Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number

Journal of Nutrition

Volumn 130, Issue 6, 2000, Pages 1548-1554

  Azain, Michael J ^a   Hausman, Dorothy B ^b   Sisk, Matthew B ^a   Flatt, William P ^a,b   Jewell, Dennis E ^c  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c Hill's Pet Nutrition Inc   (United States)

Author keywords

Adipose tissue; Cellularity; Conjugated linoleic acid; Rats

Indexed keywords

CARBON DIOXIDE; LINOLEIC ACID; MONOUNSATURATED FATTY ACID;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL SIZE; CONTROLLED STUDY; ENERGY EXPENDITURE; ENERGY METABOLISM; FEMALE; FOOD INTAKE; NONHUMAN; OXYGEN CONSUMPTION; RAT; THERMOGENESIS;

EID: 0034034673     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.6.1548     Document Type: Article

References (31)

1. Azain, M. J. (1993) Effects of adding medium chain triglycerides to sow diets during late gestation and early lactation on litter performance. J. Anim. Sci. 71: 3011-3019.
2. Belury, M. A. (1995) Conjugated dienoic linoleate: a polyunsaturated fatty acid with unique chemical properties. Nutr. Rev. 53: 83-89.
3. Brodie, A. E., Manning, V. A., Ferguson, K. R., Jewell, D. E. & Hu, C. Y. (1999) Conjugated linoleic acid inhibits differentiation of pre-and postconfluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells. J. Nutr. 129: 602-606.
4. Chin, S. F., Storkson, J. M., Albright, K. J., Cook, M. E. & Pariza, M. W. (1994) Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. J. Nutr. 124: 2344-2349.
5. Chin, S. F., Storkson, J. M., Liu, W., Albright, K. J. & Pariza, M. W. (1994) Conjugated linoleic acid (9, 11-and 10, 12-octadecanoic acid) is produced in conventional but not germ-free rats fed linoleic acid J. Nutr. 124: 694-701.
6. Chouinard, P. Y., Corneau, L., Barbano, D. M., Metzger, L. E. & Bauman, D. E. (1999) Conjugated linoleic acids alter milk fatty acid composition and inhibit milk fat secretion in dairy cows. J. Nutr. 129: 1579-1584.
7. DeLany, J. P., Blohm, F., Truett, A. A., Scimeca, J. A. & West, D. B. (1999) Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am. J. Physiol. 276: R1172-R1179.
8. Dijan, P., Roncari, D.A.K. & Hollenberg, C. H. (1983) Influence of anatomical site and age on the replication and differentiation of rat adipocyte precursors in culture. J. Clin. Investig. 72: 1200-1208.
9. Dugan, M.E.R., Aalhus, J. L., Schaefer, A. L. & Kramer, J.K.G. (1997) The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs. Can. J. Anim. Sci. 77: 723-725.
10. Faust, I. M., Johnson, P. R. & Hirsch, J. (1980) Long-term effects of early nutritional experience on the development of obesity in the rat. J. Nutr. 110: 2027-2034.
11. Ha, Y. L., Grimm, N. K. & Pariza, M. W. (1989) Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses. J. Agric. Food Chem. 37: 75-81.
12. Hayek., M. G., Man, S. N., Wu, D., Watkins, B. A., Meydani, M., Dorsey, J. L., Smith, D. E. & Meydani, S. N. (1999) Dietary conjugated linoleic acid influences the immune response of young and old C57BL/6NCrlBR mice. J. Nutr. 129: 32-38.
13. Ip, C. (1997) Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids and conjugated linoleic acid on mammary carcinogenesis in animals. Am. J. Clin. Nutr. 66 (suppl.):1523S-1529S.
14. Ip. C., Scimeca, J. A. & Thompson, H. J. (1994) Conjugated linoleic acid: a powerful anticarcinogen from animal sources. Cancer (suppl.) 74:1050-1054.
15. Lee, K. C., Azain, M. J., Hardin, M. A. & Williams, S. E. (1994a) Effect of porcine somatotropin (pST) treatment and withdrawal on performance and adipose tissue cellularity in finishing swine. J. Anim. Sci. 72: 1702-1711.
16. Lee, K. N., Pariza M. W. & Ntambi, J. M. (1998) Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase mRNA expression. Biochem. Biophys. Res. Commun. 248: 817-821.
17. Lin, H., Boylston, T. D., Chang, M. J., Luedecke, L. O. & Shultz, T. D. (1995) Survey of conjugated linoleic acid contents of dairy products. J. Dairy Sci. 78: 2358-2365.
18. Loor, J. J. & Herbein, J. H. (1998) Exogenous conjugated linoleic acid isomers reduce bovine milk fat concentration and yield by inhibiting de novo fatty acid synthesis. J. Nutr. 128: 2411-2419.
19. Marques, B. G., Hausman, D. B. & Martin, R. J. (1998) Association of fat cell size and paracrine growth factors in development of hyperplastic obesity. Am. J. Physiol. 275: R1898-R1908.
20. Mersmann, H. J. & MacNeil, M. D. (1986) Variables in estimation of adipocyte size and number with a particle counter. J. Anim. Sci. 62: 980-986.
21. Muller, H. L., Stangl, G. I. & Kirchgessner, M. (1999) Energy balance of conjugated linoleic acid-treated pigs. J. Anim. Physiol. Anim. Nutr. 81: 150-156.
22. Pariza, M. W. & Margraves, W. A. (1985) A beef-derived mutagenesis modulator inhibits initiation of mouse epidermal tumors by 7,12-dimethylbenz[a]anthracene. Carcinogenesis 8: 591-593.
23. Park., Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E. & Pariza, M. W. (1997) Effect of conjugated linoleic acid on body composition in mice. Lipids 32: 853-858.
24. Park, Y., Albright, K. J., Storkson, J. M., Liu, W., Cook, M. E. & Pariza, M. W. (1999a) Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34: 233-248.
25. Park, Y., Storkson, J. M., Albright, K. J., Liu, W. & Pariza, M. W. (1999b) Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34: 235-241.
26. Reeves, P. G., Nielsen, F. H. & Fahey, G. C., Jr. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123: 1939-1951.
27. Roberts, T. J., Azain, M. J., Hausman, G. J. & Martin, R. J. (1994) The interaction of insulin and somatotropin on body weight gain, feed intake and body composition in the rat. Am. J. Physiol. 267: E293-E299.
28. Satory, D. & Smith, S. B. (1999) Conjugated linoleic acid inhibits proliferation but stimulates lipid filling of murine 3T3-L1 preadipocytes. J. Nutr. 129: 92-97.
29. Scimeca, J. A., Thompson, H. J. & Ip, C. (1994) Effect of conjugated linoleic acid on carcinogenesis. In: Diet and Breast Cancer, pp. 59-65. American Institute for Cancer Research, Plenum Press, New York, NY.
30. West, D. B., Delany, J. P., Camet, P. M., Blohm, F., Truet, A. A. & Scimeca, J. (1998) Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am. J. Physiol. 275: R667-R672.
31. Yamasaki, M., Mansho, K., Mishima, H., Kasai, M., Sugano, M., Tachibana, H. & Yamada, K. (1999) Dietary effect of conjugated linoleic acid on lipid levels in white adipose tissue of Sprague-Dawley rats. Biosci. Biotechnol. Biochem. 63: 1104-1106.