DNA methylation in repetitive elements and post-traumatic stress disorder: A case-control study of US military service members

Epigenomics

Volumn 4, Issue 1, 2012, Pages 29-40

  Rusiecki, Jennifer A ^a   Chen, Ligong ^a   Srikantan, Vasantha ^a   Zhang, Lei ^a   Yan, Liying ^b   Polin, Matthew L ^b   Baccarelli, Andrea ^c  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b EpigenDx Inc   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Alu; combat; DNA methylation; epigenetics; LINE 1; Operation Enduring Freedom; Operation Iraqi Freedom; post traumatic stress disorder; repetitive element

Indexed keywords

DNA;

ADULT; AFGHANISTAN; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA METHYLATION; FEMALE; HUMAN; INTERSPERSED REPEAT; IRAQ; MALE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PYROSEQUENCING; SOLDIER; UNITED STATES; WAR;

ADULT; ALU ELEMENTS; CASE-CONTROL STUDIES; DNA; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; HUMANS; LOGISTIC MODELS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MALE; MILITARY PERSONNEL; ODDS RATIO; SEQUENCE ANALYSIS, DNA; STRESS DISORDERS, POST-TRAUMATIC; UNITED STATES; YOUNG ADULT;

EID: 84863155171     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.11.116     Document Type: Article

References (58)

1. Hoge C, Castro C, Messer SC, McGurk D, Cotting D, Koffman R. Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care. N. Engl. J. Med. 351, 13-22 (2004). (Pubitemid 38857243)
2. Segman R, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, Shalev A. Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol. Psychiatry 10, 500-513 (2005). (Pubitemid 40646438)
3. Zieker J, Zieker D, Jatzko A et al. Differential gene epxression in peripheral blood of patients suffering from post-traumatic stress disorder, letter to the editor. Mol. Psychiatry 12, 116-119 (2007).
4. Uddin M, Aiello A, Wildman D et al. Epigenetic and immune function profiles associated with posttraumatic stress disorder. Proc. Natl Acad. Sci. 107(20), 9470-9475 (2010).
5. Kuratomi G, Iwamoto K, Bundo M et al. Aberrant DNA methyltaion associated with bipolar disorder identified from discordant monozygotic twins. Mol. Psychiatry 13(4), 429-441 (2007).
6. Tamura Y, Kunugi H, Ohashi J, Hohjoh H. Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol. Psychiatry 12, 593-600 (2007). (Pubitemid 46816771)
7. Bollati V, Galimberti D, Pergoli L et al. DNA methylation in repetitive elements and Alzheimer disease. Brain Behav. Immun. 25(6), 1078-1083 (2011).
8. Levenson J, Sweatt J. Epigenetic mechanisms: a common theme in vertebrate and invertebrate memory formation. Cell Mol. Life Sci. 63(9), 1009-1016 (2006). (Pubitemid 43800770)
9. Sananbenesi F, Fischer A. The epigenetic bottleneck of neurodegenerative and psychiatric diseases. Biol. Chem. 390(11), 1145-1153 (2009).
10. Urdinguio RG, Sanchez-Mut JV, Esteller M. Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol. 8(11), 1056-1072 (2009).
11. Zawia NH, Lahiri DK, Cardozo-Pelaez F. Epigenetics, oxidative stress, and Alzheimer disease. Free Radic. Biol. Med. 46(9), 1241-1249 (2009).
12. Rollins RA, Haghighi F, Edwards JR et al. Large-scale structure of genomic methylation patterns. Genome Res. 16(2), 157-163 (2006). (Pubitemid 43200263)
13. Suzuki MM, Bird A. DNA methylation landscapes: provocative insights from epigenomics. Nat. Rev. Genet. 9(6), 465-476 (2008). (Pubitemid 351693975)
14. Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 21(35), 5400-5413 (2002). (Pubitemid 34983477)
15. Lander ES, Linton LM, Birren B et al. Initial sequencing and analysis of the human genome. Nature 409(6822), 860-921 (2001). (Pubitemid 32165345)
16. Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res. 32(3), e38 (2004).
17. Robertson KD. DNA methylation and human disease. Natre Rev. Genet. 6, 597-610 (2005). (Pubitemid 41044297)
18. Moore LE, Huang WY, Chung J, Hayes RB. Epidemiologic considerations to assess altered DNA methylation from environmental exposures in cancer. Ann. NY Acad. Sci. 983, 181-196 (2003). (Pubitemid 36399331)
19. Dean W, Lucifero D, Santos F. DNA methylation in mammalian development and disease. Birth Defects Res. C Embryo Today 75(2), 98-111 (2005). (Pubitemid 41153675)
20. Capomaccio S, Verini-Supplizi A, Galla G et al. Transcription of LINE-derived sequences in exercise-induced stress in horses. Anim. Genet. 41(Suppl. 2), 23-27 (2010).
21. Li TH, Schmid CW. Differential stress induction of individual Alu loci: implications for transcription and retrotransposition. Gene 276(1-2), 135-141 (2001). (Pubitemid 32925268)
22. Baccarelli A, Wright R, Bollati V et al. Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology 21(6), 819-828 (2010).
23. Cash HL, Tao L, Yuan JM et al. LINE 1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese. Int. J. Cancer 28(10), 26098 (2011).
24. Fabris S, Bollati V, Agnelli L et al. Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia. Epigenetics 6(2), 188-194 (2011).
25. Kile ML, Baccarelli A, Tarantini L, Hoffman E, Wright RO, Christiani DC. Correlation of global and gene-specific DNA methylation in maternal-infant pairs. PLoS ONE 5(10), e13730 (2010).
26. Madrigano J, Baccarelli A, Mittleman MA et al. Prolonged exposure to particulate pollution, genes associated with glutathione pathways, and DNA methylation in a cohort of older men. Environ. Health Perspect. 8, 8 (2011).
27. Zhu ZZ, Hou L, Bollati V et al. Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int. J. Epidemiol. doi:10.1093/ije/dyq154 (2010) (Epub ahead of print).
28. Dunn BK. Hypomethylation: one side of a larger picture. Ann. NY Acad. Sci. 983, 28-42 (2003). (Pubitemid 36399318)
29. Gaudet F, Hodgson G, Eden A et al. Induction of tumors in mice by genomic hypomethylation. Science 300(5618), 489-492 (2003). (Pubitemid 36444330)
30. Bredy T. Behavioural epigenetics and psychiatric disorders. Med. Hypotheses 68(2), 453 (2007). (Pubitemid 44883329)
31. Bollati V, Baccarelli A, Sartori S et al. Epigenetic effects of shiftwork on blood DNA methylation. Chronobiol. Int. 27(5), 1093-1104 (2010).
32. Schulz W, Steinhoff C, Florl A. Methylation of endogenous human retroelements in health and disease. Curr. Top. Microbiol. Immunol. 310, 211-250 (2006). (Pubitemid 47400292)
33. Yehuda R, Ledoux J. Response variation following trauma: a translational neuroscience approach to understanding PTSD. Neuron 56(1), 19-32 (2007). (Pubitemid 47484180)
34. Ressler KJ, Mercer KB, Bradley B et al. Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature 470(7335), 492-497 (2011).
35. Trollope AF, Gutierrez-Mecinas M, Mifsud KR, Collins A, Saunderson EA, Reul JM. Stress, epigenetic control of gene expression and memory formation. Exp. Neurol. doi:10.1016/j.expneurol.2011.03.022 (2011) (Epub ahead of print).
36. Uddin M, Galea S, Chang SC et al. Gene expression and methylation signatures of MAN2C1 are associated with PTSD. Dis. Markers 30(2-3), 111-121 (2011).
37. Koenen KC, Uddin M, Chang SC et al. SLC6A4 methylation modifies the effect of the number of traumatic events on risk for post traumatic stress disorder. Depress. Anxiety 28(8), 639-647 (2011).
38. Johnson PJ. A framework for the molecular classification of circulating tumor markers. Ann. NY Acad. Sci. 945, 8-21 (2001). (Pubitemid 33022427)
39. Abbaszadegan MR, Moaven O, Sima HR et al. p16 promoter hypermethylation: a useful serum marker for early detection of gastric cancer. World J. Gastroenterol. 14(13), 2055-2060 (2008). (Pubitemid 351795826)
40. An Q, Liu Y, Gao Y et al. Detection of p16 hypermethylation in circulating plasma DNA of non-small cell lung cancer patients. Cancer Lett. 188(1-2), 109-114 (2002). (Pubitemid 35292336)
41. Bastian PJ, Palapattu GS, Lin X et al. Preoperative serum DNA GSTP1 CpG island hypermethylation and the risk of early prostate-specific antigen recurrence following radical prostatectomy. Clin. Cancer Res. 11(11), 4037-4043 (2005). (Pubitemid 40791567)
42. Hsu HS, Chen TP, Hung CH et al. Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma. Cancer 110(9), 2019-2026 (2007).
43. Lavon I, Refael M, Zelikovitch B, Shalom E, Siegal T. Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades. Neuro. Oncol. 12(2), 173-180 (2010).
44. Leung WK, To KF, Chu ES et al. Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer. Br. J. Cancer 92(12), 2190-2194. (2005). (Pubitemid 40966256)
45. Reibenwein J, Pils D, Horak P et al. Promoter hypermethylation of GSTP1, AR, and 14-13-3sigma in serum of prostate cancer patients and its clinical relevance. Prostate 67(4), 427-432 (2007). (Pubitemid 46341084)
46. Tan SH, Ida H, Lau QC et al. Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3. Oncol. Rep. 18(5), 1225-1230 (2007).
47. Ulivi P, Zoli W, Calistri D et al. p16INK4A and CDH13 hypermethylation in tumor and serum of non-small cell lung cancer patients. J. Cell. Physiol. 206(3), 611-615 (2006). (Pubitemid 43191035)
48. Wakabayashi T, Natsume A, Hatano H et al. p16 promoter methylation in the serum as a basis for the molecular diagnosis of gliomas. Neurosurgery 64(3), 455-461, discussion 461-452 (2009).
49. Wang YC, Yu ZH, Liu C et al. Detection of RASSF1A promoter hypermethylation in serum from gastric and colorectal adenocarcinoma patients. World J. Gastroenterol. 14(19), 3074-3080 (2008).
50. Atamaniuk J, Hsiao YY, Mustak M et al. Analysing cell-free plasma DNA and SLE disease activity. Eur. J. Clin. Invest. 41(6), 579-583 (2011).
51. Koffler D, Agnello V, Winchester R, Kunkel HG. The occurrence of single-stranded DNA in the serum of patients with systemic lupus erythematosus and other diseases. J. Clin. Invest. 52(1), 198-204 (1973).
52. Leon SA, Ehrlich GE, Shapiro B, Labbate VA. Free DNA in the serum of rheumatoid arthritis patients. J. Rheumatol. 4(2), 139-143 (1977).
53. Shapiro B, Chakrabarty M, Cohn EM, Leon SA. Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease. Cancer 51(11), 2116-2120 (1983). (Pubitemid 13092467)
54. Fenech M. The role of folic acid and vitamin B12 in genomic stability of human cells. Mutat. Res. 475, 57-67 (2001). (Pubitemid 32280803)
55. Piyathilake CJ, Johanning GL. Cellular vitamins, DNA methylation and cancer risk. J. Nutr. 132(Suppl. 8), 2340S-2344S (2002). (Pubitemid 34848104)
56. Toh Y, Oki E, Ohgaki K et al. Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis. Int. J. Clin. Oncol. 15(2), 135-144 (2010).
57. Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat. Rev. Cancer 7(8), 599-612 (2007). (Pubitemid 47106631)
58. Schulz W. L1 retrotransposons in human cancers. J. Biomed. Biotechnol. 2006(83672), 1-12 (2006).