Mechanisms of action of conjugated linoleic acid: Evidence and speculation

Proceedings of the Society for Experimental Biology and Medicine

Volumn 223, Issue 1, 2000, Pages 8-13

  Pariza, Michael W ^a   Park, Yeonhwa ^a   Cook, Mark E ^a,b  

^a UNIVERSITY OF WISCONSIN   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONJUGATED LINOLEIC ACID; CYTOKINE; ICOSANOID; LINOLEIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ATHEROSCLEROSIS; BODY COMPOSITION; CACHEXIA; CARCINOGENESIS; CONTROLLED STUDY; DRUG MECHANISM; ENERGY METABOLISM; FAT INTAKE; FEMALE; GROWTH STIMULATION; IMMUNOSTIMULATION; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; REVIEW;

ANIMALIA;

EID: 0034126170     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1373.2000.22302.x     Document Type: Review

References (58)

1. Ha YL, Grimm NK, Pariza MW. Anticarcinogens from fried ground beef: Heat-altered derivatives of linoleic acid. Carcinogenesis 8:1881-1887, 1987.
2. Cook ME, Miller CC, Park Y, Pariza MW. Immune modulation by altered nutrient metabolism: Nutritional control of immune-induced growth depression. Poultry Sci 72:1301-1305, 1993.
3. Miller CC, Park Y, Pariza MW, Cook ME. Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection. Biochem Biophys Res Commun 198:1107-1112, 1994.
4. Chin SF, Storkson JM, Albright KJ, Cook ME, Pariza MW. Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. J Nutr 124:2344-2349, 1994.
5. Park Y, Albright KJ, Storkson JM, Cook ME, Pariza MW. Effect of conjugated linoleic acid on body composition in mice. Lipids 32:853-858, 1997.
6. Lee KN, Kritchevsky D, Pariza MW. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108:19-25, 1994.
7. Doyle E. Scientific forum explores CLA knowledge. INFORM 9:69-72, 1998.
8. Christie WW. Isomers in commercial samples of conjugated linoleic acid. J AOCS Int 74:1231, 1997.
9. Sehat N, Yurawecz MP, Roach JAG, Mossoba MM, Kramer JKG, Ku Y. Silver-ion high-performance liquid chromatographic separation and identification of conjugated linoleic acid isomers. Lipids 33:217-221, 1998.
10. Sehat N, Rickert RR, Mossoba MM, Kramer JKG, Yurawecz MP, Roach JAG, Adlof RO, Morehouse KM, Fritsche J, Eulitz KD, Steinhart H, Ku K. Improved separation of conjugated fatty acid methyl esters by silver ion-high-performance liquid chromatography. Lipids 34:407-413, 1999.
11. Chin SF, Liu W, Storkson JM, Ha YL, Pariza MW. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. J Food Comp Anal 5:185-197, 1992.
12. Parodi PW. Cows' milk fat components as potential anticarcinogenic agents. J Nutr 127:1055-1060, 1997.
13. Kramer JKG, Fellner V, Dugan MER, Sauer FD, Mossoba MM, Yurawecz MP. Evaluating acid and base catalysts in the methylation of milk and rumen fatty acids with special emphasis on conjugated dienes and total trans fatty acids. Lipids 32:1219-1228, 1997.
14. Kepler CR, Hirons KP, McNeill JJ, Tove SB. Intermediates and products of the biohydrogenation of linoleic acid by Butyrivibrio fibrisolvens. J Biol Chem 241:1350-1354, 1966.
15. Holman RT, Mahfouz MM. Cis- and trans-octadecadienoic acids as precursors of polyunsaturated fatty acids. Prog Lipid Res 20:151-156, 1980.
16. Pollard MR, Gunstone FD, James AT, Morris LJ. Desaturation of positional and geometric isomers of monoenoic fatty acids by microsomal preparations from rat liver. Lipids 15:306-314, 1980.
17. Griinari JM, Bauman DE. Biosynthesis of conjugated linoleic acid and its incorporation into meat and milk in ruminants. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson G, Eds. Advances in Conjugated Linoleic Acid Research, Vol. 1. Champaign, IL: AOCS Press, pp180-200, 1999.
18. Griinari JM, Dwyer DA, McGuire MA, Bauman DE, Palmquist DL, Nurmela KVV. Trans-octadecenoic acids and milk fat depression in lactating dairy cows. J Dairy Sci 81:1251-1261, 1998.
19. Verhulst A, Janssen G, Parmentier G, Eyssen H. Isomerization of polyunsaturated long chain fatty acids by propionibacteria. Syst Appl Microbiol 9:12-15, 1987.
20. Park Y, Pariza MW. Evidence that commercial calf and horse sera can contain substantial amounts of trans-10,cis-12 conjugated linoleic acid. Lipids 33:817-819, 1998.
21. Uchida K. Occurrence of conjugated dienoic fatty acids in the cellular lipids of Pediococcus homari. Agric Biol Chem 39:561-563, 1975.
22. Park Y, Albright KJ, Storkson JM, Liu W, Pariza MW. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34:235-241, 1999.
23. de Deckere EAM, van Amelsvoort JMM, Rudrum M, Lin Y. Effects of different conjugated linoleic acid isomers on lipid variables in the hamster. FASEB J 13:LB48, 1999.
24. Lin YG, Draijer R, Kreeft A, de Deckere EAM, Rudrum M, Tijburg L. Differential effects of conjugated linoleic acid isomers on lipid metabolism in vitro. FASEB J 13:LB207, 1999.
25. Lee KN, Pariza MW, Ntambi JM. Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase mRNA expression. Biochem Biophys Res Commun 248:817-821, 1998.
26. Yotsumoto H, Hara E, Naka S, Adlof RO, Emken EA, Yanagita T. 10trans, 12cis-linoleic acid reduces apolipoprotein B secretion in HepG2 cells. Food Res Int 31:403-409, 1999.
27. Lee KN. Conjugated linoleic acid and lipid metabolism. PhD thesis, University of Wisconsin-Madison, 1996.
28. Pariza MW, Lee KN. Method for reducing secretion of apolipoprotein B in animals by administering conjugated linoleic acid. U. S. Patent 5,837,733, 1997.
29. Nicolosi RJ, Rogers EJ, Kritchevsky D, Scimeca JA, Huth PJ. Dietary conjugated linoleic acid reduces plasma lipoproteins and early atherosclerosis in hypercholesterolemic hamsters. Artery 22:266-277, 1997.
30. Munday JS, Thompson KG, James KA. Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model. Br J Nutr 81:251-255, 1999.
31. Rudel LL. Atherosclerosis and conjugated linoleic acid. Br J Nutr 81:177-179, 1999.
32. DeVoney D, Pariza MW, Cook ME. Trans-10,cis-12 octadecadienoic acid increases lymphocyte proliferation. FASEB J 13:4565, 1999.
33. Chew BT, Wong TS, Shultz TD, Magnuson NS. Effects of conjugated dieonic derivatives of linoleic acid and β-carotene in modulating lymphocyte and macrophage function. Anticancer Res 17:1099-1106, 1997.
34. Sugano MA, Tsujita M, Yamasaki K, Ikeda I, Kritchevsky D. Lymphatic recovery, tissue distribution, and metabolic effects of conjugated linoleic acid in rats. J Nutr Biochem 8:38-43, 1997.
35. Wong MW, Chew BP, Wong TS, Hosick HL, Boylston TD, Shultz TD. Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice. Anticancer Res 17:987-993, 1997.
36. 4 from guinea pig lung, trachea, and bladder. FASEB J 13:4566, 1999.
37. Belury M, Vanden Heuvel JP. Modulation of diabetes by conjugated linoleic acid. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson G, Eds. Advances in Conjugated Linoleic Acid Research, Vol. 1. Champaign, IL: AOCS Press, pp404-411, 1999.
38. Moya-Camarena SY, Vanden Heuvel JP, Belury MA. Conjugated linoleic acid activates peroxisome proliferator-activated receptor a and b subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats. Biochim Biophys Acta 1436:331-342, 1999.
39. Ip C, Singh M, Thompson HJ, Scimeca JA. Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res 54:1212-1215, 1994.
40. Banni S, Angioni E, Casu V, Melis MP, Scrugli S, Carta G, Corongiu FP, Ip C. An increase in vitamin A status by the feeding of conjugated linoleic acid. Nutr Cancer 33:53-57, 1999.
41. Liew C, Schut HAJ, Chin SF, Pariza MW, Dashwood RH. Protection of conjugated linoleic acids against 2-amino-3-methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: A study of inhibitory mechanisms. Carcinogenesis 16:3037-3043, 1995.
42. Pariza MW, Park Y, Cook ME. Conjugated linoleic acid and the control of cancer and obesity. Toxicological Sciences, 52(Suppl):107-110, 1999.
43. Marnett LJ. Aspirin and the potential role of prostaglandins in colon cancer. Cancer Res 52:5575-5589, 1992.
44. Brodie AE, Manning VA, Ferguson KR, Jewell DE, Hu CY. Conjugated linoleic acid inhibits differentiation of pre- and post-confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells. J Nutr 129:602-606, 1999.
45. Park Y, Albright KJ, Storkson JM, Liu W, Cook ME, Pariza MW. Changes in body composition during feeding and withdrawal of dietary conjugated linoleic acid. Lipids 34:243-248, 1999.
46. 2 biosynthesis in rats fed n-6 or n-3 fatty acids. Lipids 33:417-425, 1998.
47. Sebedio JL, Juaneda P, Dobson G, Ramilison I, Martin JC, Chardigny JM, Christie WW. Metabolites of conjugated isomers of linoleic acid (CLA) in the rat. Biochim Biophys Acta 1345:5-10, 1997.
48. Pariza MW, Park Y, Albright KJ, Liu W, Storkson JM, Cook ME. Synthesis and biological activity of conjugated eicosadienoic acid. Abstracts of the 89th American Oil Chemists Society Annual Meeting, 21, 1998.
49. Pariza MW. Conjugated linoleic acid, a newly recognized nutrient. Chem Ind 12:464-466, 1997.
50. Lewis GP. Immunoregulatory activity of metabolites of arachidonic acid and their role in inflammation. Br Med Bull 39:243-248, 1983.
51. Hotamisligil GS, Spiegelman BM. TNFα: A key component of obesity-diabetes link. Diabetes 43:1271-1278, 1994.
52. Carlos TM, Schwartz BR, Kovach NL, Yee E, Rosso M, Osborn L, Chi-Rosso G, Newman B, Lobb R, Harlan JM. Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells. Blood 76:965-970, 1990.
53. Garofalo A, Chirivi RGS, Foglieni C, Pigott R, Mortarini R, Martin-Padura I, Anichini A, Gearing AJ, Sanchez-Madrid F, Dejana E, Giavazzi R. Involvement of the very late antigen 4 integrin on melanoma in interleukin 1-augmented experimental metastasis. Cancer Res 55:414-519, 1995.
54. Freeman LM, Roubenoff R. The nutrition implications of cardiac cachexia. Nutr Rev 52:340-347, 1994.
55. Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 362:801-809, 1993.
56. Okahara H, Yagita H, Miyake K, Okumura K. Involvement of very late activation antigen 4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor α enhancement of experimental metastasis. Cancer Res 54:3233-3236, 1994.
57. Suganuma M, Okabe S, Sueoka E, Iida N, Komori A, Kim SJ, Fugiki H. A new process of cancer prevention mediated through inhibition of tumor necrosis factor α expression. Cancer Res 56:3711-3715, 1996.
58. Steinhart C. Conjugated linoleic acid: The good news about animal fat. J Chem Educ 73:A302-A303, 1996.