메뉴 건너뛰기




Volumn 43, Issue 5, 2005, Pages 747-753

Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats

Author keywords

Hyperlipidemia; LDL oxidation; Lipid peroxidation; Tocotrienol rich fraction

Indexed keywords

ALKADIENE; ALPHA TOCOTRIENOL; CHOLESTEROL; CHOLIC ACID; FAT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; TRIACYLGLYCEROL;

EID: 15044339852     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2005.01.015     Document Type: Article
Times cited : (151)

References (62)
  • 3
    • 0022556171 scopus 로고
    • Precipitation methods for quantification of lipoproteins
    • P.S. Bachorik, and J.J. Albers Precipitation methods for quantification of lipoproteins Methods in Enzymology 129 1986 78 100
    • (1986) Methods in Enzymology , vol.129 , pp. 78-100
    • Bachorik, P.S.1    Albers, J.J.2
  • 4
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye-binding
    • M.M. Bradford A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye-binding Analytical Biochemistry 72 1976 248 254
    • (1976) Analytical Biochemistry , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 5
    • 0030997131 scopus 로고    scopus 로고
    • Erythrocyte vitamin e and plasma ascorbate concentrations in relation to erythrocyte peroxidation in smokers and nonsmokers: Dose response to vitamin e supplementation
    • K.M. Brown, P.C. Morrice, and G.G. Duthie Erythrocyte vitamin E and plasma ascorbate concentrations in relation to erythrocyte peroxidation in smokers and nonsmokers: dose response to vitamin E supplementation The American Journal of Clinical Nutrition 65 1997 496 502
    • (1997) The American Journal of Clinical Nutrition , vol.65 , pp. 496-502
    • Brown, K.M.1    Morrice, P.C.2    Duthie, G.G.3
  • 8
    • 0034659148 scopus 로고    scopus 로고
    • The oxidative modification hypothesis of atherogenesis: An overview
    • G.M. Chisolm, and D. Steinberg The oxidative modification hypothesis of atherogenesis: an overview Free Radical Biology and Medicine 28 2000 1815 1826
    • (2000) Free Radical Biology and Medicine , vol.28 , pp. 1815-1826
    • Chisolm, G.M.1    Steinberg, D.2
  • 10
    • 0019941618 scopus 로고
    • The mechanism of cyclic monoterpene inhibition of 3-hydroxy-3- methylglutaryl coenzyme a reductase in vivo in the rat
    • R.J. Clegg, B. Middleton, G.D. Bell, and D.A. White The mechanism of cyclic monoterpene inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vivo in the rat Journal of Biological Chemistry 257 1982 2294 2299
    • (1982) Journal of Biological Chemistry , vol.257 , pp. 2294-2299
    • Clegg, R.J.1    Middleton, B.2    Bell, G.D.3    White, D.A.4
  • 12
    • 0020546299 scopus 로고
    • Nascent hepatic lipoproteins in hypothyroid rats
    • P.J. Dolphin, and S.J. Forsyth Nascent hepatic lipoproteins in hypothyroid rats Journal of Lipid Research 24 1983 541 551
    • (1983) Journal of Lipid Research , vol.24 , pp. 541-551
    • Dolphin, P.J.1    Forsyth, S.J.2
  • 13
    • 0015500577 scopus 로고
    • Turnover rate of hepatic 3-hydroxy-3-methylglutaryl coenzyme a reductase as determined by use of cycloheximide
    • P.A. Edwards, and R.G. Gould Turnover rate of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by use of cycloheximide Journal of Biological Chemistry 247 1972 1520 1524
    • (1972) Journal of Biological Chemistry , vol.247 , pp. 1520-1524
    • Edwards, P.A.1    Gould, R.G.2
  • 14
    • 0018402928 scopus 로고
    • Improved methods for the solubilization and assay of hepatic 3-hydroxy-3-methylglutaryl coenzyme a reductase
    • P.A. Edwards, D. Lemongello, and A.M. Fogelman Improved methods for the solubilization and assay of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase Journal of Lipid Research 20 1979 40 46
    • (1979) Journal of Lipid Research , vol.20 , pp. 40-46
    • Edwards, P.A.1    Lemongello, D.2    Fogelman, A.M.3
  • 17
    • 0028877718 scopus 로고
    • The mechanism of lack of hypocholesterolemic effects of pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, in rats
    • T. Fujioka, F. Nara, Y. Tsujita, J. Fukushige, M. Fukami, and M. Kuroda The mechanism of lack of hypocholesterolemic effects of pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in rats Biochimica et Biophysica Acta 1254 1995 7 12
    • (1995) Biochimica et Biophysica Acta , vol.1254 , pp. 7-12
    • Fujioka, T.1    Nara, F.2    Tsujita, Y.3    Fukushige, J.4    Fukami, M.5    Kuroda, M.6
  • 18
    • 0028047083 scopus 로고
    • Stimulation of fatty acid biosynthesis by dietary cholesterol and of cholesterol synthesis by dietary fatty acid
    • T.V. Fungwe, J.E. Fox, L.M. Cagen, H.G. Wilcox, and M. Heimberg Stimulation of fatty acid biosynthesis by dietary cholesterol and of cholesterol synthesis by dietary fatty acid Journal of Lipid Research 35 1994 311 318
    • (1994) Journal of Lipid Research , vol.35 , pp. 311-318
    • Fungwe, T.V.1    Fox, J.E.2    Cagen, L.M.3    Wilcox, H.G.4    Heimberg, M.5
  • 19
    • 0032487487 scopus 로고    scopus 로고
    • Oxidants and antioxidants in the pathogenesis of atherosclerosis: Implications for the oxidized low-density lipoprotein hypothesis
    • J.W. Heinecke Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low-density lipoprotein hypothesis Atherosclerosis 141 1998 1 15
    • (1998) Atherosclerosis , vol.141 , pp. 1-15
    • Heinecke, J.W.1
  • 20
    • 0026538330 scopus 로고
    • Effects of guar gum and tocotrienols on cholesterol metabolism on the Japanese quail
    • R.L. Hood, and G.S. Sidhu Effects of guar gum and tocotrienols on cholesterol metabolism on the Japanese quail Nutrition Research 12 1992 117S 127S
    • (1992) Nutrition Research , vol.12
    • Hood, R.L.1    Sidhu, G.S.2
  • 21
    • 0028227192 scopus 로고
    • Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol
    • H. Hughes, B. Mathews, M.L. Lenz, and J.R. Guyton Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol Arteriosclerosis Thrombosis 14 1994 1177 1185
    • (1994) Arteriosclerosis Thrombosis , vol.14 , pp. 1177-1185
    • Hughes, H.1    Mathews, B.2    Lenz, M.L.3    Guyton, J.R.4
  • 22
    • 2442477700 scopus 로고    scopus 로고
    • Suppression of 7,12-dimethylbenz[alpha]anthracene-induced carcinogenesis and hypercholesterolaemia in rats by tocotrienol-rich fraction isolated from rice bran oil
    • J. Iqbal, M. Minhajuddin, and Z.H. Beg Suppression of 7,12-dimethylbenz[alpha]anthracene-induced carcinogenesis and hypercholesterolaemia in rats by tocotrienol-rich fraction isolated from rice bran oil European Journal of Cancer Prevention 12 2003 447 453
    • (2003) European Journal of Cancer Prevention , vol.12 , pp. 447-453
    • Iqbal, J.1    Minhajuddin, M.2    Beg, Z.H.3
  • 23
    • 10244257526 scopus 로고    scopus 로고
    • Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil
    • J. Iqbal, M. Minhajuddin, and Z.H. Beg Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil European Journal of Cancer Prevention 13 2004 515 520
    • (2004) European Journal of Cancer Prevention , vol.13 , pp. 515-520
    • Iqbal, J.1    Minhajuddin, M.2    Beg, Z.H.3
  • 24
    • 0030015296 scopus 로고    scopus 로고
    • The chemistry and antioxidant properties of tocopherols and tocotrienols
    • A. Kamal-Eldin, and L.A. Appelqvist The chemistry and antioxidant properties of tocopherols and tocotrienols Lipids 31 1996 671 701
    • (1996) Lipids , vol.31 , pp. 671-701
    • Kamal-Eldin, A.1    Appelqvist, L.A.2
  • 25
    • 0030997494 scopus 로고    scopus 로고
    • Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes
    • J.P. Kamat, H.D. Sarma, T.P. Devasagayam, K. Nesaretnam, and Y. Basiron Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes Molecular and Cellular Biochemistry 170 1997 131 137
    • (1997) Molecular and Cellular Biochemistry , vol.170 , pp. 131-137
    • Kamat, J.P.1    Sarma, H.D.2    Devasagayam, T.P.3    Nesaretnam, K.4    Basiron, Y.5
  • 26
    • 84941112474 scopus 로고
    • Antioxidant protection of low-density lipoprotein and its role in the prevention of atherosclerotic vascular disease
    • B. Frei Academic Press San Diego, CA
    • J.F. Keaney Jr., and B. Frei Antioxidant protection of low-density lipoprotein and its role in the prevention of atherosclerotic vascular disease B. Frei Natural antioxidants in human health and disease 1994 Academic Press San Diego, CA 303 352
    • (1994) Natural Antioxidants in Human Health and Disease , pp. 303-352
    • Keaney Jr., J.F.1    Frei, B.2
  • 27
    • 0028906917 scopus 로고
    • Tocotrienols inhibit HMG-CoA reductase activity in the guinea pig
    • H.T. Khor, D.Y. Chieng, and K.K. Ong Tocotrienols inhibit HMG-CoA reductase activity in the guinea pig Nutrition Research 15 1995 537 544
    • (1995) Nutrition Research , vol.15 , pp. 537-544
    • Khor, H.T.1    Chieng, D.Y.2    Ong, K.K.3
  • 31
    • 0037796416 scopus 로고
    • Different methods for the experimental production of generalized atherosclerosis in the rat
    • M.R. Malinow, D. Hojon, and A. Pellegrino Different methods for the experimental production of generalized atherosclerosis in the rat Acta Cardiologica 9 1954 480 499
    • (1954) Acta Cardiologica , vol.9 , pp. 480-499
    • Malinow, M.R.1    Hojon, D.2    Pellegrino, A.3
  • 32
    • 0032932928 scopus 로고    scopus 로고
    • A vitamin e concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations
    • R.P. Mensink, A.C. Van Houwelingen, D. Kromhout, and G. Hornstra A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations The American Journal Clinical of Nutrition 69 1999 213 219
    • (1999) The American Journal Clinical of Nutrition , vol.69 , pp. 213-219
    • Mensink, R.P.1    Van Houwelingen, A.C.2    Kromhout, D.3    Hornstra, G.4
  • 33
    • 0020616462 scopus 로고
    • Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid
    • D.W. Morel, J.R. Hessler, and G.M. Chisolm Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid Journal of Lipid Research 24 1983 1070 1076
    • (1983) Journal of Lipid Research , vol.24 , pp. 1070-1076
    • Morel, D.W.1    Hessler, J.R.2    Chisolm, G.M.3
  • 35
    • 0030729023 scopus 로고    scopus 로고
    • A cholesterol-rich diet causes a greater hypercholesterolemic response in pregnant than in nonpregnant rats and does not modify fetal lipoprotein profile
    • M.A. Munilla, and E. Herrera A cholesterol-rich diet causes a greater hypercholesterolemic response in pregnant than in nonpregnant rats and does not modify fetal lipoprotein profile The Journal of Nutrition 127 1997 2239 2245
    • (1997) The Journal of Nutrition , vol.127 , pp. 2239-2245
    • Munilla, M.A.1    Herrera, E.2
  • 39
    • 0027288196 scopus 로고
    • Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl coenzyme a reductase
    • R.A. Parker, B.C. Pearce, R.W. Clark, D.A. Gordon, and J.J. Wright Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase Journal of Biological Chemistry 268 1993 11230 11238
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 11230-11238
    • Parker, R.A.1    Pearce, B.C.2    Clark, R.W.3    Gordon, D.A.4    Wright, J.J.5
  • 40
    • 0017187285 scopus 로고
    • Effects of thyroid state on cholesterol metabolism in the rat
    • D. Pathe, and F. Chevallier Effects of thyroid state on cholesterol metabolism in the rat Biochimica et Biophysica Acta 441 1976 155 164
    • (1976) Biochimica et Biophysica Acta , vol.441 , pp. 155-164
    • Pathe, D.1    Chevallier, F.2
  • 43
    • 85166580471 scopus 로고
    • Novel hypercholesterolemic agents with antioxidant properties
    • L. Packer J. Fuchs Marcel Dekker New York
    • N. Qureshi, and A.A. Qureshi Novel hypercholesterolemic agents with antioxidant properties L. Packer J. Fuchs Vitamin E in health and disease 1993 Marcel Dekker New York 247 267
    • (1993) Vitamin e in Health and Disease , pp. 247-267
    • Qureshi, N.1    Qureshi, A.A.2
  • 47
    • 0030064856 scopus 로고    scopus 로고
    • Dietary α-tocopherol attenuates the impact of γ-tocotrienol on hepatic 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in chickens
    • A.A. Qureshi, B.C. Pearce, R.M. Nor, A. Gapor, D.M. Peterson, and C.E. Elson Dietary α-tocopherol attenuates the impact of γ-tocotrienol on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in chickens The Journal of Nutrition 126 1996 389 394
    • (1996) The Journal of Nutrition , vol.126 , pp. 389-394
    • Qureshi, A.A.1    Pearce, B.C.2    Nor, R.M.3    Gapor, A.4    Peterson, D.M.5    Elson, C.E.6
  • 48
    • 0030790784 scopus 로고    scopus 로고
    • Novel tocotrienols of rice bran modulate cardiovascular disease risk parameters of hypercholesterolemic humans
    • A.A. Qureshi, B.A. Bradlow, W.A. Salser, and L.D. Brace Novel tocotrienols of rice bran modulate cardiovascular disease risk parameters of hypercholesterolemic humans The Journal of Nutritional Biochemistry 8 1997 290 298
    • (1997) The Journal of Nutritional Biochemistry , vol.8 , pp. 290-298
    • Qureshi, A.A.1    Bradlow, B.A.2    Salser, W.A.3    Brace, L.D.4
  • 49
    • 0033857172 scopus 로고    scopus 로고
    • Isolation and identification of novel tocotrienols from rice bran with hypocholesterolemic, antioxidant, and antitumor properties
    • A.A. Qureshi, H. Mo, L. Packer, and D.M. Peterson Isolation and identification of novel tocotrienols from rice bran with hypocholesterolemic, antioxidant, and antitumor properties Journal of Agricultural and Food Chemistry 48 2000 3130 3140
    • (2000) Journal of Agricultural and Food Chemistry , vol.48 , pp. 3130-3140
    • Qureshi, A.A.1    Mo, H.2    Packer, L.3    Peterson, D.M.4
  • 53
    • 0031962759 scopus 로고    scopus 로고
    • Atherogenic lipoproteins support assembly of the prothrombinase complex and thrombin generation: Modulation by oxidation and vitamin e
    • S. Rota, N.A. McWilliam, T.P. Baglin, and C.D. Byrne Atherogenic lipoproteins support assembly of the prothrombinase complex and thrombin generation: modulation by oxidation and vitamin E Blood 91 1998 508 515
    • (1998) Blood , vol.91 , pp. 508-515
    • Rota, S.1    McWilliam, N.A.2    Baglin, T.P.3    Byrne, C.D.4
  • 54
    • 0025761230 scopus 로고
    • Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol
    • E. Serbinova, V. Kagan, D. Han, and L. Packer Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol Free Radical Biology and Medicine 10 1991 263 275
    • (1991) Free Radical Biology and Medicine , vol.10 , pp. 263-275
    • Serbinova, E.1    Kagan, V.2    Han, D.3    Packer, L.4
  • 55
    • 0026775156 scopus 로고
    • Regulation of hepatic sterol metabolism in the rat. Parallel regulation of activity and mRNA for 7 alpha-hydroxylase but not 3-hydroxy-3-methylglutaryl- coenzyme a reductase or low density lipoprotein receptor
    • D.K. Spady, and J.A. Cuthbert Regulation of hepatic sterol metabolism in the rat. Parallel regulation of activity and mRNA for 7 alpha-hydroxylase but not 3-hydroxy-3-methylglutaryl-coenzyme A reductase or low density lipoprotein receptor Journal of Biological Chemistry 267 1992 5584 5591
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 5584-5591
    • Spady, D.K.1    Cuthbert, J.A.2
  • 57
    • 0027447549 scopus 로고
    • Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins
    • C. Suarna, R.L. Hood, R.T. Dean, and R. Stocker Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins Biochimica et Biophysica Acta 1166 1993 163 170
    • (1993) Biochimica et Biophysica Acta , vol.1166 , pp. 163-170
    • Suarna, C.1    Hood, R.L.2    Dean, R.T.3    Stocker, R.4
  • 58
    • 0034977541 scopus 로고    scopus 로고
    • Impaired testicular function in rats with diet-induced hypercholesterolemia and/or streptozotocin-induced diabetes mellitus
    • M. Tanaka, S. Nakaya, T. Kumai, M. Watanabe, N. Matsumoto, and S. Kobayashi Impaired testicular function in rats with diet-induced hypercholesterolemia and/or streptozotocin-induced diabetes mellitus Endocrine Research 27 2001 109 117
    • (2001) Endocrine Research , vol.27 , pp. 109-117
    • Tanaka, M.1    Nakaya, S.2    Kumai, T.3    Watanabe, M.4    Matsumoto, N.5    Kobayashi, S.6
  • 60
    • 0028892443 scopus 로고
    • Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis
    • A.C. Tomeo, M. Geller, T.R. Watkins, A. Gapor, and M.L. Bierenbaum Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis Lipids 30 1995 1179 1183
    • (1995) Lipids , vol.30 , pp. 1179-1183
    • Tomeo, A.C.1    Geller, M.2    Watkins, T.R.3    Gapor, A.4    Bierenbaum, M.L.5
  • 61
    • 0026555296 scopus 로고
    • Differential serum responses of tocopherols and tocotrienols during vitamin supplementation in hypercholesterolaemic individuals without change in coronary risk factors
    • M.L. Wahlqvist, Z. Krivokuca-Bogetic, C.S. Lo, B. Hage, R. Smith, and W. Lukito Differential serum responses of tocopherols and tocotrienols during vitamin supplementation in hypercholesterolaemic individuals without change in coronary risk factors Nutrition Research 12 1992 S181 S201
    • (1992) Nutrition Research , vol.12
    • Wahlqvist, M.L.1    Krivokuca-Bogetic, Z.2    Lo, C.S.3    Hage, B.4    Smith, R.5    Lukito, W.6
  • 62
    • 0027330832 scopus 로고
    • Tocotrienol as a hypocholesterolemic and antioxidant agent in rats fed atherogenic diets
    • T. Watkins, P. Lenz, A. Gapor, M. Struck, A. Tomeo, and M. Bierenbaum Tocotrienol as a hypocholesterolemic and antioxidant agent in rats fed atherogenic diets Lipids 28 1993 1113 1118
    • (1993) Lipids , vol.28 , pp. 1113-1118
    • Watkins, T.1    Lenz, P.2    Gapor, A.3    Struck, M.4    Tomeo, A.5    Bierenbaum, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.