Conjugated linoleic acid suppresses the growth of human breast adenocarcinoma cells in SCID mice

Anticancer Research

Volumn 17, Issue 2 A, 1997, Pages 969-973

  Visonneau, Sophie ^a   Cesano, Alessandra ^a   Tepper, Shirley A ^a   Scimeca, Joseph A ^b   Santoli, Daniela ^a   Kritchevsky, David ^a  

^a WISTAR INSTITUTE   (United States)

^b Kraft General Foods   (United States)

Author keywords

Conjugated linoleic acid; Fatty acids; Human breast carcinoma; Nutrition; SCID mice

Indexed keywords

FATTY ACID DERIVATIVE; LINOLEIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD DISEASE; BONE MARROW METASTASIS; BREAST ADENOCARCINOMA; CANCER INHIBITION; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LUNG METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SCID MOUSE;

ADENOCARCINOMA; ANIMALS; FEMALE; HUMANS; LINOLEIC ACID; LINOLEIC ACIDS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030889624     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Doll R and Peto R: The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66: 1191-1308, 1981.
2. Caroll KK: Nutrition and cancer: fat. In: Nutrition, toxicity and cancer (Rowland IR, ed). Boca Raton, FL. CRC Press, 1991, pp 439-453.
3. Wynder EL and Gori GB: Contribution of the environment to cancer incidence: an epidemiological exorcise. J Natl Cancer Inst 58: 825-832, 1977.
4. Birt DF: The influence of dietary fat on carcinogenesis: lessons from experimental models. Nutr Rev 48: 1-5, 1990.
5. Ha YL, Grimm NK, and Pariza, MW: Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses. J Agr Food Chem 37: 75-81, 1989.
6. Ha YL, Grimm NK, and Pariza MW: Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcinogenesis 8: 1881-1887, 1987.
7. Ha YL, Storkson J, and Pariza MW: Inhibition of benzo[a]pyreneinduced mouse fore stomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Res 50: 1097-1101, 1990.
8. Ip C, Chin SF, Scimeca JA, and Pariza MW: Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res 51: 6118-6124, 1991.
9. Shullz TD, Chew BP, Seaman WR, and Luedecke LO: Inhibitory effect of conjugated dienoic derivatives of linoleic acid and ßcarotene on the in vitro growth of human cancer cells. Cancer Lett 63: 125-133, 1992.
10. l0 Visonneau S, Cesano A, Tepper SA, Scimeca JA, Santoli D, and Kritchevsky, D: Effect of different concentrations of conjugated linoleic acid (CLA) on tumor cell growth in vitro. FASEB J 10: A182, 1996.
11. Hillyard LA and Abraham S: Effect of dietary polyunsaturated fatty acids on growth of mammary adenocarcinomas in mice and rats. Cancer Res 39: 4430-4437, 1979.
12. Ip C, Carter CA, and Ip MM: Requirement for essential fatty acid for mammary tumorigenesis in the rat. Cancer Res 45:1997-2001, 1985.
13. Willen WC, Hunter DJ, Stampfer MJ. Colditz G, Manson JE, Spiegelman D, Rosner B, Hennekens CH, and Speizer FE: Dietary fat and fiber in relation to risk of breast cancer. JAMA 268: 2037-2044, 1992.
14. Chlebowski RT, Rose DP, Buzzard IM, Blackburn GL, Insull W, Jr. Grosvenor M, Elashoff R, and Wynder EL: Adjuvant dietary fat intake reduction in postmenopausal breast cancer patient management. Breast Cancer Res Treat 20: 73-84, 1992.
15. Mackinnon S, Barnett L, Bourhis JH, Black P, Heller G and O' Reilly RJ: Myeloid and lymphoid chimerism after T-cell-depleted bone marrow transplantation: evaluation of conditioning regimens using polymerase chain reaction to amplify human minisatellite regions of genomic DNA. Blood 21: 3235-3241, 1992.
16. Ip C, Singh M, Thompson HJ, and Scimeca JA: Conjugated linoleic acid suppresses mammary carcinogencsis and proliferative activity of the mammary gland in the rat. Cancer Res 54: 1212-1215, 1994.
17. Willett WC, Stampfer MJ, Colditz GA, Rosner BA, Henneckens CH, and Speizer FE: Dietary fat and the risk of breast cancer. New Engl J Med. 316: 22-28, 1987.
18. Rose DP, Connolly JM, and Meschter CL: Effect of dietary fat on human breast cancer growth and lung metastasis in nude mice. J Natl Cancer Insi 83: 1491-1495, 1991.
19. Welsch CW: Relationship between dietary fat and experimental mammary tumorigenesis. A review and critique. Cancer Res 52: 2040s-2048s, 1992.
20. Rose DP and Connolly JM: Effects of fatty acids and inhibitors of eicosanoid synthesis on the growth of a human breast cancer cell line in culture. Cancer Res 50: 7139-7144, 1990.
21. Horrobin DF: Essential fatty acids, lipid peroxidation and cancer. In: Omega-6 essential fatty acids: patbophysiology and roles in clinical medicine (Horrobin DF, ed). New York. Wiley-Liss, 1990, pp 351-377.
22. Begin ME, Ells G, and Horrobin DF: Polyunsaturated fatty acid induced cytotoxicity against tumor cells and its relationship to lipid peroxidation. J Natl Cancer Inst 80: 188-194, 1988.
23. Van den Berg JJ, Cook NE, and Tribble DL: Reinvestigation of the antioxidant properties of conjugated linoleic acid. Lipids 30: 599-605, 1995.