu steers. J. Anim. Sci., 72:2624-2628.
68. Page, A. M., Sturdivant, C. A., Lunt, D. K. and Smith, S. B. (1997). Dietary whole cottonseed depresses lipogenesis but has no effect on stearoyl coenzyme desaturease activity in bovine subcutaneous adipose tissue, Comp. Biochem. Physiol., 118B:79-84.
69. Kinsella, J. E. (1972). Stearyl CoA as a precursor of oleic acid and glycerolipids in mammary microsomes from lactating bovine: possible regulatory step in milk triglyceride synthesis. Lipids, 7:349-355.
70. Dhiman, T. R., Anand, G. R., Satter, L. D., and Pariza, M. W. (1999). Conjugated linoleic acid content of milk from cows fed different diets. J. Dairy Sci., 82:2146-2156.
71. Ward, A. T., Wittenberg, K. M., Froebe, H. M., Przybylski, R., and Malcolmson, L. (2003). Fresh forage and solin supplementation on conjugated linoleic acid levels in plasma and milk. J. Dairy Sci., 86:1742-1750.
72. Jahreis, G., Fritsche, J., and Steinhart, H. (1997). Conjugated linoleic acid in milk fat: high variation depending on production system. Nutr. Res., 17:1479-1484.
73. Kelly, M. L., Kolver, E. S., Bauman, D. E., Van Amburgh, M. E., and Muller, L. D. (1998). Effect of intake of pasture on concentrations of conjugated linoleic acid in milk of lactating cows. J. Dairy Sci., 81:1630-1636.
74. White, S. L., Bertrand, J. A., Wade, M. R., Washburn, S. P., Green Jr., J. T., and Jenkins, T. C. (2002). Comparison of fatty acid content of milk from Jersey and Holstein cows consuming pasture or a total mixed ration. J. Dairy Sci., 85:95-104.
75. Chouinard, P. Y., Corneau, L., Kelly, M. L., Griinari, J. M., and Bauman, D. E. (1998). Effect of dietary manipulation on milk conjugated linoleic acid concentrations. J. Dairy Sci., 81(suppl. 1):233. (Abstr.)
76. Harfoot, C. G., and Hazelwood, G. P. (1997). Lipid metabolism in the rumen. In: Hobson, P. N., and Stewart, C. S. (Eds.). The Rumen Microbial Ecosystem, 2nd ed., pp 382-426. New York: Blackie Academic and Professional.
77. Martin, S. A., and Jenkins, T. C. (2002). Factors affecting conjugated linoleic acid and trans-C18:1 fatty acid production by mixed ruminal bacteria. J. Anim. Sci., 80:3347-3352.
78. Kelly, M. L., Berry, J. R., Dwyer, D. A., Griinari, J. M., Chouinard, P. Y., Van Amburgh, M. E., and Bauman, D. E. (1998). Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. J. Nutr., 128:881-885.
79. Dhiman, T. R., Helmink, E. D., McMahon, D. J., Fife, R. L., and Pariza, M. W. (1999). Conjugated linoleic acid content of milk and cheese from cows fed extruded oil seeds. J. Dairy Sci., 82:412-419.
80. Gonzalez, S., Duncan, S. E., O'Keefe, S. F., Sumner, S. S., and Herbein, J. H. (2003). Oxidation and textural characteristics of butter and ice cream with modified fatty acid profiles. J. Dairy Sci., 86:70-77.
81. Loor, J. J., and Herbein, J. H. (2003). Dietary canola or soybean oil with two levels of conjugated linoleic acids (CLA) alter profiles of 18:1 and 18:2 isomers in blood plasma and milk fat from dairy cows. Anim. Feed Sci. Tech., 103:63-83.
82. Loor, J. J., and Herbein, J. H. (2003). Reduced fatty acid synthesis and desaturation due to exogenous trans10, cis12-CLA in cows fed oleic or linoleic oil. J. Dairy Sci., 86:1354-1369.
83. Polan, C. E., McNeill, J. J., and Tove, S. B. (1964). Biohydrogenation of unsaturated fatty acids by rumen bacteria. J. Bacteriol., 88:1056-1064.
84. Harfoot, C. G., Noble, R. C., and Moore, J. H. (1973). Factors influencing the extent of biohyrogenation of linoleic acid by rumen micro-organism in vitro. J. Sci. Food Agric., 24:961-970.
85. Dhiman, T. R., Satter, L. D., Pariza, M. W., Galli, M. P., Albright, K., and Tolasa, M. X. (2000). Conjugated linoleic acid (CLA) content of milk from cows offered diets rich in linoleic and linolenic acid. J. Dairy Sci., 83:1016-1027.
86. Chouinard, P. Y., Corneau, L., Butler, W. R., Chilliard, Y., Drackley, J. K., and Bauman, D. E. (2001). Effect of dietary lipid source on conjugated linoleic acid concentrations in milk fat. J. Dairy Sci., 84:680-690.
87. Stanton, C., Lawless, F., Kjellmer, G., Harrington, D., Devery, R., Connolly, J. F., and Murphy, J. (1997). Dietary influences on bovine milk cis-9, trans-11-conjugated linoleic acid content. J. Food Sci., 62:1083-1086.
88. Lawless, F., Murphy, J. J., Harrington, D., Devery, R., and Stanton, C. (1998). Elevation of conjugated cis-9, trans-11-octadecadienoic acid in bovine milk because of dietary supplementation. J. Dairy Sci., 81:3259-3267.
89. Solomon, R., Chase, L. E., Ben-Ghedalia, D., and Bauman, D. E. (2000). The effect of nonstructural carbohydrate and addition of full fat extruded soybeans on the concentration of conjugated linoleic acid in the milk fat of dairy cows. J. Dairy Sci., 83:1322-1329.
90. Ramaswamy, N., Baer, R. J., Schingoethe, D. J., Hippen, A. R., Kasperson, K. M., and Whitlock, L. A. (2001). Composition and flavor of milk and butter from cows fed fish oil, extruded soybeans, or their combination. J. Dairy Sci., 84:2144-2151.
91. Abu-Ghazaleh, A. A., Schingoethe, D. J., Hippen, A. R., Kalscheur, K. F., and Whitlock, L. A. (2002). Fatty acid profiles of milk and rumen digesta from cows fed fish oil, extruded soybeans or their blend. J. Dairy Sci., 85:2266-2276.
92. Abu-Ghazaleh, A. A., Schingoethe, D. J., Hippen, A. R., and Whitlock, L. A. (2002). Feeding fish meal and extruded soybeans enhances the conjugated linoleic acid (CLA) content of milk. J. Dairy Sci., 85:624-631.
93. Peterson, D. G., Kelsey, J. A., and Bauman, D. E. (2002). Analysis of variation in cis-9, trans-11 conjugated linoleic acid (CLA) in milk fat of dairy cows. J. Dairy Sci., 85:2164-2172.
94. Whitlock, L. A., Schingoethe, D. J., Hippen, A. R., Kalscheur, K. F., Baer, R. J., Ramaswamy, N., and Kasperson, K. M. (2002). Fish oil and extruded soybeans fed in combination increase conjugated linoleic acids in milk of dairy cows more than when fed separately. J. Dairy Sci., 85:234-243.
95. Offer, N. W., Marsden, M., Dixon, J., Speake, B. K., and Thacker, F. E. (1999). Effect of dietary fat supplements on levels of n-3 polyunsaturated fatty acids, trans acids and conjugated linoleic acid in bovine milk. Anim. Sci., 69:613-625.
96. Donovan, D. C., Schingoethe, D. J., Baer, R. J., Ryali, J., Hippen, A. R., and Franklin, S. T. (2000). Influence of dietary fish oil on conjugated linoleic acid and other fatty acids in milk fat from lactating dairy cows. J. Dairy Sci., 83:2620-2628.
97. Abu-Ghazaleh, A. A., Schingoethe, D. J., and Hippen, A. R. (2001). Conjugated linoleic acid and other beneficial fatty acids in milk fat from cows fed soybean meal, fishmeal, or both. J. Dairy Sci., 84:1845-1850.
98. Franklin, S. T., Martin, K. R., Baer, R. J., Schingoethe, D. J., and Hippen, A. R. (1999). Dietary marine algae (Schizochytrium sp.) increases concentrations of conjugated linoleic, docosahexaenoic and transvaccenic acids in milk of dairy cows. J. Nutr., 129:2048-2052.
99. Chilliard, Y., Ferlay, A., Mansbridge, R. M., and Doreau, M. (2000). Ruminant milk fat plasticity: nutritional control of saturated, polyunsaturated, trans and conjugated fatty acids. Ann. Zootech., 49:181-205.
100. Riel, R. R. (1963). Physico-chemical characteristics of Canadian milk fat. Unsaturated fatty acids. J. Dairy Sci., 46:102-106.
101. Jahreis, G., Fritsche, J., Mockel, P., Schone, F., Moller, U., and Steinhart, H. (1999). The potential anticarcinogenic conjugated linoleic acid, cis-9, trans-11 C18:2, in milk of different species: cow, goat, ewe, sow, mare, woman. Nutr. Res., 10:1541-1549.
102. Mackle, T. R., Bryant, A. M., Petch, S. F., Hill, J. P., and Auldist, M. J. (1999). Nutritional influences on the composition of milk from cows of different protein phenotypes in New Zealand. J. Dairy Sci., 82:172-180.
103. Lock, A. L., and Garnsworthy, P. C. (2003). Seasonal variation in milk conjugated linoleic acid and ?9-desaturase activity in dairy cows. Livestk. Prod. Sci., 79:47-59.
104. Lawless, F., Stanton, C., L'Escop, P., Devery, R., Dillon, P., and Murphy, J. J. (1999). Influence of breed on bovine milk cis-9, trans-11 conjugated linoleic acid content. Livest. Prod. Sci., 62:43-49.
105. Morales, M. S., Palmquist, D. L., and Weiss, W. P. (2000). Milk fat composition of Holstein and Jersey cows with control or depleted copper status and fed whole soybeans or tallow. J. Dairy Sci., 83:2112-2119.
106. Capps, V. A., DePeters, E. J., Taylor, S. J., Perez-Monti, H., Wyckoff, J. A., and Rosenberg, M. (1999). Effects of breed of dairy cattle and dietary fat on milk yield and composition. J. Dairy Sci., 82 (Suppl. 1):45. (Abstr.)
107. Dhiman, T. R., Zaman, M. S., Kilmer, L., and Gilbert, D., Breed of dairy cows has influence on conjugated linoleic acid (CLA) content of milk. J. Dairy Sci., 85 (Suppl. 1):315. (Abstr.)
108. Bell, J. A., and Kennelly, J. J. (2003). Short communication: postruminal infusion of conjugated linoleic acids negatively impacts milk synthesis in Holstein cows. J. Dairy Sci., 86:1321-1324.
109. Loor, J. J., and Herbein, J. H. (1998). Exogenous conjugated linoleic acid isomers reduce bovine milk fat concentration and yield by inhibiting de novo fatty acid synthesis. J. Nutr., 128:2411-2419.
110. Chouinard, P. Y., Corneau, L., Barbano, D. M., Metzger, L. E., and Bauman, D. E. (1999). Conjugated linoleic acids alter milk fatty acid composition and inhibit milk fat secretion in dairy cows. J. Nutr., 129:1579-1584.
111. Chouinard, P. Y., Corneau, L., Saebo, A., and Bauman, D. E. (1999). Milk yield and composition during abomasal infusion of conjugated linoleic acids in dairy cows. J. Dairy Sci., 82:2737-2745.
112. Giesy, J. G., Hanson, T. W., Robinson, M., Hafliger, H. C., Viswanadha, S., McGuire, M. A., Skarie, C. H., and Vinci, A. (1999). Effects of calcium salts of conjugated linoleic acid (CLA) on milk yield, fat and CLA content in milk fat in Holstein cows early in lactation. J. Dairy Sci., 82 (Suppl 1):83. (Abstr.)
113. Giesy, J. G., McGuire, M. A., Shafii, B., and Hanson, T. W. (2002). Effect of dose of calcium salts of conjugated linoleic acid (CLA) on percentage and fatty acid content of milk fat in midlactation Holstein cows. J. Dairy Sci., 85:2023-2029.
114. Perfield, J. W., Bernal-Santos, G., Overton, T. R., and Bauman, D. E. (2002). Effects of dietary supplementation of rumen-protected conjugated linoleic acid in dairy cows during established lactation. J. Dairy Sci., 85:2609-2617.
115. Mackle, T. R., Kay, J. K., Auldist, M. J., McGibbon, A. K. H., Philpott, B. A., Baumgard, L. H., and Bauman, D. E. (2003). Effects of abomasal infusion of conjugated linoleic acid on milk fat concentration and yield from pasture-fed dairy cows. J. Dairy Sci., 86:644-652.
116. Shantha, N. C., Moody, W. G., and Tabeidi, Z. (1997). Conjugated linoleic acid concentration in semimembranosus muscle of grass and grain-fed and zeranolimplanted beef cattle. J. Muscle Foods., 8:105-110.
117. McGuire, M. A., Duckett, S. K., Andrae, J. G., Giesy, J. G., and Hunt, C. W. (1998). Effect of high-oil corn on content of conjugated linoleic acid (CLA) in beef. J. Anim. Sci., 76(1):301. (Abstr.)
118. French, P., Stanton, C., Lawless, F., O'Riordan, E. G., Monahan, F. J., Caffrey, P. J., and Moloney, A. P. (2000). Fatty acid composition, including conjugated linoleic acid, of intramuscular fat from steers offered grazed grass, grass silage, or concentrate-based diets. J. Anim. Sci., 78:2849-2855.
119. Poulson, C. S., T. R. Dhiman, A. L. Ure, D. Cornforth, and K. C. Olson. (2004). Conjugated linoleic acid content of beef from cattle fed diets containing high grain, CLA or forages. Livestock Prod. Sci. 91:117-128.
120. Rule, D. C., Broughton, K. S., Shellito, S. M., and Maiorano, G. (2002). Comparison of muscle fatty acid profiles and cholesterol concentrations of bison, beef cattle, elk, and chicken. J. Anim. Sci., 80:1202-1211.
121. Engle, T. E., Spears, J. W., Fellner, V., and Odle, J. (2000). Effects of soybean oil and dietary copper on ruminal and tissue lipid metabolism in finishing steers. J. Anim. Sci., 78:2713-2721.
122. Beaulieu, A. D., Drackley, J. K., and Merchen, N. R. (2002). Concentrations of conjugated linoleic acid (cis-9, trans-11-octadecadienoic acid) are not increased in tissue lipids of cattle fed a high-concentrate diet supplemented with soybean oil. J. Anim. Sci., 80:847-861.
123. Dhiman, T. R., Olson, K. C., McQueen, I. S., and Pariza, M. W. (2005). Influence of feeding soybean oil on conjugated linoleic acid content in beef. J. Agric. Food Chem. 53:684-689.
124. Griswold, K. E., Apgar, G. A., Robinson, R. A., Jacobson, B. N., Johnson, D., and Woody, H. D. (2003). Effectiveness of short-term feeding strategies for altering conjugated linoleic acid content of beef. J. Anim. Sci., 81:1862-1871.
125. Mir, P. S., Ivan, M., McAllister, T. A., Okine, E. K., Goonewardene, L., Elias-Calles, J. A., Gaskins, C., Reeves, J. J., Busboom, J., Johnson, K. A., Kuber, P. S., and Mir, Z. (2001). Proceeding of the food data conference. Bratislava, Slovakia. Aug. 24-26.
126. Mir, P. S., McAllister, T. A., Zaman, S., Morgan Jones, S. D., He, M. L., Aalhus, J. L., Jeremiah, L. E., Goonewardene, L. A., Weselake, R. J., and Mir, Z. (2003). Effect of dietary sunflower oil and vitamin E on beef cattle performance, carcass characteristics and meat quality. Can. J. Anim. Sci., 83:53-66.
127. Bottger, J. D., Hixon, D. L., Moss, G. E., Hess, B. W., Funston, R. N., and Rule, D. C. (2000). Effects of feeding high-oleate and high-linoleate safflower seed on fatty acid profiles of adipose tissue, milk, and blood plasma of primiparous beef heifers. J. Anim. Sci., 78 (suppl. 1):275. (Abstr.)
128. Garcia, M. R., Amstalden, M., Morrison, C. D., Keisler, D. H., and Williams, G. L. (2003). Age at puberty, total fat and conjugated linoleic acid content of carcass, and circulating metabolic hormones in beef heifers fed a diet high in linoleic acid beginning at four months of age. J. Anim. Sci., 81:261-268.
129. Madron, M. S., Peterson, D. G., Dwyer, D. A., Corl, B. A., Baumgard, L. H., Beermann, D. H., and Bauman, D. E. (2002). Effects of extruded full-fat soybeans on conjugated linoleic acid content of intramuscular, intermuscular, and subcutaneous fat in beef steers. J. Anim. Sci., 80:1135-1143.
130. Mir, Z., Paterson, L. J., and Mir, P. S. (2000). Fatty acid composition and conjugated linoleic acid content of intramuscular fat in crossbred cattle with and without Wagyu genetics fed a barley-based diet. Can. J. Anim. Sci., 80:195-197.
131. Mir, P. S., Mir, Z., Kuber, P. S., Gaskins, C. T., Martin, E. L., Dodson, M. V., Elias Calles, J. A., Johnson, K. A., Busboom, J. R., Wood, A. J., Pittenger, G. J., and Reeves, J. J. (2002). Growth, carcass characteristics, muscle conjugated linoleic acid (CLA) content, and response to intravenous glucose challenge in high percentage Wagyu, Wagyu x Limousin, and Limousin steers fed sunflower oil-containing diets. J. Anim. Sci., 80:2996-3004.
132. Baer, R. J., Ryali, J., Schingoethe, D. J., Kasperson, K. M., Donovan, D. C., Hippen, A. R., and Franklin, S. T. (2001). Composition and properties of milk and butter from cows fed fish oil. J. Dairy Sci., 84:345-353.
133. Shantha, N. C., Ram, L. N., O'Leary, J., Hicks, C. L., and Decker, E. A. (1995). Conjugated linoleic acid concentrations in dairy products as affected by processing and storage. J. Food Sci., 60:695-697.
134. Dave, R. I., Ramaswamy, N., and Baer, R. J. (2002). Changes in fatty acid composition during yogurt processing and their effects on yogurt and probiotic bacteria in milk procured from cows fed different diets Aust. J. Dairy Technol., 57:197-202.
135. Aneja, R. P., and Murthi, T. N. (1990). Conjugated linoleic acid contents of Indian curds and ghee. Indian J. Dairy Sci., 43:231-238.
136. Shantha, N. C., Crum, A. D., and Decker, E. A. (1994). Evaluation of conjugated linoleic acid concentrations in cooked beef. J. Agric. Food Chem., 42:1757-1760.
137. Ma, D. W. L., Wierzbicki, A. A., Field, C. J., and Clandinin, M. T. (1999). Conjugated linoleic acid in Canadian dairy and beef products. J. Agric. Food Chem., 47:1956-1960.
138. Ip, C., Banni, S., Angioni, E., Carta, G., MacGinley, J., Thompson, H. J., Barbano, D., and Bauman, D. (1999). Conjugated linoleic acid-enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats. J. Nutr., 129: 2135-2142.
139. Fritsche, J., Rickert, R., and Steinhart, H. (1999). Formation, contents, and estimation of daily intake of conjugated linoleic acid isomers and trans-fatty acids in foods. In: Yurawecz, M. P., Mossoba, M. M., Kramer, J. K. G, Pariza, M. W., and Nelson, G. J. (eds.), Advances in Conjugated linoleic Acid Research, Volume 1, pp 378-396. Champaign, IL: AOCS Press.
140. Emken, E. A., Rohwedder, W. K., Adlof, R. O., DeJariais, W. J., and Gulley, R. M. (1986). Absorption and distribution of deuterium-labeled trans-and cis-11-octadecenoic acid in human plasma and lipoprotein lipids. Lipids, 21:589-595.
141. Salminen, I., Mutanen, M., Jauhiainen, M., and Aro, A. (1998). Dietary trans fatty acids increase conjugated linoleic acid levels in human serum. Nutr. Biochem., 9:93-98.
142. Turpeinen, A. M., Mutanen, M., Aro, A., Salminen, I., Basu, S., Palmquist, D. L., and Griinari, J. M. (2002). Bioconversion of vaccenic acid to conjugated linoleic acid in humans. Am. J. Clin. Nutr., 76:504-510.
143. Banni, S., Angioni, E., Murru, E., Carta, G., Melis, M. P., Bauman, D. E., Dong, Y., and IP, C. (2001). Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses the development of premalignant lesions in the rat mammary gland. Nutr. Cancer, 41:91-97.
144. Ip, C., Dong, Y., Thompson, H. J., Bauman, D. E., and Ip, M. M. (2001). Control of rat mammary epithelium proliferation by conjugated linoleic acid. Nutr. Cancer, 39:233-238.
145. Ip, C., Ip, M. M., Loftus, T., Shoemaker, S., and Shea-Eaton, W. (2000). Induction of apoptosis by conjugated-linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland. Cancer Epidemiol. Biomakr. Prev., 9:689-696.
146. Vanden Heuvel, J. P. (1999). Peroxisome proliferators-activated receptors (PPARs) and carcinogenesis. Toxicol. Sci, 47:1-8.
147. Banni, S., Angioni, E., Casu, V., Melis, M. P., Scrugli, S., Carta, G., Corongiu, F. P. and Ip, C. (1999). An increase in Vitamin A status by the feeding of conjugated linoleic acid. Nutr. Cancer, 33:53-57.
148. Banni, S., Angioni, E., Casu, V., Melis, M. P., Carta, G., Corongiu, F. P., Thompson, H., and Ip, C. (1999). Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid. Carcinogenesis 20:1019-1024.
149. Belury, M. A., Nickel, K. P., Bird, C. E., and Wu, Y. (1996). Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion. Nutr. Cancer, 26:149-157.
150. Kavanaugh, C. J., Liu, K. L., and Belury, M. A. (1999). Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. Nutr. Cancer, 33:132-138.
151. Liew, C., Schut, H. A. J., Chin, S. F., Pariza, M. W., and Dashwood, R. H. (1995). Protection of conjugated linoleic acid against 2-amino-3-methylimidazol[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. Carcinogenesis, 16:3037-3043.
152. Park, H. S., Ryu, J. H., Ha, Y. L., and Park, J. H. Y. (2001). Dietary conjugated linoleic acid (CLA) induces apoptosis of colonic mucosa in 1,2-dimethylhydrazine-treated rats: A possible mechanism of the anticarcinogenic effect by CLA. Br. J. Nutr., 86:549-555.
153. Yang, H. Y, Stuart, G. R., Glickman, B. W., and De Boer, J. G. (2001). Modulation of 2-amino-1methyl-6-phenylimidazo[4,5-b]pyridine-induced mutation in the cecum and colon of big blue rats by congulated linoleic acid and 1,2-dithiole-3-thione. Nutr. Cancer, 39:259-266.
154. Knekt, P., Jarvinen, R., Seppanen, R., Pukkala, E., and Aromaa, A. (1996). Intake of dairy products and the risk of breast cancer. Br. J. Cancer, 73:687-691.
155. Lavillonniere, F. and Bougnoux, P. (1999). Conjugated linoleic acid (CLA) and the risk of breast cancer. In: Yurawecz, M. P., Mossoba, M. M., Kramer, J. K. G, Pariza, M. W., and Nelson, G. J. (eds.), Advances in Conjugated linoleic Acid Research, Volume 1, pp 276-282. Champaign, IL: AOCS Press.
156. Pariza, M.W., Park, Y., and Cook, M. E. (2000). Mechanisms of action of conjugated linoleic acid: evidence and speculation. Proc. Soc. Exp. Biol. Med., 223: 8-13.
157. Kritchevsky, D. (2000). Antimutagenic and some other effects of conjugated linoleic acid. Br. J. Nutr., 83: 459-465.
158. Pariza, M. W., Park, Y., Xu, X., Ntambi, J., and Kang, K. (2003). Speculation on the mechanisms of action of conjugated linoleic acid. In: Sebedio, J., Christei, W. W., and Adolf, R. (Eds.), Advances in Conjugated Linoleic Acid Research. Vol. 2, pp. 251-266. Champaign, IL: AOCS Press.
159. Banni, S., Heys, C. S. D., and Wahle, K. W. J. (2003). Conjugated linoleic acid as anticancer nutrients: Studies in vivo and cellular mechanisms. In: Sebedio, J., Christei, W. W., and Adolf, R. (Eds.), Advances in Conjugated Linoleic Acid Research. Vol. 2, pp. 267-281. Champaign, IL: AOCS Press.
160. Pariza, M. W., Park, Y., and Cook M. E. (2001). The biologically active isomers of conjugated linoleic acid. Prog. Lipid Res., 40:283-298.
161. Granlund, L., Juvet, L. K., Pederson, J. I., and Nebb, H. I. (2003). Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPAR? modulator. J. Lipid Res., 44: 1441-1452.
162. Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., and Pariza, M. W. (1997). Effect of conjugated linoleic acid on body composition in mice. Lipids, 32 (8):853-858.
163. Park, Y., Albright, K. J., Storkson, J. M., Liu, W., Cook, M. E., and Pariza, M. W. (1999). Changes in body composition in mice during feeding and withrdrawal of conjugated linoleic acid. Lipids, 34:243-248.
164. Park, Y., Storkson, J. M., Albright, K. J., Liu, W., and Pariza, M. W. (1999). Evidence that the trans-10, cis-12 isomer of conjuaged linoleic acid induces body composition changes in mice. Lipids, 34:235-241.
165. Miner, J. L., Cederberg, C. A., Nielsen, M. K., Chen, X., and Baile, C. A. (2001). Conjugated linoleic acid (CLA), body fat, and apoptosis. Obes. Res., 9: 129-134.
166. Sisk, M., Hausman, D., Martin, R., and Azain, M. (2001). Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats. J. Nutr., 131:1668-1674.
167. Rahman, S. M., Wang, Y., Yotsumoto, H., Cha, J., Han, S., Inoue, S., and Yanagita, T. (2001). Effects of conjugated linoleic acid on serum leptin concentrations, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats. Nutrition, 17:385-390.
168. Azain, M. J., Hausman, D. B., Sisk, M. B., Flatt, W. P., and Jewell, D. E. (2000). Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J. Nutr., 130:1548-1554.
169. Stangl, G. I. (2000). Conjugated linoleic acids exhibit a strong fat-to-lean partitioning effect, reduce serum VLDL lipids and redistribute tissue lipids in food-restricted rats. J. Nutr., 130:1140-1146.
170. Stangl, G. I., Muller, H., and Kirchgessner, M. (1999). Conjugated linoleic acid effects on circulating hormones, metabolites and lipoproteins and its proportion in fasting serum and erythrocyte membranes of swine. Eur. J. Nutr., 38:271-277.
171. Bassaganaya-Riera, B., Hontecillas-Magarzo, R., Bregendahl, K., Wannenmuehler, M. J., and Zimmerman, D. R. (2001). Effects of dietary conjugated linoleic acid in nursery pigs of dirty and clean environments on growth, empty body composition, and immune competence. J. Anim. Sci., 79:714-721.
172. Dugan, M. E. R., Aalhus, J. L., Schaefer, A. L., and Kramer, J. K. G. (1997). The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversions in pigs. Can. J. Anim., 77:723-725.
173. O'Quinn, P. R., Nelssen, J. L., Goodband, R. D., Unruh, J. A., Woodworth, J. C., Smith, J. S., and Tokach, M. D. (2000). Effects of modified tall oil versus a commercial source of conjugated linoleic acid and increasing levels of modified tall oil on growth performance and carcass characteristics of growing-finishing pigs. J. Anim. Sci., 78:2359-2368.
174. Ostrowska, E., Muralitharan, M., Cross, R. F., Bauman, D. E., and Dunshea, F. R. (1999). Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. J. Nutr., 129:2037-2042.
175. Thiel-Cooper, R. L., Parrish, F. C., Sparks, J. C., Wiegand, B. R., and Ewan, R. C. (2001). Conjugated linoleic acid changes swine performance and carcass composition. J. Anim. Sci., 79:1821-1828.
176. Wiegand, B. R., Parrish, F. C., Swan, J. E., Larsen, S. T., and Baas, T. J. (2001). Conjugated linoleic acid improves feed efficiency, decreases subcutaneous fat, and improves certain aspects of meat quality in stress-genotype pigs. J. Anim. Sci., 79:2187-2195.
177. Ohnuki, K. S., Haramizu, K., Oki, Isihara, K., and Foshiki, T. (2001). A single oral administration of conjugated linoleic acid enhanced energy metabolism in mice. Lipids, 36: 583-587.
178. West, D., Blohm, F. Y., Truett, A. A., Delany, J. P. (2000). Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expression. J. Nutr., 130:2471-2477.
179. Thom, E., Wadstein, J., and Gudmundson, O. (2001). Conjugated linoleic acid reduces body fat in healthy exercising humans. J. Int. Med. Res., 29:392-396.
180. Blankson, H., Stakkestad, J. A., Fagertun, H., Thom, E., Wadstein, J., and Gudmundsen, O. (2000). Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J. Nutr., 130: 2943-2948.
181. Zambell, K. L., Keim, N. L., Van Loan, M. D., Gale, B., and Benito, P. (2000). Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure. Lipids, 35:777-782.
182. Zambell, K. L., Horn, W. F., and Keim N. L. (2001). Conjugated linoleic acid supplementation in humans: effects on fatty acid and glycerol kinetics. Lipids, 36:767-772.
183. Atkinson, R. L. (1999). Conjugated linoleic acid for altering composition and treating obesity, In: Yurawecz, M. P., Mossoba, M. M., Kramer, J. K. G, Pariza, M. W., and Nelson, G. J. (eds.), Advances in Conjugated linoleic Acid Research, Volume 1, pp 348-353. Champaign, IL: AOCS Press.
184. Smedman, A., and Vessby, B. (2001). Conjugated linoleic acid supplementation in humans-metabolic effects. Lipids, 36:773-781.
185. Nicolosi, R. J., Rogers, E. J., Kritchevsky, D., Scimeca, J. A., and Huth, P. J. (1997). Dietary conjugated linoleic acid redicws plasma and early aortic atherosclerosis in hyperchlesterolemic hamsters. Artery, 22:266-277.
186. Wilson, T. A., Nicolosi, R. J., Chrysam, M., and Kritchevsky, D. (2000). Conjugated linoleic acid reduces early aortic atherosclerosis greater than linoleic acid in hypercholesterolemic hamsters. Nutr. Res., 20:1795-1805.
187. Munday, J. S., Thompson, K. G., and James K. A. C. (1999). Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model. Br. J. Nutr., 81:251-255.
188. De Deckere, E. A. M, van Amelsvoort, J. M. M., Rudrum, M. and Lin, Y. (1999). Effects of different conjugated linoleic acid isomers on lipid variables in hamsters. FASEB J., 13:LB207.
189. Noone, E. J., Roche, H. M., Nugent, A. P., and Gibney, M.J. (2002). The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br. J. Nutr., 88: 243-251.
190. Belury, M. A., and Vanden Huevel, J. P. (1999). Modulation of diabetes by conjugated linoleic acid. In: Yurawecz, M. P., Mossoba, M. M., Kramer, J. K. G., Pariza, M. W., and Nelson, G. J. (Eds.). Advances in Conjugated Linoleic Acid Research. Vol. I, pp. 404-411. Champaign, IL: AOCS Press.
191. Belury, M. A. (2002). Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. J. Nutr., 132: 2995-2998.
192. Ryder, J. W., Plrtocarrero, C. P., Song, X. M., Cui, L., Yu, M., Combatsiaris, T., Galuska, D., Bauman, D. E., Barbano, D. M., Charron, M. J., Zierath, J. R., and Houseknecht, K. L. (2001). Isomer specific antidiabetic properties of conjugated linoleic acid. Diabetes, 50: 1149-1157.
193. Henriksen, E. J., Techery, M. K., Taylor, Z. C., Jacob, S., Ptock, A., Kramer, K., and Hasselwander, O. (2003). Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. Am. J. Physiol. Endocrinol. Metab., 285: E98-E105.
194. Roche, H. M., Noone, E., Sewter, C., McBennet, S., Savage, D., Gibney, M. J., O'Rahilly, S., and Vidal-Puig, A. J. (2002). Isomer-dependent metabolic effects of conjugated linoleic acid. Diabetes, 51: 2037-2044.
195. Brown, J. M., Boysen, M. S., Jensen, S. S., Morrison, R. F., Storkson, J., Lea-Currie, R., Pariza, M., Mandrup, S., and McIntosh, M. K. (2003). Isomer-specific regulation of metabolism and PPAR? signaling by CLA in human preadipocytes. J. Lipid Res., 44: 1287-1300.
196. Whigham, L. D., Higbee, A., Bjorling, D. E., Park, Y.,Pariza, M. W., and Cook, M. E. Decreased antigen-induced eicosanoid release in conjugated linoleic acid -fed Guinea pigs. Am J Physiol. Regul. Integr. Comp. Physiol., 282: R1104-R1112.
197. Cook, M. E., Miller, C. C., Park, Y., and Pariza, M. W. (1993). Immune modulations by altered nutrient metabolism: nutritional control of immune-induced growth depression. Poultry Sci., 72:1301-1305.
198. Whigham, L. D., Cook, E. B., Stahl, J. L., Saban, R., Bjorling, D. E. (2001). CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig trachea. Am. J. Physiol. Regul. Integrative Comp. Physiol., 280(3):R908-R912.
199. Cook, M. E., Butz, D., Li, G., Pariza, M., Whigham, L., and Yang, M. (2003). Conjugated linoleic acid enhances immune responses but protects against the collateral damage of immune events. In: Sebedio, J., Christie, W. W., and Adolf, R. (Eds.), Advances in Conjugated Linoleic Acid Research. Vol. 2, pp. 283-291. Champaign, IL: AOCS Press.
200. Sugano, M., Tsuijita, A., Yamasaki, M., Noguchi, M., and Yamada, K. (1998). Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats. Lipids, 33:521-527.
201. Kelley, D. S., Simon, V. A, Taylor, P. C., Rudolph, I. L., Benito, P. (2001). Dietary supplementation with conjugated linoleic acid increased its concentration in human peripheral blood mononuclear cells, but did not alter their function. Lipids, 36:669-674.
202. Li, Y., Seifert, M. F., Ney, D. M., Grahn, M., Grant, A. L. (1999). Dietary conjugated linoleic acids alter serum IGF-I and IGF binding protein concentrations and reduce bone formation in rats fed n-6 or n-3 fatty acids. J. Bone Miner. Res., 14:1153-1162.
203. Watkins, B. A., Li, Y., and Seifert, M. F. (1999). Bone metabolism and dietary cnjugated linoleic acid. In: Yurawecz, M. P., Mossoba, M. M., Kramer, J. K. G, Pariza, M. W., and Nelson, G. J. (eds.), Advances in Conjugated linoleic Acid Research, Volume 1, pp 253-275. Champaign, IL: AOCS Press.
204. Jee, W. S., Mori, S., Li, X. J., and Chan, S. (1990). Prostaglandin E2 enhances cortical bone mass and activates intracortical bone remodeling in intact and ovarictomized female rats. Bone, 11:253-266.
205. Raisz L. G. (1993). Bone cell biology: New approaches and unanswered questions. J. Bone Miner. Res., 8:S457-S465.
206. Watknis, B. A., Shen, C. L., McMurtry, J. P., Xu, H., Bain, S. D., Allen, K.G.D., and Seifert, M. F. (1997). Dietary lipids modulate bone prostaglandin E2 production, insulin-like growth factor-1 concentration and formation rate in chicks. J. Nutr., 127:1084-1091.
207. Watkins, B. A., Yong, L, Romosos, D. R., Hoffmann, W. E., Kenneth, G. D. A., and Seifert, M. F. (2003). CLA and bone modeling in rats. In: Sebedio, J., Christei, W. W., and Adolf, R. (Eds.), Advances in Conjugated Linoleic Acid Research. Vol. 2, pp. 218-250. Champaign, IL: AOCS Press.
208. McDonald, H. B. (2000). Conjugated linoleic acid and disease prevention: a review of current knowledge. J. Am. College Nutr., 19:111S-118S.
209. Wahrmund-Wyle, J. L., Harris, K. B., and Savell, J. W. (2000). Beef retail cut composition: 1. Separable tissue components, J. Food Comp. Anal., 13:233-242.
210. Windham, W. R., Lawrence, K. C., and Feldner, P. W. (2003). Prediction of fat content in poultry meat by near-infrared transmission analysis. J. Appl. Poult. Res., 12:69-73.
211. Parrish, F. C., Jr., Wiegand, B. R., Beitz, D. C., Ahn, D. U., Du, M., and Trenkle, A. H. (2003). Use of dietary CLA to improve composition and quality of animal-derived foods. In: Sebedio, J., Christei, W. W., and Adolf, R. (Eds.), Advances in Conjugated Linoleic Acid Research. Vol. 2, pp. 189-217. Champaign, IL: AOCS Press.
212. Watkins, B. A. and Y. Li. (2003). CLA in functional food: enrichment of animal products. In: Sebedio, J., Christei, W. W., and Adolf, R. (Eds.), Advances in Conjugated Linoleic Acid Research. Vol. 2, pp. 174-188. Champaign, IL: AOCS Press.
213. Lin, H., Boylston, T. D., Chang, M. J., Luedecke, L. O., and Shultz, T. D. (1995). Survey of the conjugated linoleic acid contents of dairy products. J. Dairy Sci., 78:2358-2365.
214. Fritsche, J., and Steinhart, H. (1998). Amounts of conjugated linoleic acid (CLA) in German foods and evaluation of daily intake. Z. Lebensm.-Unters.-Forsch. A., 206:77-82.
215. Shantha, N. C., Decker, E. A., and Ustunol, Z. (1992). Conjugated linoleic acid concentration in processed cheese. J. Am. Oil. Chem. Soc., 69:425-428.
216. Werner, S. A., Luedecke, L. O., and Shultz, T. D. (1992). Determination of conjugated linoleic acid content and isomer distribution in three cheddar-type cheeses: effects of cheese cultures, processing, and aging. J. Agric. Food Chem., 40:1817-1821.
217. Garcia-Lopez, S., Echeverria, E., Tsui, I., and Balch, B. (1994). Changes in the content of conjugated lionleic acid (CLA) in processed cheese during processing. Food Res. Intern., 27:61-64.
218. Boylston, T. D., and Beitz, D. C. (2002). Conjugated linoleic acid and fatty acid composition of yogurt produced from milk of cows fed soy oil and conjugated linoleic acid. J. Food Sci., 67:1973-1978.
219. Fritsche, J., and Steinhart, H. (1997). Content of trans fatty acids (TFA) in German foods and estimation of daily intake. Fett/Lipid, 99:314-318.
220. Fritsche, J., and Steinhart, H. (1998). Analysis, occurrence, and physiological properties of trans fatty acids (TFA) with particular emphasis on conjugated linoleic acid isomers (CLA)-a review. Fett/Lipid, 100:190-210.
221. Mir, Z., Rushfeldt, M. L., Mir, P. S., Paterson, L. J., and Weselake, R. J. (2000). Effect of dietary supplementation with either conjugated linoleic acid (CLA) or linoleic acid rich oil on the CLA content of lamb tissues. Small Ruminant Res., 36:25-31.
222. Kott, R. W., Hatfield, P. G., Bergman, J. W., Flynn, C. R., Van Wagoner, H., and Boles, J. A. (2003). Feedlot performance, carcass composition, and muscle and fat CLA concentrations of lambs fed diets supplemented with safflower seeds. Small Ruminant Res., 49:11-17.
223. Wachira, A. M., Sinclair, L. A., Wilkinson, R. G., Enser, M., Wood, J. D., and Fisher, A. V. (2002). Effects of dietary fat source and breed on the carcass composition, n-3 polyunsaturated fatty acid and conjugated linoleic acid content of sheep meat and adipose tissue. British J. Nutr., 88:697-709.
224. Yurawecz, M. P., Roach, J. A. G., Sehat, N., Mossoba, M. M., Kramer, J. K. G., Fritsche, J., Steinhart, H., and Ku, Y. (1998). A new conjugated linoleic acid isomer, 7 trans, 9 cis-octadecadienoic acid, in cow milk, cheese, beef and human milk and adipose tissue. Lipids, 33:803-809.
225. Ha, Y. L., Grimm, N. K., and Pariza, M. W. (1987). Anticarcinogens from fried ground beef: Heat-altered derivatives of linoleic acid. Carcinogenesis. 8:1881-1887.
226. Ha, Y. L., Storkson, J. M., Pariza, M. W. (1990). Inhibition of benzo(a)pyrene-induced Mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Res., 50:1097-1101.
227. Petrick, M. B. H., McEntee, M. F., Johnson, B. T., Obukowicz, M. G., Whelan, J. (2000). Highly unsaturated (n-3) fatty acids, but not a-linoleic or ?-linoleic acids, reduce tumorigenisis in APC Min/+ mice. J. Nutr., 130:2434-2443.
228. Demaree, S. R., Gilber, C. D., Mersmann, H. J., and Smith, S. B. (2002). Conjugated linoleic acid differentially modifies fatty acid composition in subcellular fractions of muscle and adipose tissue but not adiposity of postweanling pigs. J. Nutr., 132: 3272-3279.
229. Kritchevsky, D. (2003). Conjugated linoleic acid in experimental atherosclerosis. In: Sebedio, J., Christei, W. W., and Adolf, R. (Eds.), Advances in Conjugated Linoleic Acid Research. Vol. 2, pp. 292-301. Champaign, IL: AOCS Press.
230. Belury, M. A. (2002). Dietary conjugated linoleic acid in health: Physiological effects and mechanisms of action. Annu. Rev. Nutr., 22:505-531
231. Tsuboyama-Kasaoka, N., Takahashi, M., Tanemura, K., Kim, H., Tange, T., Okuyama, H., Kasai, M., Ikeoto, S., and Ezaki, O. (2000). Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes, 49:1534-1542.
232. Kelley, D. S., Taylor, P.C., Rudolph, I. L., Benito, P., Nelson, G. J., Mackey, B. E. and Erickson, K. L. (2000). Dietary conjugated linoleic acid did not alter immune status in young healthy women. Lipids, 35:1065-1071.
233. Yang M., Pariza, M. W., and Cook, M.E. (2000). Dietary conjugated linoleic acid protectrs against end stage disease of lupus erythematosus in the NZB/W F1 mouse. Immunopharmacol. Immunotoxicol., 22:433-449.
234. Palacios, A., Piergiacomi, V., and Catala, A. (2003). Antioxidant effect of conjugated linoleic acid and vitamin A during non-enzymatic lipid peroxidation of rat liver microsomes and mitochondria. Mol. Cell. Biochem., 250:107-113.
235. Li, Y. and Watkins, B. A. (1998). Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n-6 or n-3 fatty acids. Lipids, 33:417-425.