Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia

Brain

Volumn 134, Issue 2, 2011, Pages 375-387

  Picconi, Barbara ^a   Bagetta, Vincenza ^a   Ghiglieri, Veronica ^a   Paill, Vincent ^a   Di Filippo, Massimiliano ^a,b   Pendolino, Valentina ^a   Tozzi, Alessandro ^a,b   Giampá, Carmela ^a   Fusco, Francesca R ^a   Sgobio, Carmelo ^a   Calabresi, Paolo ^a,b  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

dyskinesia; long term depression; Parkinson's disease; phosphodiesterases; synaptic plasticity

Indexed keywords

BENSERAZIDE; CYCLIC GMP; LEVODOPA; NITRIC OXIDE; OXIDOPAMINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; UK 343664; UNCLASSIFIED DRUG; ZAPRINAST;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIORAL SCIENCE; CONTROLLED STUDY; DRUG INDUCED DISEASE; DYSKINESIA; ELECTRODE; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; INTRACELLULAR RECORDING; INVOLUNTARY MOVEMENT; LONG TERM DEPRESSION; MALE; MOTOR DYSFUNCTION; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PARKINSONISM; PATCH CLAMP; PRIORITY JOURNAL; RAT; SHAM PROCEDURE; SIGNAL TRANSDUCTION; STRIATE CORTEX; SYNAPSE; THERAPY EFFECT; WHOLE CELL;

EID: 79551716951     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq342     Document Type: Article

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