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Volumn 13, Issue 1, 2014, Pages 52-68

Understanding posttraumatic stress disorder: Insights from the methylome

Author keywords

Anxiety; CNS methylation; DNA hydroxymethylation; DNA methylation; Epigenetics; Posttraumatic stress disorder; PTSD animal models; Trauma associated methylation changes

Indexed keywords

ADDICTION; ANXIETY; ARTICLE; BRAIN FUNCTION; COGNITIVE DEFECT; CPG ISLAND; DISEASE PREDISPOSITION; DNA METHYLATION; ENVIRONMENTAL CHANGE; EPIGENETICS; FEAR; GENE EXPRESSION; GENETICS; HUMAN; LEARNING; MATERNAL DEPRIVATION; MEMORY; MENTAL DISEASE; MOOD DISORDER; NEUROLOGIC DISEASE; NONHUMAN; PERSONALIZED MEDICINE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; STRESS;

EID: 84891631360     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/gbb.12102     Document Type: Article
Times cited : (42)

References (173)
  • 2
    • 78650201378 scopus 로고    scopus 로고
    • DNA demethylating antineoplastic strategies: a comparative point of view
    • Amatori, S., Bagaloni, I., Donati, B. & Fanelli, M. (2010) DNA demethylating antineoplastic strategies: a comparative point of view. Genes Cancer 1, 197-209.
    • (2010) Genes Cancer , vol.1 , pp. 197-209
    • Amatori, S.1    Bagaloni, I.2    Donati, B.3    Fanelli, M.4
  • 3
    • 84891627151 scopus 로고    scopus 로고
    • American Psychiatric Association. () Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington, VA.
    • American Psychiatric Association. (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington, VA.
    • (2013)
  • 4
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    • Amir, R.E., Van den Veyver, I.B., Wan, M., Tran, C.Q., Francke, U. & Zoghbi, H.Y. (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23, 185-188.
    • (1999) Nat Genet , vol.23 , pp. 185-188
    • Amir, R.E.1    Van den Veyver, I.B.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 6
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: epigenetics joins genetics
    • Baylin, S.B. & Herman, J.G. (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16, 168-174.
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 7
    • 77349118985 scopus 로고    scopus 로고
    • Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample
    • Beach, S.R., Brody, G.H., Todorov, A.A., Gunter, T.D. & Philibert, R.A. (2010) Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. Am J Med Genet B Neuropsychiatr Genet 153B, 710-713.
    • (2010) Am J Med Genet B Neuropsychiatr Genet , vol.153 B , pp. 710-713
    • Beach, S.R.1    Brody, G.H.2    Todorov, A.A.3    Gunter, T.D.4    Philibert, R.A.5
  • 8
    • 77649104794 scopus 로고    scopus 로고
    • Reprogramming towards pluripotency requires AID-dependent DNA demethylation
    • Bhutani, N., Brady, J.J., Damian, M., Sacco, A., Corbel, S.Y. & Blau, H.M. (2010) Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 463, 1042-1057.
    • (2010) Nature , vol.463 , pp. 1042-1057
    • Bhutani, N.1    Brady, J.J.2    Damian, M.3    Sacco, A.4    Corbel, S.Y.5    Blau, H.M.6
  • 10
    • 3242663659 scopus 로고    scopus 로고
    • An integrated epigenetic and genetic approach to common human disease
    • Bjornsson, H.T., Fallin, M.D. & Feinberg, A.P. (2004) An integrated epigenetic and genetic approach to common human disease. Trends Genet 20, 350-358.
    • (2004) Trends Genet , vol.20 , pp. 350-358
    • Bjornsson, H.T.1    Fallin, M.D.2    Feinberg, A.P.3
  • 11
    • 34547677777 scopus 로고    scopus 로고
    • Fear conditioning in posttraumatic stress disorder: evidence for delayed extinction of autonomic, experiential, and behavioural responses
    • Blechert, J., Michael, T., Vriends, N., Margraf, J. & Wilhelm, F.H. (2007) Fear conditioning in posttraumatic stress disorder: evidence for delayed extinction of autonomic, experiential, and behavioural responses. Behav Res Ther 45, 2019-2033.
    • (2007) Behav Res Ther , vol.45 , pp. 2019-2033
    • Blechert, J.1    Michael, T.2    Vriends, N.3    Margraf, J.4    Wilhelm, F.H.5
  • 12
    • 0027476024 scopus 로고
    • A synaptic model of memory: long-term potentiation in the hippocampus
    • Bliss, T.V. & Collingridge, G.L. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39.
    • (1993) Nature , vol.361 , pp. 31-39
    • Bliss, T.V.1    Collingridge, G.L.2
  • 13
    • 83855163995 scopus 로고    scopus 로고
    • Uncovering the role of 5-hydroxymethylcytosine in the epigenome
    • Branco, M.R., Ficz, G. & Reik, W. (2012) Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet 13, 7-13.
    • (2012) Nat Rev Genet , vol.13 , pp. 7-13
    • Branco, M.R.1    Ficz, G.2    Reik, W.3
  • 14
    • 34247224239 scopus 로고    scopus 로고
    • Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear
    • Bredy, T.W., Wu, H., Crego, C., Zellhoefer, J., Sun, Y.E. & Barad, M. (2007) Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learn Mem 14, 268-276.
    • (2007) Learn Mem , vol.14 , pp. 268-276
    • Bredy, T.W.1    Wu, H.2    Crego, C.3    Zellhoefer, J.4    Sun, Y.E.5    Barad, M.6
  • 15
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron, E.E., Bachman, K.E., Myohanen, S., Herman, J.G. & Baylin, S.B. (1999) Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21, 103-107.
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 17
    • 43049156118 scopus 로고    scopus 로고
    • Epigenetic mechanisms and the transgenerational effects of maternal care
    • Champagne, F.A. (2008) Epigenetic mechanisms and the transgenerational effects of maternal care. Front Neuroendocrinol 29, 386-397.
    • (2008) Front Neuroendocrinol , vol.29 , pp. 386-397
    • Champagne, F.A.1
  • 19
    • 77953510470 scopus 로고    scopus 로고
    • DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2
    • Chertkow-Deutsher, Y., Cohen, H., Klein, E. & Ben-Shachar, D. (2010) DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2. Int J Neuropsychopharmacol 13, 347-359.
    • (2010) Int J Neuropsychopharmacol , vol.13 , pp. 347-359
    • Chertkow-Deutsher, Y.1    Cohen, H.2    Klein, E.3    Ben-Shachar, D.4
  • 20
    • 33744793463 scopus 로고    scopus 로고
    • ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning
    • Chwang, W.B., O'Riordan, K.J., Levenson, J.M. & Sweatt, J.D. (2006) ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning. Learn Mem 13, 322-328.
    • (2006) Learn Mem , vol.13 , pp. 322-328
    • Chwang, W.B.1    O'Riordan, K.J.2    Levenson, J.M.3    Sweatt, J.D.4
  • 23
    • 77956392717 scopus 로고    scopus 로고
    • Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies
    • Cornelis, M.C., Nugent, N.R., Amstadter, A.B. & Koenen, K.C. (2010) Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies. Curr Psychiatry Rep 12, 313-326.
    • (2010) Curr Psychiatry Rep , vol.12 , pp. 313-326
    • Cornelis, M.C.1    Nugent, N.R.2    Amstadter, A.B.3    Koenen, K.C.4
  • 24
    • 79952703947 scopus 로고    scopus 로고
    • Epigenetic modifications of brain and behavior: theory and practice
    • Crews, D. (2011) Epigenetic modifications of brain and behavior: theory and practice. Horm Behav 59, 393-398.
    • (2011) Horm Behav , vol.59 , pp. 393-398
    • Crews, D.1
  • 25
    • 80355145916 scopus 로고    scopus 로고
    • High sensitivity 5-hydroxymethylcytosine detection in Balb/C brain tissue
    • Davis, T. & Vaisvila, R. (2011) High sensitivity 5-hydroxymethylcytosine detection in Balb/C brain tissue. J Vis Exp 48, e2661.
    • (2011) J Vis Exp , vol.48
    • Davis, T.1    Vaisvila, R.2
  • 26
    • 77958580776 scopus 로고    scopus 로고
    • DNA methylation and memory formation
    • Day, J.J. & Sweatt, J.D. (2010) DNA methylation and memory formation. Nat Neurosci 13, 1319-1323.
    • (2010) Nat Neurosci , vol.13 , pp. 1319-1323
    • Day, J.J.1    Sweatt, J.D.2
  • 27
    • 34248370579 scopus 로고    scopus 로고
    • Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters
    • Dong, E., Guidotti, A., Grayson, D.R. & Costa, E. (2007) Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters. Proc Natl Acad Sci U S A 104, 4676-4681.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4676-4681
    • Dong, E.1    Guidotti, A.2    Grayson, D.R.3    Costa, E.4
  • 28
    • 33746724668 scopus 로고    scopus 로고
    • Effects of cytokines and infections on brain neurochemistry
    • Dunn, A.J. (2006) Effects of cytokines and infections on brain neurochemistry. Clin Neurosci Res 6, 52-68.
    • (2006) Clin Neurosci Res , vol.6 , pp. 52-68
    • Dunn, A.J.1
  • 30
    • 0035836010 scopus 로고    scopus 로고
    • Rett syndrome: clinical characteristics and recent genetic advances
    • Ellaway, C. & Christodoulou, J. (2001) Rett syndrome: clinical characteristics and recent genetic advances. Disabil Rehabil 23, 98-106.
    • (2001) Disabil Rehabil , vol.23 , pp. 98-106
    • Ellaway, C.1    Christodoulou, J.2
  • 31
    • 79952706987 scopus 로고    scopus 로고
    • Functional genomics of serotonin receptor 2A (HTR2A): interaction of polymorphism, methylation, expression and disease association
    • Falkenberg, V.R., Gurbaxani, B.M., Unger, E.R. & Rajeevan, M.S. (2011) Functional genomics of serotonin receptor 2A (HTR2A): interaction of polymorphism, methylation, expression and disease association. Neuromolecular Med 13, 66-76.
    • (2011) Neuromolecular Med , vol.13 , pp. 66-76
    • Falkenberg, V.R.1    Gurbaxani, B.M.2    Unger, E.R.3    Rajeevan, M.S.4
  • 32
    • 77950187447 scopus 로고    scopus 로고
    • Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
    • Feng, J., Zhou, Y., Campbell, S.L., Le, T., Li, E., Sweatt, J.D., Silva, A.J. & Fan, G. (2010) Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci 13, 423-430.
    • (2010) Nat Neurosci , vol.13 , pp. 423-430
    • Feng, J.1    Zhou, Y.2    Campbell, S.L.3    Le, T.4    Li, E.5    Sweatt, J.D.6    Silva, A.J.7    Fan, G.8
  • 34
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga, M.F., Ballestar, E., Paz, M.F. et al. (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 102, 10604-10609.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10604-10609
    • Fraga, M.F.1    Ballestar, E.2    Paz, M.F.3
  • 36
    • 0016670730 scopus 로고
    • Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity
    • Freeman, J.M., Finkelstein, J.D. & Mudd, S.H. (1975) Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5, 10-methylenetetrahydrofolate reductase activity. N Engl J Med 292, 491-496.
    • (1975) N Engl J Med , vol.292 , pp. 491-496
    • Freeman, J.M.1    Finkelstein, J.D.2    Mudd, S.H.3
  • 37
    • 0030883588 scopus 로고    scopus 로고
    • Posttraumatic stress disorder
    • Friedman, M.J. (1997) Posttraumatic stress disorder. J Clin Psychiatry 58 (Suppl. 9), 33-36.
    • (1997) J Clin Psychiatry , vol.58 , Issue.SUPPL. 9 , pp. 33-36
    • Friedman, M.J.1
  • 38
    • 0033988813 scopus 로고    scopus 로고
    • DNA methyltransferase Dnmt1 associates with histone deacetylase activity
    • Fuks, F., Burgers, W.A., Brehm, A., Hughes-Davies, L. & Kouzarides, T. (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet 24, 88-91.
    • (2000) Nat Genet , vol.24 , pp. 88-91
    • Fuks, F.1    Burgers, W.A.2    Brehm, A.3    Hughes-Davies, L.4    Kouzarides, T.5
  • 40
    • 67649867069 scopus 로고    scopus 로고
    • Epigenetic dysregulation in cognitive disorders
    • Graff, J. & Mansuy, I.M. (2009) Epigenetic dysregulation in cognitive disorders. Eur J Neurosci 30, 1-8.
    • (2009) Eur J Neurosci , vol.30 , pp. 1-8
    • Graff, J.1    Mansuy, I.M.2
  • 41
    • 0022432050 scopus 로고
    • The characteristics of DNA methylation in an in vitro DNA synthesizing system from mouse fibroblasts
    • Grafstrom, R.H., Yuan, R. & Hamilton, D.L. (1985) The characteristics of DNA methylation in an in vitro DNA synthesizing system from mouse fibroblasts. Nucleic Acids Res 13, 2827-2842.
    • (1985) Nucleic Acids Res , vol.13 , pp. 2827-2842
    • Grafstrom, R.H.1    Yuan, R.2    Hamilton, D.L.3
  • 42
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    • Guo, J.U., Su, Y., Zhong, C., Ming, G.L. & Song, H. (2011) Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145, 423-434.
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 43
    • 39249084254 scopus 로고    scopus 로고
    • Synaptic adhesion molecules and PSD-95
    • Han, K. & Kim, E. (2008) Synaptic adhesion molecules and PSD-95. Prog Neurobiol 84, 263-283.
    • (2008) Prog Neurobiol , vol.84 , pp. 263-283
    • Han, K.1    Kim, E.2
  • 44
    • 0038243168 scopus 로고    scopus 로고
    • The role of DNA methylation in setting up chromatin structure during development
    • Hashimshony, T., Zhang, J., Keshet, I., Bustin, M. & Cedar, H. (2003) The role of DNA methylation in setting up chromatin structure during development. Nat Genet 34, 187-192.
    • (2003) Nat Genet , vol.34 , pp. 187-192
    • Hashimshony, T.1    Zhang, J.2    Keshet, I.3    Bustin, M.4    Cedar, H.5
  • 45
    • 0035875146 scopus 로고    scopus 로고
    • The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
    • Heim, C. & Nemeroff, C.B. (2001) The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry 49, 1023-1039.
    • (2001) Biol Psychiatry , vol.49 , pp. 1023-1039
    • Heim, C.1    Nemeroff, C.B.2
  • 46
    • 13144306071 scopus 로고    scopus 로고
    • Genome-wide association studies for common diseases and complex traits
    • Hirschhorn, J.N. & Daly, M.J. (2005) Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 6, 95-108.
    • (2005) Nat Rev Genet , vol.6 , pp. 95-108
    • Hirschhorn, J.N.1    Daly, M.J.2
  • 47
    • 47749098274 scopus 로고    scopus 로고
    • How can we realize the promise of personalized antidepressant medicines?
    • Holsboer, F. (2008) How can we realize the promise of personalized antidepressant medicines? Nat Rev Neurosci 9, 638-646.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 638-646
    • Holsboer, F.1
  • 48
    • 0345412075 scopus 로고    scopus 로고
    • Synaptic plasticity and learning and memory: LTP and beyond
    • Holscher, C. (1999) Synaptic plasticity and learning and memory: LTP and beyond. J Neurosci Res 58, 62-75.
    • (1999) J Neurosci Res , vol.58 , pp. 62-75
    • Holscher, C.1
  • 49
    • 7644219666 scopus 로고    scopus 로고
    • Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids
    • Hubler, T.R. & Scammell, J.G. (2004) Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids. Cell Stress Chaperones 9, 243-252.
    • (2004) Cell Stress Chaperones , vol.9 , pp. 243-252
    • Hubler, T.R.1    Scammell, J.G.2
  • 50
    • 84875467145 scopus 로고    scopus 로고
    • Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development
    • Ichiyanagi, T., Ichiyanagi, K., Miyake, M. & Sasaki, H. (2013) Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development. Nucleic Acids Res 41, 738-745.
    • (2013) Nucleic Acids Res , vol.41 , pp. 738-745
    • Ichiyanagi, T.1    Ichiyanagi, K.2    Miyake, M.3    Sasaki, H.4
  • 52
    • 80054097425 scopus 로고    scopus 로고
    • Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos
    • Inoue, A. & Zhang, Y. (2011) Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science 334, 194.
    • (2011) Science , vol.334 , pp. 194
    • Inoue, A.1    Zhang, Y.2
  • 53
    • 79952763586 scopus 로고    scopus 로고
    • Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine
    • Iqbal, K., Jin, S.G., Pfeifer, G.P. & Szabo, P.E. (2011) Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A 108, 3642-3647.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3642-3647
    • Iqbal, K.1    Jin, S.G.2    Pfeifer, G.P.3    Szabo, P.E.4
  • 54
    • 0034015438 scopus 로고    scopus 로고
    • CpG-island methylation in aging and cancer
    • Issa, J.P. (2000) CpG-island methylation in aging and cancer. Curr Top Microbiol Immunol 249, 101-118.
    • (2000) Curr Top Microbiol Immunol , vol.249 , pp. 101-118
    • Issa, J.P.1
  • 55
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
    • Jaenisch, R. & Bird, A. (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33 (Suppl.), 245-254.
    • (2003) Nat Genet , vol.33 , Issue.SUPPL , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 56
    • 79960249232 scopus 로고    scopus 로고
    • Genomic mapping of 5-hydroxymethylcytosine in the human brain
    • Jin, S.G., Wu, X., Li, A.X. & Pfeifer, G.P. (2011) Genomic mapping of 5-hydroxymethylcytosine in the human brain. Nucleic Acids Res 39, 5015-5024.
    • (2011) Nucleic Acids Res , vol.39 , pp. 5015-5024
    • Jin, S.G.1    Wu, X.2    Li, A.X.3    Pfeifer, G.P.4
  • 57
    • 0032890965 scopus 로고    scopus 로고
    • The DNA methylation paradox
    • Jones, P.A. (1999) The DNA methylation paradox. Trends Genet 15, 34-37.
    • (1999) Trends Genet , vol.15 , pp. 34-37
    • Jones, P.A.1
  • 58
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: islands, start sites, gene bodies and beyond
    • Jones, P.A. (2012) Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 13, 484-492.
    • (2012) Nat Rev Genet , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 60
    • 0025312343 scopus 로고
    • Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial
    • Kagan, B.L., Sultzer, D.L., Rosenlicht, N. & Gerner, R.H. (1990) Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry 147, 591-595.
    • (1990) Am J Psychiatry , vol.147 , pp. 591-595
    • Kagan, B.L.1    Sultzer, D.L.2    Rosenlicht, N.3    Gerner, R.H.4
  • 64
    • 0031104930 scopus 로고    scopus 로고
    • DNA methylation directs a time-dependent repression of transcription initiation
    • Kass, S.U., Landsberger, N. & Wolffe, A.P. (1997) DNA methylation directs a time-dependent repression of transcription initiation. Curr Biol 7, 157-165.
    • (1997) Curr Biol , vol.7 , pp. 157-165
    • Kass, S.U.1    Landsberger, N.2    Wolffe, A.P.3
  • 65
    • 77649194621 scopus 로고    scopus 로고
    • Increased BDNF promoter methylation in the Wernicke area of suicide subjects
    • Keller, S., Sarchiapone, M., Zarrilli, F. et al. (2010) Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry 67, 258-267.
    • (2010) Arch Gen Psychiatry , vol.67 , pp. 258-267
    • Keller, S.1    Sarchiapone, M.2    Zarrilli, F.3
  • 66
    • 20344385026 scopus 로고    scopus 로고
    • Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
    • Kessler, R.C., Berglund, P., Demler, O., Jin, R., Merikangas, K.R. & Walters, E.E. (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62, 593-602.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 593-602
    • Kessler, R.C.1    Berglund, P.2    Demler, O.3    Jin, R.4    Merikangas, K.R.5    Walters, E.E.6
  • 71
    • 36348933468 scopus 로고    scopus 로고
    • Genetics of posttraumatic stress disorder: review and recommendations for future studies
    • Koenen, K.C. (2007) Genetics of posttraumatic stress disorder: review and recommendations for future studies. J Trauma Stress 20, 737-750.
    • (2007) J Trauma Stress , vol.20 , pp. 737-750
    • Koenen, K.C.1
  • 72
    • 77953565296 scopus 로고    scopus 로고
    • FKBP5 polymorphisms modify the effects of childhood trauma
    • Koenen, K.C. & Uddin, M. (2010) FKBP5 polymorphisms modify the effects of childhood trauma. Neuropsychopharmacology 35, 1623-1624.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1623-1624
    • Koenen, K.C.1    Uddin, M.2
  • 73
    • 79960968560 scopus 로고    scopus 로고
    • SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder
    • Koenen, K.C., Uddin, M., Chang, S.C., Aiello, A.E., Wildman, D.E., Goldmann, E. & Galea, S. (2011) SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder. Depress Anxiety 28, 639-647.
    • (2011) Depress Anxiety , vol.28 , pp. 639-647
    • Koenen, K.C.1    Uddin, M.2    Chang, S.C.3    Aiello, A.E.4    Wildman, D.E.5    Goldmann, E.6    Galea, S.7
  • 80
    • 84864129535 scopus 로고    scopus 로고
    • Distribution of 5-hydroxymethylcytosine in different human tissues
    • Li, W. & Liu, M. (2011) Distribution of 5-hydroxymethylcytosine in different human tissues. J Nucleic Acids 2011, 870726.
    • (2011) J Nucleic Acids , vol.2011 , pp. 870726
    • Li, W.1    Liu, M.2
  • 83
    • 0023657424 scopus 로고
    • Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation
    • Lock, L.F., Takagi, N. & Martin, G.R. (1987) Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation. Cell 48, 39-46.
    • (1987) Cell , vol.48 , pp. 39-46
    • Lock, L.F.1    Takagi, N.2    Martin, G.R.3
  • 84
    • 84881161107 scopus 로고    scopus 로고
    • A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus
    • Logue, M.W., Baldwin, C., Guffanti, G., Melista, E., Wolf, E.J., Reardon, A.F., Uddin, M., Wildman, D., Galea, S., Koenen, K.C. & Miller, M.W. (2013) A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus. Mol Psychiatry 18, 937-942.
    • (2013) Mol Psychiatry , vol.18 , pp. 937-942
    • Logue, M.W.1    Baldwin, C.2    Guffanti, G.3    Melista, E.4    Wolf, E.J.5    Reardon, A.F.6    Uddin, M.7    Wildman, D.8    Galea, S.9    Koenen, K.C.10    Miller, M.W.11
  • 85
    • 54949141718 scopus 로고    scopus 로고
    • G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells
    • Ma, D.K., Chiang, C.H., Ponnusamy, K., Ming, G.L. & Song, H. (2008) G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells 26, 2131-2141.
    • (2008) Stem Cells , vol.26 , pp. 2131-2141
    • Ma, D.K.1    Chiang, C.H.2    Ponnusamy, K.3    Ming, G.L.4    Song, H.5
  • 87
    • 0242300612 scopus 로고    scopus 로고
    • DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
    • Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G. & Sun, Y.E. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302, 890-893.
    • (2003) Science , vol.302 , pp. 890-893
    • Martinowich, K.1    Hattori, D.2    Wu, H.3    Fouse, S.4    He, F.5    Hu, Y.6    Fan, G.7    Sun, Y.E.8
  • 88
    • 77954504873 scopus 로고    scopus 로고
    • Conserved role of intragenic DNA methylation in regulating alternative promoters
    • Maunakea, A.K., Nagarajan, R.P., Bilenky, M. et al. (2010) Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 466, 253-257.
    • (2010) Nature , vol.466 , pp. 253-257
    • Maunakea, A.K.1    Nagarajan, R.P.2    Bilenky, M.3
  • 91
    • 84855939928 scopus 로고    scopus 로고
    • Gene x environment vulnerability factors for PTSD: the HPA-axis
    • Mehta, D. & Binder, E.B. (2012) Gene x environment vulnerability factors for PTSD: the HPA-axis. Neuropharmacology 62, 654-662.
    • (2012) Neuropharmacology , vol.62 , pp. 654-662
    • Mehta, D.1    Binder, E.B.2
  • 95
    • 34548319329 scopus 로고    scopus 로고
    • Molecular studies of major depressive disorder: the epigenetic perspective
    • Mill, J. & Petronis, A. (2007) Molecular studies of major depressive disorder: the epigenetic perspective. Mol Psychiatry 12, 799-814.
    • (2007) Mol Psychiatry , vol.12 , pp. 799-814
    • Mill, J.1    Petronis, A.2
  • 96
    • 33847614418 scopus 로고    scopus 로고
    • Covalent modification of DNA regulates memory formation
    • Miller, C.A. & Sweatt, J.D. (2007) Covalent modification of DNA regulates memory formation. Neuron 53, 857-869.
    • (2007) Neuron , vol.53 , pp. 857-869
    • Miller, C.A.1    Sweatt, J.D.2
  • 97
    • 79958071640 scopus 로고    scopus 로고
    • ICF syndrome mutations cause a broad spectrum of biochemical defects in DNMT3B-mediated de novo DNA methylation
    • Moarefi, A.H. & Chedin, F. (2011) ICF syndrome mutations cause a broad spectrum of biochemical defects in DNMT3B-mediated de novo DNA methylation. J Mol Biol 409, 758-772.
    • (2011) J Mol Biol , vol.409 , pp. 758-772
    • Moarefi, A.H.1    Chedin, F.2
  • 98
    • 21844466446 scopus 로고    scopus 로고
    • Pharmacology of 5-aza-2'-deoxycytidine (decitabine)
    • Momparler, R.L. (2005) Pharmacology of 5-aza-2'-deoxycytidine (decitabine). Semin Hematol 42, S9-S16.
    • (2005) Semin Hematol , vol.42
    • Momparler, R.L.1
  • 99
    • 0030064218 scopus 로고    scopus 로고
    • The long-term impact of the physical, emotional, and sexual abuse of children: a community study
    • Mullen, P.E., Martin, J.L., Anderson, J.C., Romans, S.E. & Herbison, G.P. (1996) The long-term impact of the physical, emotional, and sexual abuse of children: a community study. Child Abuse Negl 20, 7-21.
    • (1996) Child Abuse Negl , vol.20 , pp. 7-21
    • Mullen, P.E.1    Martin, J.L.2    Anderson, J.C.3    Romans, S.E.4    Herbison, G.P.5
  • 101
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan, X., Ng, H.H., Johnson, C.A., Laherty, C.D., Turner, B.M., Eisenman, R.N. & Bird, A. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389.
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6    Bird, A.7
  • 104
    • 0033856250 scopus 로고    scopus 로고
    • De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder
    • Orr, S.P., Metzger, L.J., Lasko, N.B., Macklin, M.L., Peri, T. & Pitman, R.K. (2000) De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. J Abnorm Psychol 109, 290-298.
    • (2000) J Abnorm Psychol , vol.109 , pp. 290-298
    • Orr, S.P.1    Metzger, L.J.2    Lasko, N.B.3    Macklin, M.L.4    Peri, T.5    Pitman, R.K.6
  • 106
    • 0015298215 scopus 로고
    • The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid
    • Penn, N.W., Suwalski, R., O'Riley, C., Bojanowski, K. & Yura, R. (1972) The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem J 126, 781-790.
    • (1972) Biochem J , vol.126 , pp. 781-790
    • Penn, N.W.1    Suwalski, R.2    O'Riley, C.3    Bojanowski, K.4    Yura, R.5
  • 107
    • 0001929132 scopus 로고    scopus 로고
    • Ethnicity, culture, and disaster response: identifying and explaining ethnic differences in PTSD six months after Hurricane Andrew
    • Perilla, J.L., Norris, F.H. & Lavizzo, E.A. (2002) Ethnicity, culture, and disaster response: identifying and explaining ethnic differences in PTSD six months after Hurricane Andrew. J Soc Clin Psychol 21, 20-45.
    • (2002) J Soc Clin Psychol , vol.21 , pp. 20-45
    • Perilla, J.L.1    Norris, F.H.2    Lavizzo, E.A.3
  • 108
    • 77249148019 scopus 로고    scopus 로고
    • Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
    • Popp, C., Dean, W., Feng, S.H., Cokus, S.J., Andrews, S., Pellegrini, M., Jacobsen, S.E. & Reik, W. (2010) Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature 463, 1101-1105.
    • (2010) Nature , vol.463 , pp. 1101-1105
    • Popp, C.1    Dean, W.2    Feng, S.H.3    Cokus, S.J.4    Andrews, S.5    Pellegrini, M.6    Jacobsen, S.E.7    Reik, W.8
  • 109
    • 79960649740 scopus 로고    scopus 로고
    • Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor
    • Radtke, K.M., Ruf, M., Gunter, H.M., Dohrmann, K., Schauer, M., Meyer, A. & Elbert, T. (2011) Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Transl Psychiatry 1, e21.
    • (2011) Transl Psychiatry , vol.1
    • Radtke, K.M.1    Ruf, M.2    Gunter, H.M.3    Dohrmann, K.4    Schauer, M.5    Meyer, A.6    Elbert, T.7
  • 110
    • 0034625064 scopus 로고    scopus 로고
    • Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
    • Ramsahoye, B.H., Biniszkiewicz, D., Lyko, F., Clark, V., Bird, A.P. & Jaenisch, R. (2000) Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci U S A 97, 5237-5242.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5237-5242
    • Ramsahoye, B.H.1    Biniszkiewicz, D.2    Lyko, F.3    Clark, V.4    Bird, A.P.5    Jaenisch, R.6
  • 111
    • 0032168678 scopus 로고    scopus 로고
    • CpG methylation, chromatin structure and gene silencing-a three-way connection
    • Razin, A. (1998) CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J 17, 4905-4908.
    • (1998) EMBO J , vol.17 , pp. 4905-4908
    • Razin, A.1
  • 112
    • 0028564741 scopus 로고
    • Homocysteinemia and schizophrenia as a case of methylation deficiency
    • Regland, B., Johansson, B.V. & Gottfries, C.G. (1994) Homocysteinemia and schizophrenia as a case of methylation deficiency. J Neural Transm Gen Sect 98, 143-152.
    • (1994) J Neural Transm Gen Sect , vol.98 , pp. 143-152
    • Regland, B.1    Johansson, B.V.2    Gottfries, C.G.3
  • 113
    • 0035093826 scopus 로고    scopus 로고
    • Evolution of imprinting mechanisms: the battle of the sexes begins in the zygote
    • Reik, W. & Walter, J. (2001) Evolution of imprinting mechanisms: the battle of the sexes begins in the zygote. Nat Genet 27, 255-256.
    • (2001) Nat Genet , vol.27 , pp. 255-256
    • Reik, W.1    Walter, J.2
  • 116
    • 0025145277 scopus 로고
    • 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes
    • Rideout, W.M. III, Coetzee, G.A., Olumi, A.F. & Jones, P.A. (1990) 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science 249, 1288-1290.
    • (1990) Science , vol.249 , pp. 1288-1290
    • Rideout III, W.M.1    Coetzee, G.A.2    Olumi, A.F.3    Jones, P.A.4
  • 117
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch, N. & Merikangas, K. (1996) The future of genetic studies of complex human diseases. Science 273, 1516-1517.
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 118
    • 78650309038 scopus 로고    scopus 로고
    • Race/ethnic differences in exposure to traumatic events, development of post-traumatic stress disorder, and treatment-seeking for post-traumatic stress disorder in the United States
    • Roberts, A.L., Gilman, S.E., Breslau, J., Breslau, N. & Koenen, K.C. (2011) Race/ethnic differences in exposure to traumatic events, development of post-traumatic stress disorder, and treatment-seeking for post-traumatic stress disorder in the United States. Psychol Med 41, 71-83.
    • (2011) Psychol Med , vol.41 , pp. 71-83
    • Roberts, A.L.1    Gilman, S.E.2    Breslau, J.3    Breslau, N.4    Koenen, K.C.5
  • 119
    • 79958765149 scopus 로고    scopus 로고
    • Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder
    • Roth, T.L., Zoladz, P.R., Sweatt, J.D. & Diamond, D.M. (2011) Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. J Psychiatr Res 45, 919-926.
    • (2011) J Psychiatr Res , vol.45 , pp. 919-926
    • Roth, T.L.1    Zoladz, P.R.2    Sweatt, J.D.3    Diamond, D.M.4
  • 120
    • 21244447049 scopus 로고    scopus 로고
    • Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies
    • Rudek, M.A., Zhao, M., He, P., Hartke, C., Gilbert, J., Gore, S.D., Carducci, M.A. & Baker, S.D. (2005) Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies. J Clin Oncol 23, 3906-3911.
    • (2005) J Clin Oncol , vol.23 , pp. 3906-3911
    • Rudek, M.A.1    Zhao, M.2    He, P.3    Hartke, C.4    Gilbert, J.5    Gore, S.D.6    Carducci, M.A.7    Baker, S.D.8
  • 121
    • 84863155171 scopus 로고    scopus 로고
    • DNA methylation in repetitive elements and post-traumatic stress disorder: a case-control study of US military service members
    • Rusiecki, J.A., Chen, L., Srikantan, V., Zhang, L., Yan, L., Polin, M.L. & Baccarelli, A. (2012) DNA methylation in repetitive elements and post-traumatic stress disorder: a case-control study of US military service members. Epigenomics 4, 29-40.
    • (2012) Epigenomics , vol.4 , pp. 29-40
    • Rusiecki, J.A.1    Chen, L.2    Srikantan, V.3    Zhang, L.4    Yan, L.5    Polin, M.L.6    Baccarelli, A.7
  • 122
    • 84891625016 scopus 로고    scopus 로고
    • Epigenetic mechanisms of gene regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • Russo, V.E.A., Martienssen, R.A. & Riggs, A.D. (1996) Epigenetic mechanisms of gene regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1996)
    • Russo, V.E.A.1    Martienssen, R.A.2    Riggs, A.D.3
  • 123
    • 0014947385 scopus 로고
    • Methylation of mouse DNA in vivo: di- and tripyrimidine sequences containing 5-methylcytosine
    • Salomon, R. & Kaye, A.M. (1970) Methylation of mouse DNA in vivo: di- and tripyrimidine sequences containing 5-methylcytosine. Biochim Biophys Acta 204, 340-351.
    • (1970) Biochim Biophys Acta , vol.204 , pp. 340-351
    • Salomon, R.1    Kaye, A.M.2
  • 124
    • 38349100549 scopus 로고    scopus 로고
    • Epigenetic events in mammalian germ-cell development: reprogramming and beyond
    • Sasaki, H. & Matsui, Y. (2008) Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat Rev Genet 9, 129-140.
    • (2008) Nat Rev Genet , vol.9 , pp. 129-140
    • Sasaki, H.1    Matsui, Y.2
  • 125
    • 18444386162 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors
    • Segman, R.H., Shefi, N., Goltser-Dubner, T., Friedman, N., Kaminski, N. & Shalev, A.Y. (2005) Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol Psychiatry 10, 500-513 425.
    • (2005) Mol Psychiatry , vol.10
    • Segman, R.H.1    Shefi, N.2    Goltser-Dubner, T.3    Friedman, N.4    Kaminski, N.5    Shalev, A.Y.6
  • 126
    • 84876820776 scopus 로고    scopus 로고
    • Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases
    • Shirane, K., Toh, H., Kobayashi, H., Miura, F., Chiba, H., Ito, T., Kono, T. & Sasaki, H. (2013) Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases. PLoS Genet 9, e1003439.
    • (2013) PLoS Genet , vol.9
    • Shirane, K.1    Toh, H.2    Kobayashi, H.3    Miura, F.4    Chiba, H.5    Ito, T.6    Kono, T.7    Sasaki, H.8
  • 128
    • 17844373572 scopus 로고    scopus 로고
    • Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
    • Silverman, M.N., Pearce, B.D., Biron, C.A. & Miller, A.H. (2005) Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection. Viral Immunol 18, 41-78.
    • (2005) Viral Immunol , vol.18 , pp. 41-78
    • Silverman, M.N.1    Pearce, B.D.2    Biron, C.A.3    Miller, A.H.4
  • 129
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
    • Silverman, L.R., McKenzie, D.R., Peterson, B.L., Holland, J.F., Backstrom, J.T., Beach, C.L. & Larson, R.A. (2006) Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 24, 3895-3903.
    • (2006) J Clin Oncol , vol.24 , pp. 3895-3903
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3    Holland, J.F.4    Backstrom, J.T.5    Beach, C.L.6    Larson, R.A.7
  • 130
  • 131
    • 0032231652 scopus 로고    scopus 로고
    • Rett syndrome: confirmation of X-linked dominant inheritance, and localization of the gene to Xq28
    • Sirianni, N., Naidu, S., Pereira, J., Pillotto, R.F. & Hoffman, E.P. (1998) Rett syndrome: confirmation of X-linked dominant inheritance, and localization of the gene to Xq28. Am J Hum Genet 63, 1552-1558.
    • (1998) Am J Hum Genet , vol.63 , pp. 1552-1558
    • Sirianni, N.1    Naidu, S.2    Pereira, J.3    Pillotto, R.F.4    Hoffman, E.P.5
  • 133
    • 33847377099 scopus 로고    scopus 로고
    • Specific targeting of cytosine methylation to DNA sequences in vivo
    • Smith, A.E. & Ford, K.G. (2007) Specific targeting of cytosine methylation to DNA sequences in vivo. Nucleic Acids Res 35, 740-754.
    • (2007) Nucleic Acids Res , vol.35 , pp. 740-754
    • Smith, A.E.1    Ford, K.G.2
  • 138
    • 34447134211 scopus 로고    scopus 로고
    • Novel therapeutics for schizophrenia: targeting glycine modulation of NMDA glutamate receptors
    • Stahl, S.M. (2007) Novel therapeutics for schizophrenia: targeting glycine modulation of NMDA glutamate receptors. CNS Spectr 12, 423-427.
    • (2007) CNS Spectr , vol.12 , pp. 423-427
    • Stahl, S.M.1
  • 139
    • 77953579241 scopus 로고    scopus 로고
    • Fooling mother nature: epigenetics and novel treatments for psychiatric disorders
    • Stahl, S.M. (2010) Fooling mother nature: epigenetics and novel treatments for psychiatric disorders. CNS Spectr 15, 358-365.
    • (2010) CNS Spectr , vol.15 , pp. 358-365
    • Stahl, S.M.1
  • 140
    • 33645284772 scopus 로고    scopus 로고
    • Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
    • Sternberg, E.M. (2006) Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nat Rev Immunol 6, 318-328.
    • (2006) Nat Rev Immunol , vol.6 , pp. 318-328
    • Sternberg, E.M.1
  • 141
    • 0012959217 scopus 로고    scopus 로고
    • Aberrant DNA methylation in cancer: potential clinical interventions
    • Strathdee, G. & Brown, R. (2002) Aberrant DNA methylation in cancer: potential clinical interventions. Expert Rev Mol Med 4, 1-17.
    • (2002) Expert Rev Mol Med , vol.4 , pp. 1-17
    • Strathdee, G.1    Brown, R.2
  • 142
    • 84870184296 scopus 로고    scopus 로고
    • Genetic deletion of Gadd45b, a regulator of active DNA demethylation, enhances long-term memory and synaptic plasticity
    • Sultan, F.A., Wang, J., Tront, J., Liebermann, D.A. & Sweatt, J.D. (2012) Genetic deletion of Gadd45b, a regulator of active DNA demethylation, enhances long-term memory and synaptic plasticity. J Neurosci 32, 17059-17066.
    • (2012) J Neurosci , vol.32 , pp. 17059-17066
    • Sultan, F.A.1    Wang, J.2    Tront, J.3    Liebermann, D.A.4    Sweatt, J.D.5
  • 143
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: provocative insights from epigenomics
    • Suzuki, M.M. & Bird, A. (2008) DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9, 465-476.
    • (2008) Nat Rev Genet , vol.9 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 144
    • 65249157050 scopus 로고    scopus 로고
    • Epigenetics, DNA methylation, and chromatin modifying drugs
    • Szyf, M. (2009) Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 49, 243-263.
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 243-263
    • Szyf, M.1
  • 145
    • 28844440383 scopus 로고    scopus 로고
    • Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat
    • Szyf, M., Weaver, I.C., Champagne, F.A., Diorio, J. & Meaney, M.J. (2005) Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat. Front Neuroendocrinol 26, 139-162.
    • (2005) Front Neuroendocrinol , vol.26 , pp. 139-162
    • Szyf, M.1    Weaver, I.C.2    Champagne, F.A.3    Diorio, J.4    Meaney, M.J.5
  • 147
    • 0022374246 scopus 로고
    • Cellular differentiation
    • Taylor, S.M. & Jones, P.A. (1985) Cellular differentiation. Int J Obes 9 (Suppl. 1), 15-21.
    • (1985) Int J Obes , vol.9 , Issue.SUPPL. 1 , pp. 15-21
    • Taylor, S.M.1    Jones, P.A.2
  • 149
    • 33645357786 scopus 로고    scopus 로고
    • Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
    • Tsankova, N.M., Berton, O., Renthal, W., Kumar, A., Neve, R.L. & Nestler, E.J. (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9, 519-525.
    • (2006) Nat Neurosci , vol.9 , pp. 519-525
    • Tsankova, N.M.1    Berton, O.2    Renthal, W.3    Kumar, A.4    Neve, R.L.5    Nestler, E.J.6
  • 150
    • 31544456085 scopus 로고    scopus 로고
    • The role of mammalian DNA methyltransferases in the regulation of gene expression
    • Turek-Plewa, J. & Jagodzinski, P.P. (2005) The role of mammalian DNA methyltransferases in the regulation of gene expression. Cell Mol Biol Lett 10, 631-647.
    • (2005) Cell Mol Biol Lett , vol.10 , pp. 631-647
    • Turek-Plewa, J.1    Jagodzinski, P.P.2
  • 151
    • 0036850325 scopus 로고    scopus 로고
    • Cellular memory and the histone code
    • Turner, B.M. (2002) Cellular memory and the histone code. Cell 111, 285-291.
    • (2002) Cell , vol.111 , pp. 285-291
    • Turner, B.M.1
  • 153
    • 33847055935 scopus 로고    scopus 로고
    • Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1
    • Valinluck, V. & Sowers, L.C. (2007) Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res 67, 946-950.
    • (2007) Cancer Res , vol.67 , pp. 946-950
    • Valinluck, V.1    Sowers, L.C.2
  • 154
    • 0020691216 scopus 로고
    • Comparison of transformation efficiency of human active and inactive X-chromosomal DNA
    • Venolia, L. & Gartler, S.M. (1983) Comparison of transformation efficiency of human active and inactive X-chromosomal DNA. Nature 302, 82-83.
    • (1983) Nature , vol.302 , pp. 82-83
    • Venolia, L.1    Gartler, S.M.2
  • 155
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • Venter, J.C., Adams, M.D., Myers, E.W. et al. (2001) The sequence of the human genome. Science 291, 1304-1351.
    • (2001) Science , vol.291 , pp. 1304-1351
    • Venter, J.C.1    Adams, M.D.2    Myers, E.W.3
  • 156
    • 0036025164 scopus 로고    scopus 로고
    • Circuits and systems in stress. II. Applications to neurobiology and treatment in posttraumatic stress disorder
    • Vermetten, E. & Bremner, J.D. (2002) Circuits and systems in stress. II. Applications to neurobiology and treatment in posttraumatic stress disorder. Depress Anxiety 16, 14-38.
    • (2002) Depress Anxiety , vol.16 , pp. 14-38
    • Vermetten, E.1    Bremner, J.D.2
  • 157
    • 0036932871 scopus 로고    scopus 로고
    • From maternal care to gene expression: DNA methylation and the maternal programming of stress responses
    • Weaver, I.C., Szyf, M. & Meaney, M.J. (2002) From maternal care to gene expression: DNA methylation and the maternal programming of stress responses. Endocr Res 28, 699.
    • (2002) Endocr Res , vol.28 , pp. 699
    • Weaver, I.C.1    Szyf, M.2    Meaney, M.J.3
  • 159
    • 28044436691 scopus 로고    scopus 로고
    • Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life
    • Weaver, I.C., Champagne, F.A., Brown, S.E., Dymov, S., Sharma, S., Meaney, M.J. & Szyf, M. (2005) Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J Neurosci 25, 11045-11054.
    • (2005) J Neurosci , vol.25 , pp. 11045-11054
    • Weaver, I.C.1    Champagne, F.A.2    Brown, S.E.3    Dymov, S.4    Sharma, S.5    Meaney, M.J.6    Szyf, M.7
  • 160
    • 33644763991 scopus 로고    scopus 로고
    • Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
    • Weaver, I.C., Meaney, M.J. & Szyf, M. (2006) Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc Natl Acad Sci U S A 103, 3480-3485.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3480-3485
    • Weaver, I.C.1    Meaney, M.J.2    Szyf, M.3
  • 161
    • 0033017734 scopus 로고    scopus 로고
    • Childhood sexual abuse as a risk factor for depression in women: psychosocial and neurobiological correlates
    • Weiss, E.L., Longhurst, J.G. & Mazure, C.M. (1999) Childhood sexual abuse as a risk factor for depression in women: psychosocial and neurobiological correlates. Am J Psychiatry 156, 816-828.
    • (1999) Am J Psychiatry , vol.156 , pp. 816-828
    • Weiss, E.L.1    Longhurst, J.G.2    Mazure, C.M.3
  • 162
    • 1042272175 scopus 로고
    • Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation
    • Wolf, S.F., Jolly, D.J., Lunnen, K.D., Friedmann, T. & Migeon, B.R. (1984) Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation. Proc Natl Acad Sci U S A 81, 2806-2810.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 2806-2810
    • Wolf, S.F.1    Jolly, D.J.2    Lunnen, K.D.3    Friedmann, T.4    Migeon, B.R.5
  • 163
    • 0036310798 scopus 로고    scopus 로고
    • Post-traumatic stress disorder: advances in psychoneuroimmunology
    • vii.
    • Wong, C.M. (2002) Post-traumatic stress disorder: advances in psychoneuroimmunology. Psychiatr Clin North Am 25, 369-383 vii.
    • (2002) Psychiatr Clin North Am , vol.25 , pp. 369-383
    • Wong, C.M.1
  • 164
    • 0032769445 scopus 로고    scopus 로고
    • Cloning, expression and chromosome locations of the human DNMT3 gene family
    • Xie, S., Wang, Z., Okano, M., Nogami, M., Li, Y., He, W.W., Okumura, K. & Li, E. (1999) Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene 236, 87-95.
    • (1999) Gene , vol.236 , pp. 87-95
    • Xie, S.1    Wang, Z.2    Okano, M.3    Nogami, M.4    Li, Y.5    He, W.W.6    Okumura, K.7    Li, E.8
  • 165
    • 84857331867 scopus 로고    scopus 로고
    • Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome
    • Xie, W., Barr, C.L., Kim, A., Yue, F., Lee, A.Y., Eubanks, J., Dempster, E.L. & Ren, B. (2012) Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome. Cell 148, 816-831.
    • (2012) Cell , vol.148 , pp. 816-831
    • Xie, W.1    Barr, C.L.2    Kim, A.3    Yue, F.4    Lee, A.Y.5    Eubanks, J.6    Dempster, E.L.7    Ren, B.8
  • 166
    • 84885424758 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder
    • Xie, P., Kranzler, H.R., Yang, C., Zhao, H., Farrer, L.A. & Gelernter, J. (2013) Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder. Biol Psychiatry 74, 656-663.
    • (2013) Biol Psychiatry , vol.74 , pp. 656-663
    • Xie, P.1    Kranzler, H.R.2    Yang, C.3    Zhao, H.4    Farrer, L.A.5    Gelernter, J.6
  • 167
    • 84859582204 scopus 로고    scopus 로고
    • Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5
    • Yang, X., Ewald, E.R., Huo, Y., Tamashiro, K.L., Salvatori, R., Sawa, A., Wand, G.S. & Lee, R.S. (2012) Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5. Biochem Biophys Res Commun 420, 570-575.
    • (2012) Biochem Biophys Res Commun , vol.420 , pp. 570-575
    • Yang, X.1    Ewald, E.R.2    Huo, Y.3    Tamashiro, K.L.4    Salvatori, R.5    Sawa, A.6    Wand, G.S.7    Lee, R.S.8
  • 168
    • 74549164152 scopus 로고    scopus 로고
    • The relevance of epigenetics to PTSD: implications for the DSM-V
    • Yehuda, R. & Bierer, L.M. (2009) The relevance of epigenetics to PTSD: implications for the DSM-V. J Trauma Stress 22, 427-434.
    • (2009) J Trauma Stress , vol.22 , pp. 427-434
    • Yehuda, R.1    Bierer, L.M.2
  • 169
    • 34748854338 scopus 로고    scopus 로고
    • Response variation following trauma: a translational neuroscience approach to understanding PTSD
    • Yehuda, R. & LeDoux, J. (2007) Response variation following trauma: a translational neuroscience approach to understanding PTSD. Neuron 56, 19-32.
    • (2007) Neuron , vol.56 , pp. 19-32
    • Yehuda, R.1    LeDoux, J.2
  • 170
    • 78649316753 scopus 로고    scopus 로고
    • Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD
    • Yehuda, R., Flory, J.D., Pratchett, L.C., Buxbaum, J., Ising, M. & Holsboer, F. (2010) Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD. Psychopharmacology (Berl) 212, 405-417.
    • (2010) Psychopharmacology (Berl) , vol.212 , pp. 405-417
    • Yehuda, R.1    Flory, J.D.2    Pratchett, L.C.3    Buxbaum, J.4    Ising, M.5    Holsboer, F.6
  • 171
    • 0030840954 scopus 로고    scopus 로고
    • Cytosine methylation and the ecology of intragenomic parasites
    • Yoder, J.A., Walsh, C.P. & Bestor, T.H. (1997) Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 13, 335-340.
    • (1997) Trends Genet , vol.13 , pp. 335-340
    • Yoder, J.A.1    Walsh, C.P.2    Bestor, T.H.3
  • 172
    • 0033180082 scopus 로고    scopus 로고
    • Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
    • Zhang, Y., Ng, H.H., Erdjument-Bromage, H., Tempst, P., Bird, A. & Reinberg, D. (1999) Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev 13, 1924-1935.
    • (1999) Genes Dev , vol.13 , pp. 1924-1935
    • Zhang, Y.1    Ng, H.H.2    Erdjument-Bromage, H.3    Tempst, P.4    Bird, A.5    Reinberg, D.6


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