Bladder and bowel dysfunction in Parkinson's disease

Journal of Neural Transmission

Volumn 115, Issue 3, 2008, Pages 443-460

  Sakakibara, R ^a,b   Uchiyama, T ^b   Yamanishi, T ^c   Shirai, K ^a   Hattori, T ^b  

^a TOHO UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Autonomic nervous system; Bladder dysfunction; Bowel dysfunction; Dopamine; Parkinson's disease

Indexed keywords

ANTIPARKINSON AGENT; APOMORPHINE; BROMOCRIPTINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CISAPRIDE; COLCHICINE; DOPAMINE; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; DULOXETINE; ERYTHROMYCIN; LEVODOPA; MILNACIPLAN; MOSAPRIDE CITRATE; NEUROTROPHIN 3; OXYBUTYNIN; PERGOLIDE; SEROTONIN; SEROTONIN AGONIST; SEROTONIN UPTAKE INHIBITOR; TEGASEROD; TRIHEXYPHENIDYL; UNCLASSIFIED DRUG;

ADD ON THERAPY; AUTONOMIC DYSFUNCTION; BASAL GANGLION; BLADDER DYSFUNCTION; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL FEATURE; COGNITIVE DEFECT; CONSTIPATION; DEFECATION; DIETARY FIBER; DIFFERENTIAL DIAGNOSIS; DRUG CONTRAINDICATION; DRUG HYPERSENSITIVITY; DRUG MECHANISM; DRUG WITHDRAWAL; ELECTROMYOGRAPHY; ELECTROSTIMULATION; FUNCTION TEST; GASTROINTESTINAL DISEASE; HUMAN; INTESTINE INNERVATION; INTESTINE TRANSIT TIME; LOWER URINARY TRACT SYMPTOM; MICTURITION DISORDER; MOTOR DYSFUNCTION; OVERACTIVE BLADDER; PARKINSON DISEASE; PERISTALSIS; POLYURIA; PREVALENCE; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SHY DRAGER SYNDROME; URINARY FREQUENCY; URINARY URGENCY; URODYNAMICS;

BOWEN'S DISEASE; HUMANS; PARKINSON DISEASE; URINARY BLADDER, NEUROGENIC;

EID: 49949152130     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-007-0855-9     Document Type: Review

References (207)

1. RD Abbott H Petrovitch LR White KH Masaki CM Tanner JD Curb A Grandinetti PL Blanchette JS Popper GW Ross 2001 Frequency of bowel movements and the future risk of Parkinson's disease Neurology 57 456 462
2. P Abrams KE Andersson JJ Buccafusco C Chapple WC de Groat AD Fryer G Kay A Laties NM Nathanson PJ Pasricha AJ Wein 2006 Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder Br J Pharmacol 148 565 578
3. P Abrams L Cardozo M Fall D Griffiths P Rosier U Ulmsten P van Kerrebroeck A Victor A Wein Standardisation Sub-committee of the International Continence Society 2002 The standardization of terminology of lower urinary tract function: report from the standardization sub-committee of the International Continence Society Neurourol Urodynam 21 167 178
4. A Albanese G Maria A Bentivoglio G Brisinda E Cassetta P Tonali 1997 Severe constipation in Parkinson's disease relieved by botulinum toxin Mov Disord 12 764 766
5. P Amborova P Hubka I Ulkova I Hulin 2003 The pacemaker activity of interstitial cells of cajal and gastric electrical activity Physiol Res 52 275 284
6. KE Andersson 2000 Treatment of overactive bladder: other drug mechanisms Urology 55 51 57
7. KE Andersson 2004 Mechanisms of disease: central nervous system involvement in overactive bladder syndrome Nat Clin Pract Urol 1 103 108
8. M Anlauf MKH Schafer L Eiden E Weihe 2003 Chemical coding of the human GI nervous system: cholinergic, VIPergic, and catecholaminergic phenotypes J Comp Neurol 459 90 111
9. I Araki M Kitahara T Oida S Kuno 2000 Voiding dysfunction and parkinson's disease: urodynamic abnormalities and urinary symptoms J Urol 164 1640 1643
10. I Araki S Kuno 2000 Assessment of voiding dysfunction in Parkinson's disease by the international prostate symptom score J Neurol Neurosurg Psychiatry 68 429 433
11. B Aranda P Cramer 1993 Effect of apomorphine and l-dopa on the parkinsonian bladder Neurourol Urodynam 12 203 209
12. H Asai F Udaka M Hirano T Minami M Oda T Kubori K Nishinaka M Kameyama S Ueno 2005 Increased gastric motility during 5-HT4 agonist therapy reduces response fluctuations in Parkinson's disease Parkinsonism Relat Disord 11 499 502
13. W Ashraf RF Pfeiffer F Park J Lof EMM Quigley 1997 Constipation in Parkinson's disease; objective assessment and response to psyllium Mov Disord 12 946 951
14. W Ashraf ZK Wszolek RF Pfeiffer M Normand K Maurer F Srb LL Edwards EM Quigley 1995 Anorectal function in fluctuating (on-off) Parkinson's disease: evaluation by combined anorectal manometry and electromyography Mov Disord 10 650 657
15. R Astarloa MA Mena V Sanchez L de la Vega JG de Yebenes 1992 Clinical and pharmacological effects of a diet rich in insoluble fiber on Parkinson's disease Clin Neuropharmacol 15 375 380
16. V Bagaev V Aleksandrov 2006 Visceral-related area in the rat insular cortex Auton Neurosci 125 16 21
17. T Banach D Zurowski K Gil A Krygowska-Wajs A Marszalek PJ Thor 2006 Peripheral mechanisms of intestinal dysmotility in rats with salsolinol induced experimental Parkinson's disease J Physiol Pharmacol 57 291 300
18. G Bassotti D Maggio E Battaglia O Giulietti F Spinozzi G Reboldi AM Serra G Emanuelli G Chiarioni 2000 Manometric investigation of anorectal function in early and late stage Parkinson's disease J Neurol Neurosurg Psychiatry 68 768 770
19. G Bassotti G de Roberto D Castellani L Sediari A Morelli 2005 Normal aspects of colorectal motility and abnormalities in slow transit constipation World J Gastroenterol 11 2691 2696
20. G Bassotti V Villanacci 2006 Slow transit constipation: a functional disorder becomes an enteric neuropathy World J Gastroenterol 12 4609 4613
21. GS Benson DM Raezer JR Anderson CD Saunders JN Corrierie Jr 1976 Effect of levodopa on urinary bladder Urology 7 24 28
22. F Bermejo Pareja P Martinez-Martin V Muradas JG de Yebenes 1985 Carbidopa dosage modifies L-dopa induced side effects and blood levels of L-dopa and other amino acids in advanced parkinsonism Acta Neurol Scand 72 506 511
23. CD Betts R Kapoor CJ Fowler 1992 Pontine pathology and voiding dysfunction Br J Urol 70 100 102
24. BF Blok H de Weerd G Holstege 1997 The pontine micturition center projects to sacral cord GABA immunoreactive neurons in the cat Neurosci Lett 233 109 112
25. BF Blok G Holstege 1999 The central control of micturition and continence: implications for urology Br J Urol Int 83 Suppl 2 1 6
26. W Bosshard R Dreher JF Schnegg CJ Bula 2004 The treatment of chronic constipation in elderly people: an update Drugs Aging 21 911 930
27. H Braak U Rub K Del Tredici 2006 Cognitive decline correlates with neuropathological stage in Parkinson's disease J Neurol Sci 248 255 258
28. P Broens D Vanbeckevoort E Bellon F Penninckx 2002 Combined radiographic and manometric study of rectal filling sensation Dis Colon Rectum 45 1016 1022
29. L Brusa F Petta A Pisani R Miano P Stanzione V Moschella S Galati EF Agro 2006 Central acute D2 stimulation worsens bladder function in patients with mild Parkinson's disease J Urol 175 202 206
30. L Bueno M Gue C Fabre JL Junien 1992 Involvement of central dopamine and D1 receptors in stress-induced colonic motor alterations in rats Brain Res Bull 29 135 140
31. F Cadeddu AR Bentivoglio F Brandara G Marniga G Brisinda G Maria 2005 Outlet type constipation in Parkinson's disease: results of botulinum toxin treatment Aliment Pharmacol Ther 22 997 1003
32. RN Campos-Sousa E Quagliato BB da Silva CR De Jr SC Ribeiro DF de Carvalho 2003 Urinary symptoms in Parkinson's disease: prevalence and associated factors Arq Neuropsiquiatr 61 359 363
33. LH Caplan HG Jacobson BM Rubinstein MZ Rotman 1965 Megacolon and volvulus in Parkinson's disease Radiology 85 73 79
34. VA Chandiramani J Palace CJ Fowler 1997 How to recognize patients with parkinsonism who should not have urological surgery Br J Urol 80 100 104
35. KR Chaudhuri DG Healy AHV Schapira National Institute for Clinical Excellence 2006 Non-motor symptoms of Parkinson's disease: diagnosis and management Lancet Neurol 5 235 245
36. YW Chia KP Gill JS Jameson AD Forti MM Henry M Swash PJ Shorvon 1996 Paradoxical puborectalis contraction is a feature of constipation in patients with multiple sclerosis J Neurol Neurosurg Psychiatry 60 31 35
37. G Chiarioni S Heymen WE Whitehead 2006 Biofeedback therapy for dyssynergic defecation World J Gastroenterol 12 7069 7074
38. TJ Christmas CR Chapple AJ Lees PA Kempster JP Frankel GM Stern 1998 Role of subcutaneous apomorphine in parkinsonian voiding dysfunction Lancet 24 31 1451 1453
39. JR Cooper FE Bloom RH Roth 2003 The biochemical basis of neuropharmacology, 8th edn. Chapter 9, Dopamine Oxford University Press Oxford 225 270
40. D Couturier S Chaussade 1988 Total and segmental colonic transit times. Measurements by radio-opaque markers Presse Med 17 69 73
41. AL Dalmose CR Bjarkam JC Sorensen JC Djurhuus TM Jorgensen 2004 Effects of high frequency deep brain stimulation on urine storage and voiding function in conscious minipigs Neurourol Urodyn 23 265 272
42. RO Dantas RC Mamede 2002 Motility of the transverse colon used for esophageal replacement J Clin Gastroenterol 34 225 228
43. KN Davies D King D Billington JA Barrett 1996 Intestinal permeability and orocaecal transit time in elderly patients with Parkinson's disease Postgrad Med J 72 164 167
44. R de Giorgio S Guerrini G Barbara C Cremon V Stanghellini R Corinaldesi 2004 New insights into human enteric neuropathy Neurogastroenterol Motil 16 Suppl 1 143 147
45. WC de Groat 2006 Integrative control of the lower urinary tract: preclinical perspective BJP 147 S25 S40
46. F de Lorijn WJ de Jonge T Wedel JM Vanderwinden MA Benninga GE Boeckxstaens 2005 Interstitial cells of Cajal are involved in the afferent limb of the rectoanal inhibitory reflex Gut 54 1107 1113
47. A Dive F Foret J Jamart P Bulpa E Installe 2000 Effect of dopamine on GI motility during critical illness Intensive Care Med 26 901 907
48. R Djaldetti M Koren I Ziv A Achiron E Melamed 1995 Effect of cisapride on response fluctuations in Parkinson's disease Mov Disord 10 81 84
49. EY Eaker GB Bixler AJ Dunn WV Moreshead JR Mathias 1987 Chronic alterations in jejunal myoelectric activity in rats due to MPTP Am J Physiol 253 809 815
50. LL Edwards RF Pfeiffer EMM Quigley R Hofman M Balluff 1991 GI symptoms in Parkinson's disease Mov Disord 6 151 156
51. LL Edwards EMM Quigley RK Harned R Hofman RF Pfeiffer 1993a Defecatory function in Parkinson's disease; response to apomorphine Ann Neurol 33 490 493
52. LL Edwards EMM Quigley R Hofman RF Pfeiffer 1993b GI symptoms in Parkinson disease: 18-month follow-up study Mov Disord 8 83 86
53. LL Edwards EMM Quigley RK Harned R Hofman RF Pfeiffer 1994 Characterisation of swallowing and defecation in Parkinson's disease Am J Gastroenterol 89 15 25
54. TE Eichhorn WH Oertel 2001 Macrogol 3350/electrolyte improves constipation in Parkinson's disease and multiple system atrophy Mov Disord 16 1176 1177
55. MS El-Bahnasawy Y Osman MA Gomha AA Shaaban 2005 Persistent and occasional nocturnal enuresis in orthotopic urinary diversion: is there a urodynamic difference? BJU International 96 1373
56. MM El-Masu AI Elmallah G Amal AG Omar F Sharabi 1999 Dopamine modulates peripheral purinergic neurotransmission through multiple presynaptic receptors: tissue-dependent effects Pharmacol Res 39 11 19
57. H Fitzmaurice CJ Fowler D Rickards RS Kirby NP Quinn CD Marsden EJ Milroy RT Turner-Warwick 1985 Micturition disturbance in Parkinson's disease Br J Urol 57 652 656
58. GA Fontana T Pantaleo F Lavorini F Benvenuti S Gagemi 1998 Defective motor control of coughing in Parkinson's disease Am J Respir Crit Care Med 158 458 464
59. CJ Fowler 2006 Integrated control of lower urinary tract: clinical perspective BJP 147 S14 S24
60. B Frenckner T Ihre 1976 Influence of autonomic nerves on the internal anal sphincter in man Gut 17 306 312
61. WP Gai WW Blessing PC Blumbergs 1995 Ubiquitinpositive degenerating neurites in the brainstem in Parkinson's disease Brain 118 1447 1459
62. RR Gainetdinov SR Jones F Fumagalli RM Wightman MG Caron 1998 Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis Brain Res Brain Res Rev 26 148 153
63. WR Gibb AJ Lees P Jenner CD Marsden 1986 The dopamine neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces histological lesions in the hypothalamus of the common marmoset Neurosci Lett 65 79 83
64. S Gilman PA Low N Quinn A Albanese Y Ben-Shlomo CJ Fowler H Kaufmann T Klockgether AE Lang PL Lantos I Litvan CJ Mathias E Oliver D Robertson I Schatz GK Wenning 1998 Consensus statement on the diagnosis of multiple system atrophy J Auton Nerv Syst 74 189 192
65. G Gravante M Sabatino F Sorbera G Ferraro V La Grutta 1985 Effects of substantia nigra stimulation on electrical and mechanical activities of the duodeno-jejunal loop, in the cat Arch Int Physiol Biochim 93 93 100
66. R Gray G Stern J Malone-Lee 1995 Lower urinary tract dysfunction in Parkinson's disease: changes relate to age and not disease Age Ageing 24 499 504
67. JR Grider AE Foxx-Orenstein JG Jin 1998 5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine Gastroenterology 115 370 380
68. D Griffiths 1995 Basics of pressure-flow studies World J Urol 13 30 33
69. GM Halliday PC Blumbergs RG Cotton WW Blessing LB Geffen 1990 Loss of brainstem serotonin- and substance P-containing neurons in Parkinson's disease Brain Res 510 104 107
70. MB Hansen 2003 Neurohumoral control of GI motility Physiol Res 52 1 30
71. K Hashimoto T Oyama T Sugiyama YC Park T Kurita 2003 Neuronal excitation in the ventral tegmental area modulates the micturition reflex mediated via the dopamine D(1) and D(2) receptors in rats J Pharmacol Sci 92 143 148
72. K Hashimoto T Oyama Y Ukay K Kimura T Sugiyama YC Park T Kurita 1997 Selective destruction of dopamine neurones of the ventral tegmental area, but not the substantia nigra, impairs reflex micturition in rats Neurourol Urodyn 16 470 471
73. Y Haskel M Hanani 1994 Inhibition of GI motility by MPTP via adrenergic and dopaminergic mechanisms Dig Dis Sci 39 2364 2367
74. T Hattori K Yasuda K Kita K Hirayama 1992 Voiding dysfunction in Parkinson's disease Jpn J Psychiatry Neurol 46 181 186
75. T Hineno M Mizobuchi K Hiratani Y Inami Y Kakimoto 1992 Disappearance of circadian rhythms in Parkinson's disease model induced by 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine in dogs Brain Res 580 92 99
76. O Hornykiewicz SJ Kish 1986 Biochemical pathophysiology of Parkinson's disease Adv Neurol 45 19 34
77. LM Howard H Markus 1992 Pseudo-obstruction secondary to anticholinergic drugs in Parkinson's disease Postgrad Med J 68 70 71
78. H Iida H Inada H Tanaka T Nagasaka K Shindo Z Shiozawa 2002 Effects of antiemetic drugs in combination with a dopamine receptor agonist, pergolide, on Parkinson's disease; a comparison between domperidone and mosapride Neurol Therapeutics 19 57 62
79. A Inui T Yoshikawa R Nagai N Yoshida T Ito 2002 Effects of mosapride citrate, a 5-HT4 receptor agonist, on colonic motility in conscious guinea pigs Jpn J Pharmacol 90 313 320
80. S Iscoe 1998 Control of abdominal muscles Prog Neurobiol 56 433 506
81. O Ishizuka H Mizusawa O Nishizawa 2002 Roles of dopaminergic receptors in bladder and erectile function at the spinal level Asian J Androl 4 287 290
82. T Ito R Sakakibara Y Sakakibara M Mori T Hattori 2004 Medulla gut Intern Med 43 1091
83. T Ito R Sakakibara T Uchiyama T Yamamoto Z Liu Y Awa T Hattori 2005 The effect of milnaciplan hydrochloride on urge incontinence due to neurogenic diseases J Japan Neurogenic Bladder Society 16 208 212 in Japanese with English abstract
84. T Ito R Sakakibara K Nakazawa T Uchiyama T Yamamoto Z Liu E Shimizu T Hattori 2006a Effects of electrical stimulation of the raphe area on the micturition reflex in cats Neuroscience 142 1273 1280
85. T Ito R Sakakibara T Uchiyama Z Liu T Yamamoto T Hattori 2006b Videomanometry of the pelvic organs; a comparison of the normal lower urinary and GI tracts Int J Urol 13 29 35
86. SS Iyer JC Morgan KD Sethi 2005 Absorption of orally disintegrating carbidopa-levodopa requires intact small bowel function Neurology 65 1507
87. H Jing KW Lin MH Mei 1995 Participation of dopamine on the muscarinergic inhibitory effect of substance P on gastric myoelectric activity and motility Sheng Li Xue Bao 47 245 252
88. MP Jones JB Dilley D Drossman MD Crowell 2006 Brain gut connections in functional GI disorders: anatomic and physiologic relationships Neurogastroenterol Motil 18 91 103
89. WH Jost 2003 Autonomic dysfunction in idiopathic Parkinson's disease J Neurol 250 Suppl 1 I28 I30
90. WH Jost K Schimrigk 1991 Constipation in Parkinson's disease Klin Wochenschr 69 906 909
91. WH Jost K Schimrigk 1997 Long-term results with cisapride in Parkinson's disease Mov Disord 12 423 425
92. WH Jost B Schrank 1998 Defecatory disorders in de novo Parkinsonians; colonic transit and electromyogram of the external anal sphincter Wien Klin Wochenschr 21 535 537
93. MA Kamm 1994 Pelvic floor tests, Chapter 17 MA Kamm JE Lennard-Jones Constipation Wrightson Biomedical Publishing Petersfield 145 153
94. T Kanesaka R Sakakibara S Ito T Ito T Odaka T Yamaguchi T Uchiyama Z Liu T Yamamoto T Hattori 2006 Intestinal pseudo-obstruction in acute myelitis Intern Med 45 35 36
95. RBC Kavia R Dasgupta CJ Fowler 2005 Functional imaging and the central control of the bladder J Comp Neurol 493 27 32
96. GG Kay MB Abou-Donia WS Messer Jr DG Murphy JW Tsao JG Ouslander 2005 Antimuscarinic drugs for overactive bladder and their potential effects on cognitive function in older patients J Am Geriatr Soc 53 2195 2201
97. JE Kellow M Delvaux F Azpiroz M Camilleri EMM Quigley DG Thompson 1999 Principles of applied neurogastroenterology: physiology/motility-sensation Gut 45 17 24
98. T Kitta H Kakizaki T Furuno K Moriya H Tanaka T Shiga N Tamaki N Yabe H Sasaki K Nonomura 2006 Brain activation during detrusor overactivity in patients with parkinson's disease: a PET study J Urol 175 994 998
99. K Krogh C Mosdal S Laurberg 2000 GI and segmental colonic transit times in patients with acute and chronic spinal cord lesions Spinal Cord 38 615 621
100. S Kuno E Mizuta S Yamasaki I Araki 2004 Effects of pergolide on nocturia in Parkinson fs disease: three female cases selected from over 400 patients Parkinsonism Related Disord 10 181 187
101. WJ Kupsky MM Grimes J Sweeting R Bertsch LJ Cote 1987 Parkinson's disease and megacolon; concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells Neurology 37 1253 1255
102. GA Lanfranchi G Bazzocchi F Fois C Brignola M Campieri B Menni 1985 Effect of domperidone and dopamine on colonic motor activity in patients with the irritable bowel syndrome Eur J Clin Pharmacol 29 307 310
103. N Langdon PN Malcolm JD Parkes 1986 Comparison of levodopa with carbidopa, and levodopa with domperidone in Parkinson's disease Clin Neuropharmacol 9 440 447
104. GE Lemack RB Dewey CG Roehrborn PE O'Suilleabhain PE Zimmern 2000 Questionnaire-based assessment of bladder dysfunction in patients with mild to moderate Parkinson's disease Urology 56 250 254
105. NG Levein E Thorn G Lindberg M Wattwil 1999a Dopamine reduces gastric tone in a dose-related manner Acta Anaesthesiol Scand 43 722 725
106. NG Levein SE Thorn M Wattwil 1999b Dopamine delays gastric emptying and prolongs orocaecal transit time in volunteers Eur J Anaesthesiol 16 246 250
107. A Lewitan L Nathanson WR Slade 1952 Megacolon and dilatation of the small bowel in Parkinsonism Gastroenterology 17 367 374
108. ZS Li C Schmauss A Cuenca E Ratcliffe MD Gershon 2006 Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice J Neurosci 26 2798 2807
109. M Liu MS Geddis Y Wen W Setlik MD Gershon 2005a Expression and function of 5-HT4 receptors in the mouse enteric nervous system Am J Physiol Gastrointest Liver Physiol 289 G1148 G1163
110. MT Liu S Rayport L Jiang DL Murphy MD Gershon 2002 Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter Am J Physiol Gastrointest Liver Physiol 283 G1398 G1411
111. Z Liu R Sakakibara K Nakazawa T Uchiyama T Yamamoto T Ito T Hattori 2004 Micturition-related neuronal firing in the periaqueductal gray area in cats Neuroscience 126 1075 1082
112. Z Liu R Sakakibara T Odaka T Uchiyama T Yamamoto T Ito M Asahina K Yamaguchi T Yamaguchi T Hattori 2005b Mosapride citrate, a novel 5-HT4 agonist and partial 5-HT3 antagonist, ameliorates constipation in parkinsonian patients Mov Disord 20 6 680 686
113. AC Lynch FA Frizelle 2006 Colorectal motility and defecation after spinal cord injury in humans Prog Brain Res 152 335 343
114. A MacDonald PJ Paterson JN Baxter IG Finlay 1993 Relationship between intra-abdominal and intrarectal pressure in the proctometrogram Br J Surg 80 1070 1071
115. K Maganti K Onyemere MP Jones 2003 Oral erythromycin and symptomatic relief of gastroparesis: a systematic review Am J Gastroenterol 98 259 263
116. C Magerkurth R Schnitzer S Braune 2005 Symptoms of autonomic failure in Parkinson's disease: prevalence and impact on daily life Clin Auton Res 15 76 82
117. L Marzio M Neri O Pieramico M Delle Donne TL Peeters F Cuccurullo 1990 Dopamine interrupts GI fed motility pattern in humans. Effect on motilin and somatostatin blood levels Dig Dis Sci 35 327 332
118. SE Mathers PA Kempster PJ Law JP Frankel CI Bartram AJ Lees GM Stern M Swash 1989 Anal sphincter dysfunction in Parkinson's disease Arch Neurol 46 1061 1064
119. G Matsumoto T Hisamitsu WC De Groat 1995 Role of glutamate and NMDA receptors in the descending limb of the spinobulbospinal micturition reflex pathway of the rat Neurosci Lett 183 58 61
120. S Matsuura JW Downie GV Allen 1998 Volume-evoked micturition reflex is mediated by the ventrolateral periaqueductal gray in anesthetized rat Am J Physiol 275 R2049 R2055
121. CW McGrother C Jagger M Clarke CM Castleden 1990 Handicaps associated with incontinence: implications for management J Epidemiol Commun Health 44 246 248
122. IG McKeith DW Dickson J Lowe M Emre JT O'Brien H Feldman J Cummings JE Duda C Lippa EK Perry D Aarsland H Arai CG Ballard B Boeve DJ Burn D Costa T Del Ser B Dubois D Galasko S Gauthier CG Goetz E Gomez-Tortosa G Halliday LA Hansen J Hardy T Iwatsubo RN Kalaria D Kaufer RA Kenny A Korczyn K Kosaka VM Lee A Lees I Litvan E Londos OL Lopez S Minoshima Y Mizuno JA Molina EB Mukaetova-Ladinska F Pasquier RH Perry JB Schulz JQ Trojanowski M Yamada Consortium on DLB 2005 Diagnosis and management of dementia with Lewy bodies: 3rd report of the DLB Consortium Neurology 65 1863 1872
123. GF Murnaghan 1961 Neurogenic disorders of the bladder in Parkinsonism Br J Urol 33 403 409
124. PW Nathan MC Smith 1953 Spinal pathways subserving defaecation and sensation from the lower bowel J Neurol Neurosurg Psychiatry 16 245 256
125. WD Neira V Sanchez MA Mena JG de Yebenes 1995 The effects of cisapride on plasma L-dopa levels and clinical response in Parkinson's disease Mov Disord 10 66 70
126. S Nour C Svarer JK Kristensen OB Paulson I Law 2000 Cerebral activation during micturition in normal men Brain 123 781 789
127. YS Nout GM Leedy S Michael MS Beattie JC Bresnahan 2005 Alterations in eliminative and sexual reflexes after spinal cord injury: defecatory function and development of spasticity in pelvic floor musculature Prog Brain Res 152 359 372
128. JA Obeso CW Olanow JG Nutt 2000 Levodopa motor complications in Parkinson's disease Trend Neurosci 23 S2 S7
129. GJ Oettle 1991 Effect of moderate exercise on bowel habit Gut 32 941 944
130. JM Park DA Bloom EJ McGuire 1997 The guarding reflex revisited Br J Urol 80 940 945
131. DC Paviour D Williams CJ Fowler NP Quinn AJ Lees 2005 Is sphincter electromyography a helpful investigation in the diagnosis of multiple system atrophy? A retrospective study with pathological diagnosis Mov Disord 20 1425 1430
132. AJ Pavlakis MB Siroky I Goldstein RJ Krane 1983 Neurourologic findings in Parkinson's disease J Urol 129 80 83
133. RF Pfeiffer K Markopoulou EMM Quigley N Stambler JM Cedarbaum 2002 Effect of NT-3 on bowel function in Parkinson's disease Mov Disord 17 223 224
134. SJ Qualman HM Haupt P Yang SR Hamilton 1984 Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similar to Parkinson's disease Gastroenterology 87 848 856
135. NW Read WG Haynes DCC Bartolo J Hall MG Read TC Donnelly AG Johnson 1983 Use of anorectal manometry during rectal infusion of saline to investigate sphincter function in incontinent patients Gastroenterology 85 105 113
136. NW Read JM Timms 1986 Defecation and the pathophysiology of constipation Clin Gastroenterol 15 937 965
137. NM Resnick SV Yalla 1987 Detrusor hyperactivity with impaired contractile function JAMA 257 3076 3081
138. MB Roberfroid 1997 Health benefits of non-digestible oligosaccharides Adv Exp Med Biol 427 211 219
139. KM Robson DK Kiely T Lembo 2000 Development of constipation in nursing home residents Dis Colon Rectum 43 940 943
140. MJ Rosenthal CE Marshall 1987 Sigmoid volvulus in association with parkinsonism. Report of four cases J Am Geriatr Soc 35 683 684
141. K Sadjadpour 1983 Pyridostigmine bromide and constipation in Parkinson's disease JAMA 249 1148
142. R Sakakibara T Hattori K Yasuda T Yamanishi 1996 Micturitional disturbance and pontine tegmental lesion; urodynamic and MRI analyses of the vascular cases J Neurol Sci 141 105 110
143. R Sakakibara T Hattori K Yasuda T Yamanishi M Tojo M Mori 1997a Micturitional disturbance in Wernicke's encephalopathy Neurourol Urodynam 16 111 115
144. R Sakakibara M Mori T Fukutake K Kita 1997b Orthostatic hypotension in a case with multiple sclerosis Clin Auton Res 7 163 165
145. R Sakakibara T Hattori T Uchiyama T Yamanishi 1999 Urinary function in the elderly with and without leukoaraiosis; in relation to cognitive and gait function J Neurol Neurosurg Psychiatry 67 658 660
146. R Sakakibara CJ Fowler 2001 Brain disease, Chapter 9 CJ Fowler Seminars in clinical neurology (by World Federation of Neurology) Neurologic bladder, bowel, and sexual function Elsevier Boston 229 243
147. R Sakakibara T Hattori T Uchiyama T Yamanishi 2001a Videourodynamic and sphincter motor unit potential analyses in Parkinson's disease and multiple system atrophy J Neurol Neurosurg Psychiatry 71 600 606
148. R Sakakibara H Shinotoh T Uchiyama M Sakuma M Kashiwado M Yoshiyama T Hattori 2001b Questionnaire-based assessment of pelvic organ dysfunction in Parkinson's disease Auton Neurosci 92 76 85
149. 123I]-beta-CIT reveals marked decline of nigrostriatal dopaminergic function in Parkinson's disease with urinary dysfunction J Neurol Sci 187 55 59
150. Sakakibara R, Uchiyama T, Hattori T, Yamanishi T (2001d) Urodynamic evaluation in Parkinson's disease before and after levodopa treatment. 9th Int. Catechecholamine Symposium, Kyoto, Japan
151. R Sakakibara K Nakazawa K Shiba Y Nakajima T Uchiyama M Yoshiyama T Yamanishi T Hattori 2002a Firing patterns of micturition-related neurons in the pontine storage centre in cats Auton Neurosci 99 24 30
152. R Sakakibara K Nakazawa T Uchiyama M Yoshiyama T Yamanishi T Hattori 2002b Micturition-related electrophysiological properties in the substantia nigra pars compacta and the ventral tegmental area in cats Auton Neurosci 102 30 38
153. R Sakakibara K Nakazawa T Uchiyama M Yoshiyama T Yamanishi T Hattori 2003a Effects of subthalamic nucleus stimulation on the micturation reflex in cats Neuroscience 120 871 875
154. R Sakakibara T Odaka T Uchiyama M Asahina K Yamaguchi T Yamaguchi T Yamanishi T Hattori 2003b Colonic transit time and rectoanal videomanometry in Parkinson's disease J Neurol Neurosurg Psychiatry 74 268 272
155. R Sakakibara T Ito T Uchiyama M Asahina Z Liu T Yamamoto Y Yamanaka T Hattori 2005 Lower urinary tract function in dementia of Lewy body type (DLB) J Neurol Neurosurg Psychiatry 76 729 732
156. R Sakakibara T Yamaguchi T Uchiyama Z Liu T Yamamoto T Ito T Odaka T Hattori 2006a Calcium polycarbophil improves constipation in non-traumatic spinal cord disorders Clin Auton Res 16 289 292
157. Sakakibara R, Yamaguchi T, Uchiyama T, Yamamoto T, Ito T, Liu Z, Odaka T, Yamaguchi C, Hattori T (2006b) Calcium polycarbophil improves constipation in primary autonomic failure and multiple system atrophy subjects. Mov Disord (Epub ahead of print)
158. R Sandyk MA Gillman 1984 Colchicine ameliorates constipation in Parkinson's disease J R Soc Med 77 1066
159. M Sasaki 2005 Role of Barrington's nucleus in micturition J Comp Neurol 493 21 26
160. R Scheife M Takeda 2005 Central nervous system safety of anticholinergic drugs for the treatment of overactive bladder in the elderly Clin Ther 27 144 153
161. S Seki Y Igawa K Kaidoh O Ishizuka O Nishizawa KE Andersson 2001 Role of dopamine D1 and D2 receptors in the micturition reflex in conscious rats Neurourol Urodyn 20 105 113
162. AP Sempere J Duarte C Cabezas LE Claveria F Coria 1995 Aggravation of parkinsonian tremor by cisapride Clin Neuropharmacol 18 76 78
163. J Shimada R Sakakibara T Uchiyama Z Liu T Yamamoto T Ito M Mori M Asahina T Hattori 2006 Intestinal pseudo-obstruction and neuroleptic malignant syndrome in a case of parkinsonian patient with chronic constipation Eur J Neurol 13 306 312
164. JS Shindler GT Finnerty K Towlson AL Dolan CL Davies JD Parkes 1984 Domperidone and levodopa in Parkinson's disease Br J Clin Pharmacol 18 959 962
165. MF Siddiqui S Rast MJ Lynn AP Auchus RF Pfeiffer 2002 Autonomic dysfunction in Parkinson's disease: a comprehensive symptom survey Parkinsonism Relat Disord 8 277 284
166. C Singaram W Ashraf EA Gaumnitz C Torbey A Sengupta R Pfeiffer EM Quigley 1995 Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation Lancet 346 861 864
167. C Singer WJ Weiner JR Sanchez-Ramos 1992 Autonomic dysfunction in men with Parkinson's disease Eur Neurol 32 134 140
168. Y Smith MD Bevan E Shink JP Bolam 1998 Microcircuitry of the direct and indirect pathways of the basal ganglia Neuroscience 86 353 387
169. I Soykan I Sarosiek J Shifflett GF Wooten W McCallum 1997 Effect of chronic oral domperidone therapy on GI symptoms and gastric emptying in patients with Parkinson's disease Mov Disord 12 952 957
170. WD Steers 2002 Pathophysiology of overactive and urge urinary incontinence Rev Urol 4 Suppl 4 S7 S18
171. F Stocchi A Carbone M Inghilleri A Monge S Ruggieri A Berardelli M Manfredi 1997 Urodynamic and neurophysiological evaluation in Parkinson's disease and multiple system atrophy J Neurol Neurosurg Psychiatry 62 507 511
172. O Suchowersky S Furtado G Rohs 1995 Beneficial effect of intranasal desmopressin for nocturnal polyuria in Parkinson's disease Mov Disord 10 337 340
173. KL Sullivan JF Staffetti RA Hauser PB Dunne TA Zesiewicz 2006 Tegaserod (Zelnorm) for the treatment of constipation in Parkinson's disease Mov Disord 21 115 116
174. S Takeda K Yamazaki T Miyakawa H Arai 1993 Parkinson's disease with involvement of the parasympathetic ganglia Acta Neuropathol (Berl) 86 397 398
175. T Tanaka LH VanKlompenberg MG Sarr 2001 Selective role of vagal and nonvagal innervation in initiation and coordination of gastric and small bowel patterns of interdigestive and postprandial motility J Gastrointest Surg 5 418 433
176. AC Thorpe JP Roberts NS Williams JP Blandy DF Badenoch 1995 Pelvic floor physiology in women with fecal incontinence and urinary symptoms Br J Surg 82 173 176
177. A Todorova B Vonderheid-Guth W Dimpfel 2001 Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system J Clin Pharmacol 41 636 644
178. M Tonini 1996 Recent advances in the pharmacology of GI prokinetics Pharmacol Res 33 217 226
179. M Tonini 2005 5-Hydroxytryptamine effects in the gut: the 3, 4, and 7 receptors Neurogastroenterol Motil 17 637 642
180. AL Towers KL Burgio JL Locher IS Merkel M Safaeian A Wald 1994 Constipation in the elderly: influence of dietary, psychological, and physiological factors J Am Geriatr Soc 42 701 716
181. AK Tuteja NJ Talley SK Joos JV Woehl DH Hickam 2005 Is constipation associated with decreased physical activity in normally active subjects? Am J Gastroenterol 100 124 129
182. T Uchiyama R Sakakibara T Hattori 2006 Lower urinary tract dysfunctions of Parkinson's disease model rat (6-hydroxydopamine treated rat) and effects of drugs Autonom Nerv Syst 43 302 308 in Japanese, review with clinical data
183. T Uchiyama R Sakakibara T Hattori T Yamanishi 2003 Short-term effect of a single levodopa dose on micturition disturbance in Parkinson's disease patients with the wearing-off phenomenon Mov Disord 18 573 578
184. A Ueki M Otsuka 2004 Life style risks of Parkinson's disease: association between decreased water intake and constipation J Neurol 251 Suppl 7 18 23
185. RJ Valentino M Kosboth M Colflesh RR Miselis 2000 Transneuronal labeling from the rat distal colon: anatomic evidence for regulation of distal colon function by a pontine corticotropin-releasing factor system J Comp Neurol 417 399 414
186. CJ Vaughan AM Aherne E Lane O Power RM Carey DP O'Connell 2000
187. K Wakabayashi H Takahachi E Ohama F Ikuta 1990 Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system Acta Neuropathol 79 581 583
188. K Wakabayashi H Takahashi 1997 Neuropathology of autonomic nervous system in Parkinson's disease Eur Neurol 38 Suppl 2 2 7
189. JK Walker RR Gainetdinov AW Mangel MG Caron MA Shetzline 2000 Mice lacking the dopamine transporter display altered regulation of distal colonic motility Am J Physiol Gastrointest Liver Physiol 279 G311 G318
190. SJ Wang JL Fuh DE Shan KK Liao KP Lin CP Tsai ZA Wu 1993 Sympathetic skin response and R-R interval variation in Parkinson's disease Mov Disord 8 151 157
191. J Weber P Denis B Mihout JM Muller F Blanquart JP Galmiche P Simon P Pasquis 1985 Effect of brain-stem lesion on colonic and anorectal motility. Study of three patients Dig Dis Sci 30 419 425
192. AJ Wein RR Rackley 2006 Overactive bladder: a better understanding of pathophysiology, diagnosis and management J Urol 175 S5 S10
193. J Wiley C Owyang 1987 Dopaminergic modulation of rectosigmoid motility: action of domperidone J Pharmacol Exp Ther 242 548 551
194. JW Wiley 2002 Aging and neural control of the GI tract III. Senescent enteric nervous system: lessons from extraintestinal sites and nonmammalian species Am J Physiol Gastrointest Liver Physiol 46 G1020 G1026
195. K Winge L Friberg L Werdelin KK Nielsen H Stimpel 2005 Relationship between nigrostriatal dopaminergic degeneration, urinary symptoms, and bladder control in Parkinson's disease Eur J Neurol 12 842 850
196. K Winge LM Werdelin KK Nielsen H Stimpel 2004 Effects of dopaminergic treatment on bladder function in Parkinson's disease Neurourol Urodyn 23 689 696
197. JR Wood M Camilleri PA Low JR Malagelada 1985 Brainstem tumor presenting as an upper gut motility disorder Gastroenterology 89 1411 1414
198. H Yaguchi H Soma Y Miyazaki J Tashiro I Yabe S Kikuchi H Sasaki H Kakizaki F Moriwaka K Tashiro 2004 A case of acute urinary retention caused by periaqueductal grey lesion J Neurol Neurosurg Psychiatry 75 1202 1203
199. M Yamamoto 1997 Pergolide improves neurogenic bladder in patients with Parkinson's disease Mov Disord 12 328
200. T Yamamoto R Sakakibara K Hashimoto K Nakazawa T Uchiyama Z Liu T Ito T Hattori 2005 Striatal dopamine level increases in the urinary storage phase in cats: an in vivo microdialysis study Neuroscience 135 299 303
201. T Yamamoto R Sakakibara T Uchiyama Z Liu T Ito Y Awa T Yamanishi T Hattori 2006 Neurological diseases that cause detrusor hyperactivity with impaired contractile function Neurourol Urodynam 25 356 360
202. O Yokoyama M Yoshiyama M Namiki WC de Groat 2002 Changes in dopaminergic and glutamatergic excitatory mechanisms of micturition reflex after middle cerebral artery occlusion in conscious rats Exp Neurol 173 129 135
203. O Yokoyama S Yotsuyanagi H Akino H Moriyama Y Matsuta M Namiki 2003 RNA synthesis in pons necessary for maintenance of bladder overactivity after cerebral infarction in rat J Urol 169 1878 1884
204. T Yokoyama I Hasegawa 2007 Ileus in Parkinson's disease Neurol Med 66 6 11
205. N Yoshimura S Kuno MB Chancellor WC de Groat S Seki 2003 Dopaminergic mechanisms underlying bladder hyperactivity in rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway Br J Pharmacol 139 1425 1432
206. N Yoshimura E Mizuta O Yoshida S Kuno 1998 Therapeutic effects of dopamine D1/D2 receptor agonists on detrusor hyperreflexia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- lesioned parkinsonian cynomolgus monkeys J Pharmacol Exp Therapeutics 286 228 233
207. N Yoshimura M Sasa O Yoshida S Takaori 1992 Dopamine D-1 receptor mediated inhibition of micturition reflex by central dopamine from the substantia nigra Neurourol Urodyn 11 535 545