Rice bran extract protects from mitochondrial dysfunction in guinea pig brains

Pharmacological Research

Volumn 76, Issue , 2013, Pages 17-27

  Hagl, Stephanie ^a   Kocher, Alexa ^b   Schiborr, Christina ^b   Eckert, Schamim H ^a   Ciobanu, Ion ^a   Birringer, Marc ^c   El Askary, Hesham ^d   Helal, Amr ^e   Khayyal, Mohamed T ^d   Frank, Jan ^b,f   Muller, Walter E ^a   Eckert, Gunter P ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF HOHENHEIM   (Germany)

^c UNIVERSITY OF APPLIED SCIENCES   (Germany)

^d CAIRO UNIVERSITY   (Egypt)

^e ITandM   (Egypt)

^f UNIVERSITY OF BONN   (Germany)

Author keywords

Bioenergetics; Brain; Cardiolipin; Mitochondria; Mitochondrial dynamics; Nitrosative stress; Nutrition; Oxidative stress; Respiration; Rice bran extract

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TOCOTRIENOL; CARDIOLIPIN; CITRATE SYNTHASE; GAMMA CARBOXYETHYL HYDROXYCHROMAN; GAMMA ORYZANOL; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; RICE BRAN EXTRACT; TOCOPHEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN LEVEL; BRAIN MITOCHONDRION; BRAIN REGION; CELL ISOLATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; EXPERIMENTAL GUINEA PIG; FRONTAL LOBE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PHYTOCHEMISTRY; PRIORITY JOURNAL;

BIOENERGETICS; BRAIN; CARDIOLIPIN; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; NITROSATIVE STRESS; NUTRITION; OXIDATIVE STRESS; RESPIRATION; RICE BRAN EXTRACT;

ANIMALS; BRAIN; CHROMANS; GUINEA PIGS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; ORYZA SATIVA; OXIDATIVE STRESS; PC12 CELLS; PLANT EXTRACTS; RATS; VITAMIN E;

EID: 84882968256     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.06.008     Document Type: Article

References (74)

1. S. Park Potential therapeutic agents against Alzheimer's disease from natural sources Archives of Pharmacal Research 33 2010 1589 1609
2. M.T. Lin, and M.F. Beal Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature 443 2006 787 795 (Pubitemid 44622683)
3. B.A. Yankner, T. Lu, and P. Loerch The aging brain Annual Review of Pathology 3 2008 41 66 (Pubitemid 351488276)
4. G. Paradies, G. Petrosillo, V. Paradies, and F.M. Ruggiero Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin Neurochemistry International 58 2011 447 457
5. S. Hauptmann, I. Scherping, S. Drose, U. Brandt, K.L. Schulz, M. Jendrach, K. Leuner, A. Eckert, and W.E. Muller Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice Neurobiology of Aging 30 2009 1574 1586
6. G.P. Eckert, K. Renner, S.H. Eckert, J. Eckmann, S. Hagl, R.M. Abdel-Kader, C. Kurz, K. Leuner, and W.E. Muller Mitochondrial dysfunction - a pharmacological target in Alzheimer's disease Molecular Neurobiology 46 2012 136 150
7. W. Müller, A. Eckert, C. Kurz, G. Eckert, and K. Leuner Mitochondrial dysfunction: common final pathway in brain aging and alzheimer's disease - therapeutic aspects Molecular Neurobiology 41 2010 159 171
8. V. Solfrizzi, V. Frisardi, D. Seripa, G. Logroscino, B.P. Imbimbo, G. D'Onofrio, F. Addante, D. Sancarlo, L. Cascavilla, A. Pilotto, and F. Panza Mediterranean diet in predementia and dementia syndromes Current Alzheimer Research 8 2011 520 542
9. B.N. Ramesh, T.S.S. Rao, A. Prakasam, K. Sambamurti, and K.S.J. Rao Neuronutrition and alzheimer's disease Journal of Alzheimer's Disease 19 2010 1123 1139
10. G.P. Eckert, U. Lipka, and W.E. Muller Omega-3 fatty acids in neurodegenerative diseases: focus on mitochondria Prostaglandins, Leukotrienes and Essential Fatty Acids 88 2013 105 114
11. S. Schaffer, H. Asseburg, S. Kuntz, W.E. Muller, and G.P. Eckert Effects of polyphenols on brain ageing and alzheimer's disease: focus on mitochondria Molecular Neurobiology 46 2012 161 178
12. L. Nijtmans, C. Ugalde, L. Heuvel, and Smeitink J Function and dysfunction of the oxidative phosphorylation system Mitochondrial Function and Biogenesis vol. 8 2004 Springer Berlin, Heidelberg 149 776 (Topics in Current Genetics)
13. D. Mokranjac, and W. Neupert Thirty years of protein translocation into mitochondria: unexpectedly complex and still puzzling Biochimica et Biophysica Acta 1793 2009 33 41
14. F. Palmieri, and C.L. Pierri Mitochondrial metabolite transport Essays in Biochemistry 47 2010 37 52
15. M.D. Brand, C. Affourtit, T.C. Esteves, K. Green, A.J. Lambert, S. Miwa, J.L. Pakay, and N. Parker Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins Free Radical Biology & Medicine 37 2004 755 767 (Pubitemid 39078548)
16. J. Smeitink, L. van den Heuvel, and S. DiMauro The genetics and pathology of oxidative phosphorylation Nature Reviews Genetics 2 2001 342 352 (Pubitemid 33673072)
17. D.J. Pagliarini, S.E. Calvo, B. Chang, S.A. Sheth, S.B. Vafai, S. Ong, G.A. Walford, C. Sugiana, A. Boneh, W.K. Chen, D.E. Hill, M. Vidal, J.G. Evans, D.R. Thorburn, and S.A. Carr A mitochondrial protein compendium elucidates complex I disease biology Cell 134 2008 112 123 (Pubitemid 351916708)
18. A. Bender, K.J. Krishnan, C.M. Morris, G.A. Taylor, A.K. Reeve, R.H. Perry, E. Jaros, J.S. Hersheson, J. Betts, T. Klopstock, R.W. Taylor, and D.M. Turnbull High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease Nature Genetics 38 2006 515 517
19. Y. Kraytsberg, E. Kudryavtseva, A.C. McKee, C. Geula, N.W. Kowall, and K. Khrapko Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons Nature Genetics 38 2006 518 520
20. A.P. Gimenez-Roqueplo, J. Favier, P. Rustin, J.J. Mourad, P.F. Plouin, P. Corvol, A. Rotig, and X. Jeunemaitre The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway The American Journal of Human Genetics 69 2001 1186 1197 (Pubitemid 33124200)
21. M. Liesa, M. Palacin, and A. Zorzano Mitochondrial dynamics in mammalian health and disease Physiological Reviews 89 2009 799 845
22. S.A. Detmer, and D.C. Chan Functions and dysfunctions of mitochondrial dynamics Nature Reviews Molecular Cell Biology 8 2007 870 879 (Pubitemid 47622562)
23. H. Chen, A. Chomyn, and D.C. Chan Disruption of fusion results in mitochondrial heterogeneity and dysfunction The Journal of Biological Chemistry 280 2005 26185 26192 (Pubitemid 41022214)
24. M.P. Murphy How mitochondria produce reactive oxygen species Biochemical Journal 417 2009 1 13
25. T. Laokuldilok, C.F. Shoemaker, S. Jongkaewwattana, and V. Tulyathan Antioxidants and antioxidant activity of several pigmented rice brans Journal of Agricultural and Food Chemistry 59 2011 193 199
26. T.S. Kahlon Rice Bran: Production, Composition, Functionality and Food Applications, Physiological Benefits 2009 CRC Press Boca Raton 2009 c2009
27. R.M. Kaup, M.T. Khayyal, and E.J. Verspohl Antidiabetic effects of a standardized Egyptian rice bran extract Phytotherapy Research 27 2013 264 271
28. A. Navarro, M.J. Bandez, J.M. Lopez-Cepero, C. Gomez, and A. Boveris High doses of vitamin E improve mitochondrial dysfunction in rat hippocampus and frontal cortex upon aging AJP: Regulatory, Integrative and Comparative Physiology 300 2011 R827
29. J. Frank, X.W.D. Chin, C. Schrader, G.P. Eckert, and G. Rimbach Do tocotrienols have potential as neuroprotective dietary factors? Ageing Research Reviews 11 2012 163 180
30. C.K. Sen, S. Khanna, and S. Roy Tocotrienol: the natural vitamin E to defend the nervous system? Annals of the New York Academy of Sciences 1031 2004 127 142 (Pubitemid 40361749)
31. S. Schaffer, W.E. Muller, and G.P. Eckert Cytoprotective effects of olive mill wastewater extract and its main constituent hydroxytyrosol in PC12 cells Pharmacological Research 62 2010 322 327
32. M. Friden, H. Ljungqvist, B. Middleton, U. Bredberg, and M. Hammarlund-Udenaes Improved measurement of drug exposure in the brain using drug-specific correction for residual blood Journal of Cerebral Blood Flow & Metabolism 30 2010 150 161
33. C. Franke, M. Nöldner, R. Abdel-Kader, L.N. Johnson-Anuna, W.W. Gibson, W.E. Muller, and G.P. Eckert Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment Neurobiology of Disease 25 2007 438 445 (Pubitemid 46138047)
34. G.P. Eckert, C. Schiborr, S. Hagl, R. Abdel-Kader, W.E. Muller, G. Rimbach, and J. Frank Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse - prone 8 Neurochemistry International 62 2013 595 602
35. S. Stadlmann, K. Renner, J. Pollheimer, P.L. Moser, A.G. Zeimet, F.A. Offner, and E. Gnaiger Preserved coupling of oxidative phosphorylation but decreased mitochondrial respiratory capacity in IL-1 beta-treated human peritoneal mesothelial cells Cell Biochemistry and Biophysics 44 2006 179 186 (Pubitemid 43172316)
36. E. Hutter, K. Renner, G. Pfister, P. Stockl, P. Jansen-Durr, and E. Gnaiger Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts Biochemical Journal 380 2004 919 928 (Pubitemid 38850535)
37. A.V. Kuznetsov, D. Strobl, E. Ruttmann, A. Königsrainer, R. Margreiter, and E. Gnaiger Evaluation of mitochondrial respiratory function in small biopsies of liver Analytical Biochemistry 305 2002 186 194 (Pubitemid 34666791)
38. U. Igbavboa, G.P. Eckert, T.M. Malo, A.E. Studniski, L.N.A. Johnson, N. Yamamoto, M. Kobayashi, S.C. Fujita, T.R. Appel, W.E. Muller, W.G. Wood, and K. Yanagisawa Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing age Journal of the Neurological Sciences 229-230 2005 225 232 (Pubitemid 40341587)
39. N. Grebenstein, and J. Frank Rapid baseline-separation of all eight tocopherols and tocotrienols by reversed-phase liquid-chromatography with a solid-core pentafluorophenyl column and their sensitive quantification in plasma and liver Journal of Chromatography A 1243 2012 39 46
40. M.D. Brand Uncoupling to survive? The role of mitochondrial inefficiency in ageing Experimental Gerontology 35 2000 811 820
41. M.D. Brand, and D.G. Nicholls Assessing mitochondrial dysfunction in cells Biochemical Journal 435 2011 297 312
42. B. Kadenbach Intrinsic and extrinsic uncoupling of oxidative phosphorylation Biochimica et Biophysica Acta 1604 2003 77 94 (Pubitemid 36588693)
43. E. Hutter, H. Unterluggauer, A. Garedew, P. Jansen-Durr, and E. Gnaiger High-resolution respirometry - a modern tool in aging research Experimental Gerontology 41 2006 103 109 (Pubitemid 43031375)
44. E. Gnaiger Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply Respiratory Physiology & Neurobiology 128 2001 277 297 (Pubitemid 33054060)
45. R. Rabøl, S. Larsen, P.M.V. Højberg, T. Almdal, R. Boushel, S.B. Haugaard, J.L. Andersen, S. Madsbad, and F. Dela Regional anatomic differences in skeletal muscle mitochondrial respiration in type 2 diabetes and obesity Journal of Clinical Endocrinology & Metabolism 95 2010 857 863
46. R.J. Youle, and A.M. van der Bliek Mitochondrial fission, fusion, and stress Science 337 2012 1062 1065
47. D.A. Hood, R. Zak, and D. Pette Chronic stimulation of rat skeletal muscle induces coordinate increases in mitochondrial and nuclear mRNAs of cytochrome-c-oxidase subunits European Journal of Biochemistry 179 1989 275 280 (Pubitemid 19051573)
48. S. Larsen, J. Nielsen, C.N. Hansen, L.B. Nielsen, F. Wibrand, N. Stride, H.D. Schroder, R. Boushel, J.W. Helge, F. Dela, and M. Hey-Mogensen Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects The Journal of Physiology 590 2012 3349 3360
49. P.J. Fernandez-Marcos, and J. Auwerx Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis The American Journal of Clinical Nutrition 93 2011 884S 890S
50. S. Diano, and Tamas L. Horvath Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism Trends in Molecular Medicine 18 2012 52 58
51. R.J. Mailloux, and M. Harper Mitochondrial proticity and ROS signaling: lessons from the uncoupling proteins Trends in Endocrinology & Metabolism 23 2012 451 458
52. A.S. Divakaruni, and M.D. Brand The regulation and physiology of mitochondrial proton leak Physiology 26 2011 192 205
53. F.L. Hoch Cardiolipins and mitochondrial proton-selective leakage Journal of Bioenergetics and Biomembranes 30 1998 511 532 (Pubitemid 29166352)
54. A.J. Chicco, and G.C. Sparagna Role of cardiolipin alterations in mitochondrial dysfunction and disease Cell Physiology: American Journal of Physiology 292 2007 C33 C44
55. M. Aoun, G. Fouret, F. Michel, B. Bonafos, J. Ramos, J. Cristol, M. Carbonneau, C. Coudray, and C. Feillet-Coudray Dietary fatty acids modulate liver mitochondrial cardiolipin content and its fatty acid composition in rats with non alcoholic fatty liver disease Journal of Bioenergetics and Biomembranes 44 2012 439 452
56. G. López-Lluch, P.M. Irusta, P. Navas, and R. de Cabo Mitochondrial biogenesis and healthy aging Experimental Gerontology 43 2008 813 819
57. B. Sheng, X. Wang, B. Su, H. Lee, G. Casadesus, G. Perry, and X. Zhu Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease Journal of Neurochemistry 120 2012 419 429
58. R.X. Santos, S.C. Correia, X. Wang, G. Perry, M.A. Smith, P.I. Moreira, and X. Zhu A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease Journal of Alzheimer's Disease 20 Suppl. 2 2010 S401 S412
59. D. Suen, K.L. Norris, and R.J. Youle Mitochondrial dynamics and apoptosis Genes & Development 22 2008 1577 1590 (Pubitemid 351846838)
60. A.B. Knott, G. Perkins, R. Schwarzenbacher, and E. Bossy-Wetzel Mitochondrial fragmentation in neurodegeneration Nature Reviews Neuroscience 9 2008 505 518 (Pubitemid 351873464)
61. J. Parrado, E. Miramontes, M. Jover, J.C. Marquez, M. Angeles Mejias, L. de Collantes Teran, E. Absi, and J. Bautista Prevention of brain protein and lipid oxidation elicited by a water-soluble oryzanol enzymatic extract derived from rice bran European Journal of Nutrition 42 2003 307 314 (Pubitemid 38055610)
62. A.F. Cicero, and A. Gaddi Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions Phytotherapy Research 15 2001 277 289 (Pubitemid 32613093)
63. A. Navarro, C. Gomez, M. Sanchez-Pino, H. Gonzalez, M.J. Bandez, A.D. Boveris, and A. Boveris Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice American Journal of Physiology - Regulatory, Integrative and Physiology 289 2005 R1392 R1399
64. A. Jolitha, M.V.V. Subramanyam, and S. Asha Devi Modification by vitamin E and exercise of oxidative stress in regions of aging rat brain: studies on superoxide dismutase isoenzymes and protein oxidation status Experimental Gerontology 41 2006 753 763 (Pubitemid 44223891)
65. S. Das, N. Gautam, S.K. Dey, T. Maiti, and S. Roy Oxidative stress in the brain of nicotine-induced toxicity: protective role of andrographis paniculata Nees and vitamin E Applied Physiology, Nutrition, and Metabolism 34 2009 124 135
66. N.M. Ayoub, S.V. Bachawal, and P.W. Sylvester γ-Tocotrienol inhibits HGF-dependent mitogenesis and Met activation in highly malignant mammary tumour cells Cell Proliferation 44 2011 516 526
67. M. Birringer, P. Pfluger, D. Kluth, N. Landes, and R. Brigelius-Flohé Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells Journal of Nutrition 132 2002 3113 3118
68. K. Hensley, Elaine J. Benaksas, Roberto Bolli, Philip Comp, Paula Grammas, Ladan Hamdheydari, Shenyun Mou, Quentin N. Pye, F. Marcus, Stoddard, Gemma Wallis, S. Kelly, Williamson, Melinda West, J. William, Wechter, and Robert A. Floyd New perspectives on vitamin E: γ-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine Free Radical Biology & Medicine 36 2004 1 15 (Pubitemid 38068287)
69. D.J. Mustacich, S.W. Leonard, N.K. Patel, and M.G. Traber Alpha-tocopherol beta-oxidation localized to rat liver mitochondria Free Radical Biology & Medicine 48 2010 73 81
70. S.P. Kim, M.Y. Kang, S.H. Nam, and M. Friedman Dietary rice bran component gamma-oryzanol inhibits tumor growth in tumor-bearing mice Molecular Nutrition & Food Research 56 2012 935 944
71. A. Berger, D. Rein, A. Schafer, I. Monnard, G. Gremaud, P. Lambelet, and C. Bertoli Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men European Journal of Nutrition 44 2005 163 173 (Pubitemid 40585515)
72. S. Fujiwara, S. Sakurai, I. Sugimoto, and N. Awata Absorption and metabolism of gamma-oryzanol in rats Chemical & Pharmaceutical Bulletin (Tokyo) 31 1983 645 652
73. C. Juliano, M. Cossu, M.C. Alamanni, and L. Piu Antioxidant activity of gamma-oryzanol: mechanism of action and its effect on oxidative stability of pharmaceutical oils International Journal of Pharmaceutics 299 2005 146 154 (Pubitemid 40962416)
74. J.S. Kim, J. Lee, P. Chang, and H.G. Lee Optimization, in vitro release and bioavailability of gamma-oryzanol-loaded calcium pectinate microparticles reinforced with chitosan New Biotechnology 27 2010 368 373