Conjugated linoleic acid-enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats

Journal of Nutrition

Volumn 129, Issue 12, 1999, Pages 2135-2142

  Ip, Clement ^a   Banni, Sebastiano ^b   Angioni, Elisabetta ^b   Carta, Gianfranca ^b   McGinley, John ^c   Thompson, Henry J ^c   Barbano, David ^d   Bauman, Dale ^d  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c UNIVERSITY OF COLORADO   (United States)

^d Department of Obstetrics Gynecology   (United States)

Author keywords

Butter fat; Conjugated linoleic acid; Mammary cancer prevention; Mammary gland morphogenesis; Rats; Tissue CLA isomers

Indexed keywords

ACYL COENZYME A DESATURASE; CYCLINE; LINOLEIC ACID; METHYLNITROSOUREA; VACCENIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; BREAST CANCER; BREAST DEVELOPMENT; BREAST EPITHELIUM; BUTTER; CANCER PREVENTION; CANCER RISK; CELL DENSITY; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; CONJUGATION; CONTROLLED STUDY; FEMALE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MORPHOGENESIS; NONHUMAN; RAT;

EID: 0032720394     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.12.2135     Document Type: Article

References (32)

1. Banni, S., Angioni, E., Casu, V., Melis, M. P., Carta, G., Corongiu, F. P., Thompson, H. & Ip, C. (1999) Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid. Carcinogenesis 20: 1019-1024.
2. Banni, S., Carta, G., Contini, M. S., Angioni, E., Deiana, M., Dessi, M. A., Melis, M. P. & Corongiu, F. P. (1996) Characterization of conjugated diene fatty acids in milk, dairy products, and lamb tissues. J. Nutr. Biochem. 7: 150-155.
3. Banni, S., Day, B. W., Evans, R. W., Corongiu, F. P. & Lombardi, B. (1994) Liquid chromatographic-mass spectrometric analysis of conjugated diene fatty acids in a partially hydrogenated fat. J. Am. Oil Chem. Soc. 71: 1321-1325.
4. Banni, S. & Martin, J. C. (1998) Conjugated linoleic acid and metabolites. In: Trans Fatty Acids in Human Nutrition (Sebedio, J. L. & Christie, W. W., eds.), pp. 261-302. Oily Press, Aberdeen, UK.
5. Baumgard, L., Corl, B., Dwyer, D., Saebo, A. & Bauman, D. E. (1999) Identification of the conjugated linoleic acid isomer which inhibits milk fat synthesis. Am. J. Physiol. (in press).
6. Belury, M. A., Bird, C., Nickel, K. P. & Wu, B. (1996) Inhibition of mouse skin tumor promotion by dietary conjugated linoleate. Nutr. Cancer 26: 149-157.
7. Cesano, A., Visonneau, S., Scimeca, J. A., Kritchevsky, D. & Santoli, D. (1998) Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. Anticancer Res. 18: 1429-1434.
8. Chouinard, P. Y., Corneau, L., Barbano, D. M., Metzer, L. E. & Bauman, D. E. (1999) Conjugated linoleic acids alter milk fatty acid composition and inhibit milk fat secretion in dairy cows. J. Nutr. 129: 1579-1584.
9. Christie, W. W. (1982) A simple procedure of rapid transmethylation of glycerolipids and cholesteryl esters. J. Lipid Res. 23: 1072-1075.
10. Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957) A simple method for the isolation and purification of total lipid from animal tissues. J. Biol. Chem. 226: 497-509.
11. Griinari, J. M. & Bauman, D. E. (1999) Biosynthesis of conjugated linoleic acid and its incorporation into meat and milk in ruminants. In: Conjugated Linoleic Acid: Biochemical, Nutritional, Clinical, Cancer, and Methodological Aspects (Yurawecz, M. P., Mossoba, M. M., Kramer, J.K.G., Nelson, G. & Pariza, M. W., eds.), pp. 180-200. AOCS Press, Champaign, IL.
12. Ha, Y. L., Storkson, J. & Pariza, M. W. (1990) Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Res. 50: 1097-1101.
13. Horvath, P. M. & Ip, C. (1983) Synergistic effect of vitamin E and selenium in chemoprevention of mammary carcinogenesis in rats. Cancer Res. 43: 5335-5341.
14. Ip, C. (1987) Fat and essential fatty acid in mammary carcinogenesis. Am. J. Clin. Nutr. 45: 218-224.
15. Ip, C. (1997) Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fattty acids, and conjugated linoleic acid on mammary carcinogenesis in animals. Am. J. Clin. Nutr. 66: 1523S-1529S.
16. Ip, C., Briggs, S. P., Haegele, A. D., Thompson, H. J., Storkson, J. & Scimeca, J. (1996) The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet. Carcinogenesis 17: 1045-1050.
17. Ip, C., Scimeca, J. A. & Thompson, H. (1995) Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. Nutr. Cancer 24: 241-247.
18. Ip, C., Scimeca, J. A. & Thompson, H. J. (1994) Conjugated linoleic acid: a powerful anticarcinogen from animal sources. Cancer 74: 1051-1054.
19. Ip, M., Masso-Welch, P. A., Shoemaker, S. F., Shea, W. K. & Ip, C. (1999) Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells in primary culture. Exp. Cell Res. 250: 22-34.
20. Kelly, M. L., Berry, J. R., Dwyer, D. A., Griinari, J. M., Chouinard, P. Y., Van Amburgh, M. E. & Bauman, D. E. (1998) Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. J. Nutr. 128: 881-885.
21. Kramer, J.K.G., Sehat, N., Dugan, M.E.R., Mossoba, M. M., Yurawecz, M. P., Roach, J.A.G., Eulitz, K., Aalhus, J. L., Schaefer, A. L. & Ku, Y. (1998) Distributions of conjugated linoleic acid (CLA) isomers in tissue lipid classes of pigs fed a commercial CLA mixture determined by gas chromatography and silver-ion high-performance liquid chromatography. Lipids 33: 549-558.
22. Liew, C., Shut, H.A.J., Chin, S. F., Pariza, M. W. & Dashwood, R. H. (1995) Protection of conjugated linoleic acids against 2-amino-3-methylimidazo[4,5-f]quinolin-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. Carcinogenesis 16: 3037-3043.
23. Moya-Camarena, S. Y., Vanden Heuvel, J. P. & Belury, M. A. (1999a) Conjugated linoleic acid activates peroxisome proliferator-activated receptor a and β subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats. Biochim. Biophys. Acta 1436: 331-342.
24. Moya-Camarena, S. Y., Vanden Heuvel, J. P., Blanchard, S. G., Leesnitzer, L. A. & Belury, M. A. (1999b) Conjugated linoleic acid is a potent naturally-occurring ligand and activator of PPARα. J. Lipid Res. 40: 1426-1433.
25. Park, Y., Storkson, J. M., Albright, K. J., Liu, W. & Pariza, M. W. (1999) Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34: 235-241.
26. Parodi, P. W. (1997) Cows' milk fat components as potential anticarcinogenic agents. J. Nutr. 127: 1055-1060.
27. Russo, J. & Russo, I. H. (1978) DNA labeling index and structure of the rat mammary gland as determinants of its susceptibility to carcinogenesis. J. Natl. Cancer Inst. 61: 1451-1459.
28. Sebedio, J. L., Juaneda, P., Dobson, G., Ramilison, I., Martin, J. C., Chardigny, J. M. & Christie, W. W. (1997) Metabolites of conjugated isomers of linoleic acid (CLA) in the rat. Biochim. Biophys. Acta 1345: 5-10.
29. Sehat, N., Yurawecz, M. P., Roach, J.A.G., Mossoba, M. M., Kramer, J.K.G. & Ku, Y. (1998) Silver-ion high-performance liquid chromatographic separation and identification of conjugated linoleic acid isomers. Lipids 33: 217-221.
30. Thompson, H., Zhu, Z., Banni, S., Darcy, K., Loftus, T. & Ip, C. (1997) Morphological and biochemical status of the mammary gland as influenced by conjugated linoleic acid: implication for a reduction in mammary cancer risk. Cancer Res. 57: 5067-5072.
31. Visonneau, S., Cesano, A., Tepper, S. A., Scimeca, J. A., Santoli, D. & Kritchevsky, D. (1997) Conjugated linoleic acid suppresses the growth of human breast adenocarcinoma cells in SCID mice. Anticancer Res. 17: 969-974.
32. Zhu, Z., Jiang, W. & Thompson, H. J. (1998) Effect of corticosterone administration on mammary gland development and p27 expression and their relationship to the effects of energy restriction on mammary carcinogenesis. Carcinogenesis 19: 2101-2106.