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Volumn 14, Issue 2, 2014, Pages 199-215

The pathomechanisms underlying Parkinson's disease

Author keywords

basal ganglia organization; clinico pathological subtypes; motor and nonmotor symptoms; nigrostriatal dopaminergic system; pathomechanisms of Parkinson's disease; pathophysiology

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR; GLUTAMATE RECEPTOR; MUSCARINIC RECEPTOR;

EID: 84893129338     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/14737175.2014.877842     Document Type: Review
Times cited : (57)

References (224)
  • 1
    • 84871089477 scopus 로고    scopus 로고
    • Neurobiology of cognitive impairment in Parkinson's disease
    • Jellinger KA. Neurobiology of cognitive impairment in Parkinson's disease. Expert Rev Neurother 2012;12:1451-66
    • (2012) Expert Rev Neurother , vol.12 , pp. 1451-1466
    • Jellinger, K.A.1
  • 2
    • 84855972240 scopus 로고    scopus 로고
    • Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts
    • Jellinger KA. Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts. Mov Disord 2012;27:8-30
    • (2012) Mov Disord , vol.27 , pp. 8-30
    • Jellinger, K.A.1
  • 3
    • 84893145851 scopus 로고    scopus 로고
    • Neurobiology of non-motor symptoms in Parkinson disease
    • Jellinger KA. Neurobiology of non-motor symptoms in Parkinson disease. J Neurol Disord Stroke 2013;2:1031
    • (2013) J Neurol Disord Stroke , vol.2 , pp. 1031
    • Jellinger, K.A.1
  • 4
    • 84859834711 scopus 로고    scopus 로고
    • Lewy pathology and neurodegeneration in premotor Parkinson's disease
    • Del Tredici K, Braak H. Lewy pathology and neurodegeneration in premotor Parkinson's disease. Mov Disord 2012;27: 597-607
    • (2012) Mov Disord , vol.27 , pp. 597-607
    • Del Tredici, K.1    Braak, H.2
  • 5
    • 84864130246 scopus 로고    scopus 로고
    • The role of alpha-synuclein in neurodegeneration - An update
    • Jellinger KA. The role of alpha-synuclein in neurodegeneration - An update. Translat Neurosci 2012;3:75-122
    • (2012) Translat Neurosci , vol.3 , pp. 75-122
    • Jellinger, K.A.1
  • 7
    • 84867581207 scopus 로고    scopus 로고
    • Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-Type synucleinopathies
    • Lue L-F, Walker DG, Adler CH, et al. Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-Type synucleinopathies. Brain Pathol 2012;22:745-56
    • (2012) Brain Pathol , vol.22 , pp. 745-756
    • Lue, L.-F.1    Walker, D.G.2    Adler, C.H.3
  • 8
    • 84879122389 scopus 로고    scopus 로고
    • The Lewy body in Parkinson's disease and related neurodegenerative disorders
    • Wakabayashi K, Tanji K, Odagiri S, et al. The Lewy body in Parkinson's disease and related neurodegenerative disorders. Mol Neurobiol 2013;47:495-508
    • (2013) Mol Neurobiol , vol.47 , pp. 495-508
    • Wakabayashi, K.1    Tanji, K.2    Odagiri, S.3
  • 9
    • 83555166040 scopus 로고    scopus 로고
    • Pale neurites, premature alpha-synuclein aggregates with centripetal extension from axon collaterals
    • Kanazawa T, Adachi E, Orimo S, et al. Pale neurites, premature alpha-synuclein aggregates with centripetal extension from axon collaterals. Brain Pathol 2012;22:67-78
    • (2012) Brain Pathol , vol.22 , pp. 67-78
    • Kanazawa, T.1    Adachi, E.2    Orimo, S.3
  • 10
    • 77957266699 scopus 로고    scopus 로고
    • Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice
    • Tanji K, Mori F, Mimura J, et al. Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice. Acta Neuropathol 2010;120:145-54
    • (2010) Acta Neuropathol , vol.120 , pp. 145-154
    • Tanji, K.1    Mori, F.2    Mimura, J.3
  • 11
    • 77957264418 scopus 로고    scopus 로고
    • The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies Parkinson's disease and Parkinson's disease dementia
    • Schulz-Schaeffer WJ. The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia. Acta Neuropathol 2010;120:131-43
    • (2010) Acta Neuropathol , vol.120 , pp. 131-143
    • Schulz-Schaeffer, W.J.1
  • 12
    • 84863188413 scopus 로고    scopus 로고
    • Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease
    • Chu Y, Morfini GA, Langhamer LB, et al. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain 2012;135: 2058-73
    • (2012) Brain , vol.135 , pp. 2058-2073
    • Chu, Y.1    Morfini, G.A.2    Langhamer, L.B.3
  • 13
    • 84857716290 scopus 로고    scopus 로고
    • Impaired neurotransmission caused by overexpression of alpha-synuclein in nigral dopamine neurons
    • Lundblad M, Decressac M, Mattsson B, Bjorklund A. Impaired neurotransmission caused by overexpression of alpha-synuclein in nigral dopamine neurons. Proc Natl Acad Sci USA 2012;109:3213-19
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 3213-3219
    • Lundblad, M.1    Decressac, M.2    Mattsson, B.3    Bjorklund, A.4
  • 14
    • 84883602232 scopus 로고    scopus 로고
    • Alpha-synuclein and neuronal cell death
    • Yasuda T, Nakata Y, Mochizuki H. Alpha-synuclein and neuronal cell death. Mol Neurobiol 2013;47:466-83
    • (2013) Mol Neurobiol , vol.47 , pp. 466-483
    • Yasuda, T.1    Nakata, Y.2    Mochizuki, H.3
  • 16
    • 84871489685 scopus 로고    scopus 로고
    • Changes in properties of serine 129 phosphorylated alpha-synuclein with progression of Lewy-Type histopathology in human brains
    • Walker DG, Lue LF, Adler CH, et al. Changes in properties of serine 129 phosphorylated alpha-synuclein with progression of Lewy-Type histopathology in human brains. Exp Neurol 2013;240: 190-204
    • (2013) Exp Neurol , vol.240 , pp. 190-204
    • Walker, D.G.1    Lue, L.F.2    Adler, C.H.3
  • 18
    • 84893028018 scopus 로고    scopus 로고
    • Synuclein and parkinson's disease: An update
    • In Martinez A, Gil C, editors The Royal Society of Chemistry London, UK
    • Jellinger KA. Synuclein and Parkinson's disease: An update. In: Martinez A, Gil C, editors. Emerging drugs and targets for Parkinson's disease. The Royal Society of Chemistry; London, UK: 2013. p. 175-214
    • (2013) Emerging Drugs And Targets For Parkinson's Disease , pp. 175-214
    • Jellinger, K.A.1
  • 19
    • 84863643572 scopus 로고    scopus 로고
    • Genetics of Parkinson disease and other movement disorders
    • Kumar KR, Lohmann K, Klein C. Genetics of Parkinson disease and other movement disorders. Curr Opin Neurol 2012;25: 466-74
    • (2012) Curr Opin Neurol , vol.25 , pp. 466-474
    • Kumar, K.R.1    Lohmann, K.2    Klein, C.3
  • 20
    • 84860214833 scopus 로고    scopus 로고
    • Update on genetics of parkinsonism
    • Fujioka S, Wszolek ZK. Update on genetics of parkinsonism. Neurodegener Dis 2012;10:257-60
    • (2012) Neurodegener Dis , vol.10 , pp. 257-260
    • Fujioka, S.1    Wszolek, Z.K.2
  • 21
    • 84865864065 scopus 로고    scopus 로고
    • The genetics and neuropathology of Parkinson's disease
    • Houlden H, Singleton AB. The genetics and neuropathology of Parkinson's disease. Acta Neuropathol 2012;124:325-38
    • (2012) Acta Neuropathol , vol.124 , pp. 325-338
    • Houlden, H.1    Singleton, A.B.2
  • 22
    • 84862689309 scopus 로고    scopus 로고
    • The neuropathology of genetic Parkinson's disease
    • Poulopoulos M, Levy OA, Alcalay RN. The neuropathology of genetic Parkinson's disease. Mov Disord 2012;27: 831-42
    • (2012) Mov Disord , vol.27 , pp. 831-842
    • Poulopoulos, M.1    Levy, O.A.2    Alcalay, R.N.3
  • 23
    • 79957606041 scopus 로고    scopus 로고
    • Etiology and pathogenesis of Parkinson's disease
    • Schapira AH, Jenner P. Etiology and pathogenesis of Parkinson's disease. Mov Disord 2011;26:1049-55
    • (2011) Mov Disord , vol.26 , pp. 1049-1055
    • Schapira, A.H.1    Jenner, P.2
  • 24
    • 84894291922 scopus 로고    scopus 로고
    • Alpha-synuclein and mitochondrial dysfunction in Parkinson's disease
    • Mullin S, Schapira A. Alpha-synuclein and mitochondrial dysfunction in Parkinson's disease. Mol Neurobiol 2013;47:587-97
    • (2013) Mol Neurobiol , vol.47 , pp. 587-597
    • Mullin, S.1    Schapira, A.2
  • 26
    • 70449713354 scopus 로고    scopus 로고
    • Acute action of rotenone on nigral dopaminergic neurons - involvement of reactive oxygen species and disruption of Ca homeostasis
    • Freestone PS, Chung KK, Guatteo E, et al. Acute action of rotenone on nigral dopaminergic neurons - involvement of reactive oxygen species and disruption of Ca homeostasis. Eur J Neurosci 2009;30: 1849-59
    • (2009) Eur J Neurosci , vol.30 , pp. 1849-1859
    • Freestone, P.S.1    Chung, K.K.2    Guatteo, E.3
  • 27
    • 84879971693 scopus 로고    scopus 로고
    • Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins
    • Hurley MJ, Brandon B, Gentleman SM, Dexter DT. Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins. Brain 2013;136:2077-97
    • (2013) Brain , vol.136 , pp. 2077-2097
    • Hurley, M.J.1    Brandon, B.2    Gentleman, S.M.3    Dexter, D.T.4
  • 28
    • 41549114279 scopus 로고    scopus 로고
    • The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
    • Pan T, Kondo S, Le W, Jankovic J. The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 2008;131: 1969-78
    • (2008) Brain , vol.131 , pp. 1969-1978
    • Pan, T.1    Kondo, S.2    Le W Jankovic, J.3
  • 29
    • 84880756245 scopus 로고    scopus 로고
    • Defective autophagy in Parkinson's disease: Role of oxidative stress
    • Janda E, Isidoro C, Carresi C, Mollace V. Defective autophagy in Parkinson's disease: Role of oxidative stress. Mol Neurobiol 2012;46:639-61
    • (2012) Mol Neurobiol , vol.46 , pp. 639-661
    • Janda, E.1    Isidoro, C.2    Carresi, C.3    Mollace, V.4
  • 30
    • 84885468645 scopus 로고    scopus 로고
    • Recent advances in alpha-synuclein functions, advanced glycation, and toxicity: Implications for Parkinson's disease
    • Guerrero E, Vasudevaraju P, Hegde ML, et al. Recent advances in alpha-synuclein functions, advanced glycation, and toxicity: Implications for Parkinson's disease. Mol Neurobiol 2013;47:525-36
    • (2013) Mol Neurobiol , vol.47 , pp. 525-536
    • Guerrero, E.1    Vasudevaraju, P.2    Hegde, M.L.3
  • 31
    • 0036298182 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions/ rearrangements in parkinson disease and related neurodegenerative disorders
    • Gu G, Reyes PE, Golden GT, et al. Mitochondrial DNA deletions/ rearrangements in parkinson disease and related neurodegenerative disorders. J Neuropathol Exp Neurol 2002;61:634-9
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 634-639
    • Gu, G.1    Reyes, P.E.2    Golden, G.T.3
  • 32
    • 84864150600 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinson's disease: Molecular mechanisms and pathophysiological consequences
    • Exner N, Lutz AK, Haass C, Winklhofer KF. Mitochondrial dysfunction in Parkinson's disease: Molecular mechanisms and pathophysiological consequences. EMBO J 2012;31:3038-62
    • (2012) EMBO J , vol.31 , pp. 3038-3062
    • Exner, N.1    Lutz, A.K.2    Haass, C.3    Winklhofer, K.F.4
  • 33
    • 79959242100 scopus 로고    scopus 로고
    • Mitochondrial contribution to Parkinson's disease pathogenesis
    • Schapira AH, Gegg M. Mitochondrial contribution to Parkinson's disease pathogenesis. Parkinsons Dis 2011;2011:159160
    • (2011) Parkinsons Dis , vol.2011 , pp. 159160
    • Schapira, A.H.1    Gegg, M.2
  • 34
    • 78650017514 scopus 로고    scopus 로고
    • Mitochondrial dynamics, cell death and the pathogenesis of Parkinson's disease
    • Bueler H. Mitochondrial dynamics, cell death and the pathogenesis of Parkinson's disease. Apoptosis 2010;15:1336-53
    • (2010) Apoptosis , vol.15 , pp. 1336-1353
    • Bueler, H.1
  • 35
    • 68649108355 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis
    • Banerjee R, Starkov AA, Beal MF, Thomas B. Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis. Biochim Biophys Acta 2009;1792:651-63
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 651-663
    • Banerjee, R.1    Starkov, A.A.2    Beal, M.F.3    Thomas, B.4
  • 36
    • 79959305691 scopus 로고    scopus 로고
    • Mitochondria: The next (neurode)generation
    • Schon EA, Przedborski S. Mitochondria: The next (neurode)generation. Neuron 2011;70: 1033-53
    • (2011) Neuron , vol.70 , pp. 1033-1053
    • Schon, E.A.1    Przedborski, S.2
  • 37
    • 84859421209 scopus 로고    scopus 로고
    • A mitochondrial etiology of alzheimer and parkinson disease
    • Coskun P, Wyrembak J, Schriner SE, et al. A mitochondrial etiology of Alzheimer and Parkinson disease. Biochim Biophys Acta 2012;1820:553-64
    • (2012) Biochim Biophys Acta , vol.1820 , pp. 553-564
    • Coskun, P.1    Wyrembak, J.2    Schriner, S.E.3
  • 38
    • 84857030799 scopus 로고    scopus 로고
    • Neurodegeneration as a consequence of failed mitochondrial maintenance
    • Karbowski M, Neutzner A. Neurodegeneration as a consequence of failed mitochondrial maintenance. Acta Neuropathol 2012;123:157-71
    • (2012) Acta Neuropathol , vol.123 , pp. 157-171
    • Karbowski, M.1    Neutzner, A.2
  • 39
    • 84857977793 scopus 로고    scopus 로고
    • Mitochondrial quality control and dynamics in Parkinson's disease
    • McCoy MK, Cookson MR. Mitochondrial quality control and dynamics in Parkinson's disease. Antioxid Redox Signal 2012;16: 869-82
    • (2012) Antioxid Redox Signal , vol.16 , pp. 869-882
    • McCoy, M.K.1    Cookson, M.R.2
  • 40
    • 84857031377 scopus 로고    scopus 로고
    • Parkin pink1 and mitochondrial integrity: Emerging concepts of mitochondrial dysfunction in Parkinson's disease
    • Pilsl A, Winklhofer KF. Parkin, PINK1 and mitochondrial integrity: Emerging concepts of mitochondrial dysfunction in Parkinson's disease. Acta Neuropathol 2012;123:173-88
    • (2012) Acta Neuropathol , vol.123 , pp. 173-188
    • Pilsl, A.1    Winklhofer, K.F.2
  • 41
    • 84890108110 scopus 로고    scopus 로고
    • Energy failure: Does it contribute to neurodegeneration?
    • Pathak D, Berthet A, Nakamura K. Energy failure: Does it contribute to neurodegeneration? Ann Neurol 2013;74: 506-16
    • (2013) Ann Neurol , vol.74 , pp. 506-516
    • Pathak, D.1    Berthet, A.2    Nakamura, K.3
  • 42
    • 78650169532 scopus 로고    scopus 로고
    • Iron species-mediated dopamine oxidation, proteasome inhibition, and dopaminergic cell demise: Implications for iron-related dopaminergic neuron degeneration
    • Zhou ZD, Lan YH, Tan EK, Lim TM. Iron species-mediated dopamine oxidation, proteasome inhibition, and dopaminergic cell demise: Implications for iron-related dopaminergic neuron degeneration. Free Radic Biol Med 2010;49:1856-71
    • (2010) Free Radic Biol Med , vol.49 , pp. 1856-1871
    • Zhou, Z.D.1    Lan, Y.H.2    Tan, E.K.3    Lim, T.M.4
  • 43
    • 80051632039 scopus 로고    scopus 로고
    • Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease
    • Lv Z, Jiang H, Xu H, et al. Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease. J Neural Transm 2011;118:361-9
    • (2011) J Neural Transm , vol.118 , pp. 361-369
    • Lv, Z.1    Jiang, H.2    Xu, H.3
  • 44
    • 80051801621 scopus 로고    scopus 로고
    • The relevance of iron in the pathogenesis of Parkinson's disease
    • Sian-Hulsmann J, Mandel S, Youdim MB, Riederer P. The relevance of iron in the pathogenesis of Parkinson's disease. J Neurochem 2011;118:939-57
    • (2011) J Neurochem , vol.118 , pp. 939-957
    • Sian-Hulsmann, J.1    Mandel, S.2    Youdim, M.B.3    Riederer, P.4
  • 45
    • 67649739079 scopus 로고    scopus 로고
    • Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis
    • Altamura S, Muckenthaler MU. Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis. J Alzheimers Dis 2009;16: 879-95
    • (2009) J Alzheimers Dis , vol.16 , pp. 879-895
    • Altamura, S.1    Muckenthaler, M.U.2
  • 46
    • 84878577036 scopus 로고    scopus 로고
    • Alpha-synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration
    • Beyer K, Ariza A. Alpha-synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration. Mol Neurobiol 2013;47: 509-24
    • (2013) Mol Neurobiol , vol.47 , pp. 509-524
    • Beyer, K.1    Ariza, A.2
  • 47
    • 85005846700 scopus 로고    scopus 로고
    • Direct detection of alpha synuclein oligomers in vivo
    • Dimant H, Kalia SK, Kalia LV, et al. Direct detection of alpha synuclein oligomers in vivo. Acta Neuropathol Commun 2013;1(1):6
    • (2013) Acta Neuropathol Commun , vol.1 , Issue.1 , pp. 6
    • Dimant, H.1    Kalia, S.K.2    Kalia, L.V.3
  • 48
    • 84862680670 scopus 로고    scopus 로고
    • Alpha-Synuclein cell-To-cell transfer and seeding in grafted dopaminergic neurons In vivo
    • Angot E, Steiner JA, Lema Tome CM, et al. Alpha-Synuclein cell-To-cell transfer and seeding in grafted dopaminergic neurons In vivo. PLoS ONE 2012;7:e39465
    • (2012) PLoS ONE , vol.7
    • Angot, E.1    Steiner, J.A.2    Lema Tome, C.M.3
  • 49
    • 77949848854 scopus 로고    scopus 로고
    • Prion-like transmission of protein aggregates in neurodegenerative diseases
    • Brundin P, Melki R, Kopito R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol 2010;11:301-7
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 301-307
    • Brundin, P.1    Melki, R.2    Kopito, R.3
  • 50
    • 84888394934 scopus 로고    scopus 로고
    • Inflammation and alpha-synuclein's prionlike behavior in Parkinson's disease-is there a link
    • Lema Tomé CM, Tyson T, Rey NL, et al. Inflammation and alpha-synuclein's prionlike behavior in Parkinson's disease-is there a link Mol Neurobiol 2013;47:561-74
    • (2013) Mol Neurobiol , vol.47 , pp. 561-574
    • Lema Tomé, C.M.1    Tyson, T.2    Rey, N.L.3
  • 51
    • 75949087271 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
    • Tansey MG, Goldberg MS. Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention. Neurobiol Dis 2010;37:510-18
    • (2010) Neurobiol Dis , vol.37 , pp. 510-518
    • Tansey, M.G.1    Goldberg, M.S.2
  • 53
    • 84893107628 scopus 로고    scopus 로고
    • Molecular pathogenesis and pathophysiology of parkinson's disease: New targets for new therapies
    • In Martinez A, Gil C, editors RSC Publishing London, UK
    • Castano JG, González C, Obeso JA, Rodriguez M. Molecular pathogenesis and pathophysiology of Parkinson's disease: New targets for new therapies. In: Martinez A, Gil C, editors. Emerging drugs and targets for Parkinson's Disease. RSC Publishing; London, UK: 2013. p. 26-57
    • (2013) Emerging drugs and targets for Parkinson's Disease , pp. 26-57
    • Castano, J.G.1    González, C.2    Obeso, J.A.3    Rodriguez, M.4
  • 54
    • 84868148328 scopus 로고    scopus 로고
    • Neuron-To-neuron transmission of alpha-synuclein fibrils through axonal transport
    • Freundt EC, Maynard N, Clancy EK, et al. Neuron-To-neuron transmission of alpha-synuclein fibrils through axonal transport. Ann Neurol 2012;72:517-24
    • (2012) Ann Neurol , vol.72 , pp. 517-524
    • Freundt, E.C.1    Maynard, N.2    Clancy, E.K.3
  • 55
    • 84862609075 scopus 로고    scopus 로고
    • Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice
    • Luk KC, Kehm VM, Zhang B, et al. Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice. J Exp Med 2012;209:975-86
    • (2012) J Exp Med , vol.209 , pp. 975-986
    • Luk, K.C.1    Kehm, V.M.2    Zhang, B.3
  • 56
    • 84858648349 scopus 로고    scopus 로고
    • A network diffusion model of disease progression in dementia
    • Raj A, Kuceyeski A, Weiner M. A network diffusion model of disease progression in dementia. Neuron 2012;73:1204-15
    • (2012) Neuron , vol.73 , pp. 1204-1215
    • Raj, A.1    Kuceyeski, A.2    Weiner, M.3
  • 57
    • 84885470591 scopus 로고    scopus 로고
    • Transfer of human alpha-synuclein from the olfactory bulb to interconnected brain regions in mice
    • Rey NL, Petit GH, Bousset L, et al. Transfer of human alpha-synuclein from the olfactory bulb to interconnected brain regions in mice. Acta Neuropathol 2013;126:555-73
    • (2013) Acta Neuropathol , vol.126 , pp. 555-573
    • Rey, N.L.1    Petit, G.H.2    Bousset, L.3
  • 59
    • 0026348872 scopus 로고
    • Pathology of Parkinson's disease Changes other than the nigrostriatal pathway
    • Jellinger KA. Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway. Mol Chem Neuropathol 1991;14: 153-97
    • (1991) NMol Chem Neuropathol , vol.14 , pp. 153-197
    • Jellinger, K.A.1
  • 60
    • 13544265328 scopus 로고    scopus 로고
    • Involvement of medullary regions controlling sympathetic output in Lewy body disease
    • Benarroch EE, Schmeichel AM, Low PA, et al. Involvement of medullary regions controlling sympathetic output in Lewy body disease. Brain 2005;128:338-44
    • (2005) Brain , vol.128 , pp. 338-344
    • Benarroch, E.E.1    Schmeichel, A.M.2    Low, P.A.3
  • 61
    • 33846618232 scopus 로고    scopus 로고
    • Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy
    • Benarroch EE, Schmeichel AM, Low PA, Parisi JE. Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy. Brain 2007;130:469-75
    • (2007) Brain , vol.130 , pp. 469-475
    • Benarroch, E.E.1    Schmeichel, A.M.2    Low, P.A.3    Parisi, J.E.4
  • 62
    • 77953021942 scopus 로고    scopus 로고
    • Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders
    • Beach TG, Adler CH, Sue LI, et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol 2010;119:689-702
    • (2010) Acta Neuropathol , vol.119 , pp. 689-702
    • Beach, T.G.1    Adler, C.H.2    Sue, L.I.3
  • 63
    • 34250841699 scopus 로고    scopus 로고
    • Hypocretin (orexin) loss in Parkinson's disease
    • Fronczek R, Overeem S, Lee SY, et al. Hypocretin (orexin) loss in Parkinson's disease. Brain 2007;130:1577-85
    • (2007) Brain , vol.130 , pp. 1577-1585
    • Fronczek, R.1    Overeem, S.2    Lee, S.Y.3
  • 64
    • 77955844658 scopus 로고    scopus 로고
    • Staging of serotonergic dysfunction in Parkinson's disease: An in vivo 11C-DASB PET study
    • Politis M, Wu K, Loane C, et al. Staging of serotonergic dysfunction in Parkinson's disease: An in vivo 11C-DASB PET study. Neurobiol Dis 2010;40:216-21
    • (2010) Neurobiol Dis , vol.40 , pp. 216-221
    • Politis, M.1    Wu, K.2    Loane, C.3
  • 65
    • 34250897889 scopus 로고    scopus 로고
    • Hypocretin (orexin) cell loss in Parkinson's disease
    • Thannickal TC, Lai YY, Siegel JM. Hypocretin (orexin) cell loss in Parkinson's disease. Brain 2007;130:1586-95
    • (2007) Brain , vol.130 , pp. 1586-1595
    • Thannickal, T.C.1    Lai, Y.Y.2    Siegel, J.M.3
  • 66
    • 80052834174 scopus 로고    scopus 로고
    • The serotonergic system in Parkinson's disease
    • Huot P, Fox SH, Brotchie JM. The serotonergic system in Parkinson's disease. Prog Neurobiol 2011;95:163-212
    • (2011) Prog Neurobiol , vol.95 , pp. 163-212
    • Huot, P.1    Fox, S.H.2    Brotchie, J.M.3
  • 67
    • 33947200337 scopus 로고    scopus 로고
    • Parkinson's disease: Lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons
    • Braak H, Sastre M, Bohl JR, et al. Parkinson's disease: Lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons. Acta Neuropathol 2007;113:421-9
    • (2007) Acta Neuropathol , vol.113 , pp. 421-429
    • Braak, H.1    Sastre, M.2    Bohl, J.R.3
  • 68
    • 57049182374 scopus 로고    scopus 로고
    • Neuroanatomy and pathology of sporadic Parkinson's disease
    • Braak H, Del Tredici K. Neuroanatomy and pathology of sporadic Parkinson's disease. Adv Anat Embryol Cell Biol 2009;201:1-119
    • (2009) Adv Anat Embryol Cell Biol , vol.201 , pp. 1-119
    • Braak, H.1    Del Tredici, K.2
  • 69
    • 84871004211 scopus 로고    scopus 로고
    • Spinal cord lesions in sporadic Parkinson's disease
    • Del Tredici K, Braak H. Spinal cord lesions in sporadic Parkinson's disease. Acta Neuropathol 2012;124:643-64
    • (2012) Acta Neuropathol , vol.124 , pp. 643-664
    • Del Tredici, K.1    Braak, H.2
  • 70
    • 43649106356 scopus 로고    scopus 로고
    • Nervous system pathology in sporadic Parkinson disease
    • Braak H, Del Tredici K. Invited Article: Nervous system pathology in sporadic Parkinson disease. Neurology 2008;70: 1916-25
    • (2008) Neurology , vol.70 , pp. 1916-1925
    • Braak, H.1    Del Tredici, K.2    Invited Article3
  • 72
    • 39749123263 scopus 로고    scopus 로고
    • Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
    • Orimo S, Uchihara T, Nakamura A, et al. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain 2008;131:642-50
    • (2008) Brain , vol.131 , pp. 642-650
    • Orimo, S.1    Uchihara, T.2    Nakamura, A.3
  • 73
    • 77953033188 scopus 로고    scopus 로고
    • Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopathies of the brain
    • Wakabayashi K, Mori F, Tanji K, et al. Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopathies of the brain. Acta Neuropathol 2010;120:1-12
    • (2010) Acta Neuropathol , vol.120 , pp. 1-12
    • Wakabayashi, K.1    Mori, F.2    Tanji, K.3
  • 74
    • 84872863398 scopus 로고    scopus 로고
    • Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease
    • Mu L, Sobotka S, Chen J, et al. Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease. J Neuropathol Exp Neurol 2013;72: 119-29
    • (2013) J Neuropathol Exp Neurol , vol.72 , pp. 119-129
    • Mu, L.1    Sobotka, S.2    Chen, J.3
  • 75
    • 41149110768 scopus 로고    scopus 로고
    • Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?
    • Phillips RJ, Walter GC, Wilder SL, et al. Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease? Neuroscience 2008;153: 733-50
    • (2008) Neuroscience , vol.153 , pp. 733-750
    • Phillips, R.J.1    Walter, G.C.2    Wilder, S.L.3
  • 76
    • 67651149794 scopus 로고    scopus 로고
    • Lesions outside the CNS in Parkinson's disease
    • Djaldetti R, Lev N, Melamed E. Lesions outside the CNS in Parkinson's disease. Mov Disord 2009;24:793-800
    • (2009) Mov Disord , vol.24 , pp. 793-800
    • Djaldetti, R.1    Lev, N.2    Melamed, E.3
  • 77
    • 13544264770 scopus 로고    scopus 로고
    • Profound cardiac sympathetic denervation occurs in Parkinson disease
    • Amino T, Orimo S, Itoh Y, et al. Profound cardiac sympathetic denervation occurs in Parkinson disease. Brain Pathol 2005;15: 29-34
    • (2005) Brain Pathol , vol.15 , pp. 29-34
    • Amino, T.1    Orimo, S.2    Itoh, Y.3
  • 78
    • 33847205751 scopus 로고    scopus 로고
    • Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease
    • Orimo S, Takahashi A, Uchihara T, et al. Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease. Brain Pathol 2007;17: 24-30
    • (2007) Brain Pathol , vol.17 , pp. 24-30
    • Orimo, S.1    Takahashi, A.2    Uchihara, T.3
  • 80
    • 84872870323 scopus 로고    scopus 로고
    • Submandibular gland biopsy for the diagnosis of Parkinson disease
    • Beach TG, Adler CH, Dugger BN, et al. Submandibular gland biopsy for the diagnosis of Parkinson disease. J Neuropathol Exp Neurol 2013;72:130-6
    • (2013) J Neuropathol Exp Neurol , vol.72 , pp. 130-136
    • Beach, T.G.1    Adler, C.H.2    Dugger, B.N.3
  • 81
    • 77953022918 scopus 로고    scopus 로고
    • Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease
    • Del Tredici K, Hawkes CH, Ghebremedhin E, Braak H. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease. Acta Neuropathol 2010;119:703-13
    • (2010) Acta Neuropathol , vol.119 , pp. 703-713
    • Del Tredici, K.1    Hawkes, C.H.2    Ghebremedhin, E.3    Braak, H.4
  • 82
    • 79960842310 scopus 로고    scopus 로고
    • Neuropathology underlying clinical variability in patients with synucleinopathies
    • Halliday GM, Holton JL, Revesz T, Dickson DW. Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol 2011;122:187-204
    • (2011) Acta Neuropathol , vol.122 , pp. 187-204
    • Halliday, G.M.1    Holton, J.L.2    Revesz, T.3    Dickson, D.W.4
  • 83
    • 79957586330 scopus 로고    scopus 로고
    • Milestones in Parkinson's disease - clinical and pathologic features
    • Halliday G, Lees A, Stern M. Milestones in Parkinson's disease - clinical and pathologic features. Mov Disord 2011;26:1015-21
    • (2011) Mov Disord , vol.26 , pp. 1015-1021
    • Halliday, G.1    Lees, A.2    Stern, M.3
  • 84
    • 67349279396 scopus 로고    scopus 로고
    • Unified staging system for Lewy body disorders: Correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
    • Beach TG, Adler CH, Lue L, et al. Unified staging system for Lewy body disorders: Correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol 2009;117: 613-34
    • (2009) Acta Neuropathol , vol.117 , pp. 613-634
    • Beach, T.G.1    Adler, C.H.2    Lue, L.3
  • 85
    • 77953024810 scopus 로고    scopus 로고
    • Alpha-Synuclein pathology in the spinal cord autonomic nuclei associates with alpha-synuclein pathology in the brain: A population-based Vantaa 85+ study
    • Oinas M, Paetau A, Myllykangas L, et al. Alpha-Synuclein pathology in the spinal cord autonomic nuclei associates with alpha-synuclein pathology in the brain: A population-based Vantaa 85+ study. Acta Neuropathol 2010;119:715-22
    • (2010) Acta Neuropathol , vol.119 , pp. 715-722
    • Oinas, M.1    Paetau, A.2    Myllykangas, L.3
  • 86
    • 84879904703 scopus 로고    scopus 로고
    • Parkinson disease affects peripheral sensory nerves in the pharynx
    • Mu L, Sobotka S, Chen J, et al. Parkinson disease affects peripheral sensory nerves in the pharynx. J Neuropathol Exp Neurol 2013;72:614-23
    • (2013) J Neuropathol Exp Neurol , vol.72 , pp. 614-623
    • Mu, L.1    Sobotka, S.2    Chen, J.3
  • 87
    • 84861692236 scopus 로고    scopus 로고
    • Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease
    • Shannon KM, Keshavarzian A, Mutlu E, et al. Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease. Mov Disord 2012;27:709-15
    • (2012) Mov Disord , vol.27 , pp. 709-715
    • Shannon, K.M.1    Keshavarzian, A.2    Mutlu, E.3
  • 88
    • 81455154253 scopus 로고    scopus 로고
    • Parkinson disease: The enteric nervous system spills its guts
    • Derkinderen P, Rouaud T, Lebouvier T, et al. Parkinson disease: The enteric nervous system spills its guts. Neurology 2011;77: 1761-7
    • (2011) Neurology , vol.77 , pp. 1761-1767
    • Derkinderen, P.1    Rouaud, T.2    Lebouvier, T.3
  • 89
    • 84891447160 scopus 로고    scopus 로고
    • Gastrointestinal manifestations in Parkinson's disease: Prevalence and occurrence before motor symptoms
    • Cersosimo MG, Raina GB, Pecci C, et al. Gastrointestinal manifestations in Parkinson's disease: Prevalence and occurrence before motor symptoms. J Neurol 2013;260:1332-8
    • (2013) J Neurol , vol.260 , pp. 1332-1338
    • Cersosimo, M.G.1    Raina, G.B.2    Pecci, C.3
  • 90
    • 84871028956 scopus 로고    scopus 로고
    • Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss
    • Annerino DM, Arshad S, Taylor GM, et al. Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss. Acta Neuropathol 2012;124: 665-80
    • (2012) Acta Neuropathol , vol.124 , pp. 665-680
    • Annerino, D.M.1    Arshad, S.2    Taylor, G.M.3
  • 91
    • 49449097043 scopus 로고    scopus 로고
    • Incidental Lewy body disease and preclinical Parkinson disease
    • DelleDonne A, Klos KJ, Fujishiro H, et al. Incidental Lewy body disease and preclinical Parkinson disease. Arch Neurol 2008;65: 1074-80
    • (2008) Arch Neurol , vol.65 , pp. 1074-1080
    • DelleDonne, A.1    Klos, K.J.2    Fujishiro, H.3
  • 92
    • 41149115508 scopus 로고    scopus 로고
    • Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease
    • Dickson DW, Fujishiro H, Delledonne A, et al. Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease. Acta Neuropathol 2008;115: 437-44
    • (2008) Acta Neuropathol , vol.115 , pp. 437-444
    • Dickson, D.W.1    Fujishiro, H.2    Delledonne, A.3
  • 93
    • 71449128214 scopus 로고    scopus 로고
    • Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: An anatomical study
    • Ghebremedhin E, Del Tredici K, Langston JW, Braak H. Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: An anatomical study. Acta Neuropathol 2009;118:777-84
    • (2009) Acta Neuropathol , vol.118 , pp. 777-784
    • Ghebremedhin, E.1    Del Tredici, K.2    Langston, J.W.3    Braak, H.4
  • 95
    • 77649284470 scopus 로고    scopus 로고
    • Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice
    • Pan-Montojo F, Anichtchik O, Dening Y, et al. Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS ONE 2010;5:e8762
    • (2010) PLoS ONE , vol.5
    • Pan-Montojo, F.1    Anichtchik, O.2    Dening, Y.3
  • 96
    • 84870769168 scopus 로고    scopus 로고
    • Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
    • Pan-Montojo F, Schwarz M, Winkler C, et al. Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Sci Rep 2012;2:898
    • (2012) Sci Rep , vol.2 , pp. 898
    • Pan-Montojo, F.1    Schwarz, M.2    Winkler, C.3
  • 97
    • 85028891387 scopus 로고    scopus 로고
    • Bodis-Wollner I. editors Humana Press; NY, USA Springer Science; Totowa, NJ, USA
    • Pfeiffer RF, Bodis-Wollner I. editors. Parkinson's disease and nonmotor dysfunction. Humana Press; NY, USA: Springer Science; Totowa, NJ, USA: 2013
    • (2013) Parkinson's Disease And Nonmotor Dysfunction
    • Pfeiffer, R.F.1
  • 98
    • 79955112282 scopus 로고    scopus 로고
    • A critical appraisal of the premotor symptoms of Parkinson's disease: Potential usefulness in early diagnosis and design of neuroprotective trials
    • Lang AE. A critical appraisal of the premotor symptoms of Parkinson's disease: Potential usefulness in early diagnosis and design of neuroprotective trials. Mov Disord 2011;26:775-83
    • (2011) Mov Disord , vol.26 , pp. 775-783
    • Lang, A.E.1
  • 99
    • 64349083816 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson's disease: Dopaminergic pathophysiology and treatment
    • Chaudhuri KR, Schapira AH. Non-motor symptoms of Parkinson's disease: Dopaminergic pathophysiology and treatment. Lancet Neurol 2009;8:464-74
    • (2009) Lancet Neurol , vol.8 , pp. 464-474
    • Chaudhuri, K.R.1    Schapira, A.H.2
  • 100
    • 84885982317 scopus 로고    scopus 로고
    • In: Schapira AHV Lang AET Fahn S Editors. Movement Disorders 4. Saunders. -Elsevier Philadelphia, PA, USA
    • Tolosa E, Santamaria J, Gaig C, Compta Y. Nonmotor aspects of Parkinson's disease. In: Schapira AHV, Lang AET, Fahn S, editors. Movement disorders 4. Saunders-Elsevier; Philadelphia, PA, USA: 2010. p. 229-51
    • (2010) Nonmotor Aspects Of Parkinson's Disease , pp. 229-251
    • Tolosa, E.1    Santamaria, J.2    Gaig, C.3    Compta, Y.4
  • 101
    • 74849129545 scopus 로고    scopus 로고
    • Non-motor symptoms in atypical and secondary parkinsonism: The PRIAMO study
    • Colosimo C, Morgante L, Antonini A, et al. Non-motor symptoms in atypical and secondary parkinsonism: The PRIAMO study. J Neurol 2010;257:5-14
    • (2010) J Neurol , vol.257 , pp. 5-14
    • Colosimo, C.1    Morgante, L.2    Antonini, A.3
  • 102
    • 72149101615 scopus 로고    scopus 로고
    • Initial clinical manifestations of Parkinson's disease: Features and pathophysiological mechanisms
    • Rodriguez-Oroz MC, Jahanshahi M, Krack P, et al. Initial clinical manifestations of Parkinson's disease: Features and pathophysiological mechanisms. Lancet Neurol 2009;8:1128-39
    • (2009) Lancet Neurol , vol.8 , pp. 1128-1139
    • Rodriguez-Oroz, M.C.1    Jahanshahi, M.2    Krack, P.3
  • 103
    • 41149173996 scopus 로고    scopus 로고
    • The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years
    • Hely MA, Reid WG, Adena MA, et al. The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years. Mov Disord 2008;23:837-44
    • (2008) Mov Disord , vol.23 , pp. 837-844
    • Hely, M.A.1    Reid, W.G.2    Adena, M.A.3
  • 104
    • 68949194368 scopus 로고    scopus 로고
    • Course in Parkinson disease subtypes: A 39-year clinicopathologic study
    • Rajput AH, Voll A, Rajput ML, et al. Course in Parkinson disease subtypes: A 39-year clinicopathologic study. Neurology 2009;73:206-12
    • (2009) Neurology , vol.73 , pp. 206-212
    • Rajput, A.H.1    Voll, A.2    Rajput, M.L.3
  • 105
    • 84855925916 scopus 로고    scopus 로고
    • Toward a redefinition of Parkinson's disease
    • Stern MB, Lang A, Poewe W. Toward a redefinition of Parkinson's disease. Mov Disord 2012;27:54-60
    • (2012) Mov Disord , vol.27 , pp. 54-60
    • Stern, M.B.1    Lang, A.2    Poewe, W.3
  • 106
    • 84861739631 scopus 로고    scopus 로고
    • Evaluation of the Braak hypo thesis: How far can it explain the pathogenesis of Parkinson's disease?
    • Halliday G, McCann H, Shepherd C. Evaluation of the Braak hypothesis: How far can it explain the pathogenesis of Parkinson's disease? Expert Rev Neurother 2012;12:673-86
    • (2012) Expert Rev Neurother , vol.12 , pp. 673-686
    • Halliday, G.1    McCann, H.2    Shepherd, C.3
  • 107
    • 70350643450 scopus 로고    scopus 로고
    • A clinico-pathological study of subtypes in Parkinson's disease
    • Selikhova M, Williams DR, Kempster PA, et al. A clinico-pathological study of subtypes in Parkinson's disease. Brain 2009;132:2947-57
    • (2009) Brain , vol.132 , pp. 2947-2957
    • Selikhova, M.1    Williams, D.R.2    Kempster, P.A.3
  • 108
    • 0015745743 scopus 로고
    • Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations
    • Bernheimer H, Birkmayer W, Hornykiewicz O, et al. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci 1973;20:415-55
    • (1973) J Neurol Sci , vol.20 , pp. 415-455
    • Bernheimer, H.1    Birkmayer, W.2    Hornykiewicz, O.3
  • 109
    • 77952926102 scopus 로고    scopus 로고
    • Clinical progression in Parkinson disease and the neurobiology of axons
    • Cheng HC, Ulane CM, Burke RE. Clinical progression in Parkinson disease and the neurobiology of axons. Ann Neurol 2010;67:715-25
    • (2010) Ann Neurol , vol.67 , pp. 715-725
    • Cheng, H.C.1    Ulane, C.M.2    Burke, R.E.3
  • 110
    • 57749095477 scopus 로고    scopus 로고
    • A critical evaluation of the Braak staging scheme for Parkinson's disease
    • Burke RE, Dauer WT, Vonsattel JP. A critical evaluation of the Braak staging scheme for Parkinson's disease. Ann Neurol 2008;64:485-91
    • (2008) Ann Neurol , vol.64 , pp. 485-491
    • Burke, R.E.1    Dauer, W.T.2    Vonsattel, J.P.3
  • 111
    • 78349236177 scopus 로고    scopus 로고
    • What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?
    • Gallagher DA, Lees AJ, Schrag A. What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them? Mov Disord 2010;25: 2493-500
    • (2010) Mov Disord , vol.25 , pp. 2493-2500
    • Gallagher, D.A.1    Lees, A.J.2    Schrag, A.3
  • 112
    • 84874210403 scopus 로고    scopus 로고
    • Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease
    • Gold A, Turkalp ZT, Munoz DG. Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease. Mov Disord 2013;28:237-40
    • (2013) Mov Disord , vol.28 , pp. 237-240
    • Gold, A.1    Turkalp, Z.T.2    Munoz, D.G.3
  • 113
    • 41049097524 scopus 로고    scopus 로고
    • New insights into the pathology of Parkinson's disease does the peripheral autonomic system become central?
    • Probst A, Bloch A, Tolnay M. New insights into the pathology of Parkinson's disease: Does the peripheral autonomic system become central? Eur J Neurol 2008; 15(Suppl(1):1-4
    • (2008) Eur J Neurol , vol.15 , Issue.SUPPL. 1 , pp. 1-4
    • Probst, A.1    Bloch, A.2    Tolnay, M.3
  • 115
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • Braak H, Del Tredici K, Rub U, et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003;24:197-211
    • (2003) Neurobiol Aging , vol.24 , pp. 197-211
    • Braak, H.1    Del Tredici, K.2    Rub, U.3
  • 116
    • 17644426053 scopus 로고    scopus 로고
    • Cognitive status correlates with neuropathologic stage in Parkinson disease
    • Braak H, Rub U, Jansen Steur EN, et al. Cognitive status correlates with neuropathologic stage in Parkinson disease. Neurology 2005;64:1404-10
    • (2005) Neurology , vol.64 , pp. 1404-1410
    • Braak, H.1    Rub, U.2    Jansen Steur, E.N.3
  • 118
    • 79953278999 scopus 로고    scopus 로고
    • Neuropathology and neurochemistry of nonmotor symptoms in Parkinson's disease
    • Ferrer I. Neuropathology and neurochemistry of nonmotor symptoms in Parkinson's disease. Parkinsons Dis 2011;2011:708404
    • (2011) Parkinsons Dis , vol.2011 , pp. 708404
    • Ferrer, I.1
  • 119
    • 77953433969 scopus 로고    scopus 로고
    • Evidence in favor of Braak staging of Parkinson's disease
    • Dickson DW, Uchikado H, Fujishiro H, Tsuboi Y. Evidence in favor of Braak staging of Parkinson's disease. Mov Disord 2010;25(Suppl 1):S78-82
    • (2010) Mov Disord , vol.25 , Issue.SUPPL. 1
    • Dickson, D.W.1    Uchikado, H.2    Fujishiro, H.3    Tsuboi, Y.4
  • 120
    • 33750349255 scopus 로고    scopus 로고
    • Critical appraisal of brain pathology staging related to presymptomatic and symptomatic cases of sporadic Parkinson's disease
    • Halliday GM, Del Tredici K, Braak H. Critical appraisal of brain pathology staging related to presymptomatic and symptomatic cases of sporadic Parkinson's disease. J Neural Transm Suppl 2006(70):99-103
    • (2006) J Neural Transm Suppl , vol.70 , pp. 99-103
    • Halliday, G.M.1    Del Tredici, K.2    Braak, H.3
  • 121
    • 22244475735 scopus 로고    scopus 로고
    • Staging of sporadic Parkinson disease-related alpha-synuclein pathology: Inter- and intra-rater reliability
    • Muller CM, de Vos RA, Maurage CA, et al. Staging of sporadic Parkinson disease-related alpha-synuclein pathology: Inter- and intra-rater reliability. J Neuropathol Exp Neurol 2005;64:623-8
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 623-628
    • Muller, C.M.1    De Vos, R.A.2    Maurage, C.A.3
  • 122
    • 68749116710 scopus 로고    scopus 로고
    • A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders
    • Jellinger KA. A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders. Biochim Biophys Acta 2009;1792:730-40
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 730-740
    • Jellinger, K.A.1
  • 123
    • 41149141259 scopus 로고    scopus 로고
    • Applicability of current staging/ categorization of alpha-synuclein pathology and their clinical relevance
    • Parkkinen L, Pirttila T, Alafuzoff I. Applicability of current staging/ categorization of alpha-synuclein pathology and their clinical relevance. Acta Neuropathol 2008;115:399-407
    • (2008) Acta Neuropathol , vol.115 , pp. 399-407
    • Parkkinen, L.1    Pirttila, T.2    Alafuzoff, I.3
  • 124
    • 33646082266 scopus 로고    scopus 로고
    • Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
    • Bloch A, Probst A, Bissig H, et al. Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol Appl Neurobiol 2006;32: 284-95
    • (2006) Neuropathol Appl Neurobiol , vol.32 , pp. 284-295
    • Bloch, A.1    Probst, A.2    Bissig, H.3
  • 125
    • 69549116777 scopus 로고    scopus 로고
    • Formation and development of Lewy pathology: A critical update
    • Jellinger KA. Formation and development of Lewy pathology: A critical update. J Neurol 2009;256(Suppl 3):270-9
    • (2009) J Neurol , vol.256 , Issue.SUPPL. 3 , pp. 270-279
    • Jellinger, K.A.1
  • 126
    • 59249102891 scopus 로고    scopus 로고
    • Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders
    • 215-16. author reply
    • Jellinger KA. Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders. Acta Neuropathol 2009;117:215-16. author reply 217-18
    • (2009) Acta Neuropathol , vol.117 , pp. 217-218
    • Jellinger, K.A.1
  • 127
    • 41349084608 scopus 로고    scopus 로고
    • Patterns and stages of alphasynucleinopathy: Relevance in a population-based cohort
    • Zaccai J, Brayne C, McKeith I, et al. Patterns and stages of alphasynucleinopathy: Relevance in a population-based cohort. Neurology 2008;70:1042-8
    • (2008) Neurology , vol.70 , pp. 1042-1048
    • Zaccai, J.1    Brayne, C.2    McKeith, I.3
  • 128
    • 47749133805 scopus 로고    scopus 로고
    • Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies
    • Fujishiro H, Tsuboi Y, Lin WL, et al. Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies. Acta Neuropathol 2008;116:17-24
    • (2008) Acta Neuropathol , vol.116 , pp. 17-24
    • Fujishiro, H.1    Tsuboi, Y.2    Lin, W.L.3
  • 129
    • 84893138415 scopus 로고    scopus 로고
    • Psychiatric issues in parkinson's disease
    • In: Schapira AHV Lang AET Fahn S Editors Saunders-Elsevier Philadelphia, PA, USA
    • Weintraub D. Psychiatric issues in Parkinson's disease. In: Schapira AHV, Lang AET, Fahn S, editors. Movement Disorders 4. Saunders-Elsevier; Philadelphia, PA, USA: 2010. p. 213-28
    • (2010) Movement Disorders 4 , pp. 213-228
    • Weintraub, D.1
  • 130
    • 84862299730 scopus 로고    scopus 로고
    • Olfactory dysfunction in Parkinson disease
    • Doty RL. Olfactory dysfunction in Parkinson disease. Nat Rev Neurol 2012;8: 329-39
    • (2012) Nat Rev Neurol , vol.8 , pp. 329-339
    • Doty, R.L.1
  • 131
    • 84860840966 scopus 로고    scopus 로고
    • Olfaction in Parkinson's disease and related disorders
    • Doty RL. Olfaction in Parkinson's disease and related disorders. Neurobiol Dis 2012;46:527-52
    • (2012) Neurobiol Dis , vol.46 , pp. 527-552
    • Doty, R.L.1
  • 132
    • 74149090746 scopus 로고    scopus 로고
    • Olfactory system pathology as a model of Lewy neurodegenerative disease
    • Duda JE. Olfactory system pathology as a model of Lewy neurodegenerative disease. J Neurol Sci 2010;289:49-54
    • (2010) J Neurol Sci , vol.289 , pp. 49-54
    • Duda, J.E.1
  • 133
    • 84890790952 scopus 로고    scopus 로고
    • Olfactory loss as a supporting feature in the diagnosis of Parkinson's disease: A pragmatic approach
    • Hoyles K, Sharma JC. Olfactory loss as a supporting feature in the diagnosis of Parkinson's disease: A pragmatic approach. J Neurol 2013;260:2951-8
    • (2013) J Neurol , vol.260 , pp. 2951-2958
    • Hoyles, K.1    Sharma, J.C.2
  • 134
    • 61749097162 scopus 로고    scopus 로고
    • Regional differences in the severity of Lewy body pathology across the olfactory cortex
    • Silveira-Moriyama L, Holton JL, Kingsbury A, et al. Regional differences in the severity of Lewy body pathology across the olfactory cortex. Neurosci Lett 2009;453:77-80
    • (2009) Neurosci Lett , vol.453 , pp. 77-80
    • Silveira-Moriyama, L.1    Holton, J.L.2    Kingsbury, A.3
  • 135
    • 19944429736 scopus 로고    scopus 로고
    • AD lesions and infarcts in demented and no-demented Japanese-American men
    • Petrovitch H, Ross GW, Steinhorn SC, et al. AD lesions and infarcts in demented and no-demented Japanese-American men. Ann Neurol 2005;57:98-103
    • (2005) Ann Neurol , vol.57 , pp. 98-103
    • Petrovitch, H.1    Ross, G.W.2    Steinhorn, S.C.3
  • 136
    • 80051578871 scopus 로고    scopus 로고
    • Correlation between progressive changes in piriform cortex and olfactory performance in early Parkinson's disease
    • Wu X, Yu C, Fan F, et al. Correlation between progressive changes in piriform cortex and olfactory performance in early Parkinson's disease. Eur Neurol 2011;66: 98-105
    • (2011) Eur Neurol , vol.66 , pp. 98-105
    • Wu, X.1    Yu, C.2    Fan, F.3
  • 137
    • 77949903007 scopus 로고    scopus 로고
    • REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorderneurodegenerative disease association, evolving concepts, controversies, and future directions
    • Boeve BF. REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorderneurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci 2010;1184: 15-54
    • (2010) Ann N Y Acad Sci , vol.1184 , pp. 15-54
    • Boeve, B.F.1
  • 138
    • 84893061754 scopus 로고    scopus 로고
    • In Chaudhuri KR, Tolosa E, Schapira A, Poewe W, editors. Non-motor symptoms of Parkinson's disease. Oxford Univ. Press Oxford, England, UK
    • Iranzo A, Tolosa E. REM sleep behaviour disorder in Parkinson's disease. In: Chaudhuri KR, Tolosa E, Schapira A, Poewe W, editors. Non-motor symptoms of Parkinson's disease. Oxford Univ. Press; Oxford, England, UK: 2009. p. 177-93
    • (2009) REM Sleep Behaviour Disorder In Parkinson's Disease , pp. 177-193
    • Iranzo, A.1    Tolosa, E.2
  • 139
    • 77649121099 scopus 로고    scopus 로고
    • The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder
    • Kim YK, Yoon IY, Kim JM, et al. The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder. Eur J Neurol 2010;17:487-92
    • (2010) Eur J Neurol , vol.17 , pp. 487-492
    • Kim, Y.K.1    Yoon, I.Y.2    Kim, J.M.3
  • 140
    • 32544442518 scopus 로고    scopus 로고
    • Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • Braak H, de Vos RA, Bohl J, Del Tredici K. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 2006;396:67-72
    • (2006) Neurosci Lett , vol.396 , pp. 67-72
    • Braak, H.1    De Vos, R.A.2    Bohl, J.3    Del Tredici, K.4
  • 141
    • 0029097763 scopus 로고
    • Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation
    • Singaram C, Ashraf W, Gaumnitz EA, et al. Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation. Lancet 1995;346: 861-4
    • (1995) Lancet , vol.346 , pp. 861-864
    • Singaram, C.1    Ashraf, W.2    Gaumnitz, E.A.3
  • 142
    • 77958558412 scopus 로고    scopus 로고
    • Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms
    • Lebouvier T, Neunlist M, Bruley des Varannes S, et al. Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms. PLoS ONE 2010;5:e12728
    • (2010) PLoS ONE , vol.5
    • Lebouvier, T.1    Neunlist, M.2    Bruley Des Varannes, S.3
  • 143
    • 84861694667 scopus 로고    scopus 로고
    • Lewy pathology in gastric and duodenal biopsies in Parkinson's Disease
    • Pouclet H, Lebouvier T, Coron E, et al. Lewy pathology in gastric and duodenal biopsies in Parkinson's Disease. Mov Disord 2012;27:708
    • (2012) Mov Disord , vol.27 , pp. 708
    • Pouclet, H.1    Lebouvier, T.2    Coron, E.3
  • 144
    • 49949152130 scopus 로고    scopus 로고
    • Bladder and bowel dysfunction in Parkinson's disease
    • Sakakibara R, Uchiyama T, Yamanishi T, et al. Bladder and bowel dysfunction in Parkinson's disease. J Neural Transm 2008;115:443-60
    • (2008) J Neural Transm , vol.115 , pp. 443-460
    • Sakakibara, R.1    Uchiyama, T.2    Yamanishi, T.3
  • 145
    • 84860841758 scopus 로고    scopus 로고
    • Pathophysiology of bladder dysfunction in Parkinson's disease
    • Sakakibara R, Tateno F, Kishi M, et al. Pathophysiology of bladder dysfunction in Parkinson's disease. Neurobiol Dis 2012;46: 565-71
    • (2012) Neurobiol Dis , vol.46 , pp. 565-571
    • Sakakibara, R.1    Tateno, F.2    Kishi, M.3
  • 147
    • 23644433306 scopus 로고    scopus 로고
    • Alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy
    • Sone M, Yoshida M, Hashizume Y, et al. Alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy. Acta Neuropathol 2005;110:19-26
    • (2005) Acta Neuropathol , vol.110 , pp. 19-26
    • Sone, M.1    Yoshida, M.2    Hashizume, Y.3
  • 148
    • 34247846268 scopus 로고    scopus 로고
    • Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease
    • Fumimura Y, Ikemura M, Saito Y, et al. Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease. J Neuropathol Exp Neurol 2007;66: 354-62
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 354-362
    • Fumimura, Y.1    Ikemura, M.2    Saito, Y.3
  • 150
    • 51649116697 scopus 로고    scopus 로고
    • Pain as a nonmotor symptom of Parkinson disease: Evidence from a case-control study
    • Defazio G, Berardelli A, Fabbrini G, et al. Pain as a nonmotor symptom of Parkinson disease: Evidence from a case-control study. Arch Neurol 2008;65:1191-4
    • (2008) Arch Neurol , vol.65 , pp. 1191-1194
    • Defazio, G.1    Berardelli, A.2    Fabbrini, G.3
  • 151
    • 1842430764 scopus 로고    scopus 로고
    • Afferent pain pathways: A neuroanatomical review
    • Almeida TF, Roizenblatt S, Tufik S. Afferent pain pathways: A neuroanatomical review. Brain Res 2004;1000:40-56
    • (2004) Brain Res , vol.1000 , pp. 40-56
    • Almeida, T.F.1    Roizenblatt, S.2    Tufik, S.3
  • 152
    • 43249102758 scopus 로고    scopus 로고
    • Role of central dopamine in pain and analgesia
    • Wood PB. Role of central dopamine in pain and analgesia. Expert Rev Neurother 2008;8:781-97
    • (2008) Expert Rev Neurother , vol.8 , pp. 781-797
    • Wood, P.B.1
  • 153
  • 154
    • 33747888888 scopus 로고    scopus 로고
    • Skin biopsy for assessment of autonomic denervation in Parkinson's disease
    • Dabby R, Djaldetti R, Shahmurov M, et al. Skin biopsy for assessment of autonomic denervation in Parkinson's disease. J Neural Transm 2006;113:1169-76
    • (2006) J Neural Transm , vol.113 , pp. 1169-1176
    • Dabby, R.1    Djaldetti, R.2    Shahmurov, M.3
  • 155
    • 77649182100 scopus 로고    scopus 로고
    • The neuropathologic substrate of Parkinson disease dementia
    • Jellinger KA. The neuropathologic substrate of Parkinson disease dementia. Acta Neuropathol 2010;119:151-3
    • (2010) Acta Neuropathol , vol.119 , pp. 151-153
    • Jellinger, K.A.1
  • 156
    • 70449523595 scopus 로고    scopus 로고
    • The morbid anatomy of dementia in Parkinson's disease
    • Kalaitzakis ME, Pearce RK. The morbid anatomy of dementia in Parkinson's disease. Acta Neuropathol 2009;118:587-98
    • (2009) Acta Neuropathol , vol.118 , pp. 587-598
    • Kalaitzakis, M.E.1    Pearce, R.K.2
  • 157
    • 77950803528 scopus 로고    scopus 로고
    • Pathologic correlates of dementia in individuals with Lewy body disease
    • Sonnen JA, Postupna N, Larson EB, et al. Pathologic correlates of dementia in individuals with Lewy body disease. Brain Pathol 2010;20:654-9
    • (2010) Brain Pathol , vol.20 , pp. 654-659
    • Sonnen, J.A.1    Postupna, N.2    Larson, E.B.3
  • 158
    • 84880932230 scopus 로고    scopus 로고
    • Disease duration and the integrity of the nigrostriatal system in Parkinson's disease
    • Kordower JH, Olanow CW, Dodiya HB, et al. Disease duration and the integrity of the nigrostriatal system in Parkinson's disease. Brain 2013;136:2419-31
    • (2013) Brain , vol.136 , pp. 2419-2431
    • Kordower, J.H.1    Olanow, C.W.2    Dodiya, H.B.3
  • 159
    • 79957606507 scopus 로고    scopus 로고
    • Milestones in research on the pathophysiology of Parkinson's disease
    • Wichmann T, DeLong MR, Guridi J, Obeso JA. Milestones in research on the pathophysiology of Parkinson's disease. Mov Disord 2011;26:1032-41
    • (2011) Mov Disord , vol.26 , pp. 1032-1041
    • Wichmann, T.1    DeLong, M.R.2    Guridi, J.3    Obeso, J.A.4
  • 160
    • 84874861183 scopus 로고    scopus 로고
    • The cerebellum in Parkinson's disease
    • Wu T, Hallett M. The cerebellum in Parkinson's disease. Brain 2013;136: 696-709
    • (2013) Brain , vol.136 , pp. 696-709
    • Wu, T.1    Hallett, M.2
  • 161
    • 84870199264 scopus 로고    scopus 로고
    • Cerebral causes and consequences of parkinsonian resting tremor: A tale of two circuits?
    • Helmich RC, Hallett M, Deuschl G, et al. Cerebral causes and consequences of parkinsonian resting tremor: A tale of two circuits? Brain 2012;135:3206-26
    • (2012) Brain , vol.135 , pp. 3206-3226
    • Helmich, R.C.1    Hallett, M.2    Deuschl, G.3
  • 163
    • 78650890392 scopus 로고    scopus 로고
    • Involvement of the cerebellothalamocortical pathway in Parkinson disease
    • Ni Z, Pinto AD, Lang AE, Chen R. Involvement of the cerebellothalamocortical pathway in Parkinson disease. Ann Neurol 2010;68:816-24
    • (2010) Ann Neurol , vol.68 , pp. 816-824
    • Ni, Z.1    Pinto, A.D.2    Lang, A.E.3    Chen, R.4
  • 164
    • 0022930826 scopus 로고
    • Parallel organization of functionally segregated circuits linking basal ganglia and cortex
    • Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 1986;9:357-81
    • (1986) Annu Rev Neurosci , vol.9 , pp. 357-381
    • Alexander, G.E.1    DeLong, M.R.2    Strick, P.L.3
  • 165
    • 0013583334 scopus 로고    scopus 로고
    • Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates
    • Bergman H, Feingold A, Nini A, et al. Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates. Trends Neurosci 1998;21:32-8
    • (1998) Trends Neurosci , vol.21 , pp. 32-38
    • Bergman, H.1    Feingold, A.2    Nini, A.3
  • 166
    • 0034106888 scopus 로고    scopus 로고
    • Basal ganglia and cerebellar loops: Motor and cognitive circuits
    • Middleton FA, Strick PL. Basal ganglia and cerebellar loops: Motor and cognitive circuits. Brain Res Brain Res Rev 2000;31: 236-50
    • (2000) Brain Res Brain Res Rev , vol.31 , pp. 236-250
    • Middleton, F.A.1    Strick, P.L.2
  • 167
    • 0024450903 scopus 로고
    • The functional anatomy of basal ganglia disorders
    • Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci 1989;12:366-75
    • (1989) Trends Neurosci , vol.12 , pp. 366-375
    • Albin, R.L.1    Young, A.B.2    Penney, J.B.3
  • 168
    • 0025298139 scopus 로고
    • Primate models of movement disorders of basal ganglia origin
    • DeLong MR. Primate models of movement disorders of basal ganglia origin. Trends Neurosci 1990;13:281-5
    • (1990) Trends Neurosci , vol.13 , pp. 281-285
    • DeLong, M.R.1
  • 169
    • 0025572196 scopus 로고
    • D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
    • Gerfen CR, Engber TM, Mahan LC, et al. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 1990;250: 1429-32
    • (1990) Science , vol.250 , pp. 1429-1432
    • Gerfen, C.R.1    Engber, T.M.2    Mahan, L.C.3
  • 170
    • 84863336429 scopus 로고    scopus 로고
    • Extrastriatal dopaminergic circuits of the Basal Ganglia
    • Rommelfanger KS, Wichmann T. Extrastriatal dopaminergic circuits of the Basal Ganglia. Front Neuroanat 2010;4:139
    • (2010) Front Neuroanat , vol.4 , pp. 139
    • Rommelfanger, K.S.1    Wichmann, T.2
  • 171
    • 84862310662 scopus 로고    scopus 로고
    • Past, present, and future of the pathophysiological model of the Basal Ganglia
    • Obeso JA, Lanciego JL. Past, present, and future of the pathophysiological model of the Basal Ganglia. Front Neuroanat 2011;5:39
    • (2011) Front Neuroanat , vol.5 , pp. 39
    • Obeso, J.A.1    Lanciego, J.L.2
  • 172
    • 77958465056 scopus 로고    scopus 로고
    • Goal-directed and habitual control in the basal ganglia: Implications for Parkinson's disease
    • Redgrave P, Rodriguez M, Smith Y, et al. Goal-directed and habitual control in the basal ganglia: Implications for Parkinson's disease. Nat Rev Neurosci 2010;11:760-72
    • (2010) Nat Rev Neurosci , vol.11 , pp. 760-772
    • Redgrave, P.1    Rodriguez, M.2    Smith, Y.3
  • 173
    • 0033623794 scopus 로고    scopus 로고
    • Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey
    • Nambu A, Tokuno H, Hamada I, et al. Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey. J Neurophysiol 2000;84:289-300
    • (2000) J Neurophysiol , vol.84 , pp. 289-300
    • Nambu, A.1    Tokuno, H.2    Hamada, I.3
  • 174
    • 0033981146 scopus 로고    scopus 로고
    • Organization of nonprimary motor cortical inputs on pyramidal and nonpyramidal tract neurons of primary motor cortex: An electrophysiological study in the macaque monkey
    • Tokuno H, Nambu A. Organization of nonprimary motor cortical inputs on pyramidal and nonpyramidal tract neurons of primary motor cortex: An electrophysiological study in the macaque monkey. Cereb Cortex 2000;10:58-68
    • (2000) Cereb Cortex , vol.10 , pp. 58-68
    • Tokuno, H.1    Nambu, A.2
  • 175
  • 176
    • 60149088953 scopus 로고    scopus 로고
    • Synaptic plasticity, dopamine and Parkinson's disease: One step ahead
    • Calabresi P, Mercuri NB, Di Filippo M. Synaptic plasticity, dopamine and Parkinson's disease: One step ahead. Brain 2009;132:285-7
    • (2009) Brain , vol.132 , pp. 285-287
    • Calabresi, P.1    Mercuri, N.B.2    Di Filippo, M.3
  • 179
    • 42049097441 scopus 로고    scopus 로고
    • Globus pallidus dopamine and Parkinson motor subtypes: Clinical and brain biochemical correlation
    • Rajput AH, Sitte HH, Rajput A, et al. Globus pallidus dopamine and Parkinson motor subtypes: Clinical and brain biochemical correlation. Neurology 2008;70:1403-10
    • (2008) Neurology , vol.70 , pp. 1403-1410
    • Rajput, A.H.1    Sitte, H.H.2    Rajput, A.3
  • 180
    • 13244287684 scopus 로고    scopus 로고
    • Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease
    • Zaja-Milatovic S, Milatovic D, Schantz AM, et al. Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease. Neurology 2005;64:545-7
    • (2005) Neurology , vol.64 , pp. 545-547
    • Zaja-Milatovic, S.1    Milatovic, D.2    Schantz, A.M.3
  • 181
    • 25844469660 scopus 로고    scopus 로고
    • Direct receptor cross-Talk can mediate the modulation of excitatory and inhibitory neurotransmission by dopamine
    • Lee FJ, Wang YT, Liu F. Direct receptor cross-Talk can mediate the modulation of excitatory and inhibitory neurotransmission by dopamine. J Mol Neurosci 2005;26: 245-52
    • (2005) J Mol Neurosci , vol.26 , pp. 245-252
    • Lee, F.J.1    Wang, Y.T.2    Liu, F.3
  • 182
    • 0036140132 scopus 로고    scopus 로고
    • Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: Studies combining in vivo intracellular recordings and reverse microdialysis
    • West AR, Grace AA. Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: Studies combining in vivo intracellular recordings and reverse microdialysis. J Neurosci 2002;22:294-304
    • (2002) J Neurosci , vol.22 , pp. 294-304
    • West, A.R.1    Grace, A.A.2
  • 183
    • 61449253124 scopus 로고    scopus 로고
    • Structural findings in the basal ganglia in genetically determined and idiopathic Parkinson's disease
    • Reetz K, Gaser C, Klein C, et al. Structural findings in the basal ganglia in genetically determined and idiopathic Parkinson's disease. Mov Disord 2009;24:99-103
    • (2009) Mov Disord , vol.24 , pp. 99-103
    • Reetz, K.1    Gaser, C.2    Klein, C.3
  • 184
    • 41149155444 scopus 로고    scopus 로고
    • Alpha-Synuclein pathology in the neostriatum in Parkinson's disease
    • Mori F, Tanji K, Zhang H, et al. Alpha-Synuclein pathology in the neostriatum in Parkinson's disease. Acta Neuropathol 2008;115:453-9
    • (2008) Acta Neuropathol , vol.115 , pp. 453-459
    • Mori, F.1    Tanji, K.2    Zhang, H.3
  • 185
    • 33747778859 scopus 로고    scopus 로고
    • Striatal dopaminergic neurons are lost with Parkinson's disease progression
    • Porritt MJ, Kingsbury AE, Hughes AJ, Howells DW. Striatal dopaminergic neurons are lost with Parkinson's disease progression. Mov Disord 2006;21:2208-11
    • (2006) Mov Disord , vol.21 , pp. 2208-2211
    • Porritt, M.J.1    Kingsbury, A.E.2    Hughes, A.J.3    Howells, D.W.4
  • 186
    • 84883544182 scopus 로고    scopus 로고
    • Parkinson's disease rigidity: Relation to brain connectivity and motor performance
    • Baradaran N, Tan SN, Liu A, et al. Parkinson's disease rigidity: Relation to brain connectivity and motor performance. Front Neurol 2013;4:67
    • (2013) Front Neurol , vol.4 , pp. 67
    • Baradaran, N.1    Tan, S.N.2    Liu, A.3
  • 187
    • 0026076047 scopus 로고
    • The neuropathologic basis of different clinical subgroups of Parkinson's disease
    • Paulus W, Jellinger K. The neuropathologic basis of different clinical subgroups of Parkinson's disease. J Neuropathol Exp Neurol 1991;50:743-55
    • (1991) J Neuropathol Exp Neurol , vol.50 , pp. 743-755
    • Paulus, W.1    Jellinger, K.2
  • 189
    • 62549114415 scopus 로고    scopus 로고
    • Morphological differences in Parkinson's disease with and without rest tremor
    • Benninger DH, Thees S, Kollias SS, et al. Morphological differences in Parkinson's disease with and without rest tremor. J Neurol 2009;256:256-63
    • (2009) J Neurol , vol.256 , pp. 256-263
    • Benninger, D.H.1    Thees, S.2    Kollias, S.S.3
  • 190
    • 79952500499 scopus 로고    scopus 로고
    • Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor
    • Helmich RC, Janssen MJ, Oyen WJ, et al. Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor. Ann Neurol 2011;69:269-81
    • (2011) Ann Neurol , vol.69 , pp. 269-281
    • Helmich, R.C.1    Janssen, M.J.2    Oyen, W.J.3
  • 191
    • 78649687189 scopus 로고    scopus 로고
    • Parkinson's disease tremor-related metabolic network: Characterization, progression, and treatment effects
    • Mure H, Hirano S, Tang CC, et al. Parkinson's disease tremor-related metabolic network: Characterization, progression, and treatment effects. Neuroimage 2011;54: 1244-53
    • (2011) Neuroimage , vol.54 , pp. 1244-1253
    • Mure, H.1    Hirano, S.2    Tang, C.C.3
  • 192
    • 84890708386 scopus 로고    scopus 로고
    • A direct relationship between oscillatory subthalamic nucleus-cortex coupling and rest tremor in Parkinson's disease
    • Hirschmann J, Hartmann CJ, Butz M, et al. A direct relationship between oscillatory subthalamic nucleus-cortex coupling and rest tremor in Parkinson's disease. Brain 2013
    • (2013) Brain
    • Hirschmann, J.1    Hartmann, C.J.2    Butz, M.3
  • 193
    • 84878322665 scopus 로고    scopus 로고
    • Timing of deep brain stimulation in Parkinson disease: A need for reappraisal?
    • Desouza RM, Moro E, Lang AE, Schapira AH. Timing of deep brain stimulation in Parkinson disease: A need for reappraisal? Ann Neurol 2013;73:565-75
    • (2013) Ann Neurol , vol.73 , pp. 565-575
    • Desouza, R.M.1    Moro, E.2    Lang, A.E.3    Schapira, A.H.4
  • 195
    • 78650886621 scopus 로고    scopus 로고
    • Are we making progress in the understanding of tremor in Parkinson's disease?
    • Hallett M, Deuschl G. Are we making progress in the understanding of tremor in Parkinson's disease? Ann Neurol 2010;68: 780-1
    • (2010) Ann Neurol , vol.68 , pp. 780-781
    • Hallett, M.1    Deuschl, G.2
  • 196
    • 84855935795 scopus 로고    scopus 로고
    • Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of FP-CIT SPECT
    • Eggers C, Kahraman D, Fink GR, et al. Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of FP-CIT SPECT. Basal Ganglia 2011;1:34
    • (2011) Basal Ganglia , vol.1 , pp. 34
    • Eggers, C.1    Kahraman, D.2    Fink, G.R.3
  • 197
    • 0036322266 scopus 로고    scopus 로고
    • Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
    • Duda JE, Giasson BI, Mabon ME, et al. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Ann Neurol 2002;52:205-10
    • (2002) Ann Neurol , vol.52 , pp. 205-210
    • Duda, J.E.1    Giasson, B.I.2    Mabon, M.E.3
  • 198
    • 38949177433 scopus 로고    scopus 로고
    • Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism
    • Deutch AY, Colbran RJ, Winder DJ. Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism. Parkinsonism Relat Disord 2007; 13(Suppl 3):S251-8
    • (2007) Parkinsonism Relat Disord , vol.13 , Issue.SUPPL. 3
    • Deutch, A.Y.1    Colbran, R.J.2    Winder, D.J.3
  • 199
    • 0029956583 scopus 로고    scopus 로고
    • Striatal efferent involvement and its correlation to levodopa efficacy in patients with multiple system atrophy
    • Ito H, Kusaka H, Matsumoto S, Imai T. Striatal efferent involvement and its correlation to levodopa efficacy in patients with multiple system atrophy. Neurology 1996;47:1291-9
    • (1996) Neurology , vol.47 , pp. 1291-1299
    • Ito, H.1    Kusaka, H.2    Matsumoto, S.3    Imai, T.4
  • 200
    • 0033768218 scopus 로고    scopus 로고
    • Dyskinesias and motor fluctuations in Parkinson's disease
    • Schrag A, Quinn N. Dyskinesias and motor fluctuations in Parkinson's disease. A community-based study. Brain 2000; 123(Pt 11):2297-305
    • (2000) A community-based study. Brain , vol.123 , Issue.PART 11 , pp. 2297-2305
    • Schrag, A.1    Quinn, N.2
  • 201
    • 79551716951 scopus 로고    scopus 로고
    • Inhibition of phosphodiesterases rescues striatal long-Term depression and reduces levodopa-induced dyskinesia
    • Picconi B, Bagetta V, Ghiglieri V, et al. Inhibition of phosphodiesterases rescues striatal long-Term depression and reduces levodopa-induced dyskinesia. Brain 2011;134:375-87
    • (2011) Brain , vol.134 , pp. 375-387
    • Picconi, B.1    Bagetta, V.2    Ghiglieri, V.3
  • 202
    • 38149033506 scopus 로고    scopus 로고
    • L-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation
    • Picconi B, Paille V, Ghiglieri V, et al. L-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation. Neurobiol Dis 2008;29: 327-35
    • (2008) Neurobiol Dis , vol.29 , pp. 327-335
    • Picconi, B.1    Paille, V.2    Ghiglieri, V.3
  • 203
    • 79551662648 scopus 로고    scopus 로고
    • Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in parkinsonian mice
    • Ding Y, Won L, Britt JP, et al. Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in parkinsonian mice. Proc Natl Acad Sci USA 2011;108:840-5
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 840-845
    • Ding, Y.1    Won, L.2    Britt, J.P.3
  • 204
    • 44949236082 scopus 로고    scopus 로고
    • Sprouting of dopamine terminals and altered dopamine release and uptake in Parkinsonian dyskinaesia
    • Lee J, Zhu WM, Stanic D, et al. Sprouting of dopamine terminals and altered dopamine release and uptake in Parkinsonian dyskinaesia. Brain 2008;131: 1574-87
    • (2008) Brain , vol.131 , pp. 1574-1587
    • Lee, J.1    Zhu, W.M.2    Stanic, D.3
  • 205
    • 79953647380 scopus 로고    scopus 로고
    • Glutamate NMDA receptor dysregulation in Parkinson's disease with dyskinesias
    • Ahmed I, Bose SK, Pavese N, et al. Glutamate NMDA receptor dysregulation in Parkinson's disease with dyskinesias. Brain 2011;134:979-86
    • (2011) Brain , vol.134 , pp. 979-986
    • Ahmed, I.1    Bose, S.K.2    Pavese, N.3
  • 206
    • 77957966489 scopus 로고    scopus 로고
    • Levodopa-induced dyskinesias in patients with Parkinson's disease:
    • Calabresi P, Di Filippo M, Ghiglieri V, et al. Levodopa-induced dyskinesias in patients with Parkinson's disease: Filling the bench-To-bedside gap. Lancet Neurol 2010;9:1106-17
    • (2010) Lancet Neurol , vol.9 , pp. 1106-1117
    • Calabresi, P.1    Di Filippo, M.2    Ghiglieri, V.3
  • 208
    • 84880965342 scopus 로고    scopus 로고
    • Asymmetric pedunculopontine network connectivity in parkinsonian patients with freezing of gait
    • Fling BW, Cohen RG, Mancini M, et al. Asymmetric pedunculopontine network connectivity in parkinsonian patients with freezing of gait. Brain 2013;136:2405-18
    • (2013) Brain , vol.136 , pp. 2405-2418
    • Fling, B.W.1    Cohen, R.G.2    Mancini, M.3
  • 209
    • 84887054576 scopus 로고    scopus 로고
    • The role of frontostriatal impairment in freezing of gait in Parkinson's disease
    • Shine JM, Moustafa AA, Matar E, et al. The role of frontostriatal impairment in freezing of gait in Parkinson's disease. Front Syst Neurosci 2013;7:61
    • (2013) Front Syst Neurosci , vol.7 , pp. 61
    • Shine, J.M.1    Moustafa, A.A.2    Matar, E.3
  • 210
    • 84887100429 scopus 로고    scopus 로고
    • Freezing of gait in Parkinson's disease is associated with functional decoupling between the cognitive control network and the basal ganglia
    • Shine JM, Matar E, Ward PB, et al. Freezing of gait in Parkinson's disease is associated with functional decoupling between the cognitive control network and the basal ganglia. Brain 2013
    • (2013) Brain
    • Shine, J.M.1    Matar, E.2    Ward, P.B.3
  • 211
    • 0032526957 scopus 로고    scopus 로고
    • Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway
    • Ingham CA, Hood SH, Taggart P, Arbuthnott GW. Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway. J Neurosci 1998;18:4732-43
    • (1998) J Neurosci , vol.18 , pp. 4732-4743
    • Ingham, C.A.1    Hood, S.H.2    Taggart, P.3    Arbuthnott, G.W.4
  • 212
    • 58149488975 scopus 로고    scopus 로고
    • Dopaminergic denervation and spine loss in the striatum of MPTP-Treated monkeys
    • Villalba RM, Lee H, Smith Y. Dopaminergic denervation and spine loss in the striatum of MPTP-Treated monkeys. Exp Neurol 2009;215:220-7
    • (2009) Exp Neurol , vol.215 , pp. 220-227
    • Villalba, R.M.1    Lee, H.2    Smith, Y.3
  • 213
    • 31544465246 scopus 로고    scopus 로고
    • Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models
    • Day M, Wang Z, Ding J, et al. Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models. Nat Neurosci 2006;9: 251-9
    • (2006) Nat Neurosci , vol.9 , pp. 251-259
    • Day, M.1    Wang, Z.2    Ding, J.3
  • 214
    • 20144389550 scopus 로고    scopus 로고
    • Evidence of a breakdown of corticostriatal connections in Parkinson's disease
    • Stephens B, Mueller AJ, Shering AF, et al. Evidence of a breakdown of corticostriatal connections in Parkinson's disease. Neuroscience 2005;132:741-54
    • (2005) Neuroscience , vol.132 , pp. 741-754
    • Stephens, B.1    Mueller, A.J.2    Shering, A.F.3
  • 215
    • 33646139645 scopus 로고    scopus 로고
    • Dopaminergic control of corticostriatal long-Term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons
    • Wang Z, Kai L, Day M, et al. Dopaminergic control of corticostriatal long-Term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron 2006;50:443-52
    • (2006) Neuron , vol.50 , pp. 443-452
    • Wang, Z.1    Kai, L.2    Day, M.3
  • 216
    • 33646014126 scopus 로고    scopus 로고
    • Consequences of unilateral nigrostriatal denervation on the thalamostriatal pathway in rats
    • Aymerich MS, Barroso-Chinea P, Perez-Manso M, et al. Consequences of unilateral nigrostriatal denervation on the thalamostriatal pathway in rats. Eur J Neurosci 2006;23:2099-108
    • (2006) Eur J Neurosci , vol.23 , pp. 2099-2108
    • Aymerich, M.S.1    Barroso-Chinea, P.2    Perez-Manso, M.3
  • 217
    • 0033621975 scopus 로고    scopus 로고
    • Degeneration of the centre median-parafascicular complex in Parkinson's disease
    • Henderson JM, Carpenter K, Cartwright H, Halliday GM. Degeneration of the centre median-parafascicular complex in Parkinson's disease. Ann Neurol 2000;47: 345-52
    • (2000) Ann Neurol , vol.47 , pp. 345-352
    • Henderson, J.M.1    Carpenter, K.2    Cartwright, H.3    Halliday, G.M.4
  • 218
    • 0025006601 scopus 로고
    • Trastriatal dopamine in symptomatic and asymptomatic rhesus monkeys treated with 1-methyl-4-phenyl- 1 2 36-Tetrahydropyridine (MPTP
    • Pifl C, Bertel O, Schingnitz G, Hornykiewicz O. Extrastriatal dopamine in symptomatic and asymptomatic rhesus monkeys treated with 1-methyl-4-phenyl- 1,2,3,6-Tetrahydropyridine (MPTP). Neurochem Int 1990;17:263-70
    • (1990) Urochem Int , vol.17 , pp. 263-270
    • Pifl, C.1    Bertel, O.2    Schingnitz, G.3    Hornykiewicz, O.4
  • 219
    • 84876909650 scopus 로고    scopus 로고
    • Fung VS pathophysiology and management
    • Kim SD, Allen NE, Canning CG, Fung VS pathophysiology and management. CNS Drugs 2013;27:97-112
    • (2013) CNS Drugs , vol.27 , pp. 97-112
    • Kim, S.D.1    Allen, N.E.2    Canning, C.G.3
  • 221
    • 84864564522 scopus 로고    scopus 로고
    • Heterogeneity of cholinergic denervation in Parkinson's disease without dementia
    • Bohnen NI, Muller ML, Kotagal V, et al. Heterogeneity of cholinergic denervation in Parkinson's disease without dementia. J Cereb Blood Flow Metab 2012;32: 1609-17
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 1609-1617
    • Bohnen, N.I.1    Muller, M.L.2    Kotagal, V.3
  • 222
    • 84890522859 scopus 로고    scopus 로고
    • Thalamic cholinergic innervation and postural sensory integration function in Parkinson's disease
    • Muller ML, Albin RL, Kotagal V, et al. Thalamic cholinergic innervation and postural sensory integration function in Parkinson's disease. Brain 2013;136:3282-9
    • (2013) Brain , vol.136 , pp. 3282-3289
    • Muller, M.L.1    Albin, R.L.2    Kotagal, V.3
  • 223
    • 84866357310 scopus 로고    scopus 로고
    • Cholinergic dysfunction contributes to gait disturbance in early Parkinson's disease
    • Rochester L, Yarnall AJ, Baker MR, et al. Cholinergic dysfunction contributes to gait disturbance in early Parkinson's disease. Brain 2012;135:2779-88
    • (2012) Brain , vol.135 , pp. 2779-2788
    • Rochester, L.1    Yarnall, A.J.2    Bakerrfnet, M.R.3
  • 224
    • 68649112842 scopus 로고    scopus 로고
    • Oxidative and nitrosative stress in Parkinson's disease
    • Tsang AH, Chung KK. Oxidative and nitrosative stress in Parkinson's disease. Biochim Biophys Acta 2009;1792: 643-50
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 643-650
    • Tsang, A.H.1    Chung, K.K.2


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