A review of the research progress on the bioactive ingredients and physiological activities of rice bran oil

European Food Research and Technology

Volumn 238, Issue 2, 2014, Pages 169-176

  Liang, Ying ^a   Gao, Yu ^a   Lin, Qinlu ^a   Luo, Feijun ^a   Wu, Wei ^a   Lu, Qian ^a   Liu, Ying ^a  

^a CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY   (China)

Author keywords

Anticancer; Antioxidant; Apoptosis; Hypercholesterolemia; Insulin resistance; Rice bran oil

Indexed keywords

EID: 84895065044     PISSN: 14382377     EISSN: 14382385     Source Type: Journal    
DOI: 10.1007/s00217-013-2149-9     Document Type: Review

References (90)

1. Sharma RD, Rukmini C (1986) Rice bran oil and hypocholesterolemia in rats. Lipids 21: 715-717.
2. Rajam L, Kumar D, Sundaresan A, Arumughan C (2005) A novel process for physically refining rice bran oil through simultaneous degumming and dewaxing. J Am Oil Chem Soc 82: 213-220.
3. Da Silva MA, Sanches C, Amante ER (2005) Prevention of hydrolytic rancidity in rice bran. J Food Eng 75: 487-491.
4. Danielski L, Zetzl C, Hense H, Brunner G (2005) A process line for the production of raffinated rice oil from rice bran. J Supercrit Fluids 34: 133-141.
5. Daniela S, Tatiana A, Naira R, Josiane B, Gisely SV, Gustavo CO, Pedro A (2011) Formation and stability of oil-in-water nanoemulsion containing rice bran oil: in vitro and in vivo assessments. J Nanobiotechnol 9(44): 1-9.
6. Kampon K, Sarayut D, Pinatta N, Jutarat N, Panida C (2012) Effect of gamma-oryzanol-enriched rice bran oil on quality of cryopreserved boar semen. J Vet MedSci 74(9): 1149-1153.
7. Ammar HO, Al-Okbi SY, Mostafa DM, Helal AM (2012) Rice bran oil: preparation and evaluation of novel liquisolid and semisolid formulations. Int J Pharm Compd 16(6): 516-523.
8. Kaneto H, Katakami N, Matsuhisa M, Matsuoka T (2010) Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediators Inflamm 2010: 1-11.
9. Posuwan J, Prangthip P, Leardkamolkarn V, Yamborisut U, Surasiang R, Charoensiri R, Kongkachuichai R (2013) Long-term supplementation of high pigmented rice bran oil (Oryza sativa L.) on amelioration of oxidative stress and histological changes in streptozotocin-induced diabetic rats fed a high fat diet; Riceberry bran oil. Food Chem 138(1): 501-508.
10. Arab F, Alemzadeh I, Maghsoudi V (2011) Determination of antioxidant component and activity of rice bran extract. Scientia Iranica C 18(6): 1402-1406.
11. Shih CK, Ho CJ, Li SC, Yang SH, Hou WC, Cheng HH (2011) Preventive effects of rice bran oil on 1, 2-dimethylhydrazine/dextran sodium sulphate-induced colon carcinogenesis in rats. Food Chem 126: 562-567.
12. Stephanie H, Alexa K, Christina S, Schamim H, Ion C, Marc B, Hesham E, Amr H, Mohamed TK, Jan F, Walter E, Gunter P (2013) Rice bran extract protects from mitochondrial dysfunction in guinea pig brains. Pharmacol Res 76: 17-27.
13. Amonrat T, Surapote W, David J, Eric A (2012) Effect of stabilization of rice bran by domestic heating on mechanical extraction yield, quality, and antioxidant properties of cold-pressed rice bran oil (Oryza saltiva L.). LWT-Food Sci Technol 48: 231-236.
14. Devi R, Arumughan C (2007) Phytochemical characterization of defatted rice bran and optimization of a process for their extraction and enrichment. Bioresour Technol 98: 3037-3043.
15. Gopala K, Khatoon S, Shiela C, Indira TN, Mishra A (2001) Effect of refining of crude rice bran oil on the retention of oryzanol in the refined oil. J Am Oil Chem Soc 78: 127-132.
16. Mezouri Sand Eichner K (2007) Comparative study on the stability of crude and refined rice bran oil during long-term storage at room temperature. Eur J Lipid Sci Technol 109: 198-205.
17. Rupali D, Pubali Dand Mahua G (2012) Dietary effects of pure and diacylglycerol-rich rice bran oil on growth pattern and lipid profile of rats. J Oleo Sci 61(7): 369-375.
18. Afinisha D, Arumughan C (2012) Effect of saponification on composition of unsaponifiable matter in rice bran oil. J Oleo Sci 61(7): 241-247.
19. Khongsak S, Maythawinee P (2011) Simple techniques to increase the production yield and enhance the quality of organic rice bran oil. J Oleo Sci 60(1): 1-5.
20. Gopala K, Hemakumar KH, Khatoon S (2006) Study on the composition of rice bran oil and its higher free fatty acids value. J Am Oil Chem Soc 83(2): 117-120.
21. Ghatak SB, Panchal SJ (2012) Anti-hyperlipidemic activity of oryzanol, isolated from crude rice bran oil, on Triton WR-1339-induced acute hyperlipidemia in rats. Rev Bras Farmacogn 22: 642-648.
22. Patel M, Naik SN (2004) Gamma-oryzanol from rice bran oil-a review. J Sci Ind Res 63: 569-578.
23. Yoshino G, Kazumi T, Amano M, Tateiwa M, Yamasaki T, Takashima S, Iwai M, Hatanaka H, Baba S (1989) Effects of gamma-oryzanol and probucol on hyperlipidemia. Curr Ther Res 45: 975-982.
24. Gerhardt AL, Gallo NB (1998) Full fat rice bran and oat bran similarly reduced hypercholesterolemia in humans. J Nutr 128: 865-869.
25. Seetharamaiah GS, Krishnakantha TP, Chandrasekhara N (1990) Influence of oryzanol on platelet aggregation in rats. J Nutr Sci Vitaminol 36: 291-297.
26. Nakayama S, Manabe A, Suzuki J, Sakamoto K, Inagaki T (1987) Comparative effects of two forms of gamma-oryzanol in different sterol compositions on hyperlipidemia induced by cholesterol diet in rats. Japan J Pharmacol 44: 135-143.
27. Murase Y, Lishima H (1963) Clinical studies of oral administration of gamma-oryzanol on climacteric complaints and its syndrome. Obstet Gynecol Pract 12: 147-149.
28. Bonner B, Warren B, Bucci L (1990) Influence of ferulate supplementation on postexercise stress hormone levels after repeated exercise stress. J Appl Spots Sci Res 4: 10.
29. Merkler M, Reiner Z (2007) The burden of hyperlipidaemia and diabetes in cardiovascular diseases. Fundam Clin Pharmacol 21: 1-3.
30. Sum CF, Tan CE, Chew LS (1995) Management of hyperlipidaemia. Singapore Med J 36(4): 410-416.
31. Soehnlein O, Drechsler M, Hristov M, Weber C (2009) Functional alterations of myeloid cell subsets in hyperlipidaemia: relevance for atherosclerosis. J Cell Mol Med 13: 11-12.
32. Chen CW, Cheng HH (2006) A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J Nutr 136(6): 1472-1476.
33. Chou TW, Ma CY, Cheng HH (2009) A rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J Clin Biochem Nutr 45: 29-36.
34. Nagao K, Sato M, Takenaka M, Ando M, Iwamoto M, Imaizumi K (2001) Feeding unsaponifiable compounds from rice bran oil does not alter hepatic mRNA abundance for cholesterol metabolism-related proteins in hyper-cholesterolemic rats. Biosci Biotechnol Biochem 65(2): 371-377.
35. Vissers MN, Zock PL, Meijer GW, Katan MB (2000) Effect of plant sterols from rice bran oil and triterpene alcohols from sheanut oil on serum lipoprotein concentrations in humans. Am J Clin Nutr 72(6): 1510-1515.
36. Heinemann T, Axtmann G, von Bergmann K (1993) Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur J Clin Invest 23: 827-831.
37. Wilson TA, Nicolosi RJ, Woolfrey B, Kritchevsky D (2007) Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters. J Nutr Biochem 18(2): 105-112.
38. Ausman LM, Rong N, Nicolosi RJ (2005) Hypocholesterolemic effect of physically refined rice bran oil: studies of cholesterol metabolism and early atherosclerosis in hypercholesterolemic hamsters. J Nutr Biochem 16(9): 521-529.
39. Minhajuddin M, Beg ZH, Iqbal J (2005) Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food Chem Toxicol 43(5): 747-753.
40. Sugano M, Koba K, Tsuji E (1999) Health benefits of rice bran oil. Anticancer Res 19(5A): 3651-3657.
41. Malve H, Kerkar P, Mishra N (2010) LDL-cholesterol lowering activity of a blend of rice bran oil and safflower oil (8: 2) in patients with hyperlipidaemia: a proof of concept, double blind, controlled, randomised parallel group study. J Indian Med Assoc 108(11): 785-788.
42. Koba K, Liu JW, Bobik E, Sugano M, Huang YS (2000) Cholesterol supple- mentation attenuates the hypocholesterolemic effect of rice bran oil in rats. J Nutr Sci Vitaminol 46(2): 58-64.
43. Reena MB, Lokesh BR (2007) Hypolipidemic effect of oils with balanced amounts of fatty acids obtained by blending and interesterification of coconut oil with rice bran oil or sesame oil. J Agric Food Chem 55(25): 10461-10469.
44. Jones P, MacDougall DE, Ntanios F, Vanstone CA (1997) Dietary phytosterols as cholesterol- lowering agents in humans. Can J Physiol Phyrmacol 75: 217-227.
45. Ikeda I, Sugano M (1998) Inhibition of cholesterol absorption by plant sterols for mass interventions. Curr Opin Lipids 9: 527-531.
46. Siddiqui S, Rashid KM, Siddiqui WA (2010) Comparative hypoglycemic and nephroprotective effects of tocotrienol rich fraction (TRF) from palm oil and rice bran oil against hyperglycemia induced nephropathy in type 1 diabetic rats. Chem Biol Interact 188(3): 651-658.
47. Xu Z, Hua N, Godber JS (2001) Antioxidant activity of tocopherols, tocotrienols, and gamma-oryzanol components from rice bran against cholesterol oxidation accelerated by 2, 2′-azobis(2-methylpropionamidine) dihydrochloride. J Agric Food Chem 49: 2077-2081.
48. Andreasen MF, Landbo AK, Christensen LP, Hansen A, Meyer AS (2001) Antioxidant effects of phenolic rye (Secale cereale L.) extracts, monomeric hydro-xycinamates and ferulic acid ehydrodimers on human low-density lipoproteins. J Agric Food Chem 49: 4090-4096.
49. Kikuzaki H, Hisamoto M, Hirose K (2002) Antioxidant properties of ferulic acid and its related compounds. J Agric Food Chem 50: 2161-2168.
50. Ju YH, Zullaikah S (2013) Effect of acid-catalyzed methanolysis on the bioactive components of rice bran oil. J Taiwan Inst Chem Eng 44: 924-928.
51. Kuchino YF, Mori H, Inoue H, Miura K, Ohtsuka E, Nishimura S (1987) Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature 327: 77-79.
52. Hsieh RH, Lien LM, Lin SH, Chen CW, Cheng HJ, Cheng HH (2005) Alleviation of oxidative damage in multiple tissues in rats with streptozotocin-induced diabetes by rice bran oil supplementation. Ann NY Acad Sci 1042: 365-371.
53. Gunawan S, Kasim NS, Ju YH (2008) Separation and purification of squalene from soybean oil deodorizer distillate. Sep Purif Technol 60: 128-135.
54. Iqbal J, Minhajuddin M, Beg ZH (2004) Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil. Eur J Cancer Prev 13(6): 515-520.
55. Rajnarayana K, Prabhakar MC, Krishna DR (2001) Influence of rice bran oil on serum lipid peroxides and lipids in human subjects. Indian J Physiol Pharmacol 45(4): 442-444.
56. Kamal-Eldin A, Appelquist LA (1996) The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31: 671-701.
57. Hanley AJ, Williams K, Stern MP, Haffner SM (2002) Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. Diabetes Care 25: 1177-1184.
58. Dupre J, Baer A, Lee M, McDonald TJ, Radziuk J, Rodger NW, Sullivan S (1985) Insulin-mediated and non-insulin-mediated metabolic effects of gastroenteropancreatic peptides in type-I and type-II diabetes. Adv Exp Med Biol 189: 207-225.
59. Ryysy L, Häkkinen AM, Goto T, Vehkavaara S, Westerbacka J, Halavaara J, Yki-Järvinen H (2000) Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 49: 749-758.
60. Groop L, Widen E, Franssila KA, Ekstrand A, Saloranta C, Schalin C, Eriksson J (1989) Different effects of insulin and oral antidiabetic agents on glucose and energy metabolism in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 32: 599-605.
61. Ginsberg HN (1994) Lipoprotein metabolism and its relationship to atherosclerosis. Med Clin North Am 78: 1-20.
62. Maria LJ, Manila C, Ana PD, Maria AS, Juan P, Elisabet V, Maria DH, Rosalia RR (2013) Rice bran enzymatic extract restores endothelial function and vascular contractility in obese rats by reducing vascular inflammation and oxidative stress. J Nutr Biochem 24: 1453-1461.
63. Manila C, Maria LJ, Angelica C, Rosalia RR, Maria DH (2013) Rice bran enzymatic extract supplemented diets modulate adipose tissue inflammation markers in Zucker rats. Nutrition. doi: 10. 1016/j. nut. 2013. 09. 016.
64. Justo ML, Rodriguez-Rodriguez R, Claro CM, Alvarez de Sotomayor M, Parrado J, Herrera MD (2012) Water-soluble rice bran enzymatic extract attenuates dyslipidemia, hypertension and insulin resistance in obese Zucker rats. Eur J Nutr 52: 789-797.
65. Yudkin JS (2007) Inflammation, obesity, and the metabolic syndrome. Horm Metab Res 39: 707-709.
66. Khasnavis S, Jana A, Roy A, Mazumder M, Bhushan B, Wood T, Ghosh S, Watson R, Pahan K (2012) Supression of nuclear factor-kappa B activation and inflammation in microglia by a physically-modified saline. J Biol Chem 287: 29529-29542.
67. Parillo M, Rivellese AA, Ciardullo AV, Capaldo B, Giacco A, Genovese S, Riccardi G (1992) A high-monounsaturated-fat/low-carbohydrate diet improves peripheral insulin sensitivity in non-insulin-dependent diabetic patients. Metabolism 41: 1373-1378.
68. McGarry JD (2001) Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51: 7-18.
69. Brynes AE, Edwards CM, Jadhav A, Ghatei MA, Bloom SR, Frost GS (2000) Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes. Am J Clin Nutr 72: 1111-1118.
70. Li Y, Hou MJ, Ma J, Tang ZH, Zhu HL, Ling WH (2005) Dietary fatty acids regulate cholesterol induction of liver CYP7alpha1 expression and bile acid production. Lipids 40: 455-462.
71. Parillo M, Rivellese AA, Ciardullo AV (1992) A high-monounsaturated-fat/low- carbohydrate diet improves peripheral insulin sensitivity in non-insulin-dependent diabetic patients. Metabolism 41: 1373-1378.
72. Tourneur L, Chiocchia G (2010) FADD: a regulator of life and death. Trends Immunol 31: 260-269.
73. Tabas I, Ron D (2011) Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 13: 184-190.
74. Mongiat M, Ligresti G, Marastoni S, Lorenzon E, Doliana R, Colombatti A (2007) Regulation of the extrinsic apoptotic pathway by the extracellular matrix glycoprotein EMILIN2. Mol Cell Biol 27(20): 7176-7187.
75. Landers T, Martinou JC (2011) Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission. Biochim Biophys Acta 1813: 540-545.
76. Kannappan R, Ravindran J, Prasad S (2010) Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors. Mol Cancer Ther 9(8): 2196-2207.
77. Sun W, Xu W, Liu H (2009) Gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. J Nutr Biochem 20(4): 276-284.
78. Zhang Y, Xue R, Zhang ZN (2012) Palmitic and linoleic acids induce ER stress and apoptosis in hepatoma cells. Lipids Health Dis 11: 1-8.
79. Timmer JC, Salvesen GS (2007) Caspase substrates. Cell Death Differ 14: 66-72.
80. Yu Z, Zhang W, Kone BC (2002) Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB. Biochem J J367: 97-105.
81. Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Yadav VR, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB (2010) γ-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer Res 70(21): 8695-8705.
82. Kannappan R, Yadav VR, Aggarwal BB (2010) γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents. J Biol Chem 285(43): 33520-33528.
83. Evans NP, Misyak SA, Schmelz EM (2010) Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARγ. J Nutr 140(3): 515-521.
84. Uusitupa M, Siitonen O, Aro A, Pyorala K (1985) Prevalence of coronary heart disease: left ventricular failure and hypertension in middle-aged newly diagnosed Type 2 (non-insulindependent) diabetic subjects. Diabetologia 28: 22-27.
85. Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M (1998) Mortality from coronary heart disease insubjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339: 229-234.
86. Turner RC, Millns H, Neil HA (1998) Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23). BMJ 316: 823-828.
87. Białek A, Tokarz A, Dudek A (2010) Influence of diet enriched with conjugated linoleic acids on their distribution in tissues of rats with DMBA induced tumors. Lipids Health Dis 9: 126-134.
88. Soto GA, Navarro TN, Castro SL (2010) Oleic acid promotes MMP-9 secretion and invasion in breast cancer cells. Clin Exp Metastasis 27(7): 505-515.
89. Menendez JA, Vellon L, Colomer R, Lupu R (2005) Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification. Ann Oncol 16(3): 359-371.
90. Flowers M, Schroeder JA, Borowsky AD, Besselsen DG, Thomson CA, Pandey R, Thompson PA (2010) Pilot study on the effects of dietary conjugated linoleic acid on tumorigenesis and gene expression in PyMT transgenic mice. Carcinogenesis 31(9): 1642-1649.