Gene × environment vulnerability factors for PTSD: The HPA-axis

Neuropharmacology

Volumn 62, Issue 2, 2012, Pages 654-662

  Mehta, Divya ^a   Binder, Elisabeth B ^a,b  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gene environment interaction; PTSD

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; MESSENGER RNA; STRESS HORMONE;

BIOLOGICAL TRAIT; CHILD PARENT RELATION; CRHR1 GENE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DNA METHYLATION; DNA MODIFICATION; ENVIRONMENTAL STRESS; EPIGENETICS; FKBP5 GENE; GENE; GENE CONTROL; GENE EXPRESSION PROFILING; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HETEROZYGOTE; HORMONE SENSITIVITY; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SEROTONIN TRANSPORTER GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; PITUITARY-ADRENAL SYSTEM; RISK FACTORS; STRESS DISORDERS, POST-TRAUMATIC;

EID: 84855939928     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.03.009     Document Type: Review

References (119)

1. A.W. Bachmann Glucocorticoid receptor polymorphisms and post-traumatic stress disorder Psychoneuroendocrinology 30 3 2005 297 306
2. C.E. Bearden, and N.B. Freimer Endophenotypes for psychiatric disorders: ready for primetime? Trends Genet. 22 6 2006 306 313
3. E.B. Binder Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment Nat. Genet. 36 12 2004 1319 1325
4. E.B. Binder Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults JAMA 299 11 2008 1291 1305
5. E.B. Binder Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response Arch. Gen. Psychiatry 67 4 2010 369 379
6. E.B. Binder The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders Psychoneuroendocrinology 34 Suppl. 1 2009 S186 S195
7. R.G. Bradley Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene Arch. Gen. Psychiatry 65 2 2008 190 200
8. N. Breslau Trauma and posttraumatic stress disorder in the community: the 1996 detroit area survey of trauma Arch. Gen. Psychiatry 55 7 1998 626 632
9. N. Breslau The epidemiology of posttraumatic stress disorder: what is the extent of the problem? J. Clin. Psychiatry 62 Suppl. 17 2001 16 22
10. C.R. Brewin, B. Andrews, and J.D. Valentine Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults J. Consult. Clin. Psychol. 68 5 2000 748 766
11. B.F. Broekman, M. Olff, and F. Boer The genetic background to PTSD Neurosci. Biobehav. Rev. 31 3 2007 348 362
12. J.P. Brouwer Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression Psychoneuroendocrinology 31 10 2006 1154 1163
13. R.J. Cadoret Genetic-environmental interaction in the genesis of aggressivity and conduct disorders Arch. Gen. Psychiatry 52 11 1995 916 924
14. A. Caspi, and T.E. Moffitt Gene-environment interactions in psychiatry: joining forces with neuroscience Nat. Rev. Neurosci. 7 7 2006 583 590
15. A. Caspi Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits Am. J. Psychiatry 167 5 2010 509 527
16. A. Caspi Role of genotype in the cycle of violence in maltreated children Science 297 5582 2002 851 854
17. A. Caspi Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 5631 2003 386 389
18. W.G. Chen Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2 Science 302 5646 2003 885 889
19. M.C. Clarke Evidence for an interaction between familial liability and prenatal exposure to infection in the causation of schizophrenia Am. J. Psychiatry 166 9 2009 1025 1030
20. J.F. Costello, and C. Plass Methylation matters J. Med. Genet. 38 5 2001 285 303
21. E.R. de Kloet, M. Joels, and F. Holsboer Stress and the brain: from adaptation to disease Nat. Rev. Neurosci. 6 6 2005 463 475
22. D.L. Delahanty The Psychobiology of Trauma 2008 Jason Aronson Northvale, NJ
23. R.H. DeRijk A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness J. Clin. Endocrinol. Metab. 91 12 2006 5083 5089
24. D.M. Dick Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction J. Stud. Alcohol. 67 2 2006 185 194
25. L. Eaves, D. Foley, and J. Silberg Has the "Equal Environments" assumption been tested in twin studies? Twin Res. 6 6 2003 486 489
26. H.J. Edenberg Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations Am. J. Hum. Genet. 74 4 2004 705 714
27. J.N. Epstein, B.E. Saunders, and D.G. Kilpatrick Predicting PTSD in women with a history of childhood rape J. Trauma Stress 10 4 1997 573 588
28. M. Flavin Nature of the accessible chromatin at a glucocorticoid- responsive enhancer Mol. Cell. Biol. 24 18 2004 7891 7901
29. J.M. Gatt Early life stress combined with serotonin 3A Receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression Biol. Psychiatry 2010
30. N.A. Gillespie The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression Psychol. Med. 35 1 2005 101 111
31. J. Goldberg A twin study of the effects of the Vietnam War on posttraumatic stress disorder J. Am. Med. Assoc. 263 9 1990 1227 1232
32. Gottesman II, and T.D. Gould The endophenotype concept in psychiatry: etymology and strategic intentions Am. J. Psychiatry 160 4 2003 636 645
33. H.J. Grabe Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010
34. I. Grad, and D. Picard The glucocorticoid responses are shaped by molecular chaperones Mol. Cell. Endocrinol. 275 1-2 2007 2 12
35. B.L. Green Risk factors for PTSD and other diagnoses in a general sample of Vietnam veterans Am. J. Psychiatry 147 6 1990 729 733
36. P. Hamet, and J. Tremblay Genetics and genomics of depression Metabolism 54 5 Suppl. 1 2005 10 15
37. C. Heim, and C.B. Nemeroff Neurobiology of posttraumatic stress disorder CNS Spectr. 14 1 Suppl. 1 2009 13 24
38. C. Heim Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene Front. Behav. Neurosci. 3 2009 41
39. A. Hmadcha Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production J. Exp. Med. 190 11 1999 1595 1604
40. T.R. Hubler, and J.G. Scammell Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids Cell Stress Chaperones 9 3 2004 243 252
41. T.R. Hubler The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness Endocrinology 144 6 2003 2380 2387
42. M. Ising Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls Eur. J. Neurosci. 28 2 2008 389 398
43. T. Jovanovic Impaired fear inhibition is a biomarker of PTSD but not depression Depress Anxiety 27 3 2010 244 251
44. K. Karg The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited: Evidence of Genetic Moderation Arch Gen Psychiatry 2011
45. J. Kaufman Arguable assumptions, debatable conclusions Biol Psychiatry 67 4 2010 e19 e20; author reply e21-e23
46. K.S. Kendler, and L.J. Eaves Models for the joint effect of genotype and environment on liability to psychiatric illness Am. J. Psychiatry 143 3 1986 279 289
47. K.S. Kendler The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication Arch. Gen. Psychiatry 62 5 2005 529 535
48. R.C. Kessler Posttraumatic stress disorder in the National comorbidity survey Arch. Gen. Psychiatry 52 12 1995 1048 1060
49. D.G. Kilpatrick The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults Am. J. Psychiatry 164 11 2007 1693 1699
50. K.C. Koenen Co-twin control study of relationships among combat exposure, combat-related PTSD, and other mental disorders J. Trauma Stress 16 5 2003 433 438
51. K.C. Koenen Risk factors for course of posttraumatic stress disorder among Vietnam veterans: a 14-year follow-up of American legionnaires J. Consult. Clin. Psychol. 71 6 2003 980 986
52. K.C. Koenen Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children Mol. Psychiatry 10 12 2005 1058 1059
53. K.C. Koenen Modification of the association between serotonin transporter genotype and risk of posttraumatic stress disorder in adults by county-level social environment Am. J. Epidemiol. 169 6 2009 704 711
54. K.C. Koenen, A.B. Amstadter, and N.R. Nugent Gene-environment interaction in posttraumatic stress disorder: an update J. Trauma Stress 2009
55. C. Kress, H. Thomassin, and T. Grange Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks Proc. Natl. Acad. Sci. U S A 103 30 2006 11112 11117
56. M. Kuningas Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors Neuropsychopharmacology 32 6 2007 1295 1301
57. C.O. Ladd Long-term behavioral and neuroendocrine adaptations to adverse early experience Prog. Brain Res. 122 2000 81 103
58. J.A. Lasky-Su Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders Am. J. Med. Genet. B Neuropsychiatr. Genet. 133B 1 2005 110 115
59. R.S. Lee Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice Endocrinology 151 9 2010 4332 4343
60. M.P. Luijk FKBP5 and resistant attachment predict cortisol reactivity in infants: gene-environment interaction Psychoneuroendocrinology 2010
61. J.A. Magee Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element Endocrinology 147 1 2006 590 598
62. L. Manenschijn Clinical features associated with glucocorticoid receptor polymorphisms. An overview Ann. N. Y. Acad. Sci. 1179 2009 179 198
63. K. Martinowich DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation Science 302 5646 2003 890 893
64. P.O. McGowan Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse Nat. Neurosci. 12 3 2009 342 348
65. M.J. Meaney, and A.C. Ferguson-Smith Epigenetic regulation of the neural transcriptome: the meaning of the marks Nat. Neurosci. 13 11 2010 1313 1318
66. M.J. Meaney Epigenetics and the biological definition of gene × environment interactions Child Dev. 81 1 2010 41 79
67. Mehta, D., et al., Polymorphisms in FKBP5 define biologically distinct subtypes of PTSD: evidence from endocrine and gene expression studies. Arch. Gen. Psychiatry, accepted.
68. K.R. Merikangas, and J.D. Swendsen Genetic epidemiology of psychiatric disorders Epidemiol. Rev. 19 1 1997 144 155
69. J. Mill, and A. Petronis Molecular studies of major depressive disorder: the epigenetic perspective Mol. Psychiatry 12 9 2007 799 814
70. M.R. Munafo Gene × environment interactions at the serotonin transporter locus Biol. Psychiatry 65 3 2009 211 219
71. C. Murgatroyd Dynamic DNA methylation programs persistent adverse effects of early-life stress Nat. Neurosci. 12 12 2009 1559 1566
72. C. Murgatroyd Genes learn from stress: how infantile trauma programs us for depression Epigenetics 5 3 2010
73. C. Newton-Cheh, and J.N. Hirschhorn Genetic association studies of complex traits: design and analysis issues Mutat. Res. 573 1-2 2005 54 69
74. M. Panarelli Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects J. Clin. Endocrinol. Metab. 83 6 1998 1846 1852
75. R. Plomin, K. Asbury, and J. Dunn Why are children in the same family so different? Nonshared environment a decade later Can. J. Psychiatry 46 3 2001 225 233
76. W.B. Pratt, and D.O. Toft Steroid receptor interactions with heat shock protein and immunophilin chaperones Endocr. Rev. 18 3 1997 306 360
77. H.G. Prigerson, P.K. Maciejewski, and R.A. Rosenheck Combat trauma: trauma with highest risk of delayed onset and unresolved posttraumatic stress disorder symptoms, unemployment, and abuse among men J. Nerv. Ment. Dis. 189 2 2001 99 108
78. K.J. Ressler Polymorphisms in CRHR1 and the serotonin transporter loci: gene × gene × environment interactions on depressive symptoms Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B 3 2009 812 824
79. K.J. Ressler Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor Nature 470 7335 2011 492 497
80. N. Risch Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis J. Am. Med. Assoc. 301 23 2009 2462 2471
81. R.M. Sapolsky, L.M. Romero, and A.U. Munck How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions Endocr. Rev. 21 1 2000 55 89
82. J.G. Scammell Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates Gen. Comp. Endocrinol. 124 2 2001 152 165
83. S.H. Scharf, C. Liebl, E.B. Binder, M. Schmidt, and M. Müller Expression and regulation of the fkbp5 gene in the adult mouse brain PLoS One 6 2 2011 e16883
84. R.H. Segman, and A.Y. Shalev Genetics of posttraumatic stress disorder CNS Spectr. 8 9 2003 693 698
85. R.H. Segman Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors Mol. Psychiatry 10 5 2005 500 513 425
86. P.G. Smith, and N.E. Day The design of case-control studies: the influence of confounding and interaction effects Int. J. Epidemiol. 13 3 1984 356 365
87. M.B. Stein Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study Am. J. Psychiatry 159 10 2002 1675 1681
88. M.B. Stein, K.L. Jang, and W.J. Livesley Heritability of social anxiety-related concerns and personality characteristics: a twin study J. Nerv. Ment. Dis. 190 4 2002 219 224
89. P.F. Sullivan The psychiatric GWAS consortium: big science comes to psychiatry Neuron 68 2 2010 182 186
90. D. Thomas Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies Annu. Rev. Public Health 31 2010 21 36
91. H. Thomassin Glucocorticoid-induced DNA demethylation and gene memory during development EMBO J. 20 8 2001 1974 1983
92. W.R. True A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms Arch. Gen. Psychiatry 50 4 1993 257 264
93. A.R. Tyrka Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic- pituitary-adrenal axis reactivity Biol. Psychiatry 66 7 2009 681 685
94. M. Uddin Epigenetic and immune function profiles associated with posttraumatic stress disorder Proc. Natl. Acad. Sci. U S A 107 20 2010 9470 9475
95. J. van Os, B.P. Rutten, and R. Poulton Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions Schizophr. Bull. 34 6 2008 1066 1082
96. E.F. van Rossum Polymorphisms of the glucocorticoid receptor gene and major depression Biol. Psychiatry 59 8 2006 681 688
97. D. van West Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression Neuropsychopharmacology 31 3 2006 620 627
98. M. van Zuiden Pre-Existing High Glucocorticoid Receptor Number Predicting Development of Posttraumatic Stress Symptoms After Military Deployment Am J Psychiatry 2010
99. H. Vermeer Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability J. Clin. Endocrinol. Metab. 88 1 2003 277 284
100. J.T. Walters, and M.J. Owen Endophenotypes in psychiatric genetics Mol. Psychiatry 12 10 2007 886 890
101. I.C. Weaver Epigenetic programming by maternal behavior Nat. Neurosci. 7 8 2004 847 854
102. G.M. Wochnik FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells J Biol Chem 280 6 2005 4609 4616
103. M.Y. Wong The detection of gene-environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement? Int. J. Epidemiol. 32 1 2003 51 57
104. C.M. Worthman, B.A. Kohrt, K.J. Ressler, and E.B. Binder Early, maltreatment, adrenal regulation, and adult depression among rural Nepali: gene-environment interactions in life history Am. J. Phys. Anthropol. 2010
105. N.R. Wray Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned Mol. Psychiatry 2010
106. P. Xie Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder Neuropsychopharmacology 35 8 2010 1684 1692
107. J. Yang The impact of stress on depressive symptoms is moderated by social support in Chinese adolescents with subthreshold depression: A multi-wave longitudinal study J. Affect. Disord. 2010
108. R. Yehuda, S.L. Halligan, and L.M. Bierer Cortisol levels in adult offspring of Holocaust survivors: relation to PTSD symptom severity in the parent and child Psychoneuroendocrinology 27 1-2 2002 171 180
109. R. Yehuda Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy J. Clin. Endocrinol. Metab. 90 7 2005 4115 4118
110. R. Yehuda Parental posttraumatic stress disorder as a vulnerability factor for low cortisol trait in offspring of holocaust survivors Arch. Gen. Psychiatry 64 9 2007 1040 1048
111. R. Yehuda Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks Biol. Psychiatry 66 7 2009 708 711
112. R. Yehuda Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD Psychopharmacology (Berl) 212 3 2010 405 417
113. R. Yehuda Post-traumatic stress disorder N. Engl. J. Med. 346 2 2002 108 114
114. R. Yehuda Status of glucocorticoid alterations in post-traumatic stress disorder Ann. N Y Acad. Sci. 1179 2009 56 69
115. S. Zammit, M.J. Owen, and G. Lewis Misconceptions about gene-environment interactions in psychiatry Evid. Based Ment. Health 2010
116. T.Y. Zhang, and M.J. Meaney Epigenetics and the environmental regulation of the genome and its function Annu. Rev. Psychol. 61 2009 439 466 C1-3
117. X. Zhang, A.F. Clark, and T. Yorio FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness Invest. Ophthalmol. Vis. Sci. 49 3 2008 1037 1047
118. J. Zieker Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder Mol. Psychiatry 12 2 2007 116 118
119. P.B.T. Zimmermann, H. Pfister, R. Lieb, H.U. Wittchen, F. Holsboer, M. Ising, E.B. Binder, M. Uhr, and A. Nocon The interplay of variations in the FKBP5 gene and adverse life events in predicting the first onset of depression during a ten-year follow-up Pharmacopsychiatry 42 5 2009 249