Neuropathology and neurochemistry of nonmotor symptoms in Parkinson's disease

Parkinson's Disease

Volumn , Issue , 2011, Pages

  Ferrer, Isidro ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN;

AUTONOMIC NERVOUS SYSTEM; BEHAVIOR DISORDER; BRAIN CORTEX; CELL LOSS; CLINICAL FEATURE; COGNITION; COGNITIVE DEFECT; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DYSAUTONOMIA; ENERGY YIELD; HUMAN; LEWY BODY; NEUROCHEMISTRY; NEUROPATHOLOGY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; SLEEP DISORDER; SMELLING DISORDER;

EID: 79953278999     PISSN: None     EISSN: 20420080     Source Type: Journal    
DOI: 10.4061/2011/708404     Document Type: Review

References (214)

1. Forno L. S., Neuropathology of Parkinson's disease Journal of Neuropathology and Experimental Neurology 1996 55 3 259 272 (Pubitemid 26085575)
2. Jellinger K., Mizuno Y., Dickson D., Parkinson's disease Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders 2003 Basel, Switzerland ISN Neuropathol Press 159 187
3. Braak H., Sandmann-Keil D., Gai W., Braak E., Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by -synuclein immunocytochemistry Neuroscience Letters 1999 265 1 67 69 (Pubitemid 29210200)
4. Dickson D. W., Synuclein and the Lewy body disorders Current Opinion in Neurology 2001 14 4 423 432
5. Goedert M., Parkinson's disease and other -synucleinopathies Clinical Chemistry and Laboratory Medicine 2001 39 4 308 312
6. Braak H., Del Tredici K., Cortico-basal ganglia-cortical circuitry in Parkinson's disease reconsidered Experimental Neurology 2008 212 1 226 229
7. Dickson D. W., Braak H., Duda J. E., Duyckaerts C., Gasser T., Halliday G. M., Hardy J., Leverenz J. B., Del Tredici K., Wszolek Z. K., Litvan I., Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria The Lancet Neurology 2009 8 12 1150 1157
8. Ince P. G., McKeith I. G., Dickson D., Dementia with Lewy bodies Neurodegeneration 2003 Basel, Switzerland ISN Neuropath Press 188 199
9. McKeith I., Duyckaerts D. C., Litvan I., Clinical aspects of dementia with Lewy bodies Handbook of Clinical Neurology 2008 89 3rd New York, NY, USA Elsevier 306 311
10. Lowe J., Duyckaerts D. C., Litvan I., Neuropathology of dementia with Lewy bodies Handbook of Clinical Neurology 2008 89 3rd New York, NY, USA Elsevier 321 330
11. Shults C. W., Lewy bodies Proceedings of the National Academy of Sciences of the United States of America 2006 103 6 1661 1668 (Pubitemid 43228751)
12. Wakabayashi K., Tanji K., Mori F., Takahashi H., The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of -synuclein aggregates Neuropathology 2007 27 5 494 506 (Pubitemid 47459715)
13. Leverenz J. B., Umar I., Wang Q., Montine T. J., McMillan P. J., Tsuang D. W., Jin J., Pan C., Shin J., Zhu D., Zhang J., Proteomic identification of novel proteins in cortical Lewy bodies Brain Pathology 2007 17 2 139 145 (Pubitemid 46466133)
14. Xia Q., Liao L., Cheng D., Duong D. M., Gearing M., Lah J. J., Levey A. I., Peng J., Proteomic identification of novel proteins associated with Lewy bodies Frontiers in Bioscience 2008 13 10 3850 3856 (Pubitemid 351594664)
15. Spillantini M. G., Schmidt M. L., Lee V. M. Y., Trojanowski J. Q., Jakes R., Goedert M., synuclein in Lewy bodies Nature 1997 388 6645 839 840
16. Wakabayashi K., Matsumoto K., Takayama K., Yoshimoto M., Takahashi H., NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease Neuroscience Letters 1997 249 180 182
17. Baba M., Nakajo S., Tu P. H., Tomita T., Nakaya K., Lee V. M. Y., Trojanowski J. Q., Iwatsubo T., Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies American Journal of Pathology 1998 152 4 879 884 (Pubitemid 28173348)
18. Hashimoto M., Masliah E., Alpha-synuclein in Lewy body disease and Alzheimer's disease Brain Pathology 1999 9 4 707 720 (Pubitemid 29470963)
19. Duda J. E., Giasson B. I., Chen Q., Gur T. L., Hurtig H. I., Stern M. B., Gollomp S. M., Ischiropoulos H., Lee V. M. Y., Trojanowski J. Q., Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies American Journal of Pathology 2000 157 5 1439 1445
20. Giasson B. I., Duda J. E., Murray I. V. J., Chen Q., Souza J. M., Hurtig H. I., Ischiropoulos H., Trojanowski J. Q., Lee V. M. Y., Oxidative damage linked to neurodegeneration by selective -synuclein nitration in synucleinopathy lesions Science 2000 290 5493 985 989
21. Fujiwara H., Hasegawa M., Dohmae N., Kawashima A., Masliah E., Goldberg M. S., Shen J., Takio K., Iwatsubo T., -synuclein is phosphorylated in synucleinopathy lesions Nature Cell Biology 2002 4 2 160 164
22. Iwatsubo T., Aggregation of -synuclein in the pathogenesis of Parkinson's disease Journal of Neurology, Supplement 2003 250 supplement 3 11 14 (Pubitemid 37297081)
23. Anderson J. P., Walker D. E., Goldstein J. M., De Laat R., Banducci K., Caccavello R. J., Barbour R., Huang J., Kling K., Lee M., Diep L., Keim P. S., Shen X., Chataway T., Schlossmacher M. G., Seubert P., Schenk D., Sinha S., Gai W. P., Chilcote T. J., Phosphorylation of Ser-129 is the dominant pathological modification of -synuclein in familial and sporadic Lewy body disease Journal of Biological Chemistry 2006 281 40 29739 29752 (Pubitemid 44536983)
24. Polymeropoulos M. H., Lavedan C., Leroy E., Ide S. E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E. S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W. G., Lazzarini A. M., Duvoisin R. C., Di Iorio G., Golbe L. I., Nussbaum R. L., Mutation in the -synuclein gene identified in families with Parkinson's disease Science 1997 276 5321 2045 2047 (Pubitemid 27443610)
25. Krger R., Kuhn W., Mller T., Woitalla D., Graeber M., Ksel S., Przuntek H., Epplen J. T., Schls L., Riess O., Ala30Pro mutation in the gene encoding -synuclein in Parkinson's disease Nature Genetics 1998 18 2 106 108
26. Zarranz J. J., Alegre J., Gmez-Esteban J. C., Lezcano E., Ros R., Ampuero I., Vidal L., Hoenicka J., Rodriguez O., Atars B., Llorens V., Gomez Tortosa E., Del Ser T., Muoz D. G., De Yebenes J. G., The new mutation, E46K, of -synuclein causes Parkinson and Lewy body dementia Annals of Neurology 2004 55 2 164 173 (Pubitemid 38166992)
27. Singleton A. B., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., Hulihan M., Peuralinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Maraganore D., Adler C., Cookson M. R., Muenter M., Baptista M., Miller D., Blancato J., Hardy J., Gwinn-Hardy K., α-synuclein locus triplication causes Parkinson's disease Science 2003 302 5646 841 (Pubitemid 37339619)
28. Chartier-Harlin M. C., Kachergus J., Roumier C., Mouroux V., Douay X., Lincoln S., Levecque C., Larvor L., Andrieux J., Hulihan M., Waucquier N., Defebvre L., Amouyel P., Farrer M., Deste A., -synuclein locus duplication as a cause of familial Parkinson's disease The Lancet 2004 364 9440 1167 1169 (Pubitemid 39296604)
29. Ibez P., Bonnet A. M., Dbarges B., Lohmann E., Tison F., Pollak P., Agid Y., Drr A., Brice P. A., Causal relation between -synuclein gene duplication and familial Parkinson's disease The Lancet 2004 364 9440 1169 1171 (Pubitemid 39296605)
30. Nishioka K., Hayashi S., Farrer M. J., Singleton A. B., Yoshino H., Imai H., Kitami T., Sato K., Kuroda R., Tomiyama H., Mizoguchi K., Murata M., Toda T., Imoto I., Inazawa J., Mizuno Y., Hattori N., Clinical heterogeneity of -synuclein gene duplication in Parkinson's disease Annals of Neurology 2006 59 2 298 309 (Pubitemid 43202483)
31. Jowaed A., Schmitt I., Kaut O., Wllner U., Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains Journal of Neuroscience 2010 30 18 6355 6359
32. Doxakis E., Post-transcriptional regulation of -synuclein expression by mir-7 and mir-153 Journal of Biological Chemistry 2010 285 17 12726 12734
33. Junn E., Lee K. W., Byeong S. J., Chan T. W., Im J. Y., Mouradian M. M., Repression of -synuclein expression and toxicity by microRNA-7 Proceedings of the National Academy of Sciences of the United States of America 2009 106 31 13052 13057
34. Wang G., van der Walt J. M., Mayhew G., Li Y.-J., Zchner S., Scott W. K., Martin E. R., Vance J. M., Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of -synuclein American Journal of Human Genetics 2008 82 2 283 289
35. Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y., Shimizu N., Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism Nature 1998 392 6676 605 608 (Pubitemid 28207717)
36. Bonifati V., Rizzu P., Van Baren M. J., Schaap O., Breedveld G. J., Krieger E., Dekker M. C. J., Squitieri F., Ibanez P., Joosse M., Van Dongen J. W., Vanacore N., Van Swieten J. C., Brice A., Meco G., Van Duijn C. M., Oostra B. A., Heutink P., Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism Science 2003 299 5604 256 259 (Pubitemid 36131051)
37. Valente E. M., Abou-Sleiman P. M., Caputo V., Muqit M. M.K., Harvey K., Gispert S., Ali Z., Del Turco D., Bentivoglio A. R., Healy D. G., Albanese A., Nussbaum R., Gonzlez-Maldonado R., Deller T., Salvi S., Cortelli P., Gilks W. P., Latchman D. S., Harvey R. J., Dallapiccola B., Auburger G., Wood N. W., Hereditary early-onset Parkinson's disease caused by mutations in PINK1 Science 2004 304 5674 1158 1160 (Pubitemid 38661852)
38. Zimprich A., Biskup S., Leitner P., Lichtner P., Farrer M., Lincoln S., Kachergus J., Hulihan M., Uitti R. J., Calne D. B., Stoessl A. J., Pfeiffer R. F., Patenge N., Carbajal I. C., Vieregge P., Asmus F., Mller-Myhsok B., Dickson D. W., Meitinger T., Strom T. M., Wszolek Z. K., Gasser T., Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology Neuron 2004 44 4 601 607 (Pubitemid 39531225)
39. Paisn-Ruz C., Jain S., Evans E. W., Gilks W. P., Simn J., Van Der Brug M., De Munain A. L., Aparicio S., Gil A. M., Khan N., Johnson J., Martinez J. R., Nicholl D., Carrera I. M., Pea A. S., De Silva R., Lees A., Mart-Mass J. F., Prez-Tur J., Wood N. W., Singleton A. B., Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease Neuron 2004 44 4 595 600 (Pubitemid 39531224)
40. Strauss K. M., Martins L. M., Plun-Favreau H., Marx F. P., Kautzmann S., Berg D., Gasser T., Wszolek Z., Mller T., Bornemann A., Wolburg H., Downward J., Riess O., Schulz J. B., Krger R., Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease Human Molecular Genetics 2005 14 15 2099 2111 (Pubitemid 41418010)
41. Leroy E., Boyer R., Auburger G., Leube B., Ulm G., Mezey E., Harta G., Brownstein M. J., Jonnalagada S., Chernova T., Dehejia A., Lavedan C., Gasser T., Steinbach P. J., Wilkinson K. D., Polymeropoulos M. H., The ubiquitin pathway in Parkinson's disease Nature 1998 395 6701 451 452
42. Sidransky E., Nalls M. A., Aasly J. O., Aharon-Peretz J., Annesi G., Barbosa E. R., Bar-Shira A., Berg D., Bras J., Brice A., Chen C.-M., Clark L. N., Condroyer C., De Marco E. V., Drr A., Eblan M. J., Fahn S., Farrer M. J., Fung H.-C., Gan-Or Z., Gasser T., Gershoni-Baruch R., Giladi N., Griffith A., Gurevich T., Januario C., Kropp P., Lang A. E., Lee-Chen G.-J., Lesage S., Marder K., Mata I. F., Mirelman A., Mitsui J., Mizuta I., Nicoletti G., Oliveira C., Ottman R., Orr-Urtreger A., Pereira L. V., Quattrone A., Rogaeva E., Rolfs A., Rosenbaum H., Rozenberg R., Samii A., Samaddar T., Schulte C., Sharma M., Singleton A., Spitz M., Tan E.-K., Tayebi N., Toda T., Troiano A. R., Tsuji S., Wittstock M., Wolfsberg T. G., Wu Y.-R., Zabetian C. P., Zhao Y., Ziegler S. G., Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease New England Journal of Medicine 2009 361 17 1651 1661
43. Gasser T., Molecular pathogenesis of Parkinson disease: insights from genetic studies Expert reviews in molecular medicine 2009 11, article e22
44. Thomas B., Beal M. F., Parkinson's disease Human molecular genetics 2007 16 R183 194
45. Hardy J., Lewis P., Revesz T., Lees A., Paisan-Ruiz C., The genetics of Parkinson's syndromes: a critical review Current Opinion in Genetics and Development 2009 19 3 254 265
46. Santpere G., Ferrer I., LRRK2 and neurodegeneration Acta Neuropathologica 2009 117 3 227 246
47. Samaranch L., Lorenzo-Betancor O., Arbelo J. M., Ferrer I., Lorenzo E., Irigoyen J., Pastor M. A., Marrero C., Isla C., Herrera-Henriquez J., Pastor P., PINK1-linked parkinsonism is associated with Lewy body pathology Brain 2010 133 4 1128 1142
48. Braak H., Del Tredici K., Bratzke H., Hamm-Clement J., Sandmann-Keil D., Rb U., Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages) Journal of Neurology, Supplement 2002 249 3 III1 III5
49. Braak H., Del Tredici K., Rb U., De Vos R. A. I., Jansen Steur E. N. H., Braak E., Staging of brain pathology related to sporadic Parkinson's disease Neurobiology of Aging 2003 24 2 197 211 (Pubitemid 36007810)
50. Braak H., Ghebremedhin E., Rb U., Bratzke H., Del Tredici K., Stages in the development of Parkinson's disease-related pathology Cell and Tissue Research 2004 318 1 121 134 (Pubitemid 39362633)
51. Frigerio R., Fujishiro H., Maraganore D. M., Klos K. J., DelleDonne A., Heckman M. G., Crook J. E., Josephs K. A., Parisi J. E., Boeve B. F., Dickson D. W., Ahlskog J. E., Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease Archives of Neurology 2009 66 9 1114 1119
52. Uchikado H., Lin W.-L., Delucia M. W., Dickson D. W., Alzheimer disease with amygdala Lewy bodies: a distinct form of -synucleinopathy Journal of Neuropathology and Experimental Neurology 2006 65 7 685 697 (Pubitemid 44297259)
53. Kosaka K., Dementia and neuropathology in Lewy body disease Advances in neurology 1993 60 456 463
54. Zaccai J., Brayne C., McKeith I., Matthews F., Ince P. G., MRC cognitive function, ageing neuropathology study, patterns and stages of -synucleinopathy: relevance in a population-based cohort Neurology 2008 70 1042 1048 (Pubitemid 351451312)
55. Jellinger K. A., Lewy body-related -synucleinopathy in the aged human brain Journal of Neural Transmission 2004 111 10-11 1219 1235 (Pubitemid 39468387)
56. Braak H., De Vos R. A. I., Bohl J., Del Tredici K., Gastric -synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology Neuroscience Letters 2006 396 1 67 72 (Pubitemid 43233790)
57. Jellinger K. A., A critical reappraisal of current staging of Lewy-related pathology in human brain Acta Neuropathologica 2008 116 1 1 16
58. Jellinger K. A., A critical evaluation of current staging of -synuclein pathology in Lewy body disorders Biochimica et Biophysica Acta 2009 1792 7 730 740
59. Chaudhuri K. R., Yates L., Martinez-Martin P., The non-motor symptom complex of Parkinson's disease: a comprehensive assessment is essential Current Neurology and Neuroscience Reports 2005 5 4 275 283 (Pubitemid 41149661)
60. Postuma R. B., Lang A. E., Massicotte-Marquez J., Montplaisir J., Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder Neurology 2006 66 6 845 851 (Pubitemid 43739758)
61. Iranzo A., Molinuevo J. L., Santamara J., Serradell M., Mart M. J., Valldeoriola F., Tolosa E., Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study Lancet Neurology 2006 5 7 572 577 (Pubitemid 43867426)
62. Siderowf A., Stern M. B., Preclinical diagnosis of Parkinson's disease: are we there yet? Current Neurology and Neuroscience Reports 2006 6 4 295 301 (Pubitemid 44069968)
63. Tolosa E., Compta Y., Gaig C., The premotor phase of Parkinson's disease Parkinsonism and Related Disorders 2007 13 S2 S7
64. Poewe W., Dysautonomia and cognitive dysfunction in Parkinson's disease Movement Disorders 2007 22 supplement 17 S374 S378
65. Ziemssen T., Reichmann H., Non-motor dysfunction in Parkinson's disease Parkinsonism and Related Disorders 2007 13 6 323 332 (Pubitemid 47212791)
66. Herting B., Schulze S., Reichmann H., Haehner A., Hummel T., A longitudinal study of olfactory function in patients with idiopathic Parkinson's disease Journal of Neurology 2008 255 3 367 370
67. Wolters E. C. H., Braak H., Parkinson's disease: premotor clinico-pathological correlations Journal of Neural Transmission, Supplement 2006 70 309 319 (Pubitemid 44622216)
68. Poewe W., Non-motor symptoms in Parkinson's disease European Journal of Neurology 2008 15 supplement 1 14 20 (Pubitemid 351421304)
69. Ross G. W., Petrovitch H., Abbott R. D., Tanner C. M., Popper J., Masaki K., Launer L., White L. R., Association of olfactory dysfunction with risk for future Parkinson's disease Annals of Neurology 2008 63 2 167 173 (Pubitemid 351355295)
70. Natale G., Pasquali L., Ruggieri S., Paparelli A., Fornai F., Parkinson's disease and the gut: a well known clinical association in need of an effective cure and explanation Neurogastroenterology and Motility 2008 20 7 741 749 (Pubitemid 351814395)
71. Daniel S. E., Hawkes C. H., Preliminary diagnosis of Parkinson's disease by olfactory bulb pathology The Lancet 1992 340 8812 186
72. Pearce R. K. B., Hawkes C. H., Daniel S. E., The anterior olfactory nucleus in Parkinson's disease Movement Disorders 1995 10 3 283 287
73. Del Tredici K., Rb U., De Vos R. A. I., Bohl J. R. E., Braak H., Where does Parkinson disease pathology begin in the brain? Journal of Neuropathology and Experimental Neurology 2002 61 5 413 426 (Pubitemid 34533671)
74. Bloch A., Probst A., Bissig H., Adams H., Tolnay M., -Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects Neuropathology and Applied Neurobiology 2006 32 3 284 295
75. Hubbard P. S., Esiri M. M., Reading M., McShane R., Nagy Z., Alpha-synuclein pathology in the olfactory pathways of dementia patients Journal of Anatomy 2007 211 1 117 124 (Pubitemid 47034515)
76. Fujishiro H., Frigerio R., Burnett M., Klos K. J., Josephs K. A., DelleDonne A., Parisi J. E., Ahlskog J. E., Dickson D. W., Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease Movement Disorders 2008 23 8 1085 1092
77. Ubeda-Baon I., Saiz-Sanchez D., De La Rosa-Prieto C., Argandoa-Palacios L., Garcia-Muozguren S., Martinez-Marcos A., -Synucleinopathy in the human olfactory system in Parkinson's disease: involvement of calcium-binding protein- and substance P-positive cells Acta Neuropathologica 2010 119 6 723 735
78. Beach T. G., White C. L. 3rd, Hladik C. L., Arizona Parkinson's Disease Consortium. Olfactory bulb -synucleinopathy has high specificity and sensitivity for Lewy body disorders Acta Neuropathologica 2009 117 2 215 216
79. Parkkinen L., Silveira-Moriyama L., Holton J. L., Lees A. J., Revesz T., Can olfactory bulb biopsy be justified for the diagnosis of Parkinson's disease? Comments on "olfactory bulb -synucleinopathy has high specificity and sensitivity for Lewy body disorders" Acta Neuropathologica 2009 117 2 213 214
80. Biagiotti E., Ferri P., Dringen R., Del Grande P., Ninfali P., Glucose-6-phosphate dehydrogenase and NADPH-consuming enzymes in the rat olfactory bulb Journal of Neuroscience Research 2005 80 3 434 441 (Pubitemid 40780832)
81. Vaishnav R. A., Getchell M. L., Poon H. F., Barnett K. R., Hunter S. A., Pierce W. M., Klein J. B., Butterfield D. A., Getchell T. V., Oxidative stress in the aging murine olfactory bulb: redox proteomics and cellular localization Journal of Neuroscience Research 2007 85 2 373 385 (Pubitemid 46219305)
82. Hosokawa M., A higher oxidative status accelerates senescence and aggravates age-dependent disorders in SAMP strains of mice Mechanisms of Ageing and Development 2002 123 12 1553 1561 (Pubitemid 35449219)
83. Bohnen N. I., Mller M. L. T. M., Kotagal V., Koeppe R. A., Kilbourn M. A., Albin R. L., Frey K. A., Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson's disease Brain 2010 133 6 1747 1754
84. Healy D. G., Falchi M., O'Sullivan S. S., Bonifati V., Durr A., Bressman S., Brice A., Aasly J., Zabetian C. P., Goldwurm S., Ferreira J. J., Tolosa E., Kay D. M., Klein C., Williams D. R., Marras C., Lang A. E., Wszolek Z. K., Berciano J., Schapira A. H., Lynch T., Bhatia K. P., Gasser T., Lees A. J., Wood N. W., Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study The Lancet Neurology 2008 7 7 583 590
85. Kgi G., Klein C., Wood N. W., Schneider S. A., Pramstaller P. P., Tadic V., Quinn N. P., Van De Warrenburg B. P.C., Bhatia K. P., Nonmotor symptoms in Parkin gene-related parkinsonism Movement Disorders 2010 25 9 1279 1284
86. Wakabayashi K., Takahashi H., Ohama E., Ikuta F., Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system Acta Neuropathologica 1990 79 6 581 583 (Pubitemid 20170333)
87. Takeda S., Yamazaki K., Miyakawa T., Arai H., Parkinson's disease with involvement of the parasympathetic ganglia Acta Neuropathologica 1993 86 4 397 398 (Pubitemid 23280124)
88. Wakabayashi K., Takahashi H., Neuropathology of autonomic nervous system in Parkinson's disease European Neurology 1997 38 supplement 2 2 7 (Pubitemid 27453771)
89. Hague K., Lento P., Morgello S., Caro S., Kaufmann H., The distribution of Lewy bodies in pure autonomic failure: autopsy findings and review of the literature Acta Neuropathologica 1997 94 2 192 196 (Pubitemid 27338509)
90. Micieli G., Tosi P., Marcheselli S., Cavallini A., Autonomic dysfunction in Parkinson's disease Neurological Sciences 2003 24 supplement 1 S32 S34
91. Benarroch E. E., Schmeichel A. M., Low P. A., Boeve B. F., Sandroni P., Parisi J. E., Involvement of medullary regions controlling sympathetic output in Lewy body disease Brain 2005 128 2 338 344 (Pubitemid 40222602)
92. Minguez-Castellanos A., Chamorro C. E., Escamilla-Sevilla F., Ortega-Moreno A., Rebollo A. C., Gomez-Rio M., Concha A., Munoz D. G., Do -synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study Neurology 2007 68 23 2012 2018 (Pubitemid 46869706)
93. Probst A., Bloch A., Tolnay M., New insights into the pathology of Parkinson's disease: does the peripheral autonomic system become central? European Journal of Neurology 2008 15 supplement 1 1 4 (Pubitemid 351421305)
94. Oinas M., Paetau A., Myllykangas L., Notkola I. L., Kalimo H., Polvikoski T., -Synuclein pathology in the spinal cord autonomic nuclei associates with -synuclein pathology in the brain: a population-based Vantaa 85+ study Acta Neuropathologica 2010 119 6 715 722
95. Wakabayashi K., Takahashi H., Takeda S., Ohama E., Ikuta F., Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses Acta Neuropathologica 1988 76 3 217 221
96. Beach T. G., Adler C. H., Sue L. I., Vedders L., Lue L. F., White III C. L., Akiyama H., Caviness J. N., Shill H. A., Sabbagh M. N., Walker D. G., Arizona Parkinsons Disease Consortium. Multi-organ distribution of phosphorylated -synuclein histopathology in subjects with Lewy body disorders Acta Neuropathologica 2010 119 6 689 702
97. Iwanaga K., Wakabayashi K., Yoshimoto M., Tomita I., Satoh H., Takashima H., Satoh A., Seto M., Tsujihata M., Takahashi H., Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases Neurology 1999 52 6 1269 1271 (Pubitemid 29177934)
98. Takatsu H., Nishida H., Matsuo H., Watanabe S., Nagashima K., Wada H., Noda T., Nishigaki K., Fujiwara H., Cardiac sympathetic denervation from the early stage of Parkinson's disease: clinical and experimental studies with radiolabeled MIBG Journal of Nuclear Medicine 2000 41 1 71 77 (Pubitemid 30046686)
99. Mitsui J., Saito Y., Momose T., Shimizu J., Arai N., Shibahara J., Ugawa Y., Kanazawa I., Tsuji S., Murayama S., Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I- metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease Journal of the Neurological Sciences 2006 243 1-2 101 104
100. Kashihara K., Ohno M., Kawada S., Okumura Y., Reduced cardiac uptake and enhanced washout of123I-MIBG in pure autonomic failure occurs conjointly with Parkinson's disease and dementia with Lewy bodies Journal of Nuclear Medicine 2006 47 7 1099 1101 (Pubitemid 47544904)
101. Oka H., Morita M., Onouchi K., Yoshioka M., Mochio S., Inoue K., Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease Journal of the Neurological Sciences 2007 254 1-2 72 77 (Pubitemid 46330412)
102. Sawada H., Oeda T., Yamamoto K., Kitagawa N., Mizuta E., Hosokawa R., Ohba M., Nishio R., Yamakawa K., Takeuchi H., Shimohama S., Takahashi R., Kawamura T., Diagnostic accuracy of cardiac metaiodobenzylguanidine scintigraphy in Parkinson disease European Journal of Neurology 2009 16 2 174 182
103. Orimo S., Amino T., Itoh Y., Takahashi A., Kojo T., Uchihara T., Tsuchiya K., Mori F., Wakabayashi K., Takahashi H., Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease Acta Neuropathologica 2005 109 6 583 588 (Pubitemid 40974147)
104. Orimo S., Takahashi A., Uchihara T., Mori F., Kakita A., Wakabayashi K., Takahashi H., Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease Brain Pathology 2007 17 1 24 30
105. Orimo S., Uchihara T., Nakamura A., Mori F., Kakita A., Wakabayashi K., Takahashi H., Axonal -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease Brain 2008 131 3 642 650 (Pubitemid 351294710)
106. Stiasny-Kolster K., Doerr Y., Mller J. C., Hffken H., Behr T. M., Oertel W. H., Mayer G., Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for -synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT Brain 2005 128 1 126 137 (Pubitemid 40070527)
107. Tijero B., Gomez-Esteban J. C., Llorens V., Lezcano E., Gonzalez-Fernndez M. C., De Pancorbo M. M., Ruiz-Martinez J., Cembellin J. C., Zarranz J. J., Cardiac sympathetic denervation precedes nigrostriatal loss in the E46K mutation of the -synuclein gene (SNCA) Clinical Autonomic Research 2010 20 4 267 269
108. Goetz C. G., Ouyang B., Negron A., Stebbins G. T., Hallucinations and sleep disorders in PD: ten-year prospective longitudinal study Neurology 2010 75 20 1773 1779
109. Manni R., Terzaghi M., Repetto A., Zangaglia R., Pacchetti C., Complex paroxysmal nocturnal behaviors in Parkinson's disease Movement Disorders 2010 25 8 985 990
110. Boeve B. F., REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions Annals of the New York Academy of Sciences 2010 1184 15 54
111. Claassen D. O., Josephs K. A., Ahlskog J. E., Silber M. H., Tippmann-Peikert M., Boeve B. F., REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century Neurology 2010 75 6 494 499
112. Arnulf I., Ferraye M., Fraix V., Benabid A. L., Chabards S., Goetz L., Pollak P., Deb B., Sleep induced by stimulation in the human pedunculopontine nucleus area Annals of Neurology 2010 67 4 546 549
113. Marques A., Dujardin K., Boucart M., Pins D., Delliaux M., Defebvre L., Derambure P., Monaca C., REM sleep behaviour disorder and visuoperceptive dysfunction: a disorder of the ventral visual stream? Journal of Neurology 2010 257 3 383 391
114. Thannickal T. C., Lai Y. Y., Siegel J. M., Hypocretin (orexin) cell loss in Parkinson's disease Brain 2007 130 6 1586 1595 (Pubitemid 47355933)
115. Fronczek R., Overeem S., Lee S. Y. Y., Hegeman I. M., Van Pelt J., Van Duinen S. G., Lammers G. J., Swaab D. F., Hypocretin (orexin) loss in Parkinson's disease Brain 2007 130 6 1577 1585 (Pubitemid 47355929)
116. Compta Y., Santamaria J., Ratti L., Tolosa E., Iranzo A., Muoz E., Valldeoriola F., Casamitjana R., Ros J., Marti M. J., Cerebrospinal hypocretin, daytime sleepiness and sleep architecture in Parkinson's disease dementia Brain 2009 132 12 3308 3317
117. Asai H., Hirano M., Furiya Y., Udaka F., Morikawa M., Kanbayashi T., Shimizu T., Ueno S., Cerebrospinal fluid-orexin levels and sleep attacks in four patients with Parkinson's disease Clinical Neurology and Neurosurgery 2009 111 4 341 344
118. Kulisevsky J., Pagonbarraga J., Pascual-Sedano B., Garca-Snchez C., Gironell A., Prevalence and correlates of neuropsychiatric symptoms in Parkinson's disease without dementia Movement Disorders 2008 23 13 1889 1896
119. Ferrer I., Early involvement of the cerebral cortex in Parkinson's disease: convergence of multiple metabolic defects Progress in Neurobiology 2009 88 2 89 103
120. Braak H., Rb U., Jansen Steur E. N. H., Del Tredici K., De Vos R. A. I., Cognitive status correlates with neuropathologic stage in Parkinson disease Neurology 2005 64 8 1404 1410 (Pubitemid 40570509)
121. Dickson D. W., Uchikado H., Fujishiro H., Tsuboi Y., Evidence in favor of Braak staging of Parkinson's disease Movement Disorders 2010 25 supplement 1 S78 82
122. Mattila P. M., Rinne J. O., Helenius H., Dickson D. W., Rytt M., Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease Acta Neuropathologica 2000 100 3 285 290 (Pubitemid 30456155)
123. Molano J., Boeve B., Ferman T., Smith G., Parisi J., Dickson D., Knopman D., Graff-Radford N., Geda Y., Lucas J., Kantarci K., Shiung M., Jack C., Silber M., Pankratz V. S., Petersen R., Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study Brain 2010 133 2 540 556
124. Parkkinen L., Kauppinen T., Pirttil T., Autere J. M., Alafuzoff I., -synuclein pathology does not predict extrapyramidal symptoms or dementia Annals of Neurology 2005 57 1 82 91 (Pubitemid 40053318)
125. Parkkinen L., Pirttil T., Tervahauta M., Alafuzoff I., Widespread and abundant -synuclein pathology in a neurologically unimpaired subject Neuropathology 2005 25 4 304 314 (Pubitemid 43943239)
126. Weisman D., Cho M., Taylor C., Adame A., Thal L. J., Hansen L. A., In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution Neurology 2007 69 4 356 359 (Pubitemid 47205662)
127. Parkkinen L., Pirttil T., Alafuzoff I., Applicability of current staging/categorization of -synuclein pathology and their clinical relevance Acta Neuropathologica 2008 115 4 399 407
128. Burke R. E., Dauer W. T., Vonsattel J. P. G., A critical evaluation of the Braak staging scheme for Parkinson's disease Annals of Neurology 2008 64 5 485 491
129. Halliday G., Hely M., Reid W., Morris J., The progression of pathology in longitudinally followed patients with Parkinson's disease Acta Neuropathologica 2008 115 4 409 415
130. Harding A. J., Broe G. A., Halliday G. M., Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe Brain 2002 125 2 391 403 (Pubitemid 34127441)
131. Yamamoto R., Iseki E., Murayama N., Minegishi M., Marui W., Togo T., Katsuse O., Kosaka K., Kato M., Iwatsubo T., Arai H., Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies Neuroscience Letters 2007 415 3 219 224 (Pubitemid 46400260)
132. Kalaitzakis M. E., Christian L. M., Moran L. B., Graeber M. B., Pearce R. K. B., Gentleman S. M., Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease Parkinsonism and Related Disorders 2009 15 3 196 204
133. Muntan G., Dalf E., Martinez A., Ferrer I., Phosphorylation of tau and -synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related -synucleinopathies Neuroscience 2008 152 4 913 923
134. Schulz-Schaeffer W. J., The synaptic pathology of -synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia Acta Neuropathologica 2010 120 131 143
135. Tanji K., Mori F., Mimura J., Itoh K., Kakita A., Takahashi H., Wakabayashi K., Proteinase K-resistant -synuclein is deposited in presynapses in human Lewy body disease and A53T -synuclein transgenic mice Acta Neuropathologica 2010 120 2 145 154
136. Dalf E., Barrachina M., Rosa J. L., Ambrosio S., Ferrer I., Abnormal -synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease Neurobiology of Disease 2004 16 1 92 97 (Pubitemid 38569800)
137. Dalf E., Albasanz J. L., Martn M., Ferrer I., Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular -synuclein/phospholipase C (PLC 1) interactions Brain Pathology 2004 14 4 388 398 (Pubitemid 39524968)
138. Owen A. M., Doyon J., Dagher A., Sadikot A., Evans A. C., Abnormal basal ganglia outflow in Parkinson's disease identified with PET. Implications for higher cortical functions Brain 1998 121 5 949 965 (Pubitemid 28220900)
139. Dirnberger G., Frith C. D., Jahanshahi M., Executive dysfunction in Parkinson's disease is associated with altered pallidal-frontal processing NeuroImage 2005 25 2 588 599 (Pubitemid 40387341)
140. Cools R., Stefanova E., Barker R. A., Robbins T. W., Owen A. M., Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET Brain 2002 125 3 584 594 (Pubitemid 34194413)
141. Monchi O., Petrides M., Mejia-Constain B., Strafella A. P., Cortical activity in Parkinson's disease during executive processing depends on striatal involvement Brain 2007 130 1 233 244 (Pubitemid 46026238)
142. Marklund P., Larsson A., Elgh E., Linder J., Riklund K., Forsgren L., Nyberg L., Temporal dynamics of basal ganglia under-recruitment in Parkinson's disease: transient caudate abnormalities during updating of working memory Brain 2009 132 2 336 346
143. Moore R. Y., Whone A. L., Brooks D. J., Extrastriatal monoamine neuron function in Parkinson's disease: an 18F-dopa PET study Neurobiology of Disease 2008 29 3 381 390
144. Cropley V. L., Fujita M., Bara-Jimenez W., Brown A. K., Zhang X. Y., Sangare J., Herscovitch P., Pike V. W., Hallett M., Nathan P. J., Innis R. B., Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [F]FDOPA Psychiatry Research 2008 163 2 171 182
145. Sawamoto N., Piccini P., Hotton G., Pavese N., Thielemans K., Brooks D. J., Cognitive deficits and striato-frontal dopamine release in Parkinson's disease Brain 2008 131 5 1294 1302
146. Zarow C., Lyness S. A., Mortimer J. A., Chui H. C., Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases Archives of Neurology 2003 60 3 337 341 (Pubitemid 36314358)
147. Bosboom J. L. W., Stoffers D., Wolters E. CH., The role of acetylcholine and dopamine in dementia and psychosis in Parkinson's disease Journal of Neural Transmission, Supplement 2003 65 185 195 (Pubitemid 38339955)
148. Hilker R., Thomas A. V., Klein J. C., Weisenbach S., Kalbe E., Burghaus L., Jacobs A. H., Herholz K., Heiss W. D., Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways Neurology 2005 65 11 1716 1722
149. Baloyannis S. J., Costa V., Baloyannis I. S., Morphological alterations of the synapses in the locus coeruleus in Parkinson's disease Journal of the Neurological Sciences 2006 248 1-2 35 41 (Pubitemid 44647280)
150. Dubois B., Pillon B., Lhermitte F., Agid Y., Cholinergic deficiency and frontal dysfunction in Parkinson's disease Annals of Neurology 1990 28 2 117 121 (Pubitemid 20244511)
151. Calabresi P., Picconi B., Parnetti L., Di Filippo M., A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance Lancet Neurology 2006 5 11 974 983 (Pubitemid 44556553)
152. Shimada H., Hirano S., Shinotoh H., Aotsuka A., Sato K., Tanaka N., Ota T., Asahina M., Fukushi K., Kuwabara S., Hattori T., Suhara T., Irie T., Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET Neurology 2009 73 4 273 278
153. Bohnen N. I., Albin R. L., Cholinergic denervation occurs early in Parkinson disease Neurology 2009 73 4 256 257
154. Bohnen N. I., Albin R. L., The cholinergic system and Parkinson disease. Behavioural Brain Research. In press
155. Roselli F., Pisciotta N. M., Pennelli M., Aniello M. S., Gigante A., De Caro M. F., Ferrannini E., Tartaglione B., Niccoli-Asabella A., Defazio G., Livrea P., Rubini G., Midbrain SERT in degenerative parkinsonisms: a 123I-FP-CIT SPECT study Movement Disorders 2010 25 12 1853 1859
156. Yong S. W., Yoon J. K., An Y. S., Lee P. H., A comparison of cerebral glucose metabolism in Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies European Journal of Neurology 2007 14 12 1357 1362 (Pubitemid 350135301)
157. Wallin A., Ekberg S., Lind K., Milos V., Granrus A.-K., Granerus G., Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson's diseasea rCBF scintigraphy study Acta Neurologica Scandinavica 2007 116 6 347 354 (Pubitemid 350045498)
158. Huang C., Tang C., Feigin A., Lesser M., Ma Y., Pourfar M., Dhawan V., Eidelberg D., Changes in network activity with the progression of Parkinson's disease Brain 2007 130 7 1834 1846 (Pubitemid 47343798)
159. Huang C., Mattis P., Perrine K., Brown N., Dhawan V., Eidelberg D., Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease Neurology 2008 70 16 1470 1477 (Pubitemid 351521942)
160. Tessa C., Giannelli M., Della Nave R., Lucetti C., Berti C., Ginestroni A., Bonuccelli U., Mascalchi M., A whole-brain analysis in de novo Parkinson disease American Journal of Neuroradiology 2008 29 4 674 680 (Pubitemid 351571545)
161. Karagulle Kendi A. T., Lehericy S., Luciana M., Ugurbil K., Tuite P., Altered diffusion in the frontal lobe in Parkinson disease American Journal of Neuroradiology 2008 29 3 501 505 (Pubitemid 351424064)
162. Lee S.-J., Kim J.-S., Yoo J.-Y., Song I.-U., Kim B.-S., Jung S.-L., Yang D.-W., Kim Y.-I., Jeong D.-S., Lee K.-S., Influence of white matter hyperintensities on the cognition of patients with parkinson disease Alzheimer Disease and Associated Disorders 2010 24 3 227 233
163. Jellinger K. A., Prevalence and impact of cerebrovascular lesions in Alzheimer and Lewy body diseases Neurodegenerative Diseases 2010 7 13 112 115
164. Schapira A. H., Mitochondria in the aetiology and pathogenesis of Parkinson's disease The Lancet Neurology 2008 7 1 97 109 (Pubitemid 350251942)
165. Sack G. H., Mitochondrial matters in Parkinson disease: introduction Journal of Bioenergetics and Biomembranes 2009 41 6 465 467
166. Winklhofer K. F., Haass C., Mitochondrial dysfunction in Parkinson's disease Biochimica et Biophysica Acta 2010 1802 1 29 44
167. Abou-Sleiman P. M., Muqit M. M. K., Wood N. W., Expanding insights of mitochondrial dysfunction in Parkinson's disease Nature Reviews Neuroscience 2006 7 3 207 219 (Pubitemid 43292466)
168. Yang Y., Gehrke S., Haque MD. E., Imai Y., Kosek J., Yang L., Beal M. F., Nishimura I., Wakamatsu K., Ito S., Takahashi R., Lu B., Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling Proceedings of the National Academy of Sciences of the United States of America 2005 102 38 13670 13675 (Pubitemid 41420906)
169. Ved R., Saha S., Westlund B., Perier C., Burnam L., Sluder A., Hoener M., Rodrigues C. M.P., Alfonso A., Steer C., Liu L., Przedborski S., Wolozin B., Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of -synuclein, parkin, and DJ-1 in Caenorhabditis elegans Journal of Biological Chemistry 2005 280 52 42655 42668 (Pubitemid 43049224)
170. Silvestri L., Caputo V., Bellacchio E., Atorino L., Dallapiccola B., Valente E. M., Casari G., Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism Human Molecular Genetics 2005 14 22 3477 3492 (Pubitemid 41672130)
171. Park J., Lee S. B., Lee S., Kim Y., Song S., Kim S., Bae E., Kim J., Shong M., Kim J. M., Chung J., Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin Nature 2006 441 7097 1157 1161 (Pubitemid 43990737)
172. Clark I. E., Dodson M. W., Jiang C., Cao J. H., Huh J. R., Seol J. H., Yoo S. J., Hay B. A., Guo M., Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Nature 2006 441 7097 1162 1166 (Pubitemid 43990738)
173. Poole A. C., Thomas R. E., Andrews L. A., McBride H. M., Whitworth A. J., Pallanck L. J., The PINK1/Parkin pathway regulates mitochondrial morphology Proceedings of the National Academy of Sciences of the United States of America 2008 105 5 1638 1643 (Pubitemid 351346567)
174. Smith W. W., Pei Z., Jiang H., Moore D. J., Liang Y., West A. B., Dawson V. L., Dawson T. M., Ross C. A., Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration Proceedings of the National Academy of Sciences of the United States of America 2005 102 51 18676 18681 (Pubitemid 43011285)
175. Suzuki Y., Imai Y., Nakayama H., Takahashi K., Takio K., Takahashi R., A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death Molecular Cell 2001 8 3 613 621 (Pubitemid 32946938)
176. Dodson M. W., Guo M., Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease Current Opinion in Neurobiology 2007 17 3 331 337 (Pubitemid 46880329)
177. Dagda R. K., Chu C. T., Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis Journal of Bioenergetics and Biomembranes 2009 41 6 473 479
178. Jendrach M., Gispert S., Ricciardi F., Klinkenberg M., Schemm R., Auburger G., The mitochondrial kinase PINK1, stress response and Parkinson's disease Journal of Bioenergetics and Biomembranes 2009 41 6 481 486
179. Whitworth A. J., Pallanck L. J., The PINK1/Parkin pathway: a mitochondrial quality control system? Journal of Bioenergetics and Biomembranes 2009 41 6 499 503
180. Papa S., Sardanelli A. M., Capitanio N., Piccoli C., Mitochondrial respiratory dysfunction and mutations in mitochondrial DNA in PINK1 familial Parkinsonism Journal of Bioenergetics and Biomembranes 2009 41 6 509 516
181. Navarro A., Boveris A., Bndez M. J., Snchez-Pino M. J., Gmez C., Muntan G., Ferrer I., Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies Free Radical Biology and Medicine 2009 46 12 1574 1580
182. Navarro A., Boveris A., Brain mitochondrial dysfunction and oxidative damage in Parkinson's disease Journal of Bioenergetics and Biomembranes 2009 41 6 517 521
183. Keeney P. M., Xie J., Capaldi R. A., Bennett J. P., Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled Journal of Neuroscience 2006 26 19 5256 5264 (Pubitemid 44315308)
184. Hattingen E., Magerkurth J., Pilatus U., Mozer A., Seifried C., Steinmetz H., Zanella F., Hilker R., Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease Brain 2009 132 12 3285 3297
185. Alam Z. I., Daniel S. E., Lees A. J., Marsden D. C., Jenner P., Halliwell B., A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease Journal of Neurochemistry 1997 69 3 1326 1329 (Pubitemid 27364859)
186. Dalf E., Portero-Otn M., Ayala V., Martnez A., Pamplona R., Ferrer I., Evidence of oxidative stress in the neocortex in incidental Lewy body disease Journal of Neuropathology and Experimental Neurology 2005 64 9 816 830 (Pubitemid 41285815)
187. Dalf E., Ferrer I., Early -synuclein lipoxidation in neocortex in Lewy body diseases Neurobiology of Aging 2008 29 3 408 417 (Pubitemid 351222679)
188. Choi J., Levey A. I., Weintraub S. T., Rees H. D., Gearing M., Chin L. S., Li L., Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic Parkinson's and Alzheimer's Diseases Journal of Biological Chemistry 2004 279 13 13256 13264 (Pubitemid 38445905)
189. Choi J., Rees H. D., Weintraub S. T., Levey A. I., Chin L. S., Li L., Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with alzheimer and Parkinson diseases Journal of Biological Chemistry 2005 280 12 11648 11655 (Pubitemid 40418479)
190. Choi J., Sullards M. C., Olzmann J. A., Rees H. D., Weintraub S. T., Bostwick D. E., Gearing M., Levey A. I., Chin L. S., Li L., Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases Journal of Biological Chemistry 2006 281 16 10816 10824 (Pubitemid 43855504)
191. Gmez A., Ferrer I., Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases Journal of Neuroscience Research 2009 87 4 1002 1013
192. Power J. H. T., Blumbergs P. C., Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies Acta Neuropathologica 2009 117 1 63 73
193. Tang C. C., Poston K. L., Dhawan V., Eidelberg D., Abnormalities in metabolic network activity precede the onset of motor symptoms in Parkinson's disease Journal of Neuroscience 2010 30 3 1049 1056
194. Fabelo N., Martn V., Santpere G., Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinsons disease and incidental Parkinsons disease. submitted
195. Ferrer I., Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease Journal of Bioenergetics and Biomembranes 2009 41 5 425 431
196. Gomez A., Ferrer I., Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment Acta Neuropathologica 2010 20 155 167
197. McKinlay A., Grace R. C., Dalrymple-Alford J. C., Roger D., Cognitive characteristics associated with mild cognitive impairment in parkinson's disease Dementia and Geriatric Cognitive Disorders 2009 28 2 121 129
198. Pedersen K. F., Alves G., Aarsland D., Larsen J. P., Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study Journal of Neurology, Neurosurgery and Psychiatry 2009 80 11 1279 1282
199. Sanchez-Ramos J. R., Ortoll R., Paulson G. W., Visual hallucinations associated with Parkinson disease Archives of Neurology 1996 53 12 1265 1268 (Pubitemid 26425072)
200. Inzelberg R., Kipervasser S., Korczyn A. D., Auditory hallucinations in Parkinson's disease Journal of Neurology Neurosurgery and Psychiatry 1998 64 4 533 535 (Pubitemid 28195958)
201. Wolters E. CH., Intrinsic and extrinsic psychosis in Parkinson's disease Journal of Neurology, Supplement 2001 248 supplement 3 III22 III27
202. de Maindreville A. D., Fnelon G., Mahieux F., Hallucinations in Parkinson's disease: a follow-up study Movement Disorders 2005 20 2 212 217 (Pubitemid 40361126)
203. Papapetropoulos S., Mash D. C., Psychotic symptoms in Parkinson's disease: from description to etiology Journal of Neurology 2005 252 7 753 764 (Pubitemid 40984849)
204. Birkmayer W., Riederer P., Responsibility of extrastriatal areas for the appearance of psychotic symptoms. (Clinical and biochemical human post mortem findings) Journal of Neural Transmission 1975 37 2 175 182
205. Mayeux R., Stern Y., Williams J. B.W., Clinical and biochemical features of depression in Parkinson's disease American Journal of Psychiatry 1986 143 6 756 759 (Pubitemid 16050848)
206. Perry E. K., McKeith I., Thompson P., Marshall E., Kerwin J., Jabeen S., Edwardson J. A., Ince P., Blessed G., Irving D., Perry R. H., Topography, extent, and clinical relevance of neurochemical deficits in dementia of Lewy body type, Parkinson's disease, and Alzheimer's disease Annals of the New York Academy of Sciences 1991 640 197 202
207. Remy P., Doder M., Lees A., Turjanski N., Brooks D., Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system Brain 2005 128 6 1314 1322 (Pubitemid 40826185)
208. Frisina P. G., Haroutunian V., Libow L. S., The neuropathological basis for depression in Parkinson's disease Parkinsonism and Related Disorders 2009 15 2 144 148
209. Parkinson J. A., Robbins T. W., Everitt B. J., Dissociable roles of the central and basolateral amygdala in appetitive emotional learning European Journal of Neuroscience 2000 12 1 405 413 (Pubitemid 30068449)
210. Everitt B. J., Cardinal R. N., Parkinson J. A., Robbins T. W., Appetitive behavior: impact of amygdala-dependent mechanisms of emotional learning Annals of the New York Academy of Sciences 2003 985 233 250 (Pubitemid 36521118)
211. Kan Y., Kawamura M., Hasegawa Y., Mochizuki S., Nakamura K., Recognition of emotion from facial, prosodic and written verbal stimuli in Parkinson's disease Cortex 2002 38 4 623 630 (Pubitemid 35373459)
212. Yoshimura N., Kawamura M., Masaoka Y., Homma I., The amygdala of patients with Parkinson's disease is silent in response to fearful facial expressions Neuroscience 2005 131 2 523 534 (Pubitemid 40222459)
213. Ibarretxe-Bilbao N., Junque C., Tolosa E., Marti M. J., Valldeoriola F., Bargallo N., Zarei M., Neuroanatomical correlates of impaired decision-making and facial emotion recognition in early Parkinson's disease European Journal of Neuroscience 2009 30 6 1162 1171
214. Delaveau P., Salgado-Pineda P., Witjas T., Micallef-Roll J., Fakra E., Azulay J. P., Blin O., Dopaminergic modulation of amygdala activity during emotion recognition in patients with parkinson disease Journal of Clinical Psychopharmacology 2009 29 6 548 554