Regulation of the extrinsic apoptotic pathway by the extracellular matrix glycoprotein EMILIN2

Molecular and Cellular Biology

Volumn 27, Issue 20, 2007, Pages 7176-7187

  Mongiat, Maurizio ^a   Ligresti, Giovanni ^a   Marastoni, Stefano ^a   Lorenzon, Erica ^a   Doliana, Roberto ^a   Colombatti, Alfonso ^a,b  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DEATH RECEPTOR 4; DEATH RECEPTOR 5; ELASTIN MICROFIBRIL INTERFACE LOCATED PROTEIN; GLYCOPROTEIN; PROTEIN EMILIN2; SCLEROPROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CELL SURVIVAL; CELL TRANSFORMATION; CLONOGENESIS; CONTROLLED STUDY; ELASTIN SYNTHESIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPERTENSION; LIPID RAFT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; THREE DIMENSIONAL IMAGING;

ANIMALS; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; ENZYME ACTIVATION; FIBROBLASTS; GLYCOPROTEINS; HUMANS; PROTEIN PRECURSORS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION;

EID: 35148865583     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00696-07     Document Type: Article

References (41)

1. Ashkenazi, A., and V. M. Dixit. 1998. Death receptors: signaling and modulation. Science 281:1305-1308.
2. Bhowmick, N. A., E. G. Neilson, and H. L. Moses. 2004. Stromal fibroblasts in cancer initiation and progression. Nature 432:332-337.
3. Bodmer, J. L., N. Holler, S. Reynard, P. Vinciguerra, P. Schneider, P. Juo, J. Blenis, and J. Tschopp. 2000. TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat. Cell Biol. 2:241-243.
4. Braghetta, P., A. Ferrari, P. de Gemmis, M. Zanetti, D. Volpin, P. Bonaldo, and G. M. Bressan. 2004. Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family. Matrix Biol. 22:549-556.
5. Bressan, G. M., D. Daga-Gordini, A. Colombatti, I. Castellani, V. Marigo, and D. Volpin. 1993. Emilin, a component of elastic fibers preferentially located at the elastin-microfibrils interface. J. Cell Biol. 121:201-212.
6. Colombatti, A., G. M. Bressan, I. Castellani, and D. Volpin. 1985. Glycoprotein 115, a glycoprotein isolated from chick blood vessels, is widely distributed in connective tissue. J. Cell Biol. 100:18-26.
7. Colombatti, A., A. Poletti, G. M. Bressan, A. Carbone, and D. Volpin. 1987. Widespread codistribution of glycoprotein gp115 and elastin in chick eye and other tissues. Coll. Relat. Res. 7:259-275.
8. Comoglio, P. M., and L. Trusolino. 2005. Cancer: the matrix is now in control. Nat. Med. 11:1156-1159.
9. Degterev, A., M. Boyce, and J. Yuan. 2003. A decade of caspases. Oncogene 22:8543-8567.
10. Delmas, D., C. Rébé, O. Micheau, A. Athias, P. Gambert, S. Grazide, G. Laurent, N. Latruffe, and E. Solary. 2004. Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. Oncogene 23:8979-8986.
11. Doliana, R., S. Bot, P. Bonaldo, and A. Colombatti. 2000. EMI, a novel cysteine-rich domain of EMILINs and other extracellular proteins, interacts with the gC1q domains and participates in multimerization. FEBS Lett. 484:164-168.
12. Doliana, R., S. Bot, G. Mungiguerra, A. Canton, S. P. Cilli, and A. Colombatti. 2000. Isolation and characterization of EMILIN2, a new component of the growing EMILINs family and a member of the EMI domain-containing superfamily. J. Biol. Chem. 276:12003-12011.
13. Dorr, J., I. Bechmann, S. Waiczies, S. Akatas, H. Walczak, P. H. Krammer, R. Nitsch, and F. Zipp. 2002. Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. J. Neurosi. 22(RC209):1-5.
14. Giancotti, F. G., and E. Ruoslahti. 1999. Integrin signaling. Science 285:1028-1033.
15. Grossmann, J. 2002. Molecular mechanisms of detachment-induced apoptosis - "Anoikis." Apoptosis 7:247-260.
16. Hengartner, M. O. 2000. The biochemistry of apoptosis. Nature 407:770-776.
17. Hueber, A. O., A. M. Bernard, Z. Hérincs, A. Couzinet, and H. T. He. 2002. An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes. EMBO Rep. 3:190-196.
18. Irmler, M., M. Thome, M. Hahne, P. Schneider, K. Hofmann, V. Steiner, J. L. Bodmer, M. Schroter, K. Burns, C. Mattmann, D. Rimoldi, L. E. French, and J. Tschopp. 1997. Inhibition of death receptor signals by cellular FLIP. Nature 388:190-195.
19. Jiménez, B., O. V. Volpert, S. E. Crawford, M. Febbraio, R. L. Silverstein, and N. Bouck. 2000. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat. Med. 6:41-48.
20. Karlseder, J., A. Smogorzewska, and T. de Lange. 2002. Senescence induced by altered telomere state, not telomere loss. Science 295:2446-2449.
21. Krammer, P. H. 2000. CD95's deadly mission in the immune system. Nature 407:789-795.
22. LeBlanc, H. N., and A. Ashkenazi. 2003. Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ. 10:66-75.
23. Locksley, R. M., N. Killeen, and M. J. Lenardo. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487-501.
24. Mitsiades, N., V. Poulaki, C. Mitsiades, and M. Tsokos. 2001. Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5. Cancer Res. 61:2704-2712.
25. Mongiat, M., G. Mungiguerra, S. Bot, M. T. Mucignat, E. Giacomello, R. Doliana, and A. Colombatti. 2000. Self-assembly and supramolecular organization of EMILIN. J. Biol. Chem. 275:25471-25480.
26. Muppidi, J. R., J. Tschopp, and R. M. Siegel. 2004. Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity 21:461-465.
27. Okada, H., and T. W. Mak. 2004. Pathways of apoptotic and non-apoptotic death in tumor cells. Nat. Rev. Cancer 4:592-603.
28. Pan, G., K. O'Rourke, A. M. Chinnaiyan, R. Gentz, R. Ebner, J. Ni, and V. M. Dixit. 1997. The receptor for the cytotoxic ligand TRAIL. Science 276:111-113.
29. Paszek, M. J., N. Zahir, K. R. Johnson, J. N. Lakins, G. I. Rozenberg, A. Gefen, C. A. Reinhart-King, S. S. Margulies, M. Dembo, D. Boettiger, D. A. Hammer, and V. M. Weaver. 2005. Tensional homeostasis and the malignant phenotype. Cancer Cell 8:241-254.
30. Puolakkainen, P. A., R. A. Brekken, S. Muneer, and E. H. Sage. 2004. Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis. Mol. Cancer Res. 2:215-224.
31. Ramaswamy, M., E. V. Efiomova, O. Martinez, N. U. Mulherkar, S. P. Singh, and B. S. Prabhakar. 2004. IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC. Oncogene 23:6083-6094.
32. Seger, Y. R., M. García-Cao, S. Piccinin, C. L. Cunsolo, C. Doglioni, M. A. Blasco, G. J. Hannen, and R. Maestro. 2002. Transformation of normal human cells in the absence of telomerase activation. Cancer Cell 2:401-413.
33. Shichiri, M., and Y. Hirata. 2001. Antiangiogenesis signals by endostatin. EMBO J. 15:1044-1053.
34. Siegel, R. M., J. R. Muppidi, M. Sarker, A. Lobito, M. Jen, D. Martin, S. E. Straus, and M. J. Lenardo. 2004. SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane. J. Cell Biol. 167:735-744.
35. Sprick, M. R., M. A. Weigand, E. Rieser, C. T. Rauch, P. Juo, J. Blenis, P. H. Krammer, and H. Walczak. 2000. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 12:599-609.
36. Todorovicç, V., C. C. Chen, N. Hay, and L. F. Lau. 2005. The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J. Cell Biol. 171:559-568.
37. Truneh, A., S. Sharma, C. Silverman, S. Khandekar, M. P. Reddy, K. C. Deen, M. M. McLaughlin, S. M. Srinivesula, G. P. Livi, L. A. Marshall, E. S. Alnemri, W. V. Williams, and M. L. Doyle. 2000. Temperature-sensitive differential affinity of TRAIL for its receptors. J. Biol. Chem. 275:23319-23325.
38. Walczak, H., M. A. Degli-Esposti, R. S. Johnson, P. J. Smolak, J. Y. Waugh, N. Boiani, M. S. Timour, M. J. Gerhart, K. A. Schooley, C. A. Smith, R. G. Goodwin, and C. T. Rauch. 1997. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16:5386-5397.
39. Wang, J., H. J. Chun, W. Wong, D. M. Spencer, and M. J. Lenardo. 2001. Caspase-10 is an initiator caspase in death receptor signalling. Proc. Natl. Acad. Sci. USA 98:13884-13888.
40. Zacchigna, L., C. Vecchione, A. Notte, M. Cordenonsi, S. Dupont, S. Maretto, G. Cifelli, A. Ferrari, A. Maffei, C. Fabbro, P. Braghetta, G. Marino, G. Selvetella, A. Aretini, C. Colonnese, U. Bettarini, G. Russo, S. Soligo, M. Adorno, P. Bonaldo, D. Volpin, S. Piccolo, G. Lembo, and G. M. Bressan. 2006. Emilin1 links TGF-beta maturation to blood pressure homeostasis. Cell 124:929-942.
41. Zanetti, M., P. Braghetta, P. Sabatelli, I. Mura, R. Doliana, A. Colombatti, D. Volpin, P. Bonaldo, and G. M. Bressan. 2004. EMILIN-1 deficiency induces elastogenesis and vascular cell defects. Mol. Cell. Biol. 24:638-650.