Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory

Learning and Memory

Volumn 19, Issue 8, 2012, Pages 319-324

  Leach, Prescott T ^a   Poplawski, Shane G ^b   Kenney, Justin W ^c   Hoffman, Barbara ^d   Liebermann, Dan A ^d   Abel, Ted ^b   Gould, Thomas J ^a  

^a TEMPLE UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; COGNITIVE DEFECT; CONDITIONING; FEAR; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; KNOCKOUT MOUSE; LONG TERM MEMORY; MALE; MEMORY CONSOLIDATION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, DIFFERENTIATION; CONDITIONING (PSYCHOLOGY); ELECTROSHOCK; FEAR; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MALE; MEMORY DISORDERS; MEMORY, LONG-TERM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; RNA, MESSENGER;

EID: 84865228396     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.024984.111     Document Type: Article

References (55)

1. Abdollahi A, Lord KA, Hoffman-Liebermann B, Liebermann DA. 1991. Sequence and expression of a cDNA encoding MyD118: A novel myeloid differentiation primary response gene induced by multiple cytokines. Oncogene 6: 165-167.
2. Abel T, Nguyen PV, Barad M, Deuel TA, Kandel ER, Bourtchouladze R. 1997. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88: 615-626.
3. Akshoomoff N. 2005. The neuropsychology of autistic spectrum disorders. Dev Neuropsychol 27: 307-310.
4. Aman MG, Hollway JA, McDougle CJ, Scahill L, Tierney E, McCracken JT, Arnold LE, Vitiello B, Ritz L, Gavaletz A, et al. 2008. Cognitive effects of risperidone in children with autism and irritable behavior. J Child Adolesc Psychopharmacol 18: 227-236.
5. Anagnostaras SG, Maren S, Sage JR, Goodrich S, Fanselow MS. 1999. Scopolamine and Pavlovian fear conditioning in rats: Dose-effect analysis. Neuropsychopharmacology 21: 731-744.
6. Bailey A, Luthert P, Dean A, Harding B, Janota I, Montgomery M, Rutter M, Lantos P. 1998. A clinicopathological study of autism. Brain 121: 889-905.
7. Barch DM. 2005. The cognitive neuroscience of schizophrenia. Annu Rev Clin Psychol 1: 321-353.
8. Barnard L, Young AH, Pearson J, Geddes J, O'Brien G. 2002. A systematic reviewof the use of atypical antipsychotics in autism. J Psychopharmacol 16: 93-101.
9. Baron-Cohen S. 2004. The cognitive neuroscience of autism. J Neurol Neurosurg Psychiatry 75: 945-948.
10. Barreto G, Schafer A, Marhold J, Stach D, Swaminathan SK, Handa V, Doderlein G, Maltry N, Wu W, Lyko F, et al. 2007. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 445: 671-675.
11. Ben-Ari Y, Represa A. 1990. Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus. Trends Neurosci 13: 312-318.
12. Blanchard RJ, Blanchard DC. 1969. Crouching as an index of fear. J Comp Physiol Psychol 67: 370-375.
13. Bliss TV, Collingridge GL. 1993. A synaptic model of memory: Long-term potentiation in the hippocampus. Nature 361: 31-39.
14. Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, Silva AJ. 1994. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79: 59-68.
15. Bourtchouladze R, Abel T, Berman N, Gordon R, Lapidus K, Kandel ER. 1998. Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. Learn Mem 5: 365-374.
16. Bramham CR, Messaoudi E. 2005. BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis. Prog Neurobiol 76: 99-125.
17. Bruel-Jungerman E, Davis S, Laroche S. 2007. Brain plasticity mechanisms and memory: A party of four. Neuroscientist 13: 492-505.
18. Conner DA. 2002. Mouse colony management. Curr Protoc Mol Biol doi: 10.1002/ 0471142727.mb2308s57.
19. Czerniawski J, Ree F, Chia C, Ramamoorthi K, Kumata Y, Otto TA. 2011. The importance of having arc: Expression of the immediate-early gene arc is required for hippocampus-dependent fear conditioning and blocked by NMDA Receptor Antagonism. J Neurosci 31: 11200-11207.
20. Garbett K, Ebert PJ, Mitchell A, Lintas C, Manzi B, Mirnics K, Persico AM. 2008. Immune transcriptome alterations in the temporal cortex of subjects with autism. Neurobiol Dis 30: 303-311.
21. Gavin DP, Grayson DR, Guidotti A, Sharma RP. 2011a. Growth arrest and DNA-damage-inducible, β (GADD45b) in psychosis. Program No 68120 Neuroscience Meeting Planner, Society for Neuroscience,Washington, DC.
22. Gavin DP, Sharma RP, Chase KA, Matrisciano F, Dong E, Guidotti A. 2011b. Growth Arrest and DNA-damage-inducible, β (GADD45b)-mediated dna demethylation in major psychosis. Neuropsychopharmacology 37: 531-542.
23. Goeldner C, Reiss D, Wichmann J, Kieffer BL, Ouagazzal AM. 2009. Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms. Neurobiol Learn Mem 91: 393-401.
24. Gould TJ, Lewis MC. 2005. Coantagonism of glutamate receptors and nicotinic acetylcholinergic receptors disrupts fear conditioning and latent inhibition of fear conditioning. Learn Mem 12: 389-398.
25. Gould TJ, McCarthy MM, Keith RA. 2002. MK-801 disrupts acquisition of contextual fear conditioning but enhances memory consolidation of cued fear conditioning. Behav Pharmacol 13: 287-294.
26. Gupta M, Gupta SK, Balliet AG, Hollander MC, Fornace AJ, Hoffman B, Liebermann DA. 2005. Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis. Oncogene 24: 7170-7179.
27. Hall J, Thomas KL, Everitt BJ. 2000. Rapid and selective induction of BDNF expression in the hippocampus during contextual learning. Nat Neurosci 3: 533-535.
28. Hevroni D, Rattner A, Bundman M, Lederfein D, Gabarah A, Mangelus M, Silverman MA, Kedar H, Naor C, Kornuc M, et al. 1998. Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. J Mol Neurosci 10: 75-98.
29. Keeley MB,Wood MA, Isiegas C, Stein J, Hellman K, Hannenhalli S, Abel T. 2006. Differential transcriptional response to nonassociative and associative components of classical fear conditioning in the amygdala and hippocampus. Learn Mem 13: 135-142.
30. Kenney JW, Florian C, Portugal GS, Abel T, Gould TJ. 2010. Involvement of hippocampal jun-N terminal kinase pathway in the enhancement of learning and memory by nicotine. Neuropsychopharmacology 35: 483-492.
31. Lemberger T, Parkitna JR, Chai M, Schutz G, Engblom D. 2008. CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis. FASEB J 22: 2872-2879.
32. Liebermann DA, Hoffman B. 1998. MyD genes in negative growth control. Oncogene 17: 3319-3329.
33. Linnarsson S, Bjorklund A, Ernfors P. 1997. Learning deficit in BDNF mutant mice. Eur J Neurosci 9: 2581-2587.
34. Logue SF, Paylor R,Wehner JM. 1997. Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task. Behav Neurosci 111: 104-113.
35. Lu Y, Christian K, Lu B. 2008. BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem 89: 312-323.
36. Lubin FD, Roth TL, Sweatt JD. 2008. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J Neurosci 28: 10576-10586.
37. Ma DK, Guo JU, Ming GL, Song H. 2009a. DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle 8: 1526-1531.
38. Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H. 2009b. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 323: 1074-1077.
39. Matrisciano F, Dong E, Gavin DP, Nicoletti F, Guidotti A. 2011. Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain. Mol Pharmacol 80: 174-182.
40. Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L, Jia P, Assadzadeh A, Flanagan J, Schumacher A, et al. 2008. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet 82: 696-711.
41. Moser E, Moser MB, Andersen P. 1993. Synaptic potentiation in the rat dentate gyrus during exploratory learning. Neuroreport 5: 317-320.
42. Nedivi E, Hevroni D, Naot D, Israeli D, Citri Y. 1993. Numerous candidate plasticity-related genes revealed by differential cDNA cloning. Nature 363: 718-722.
43. Nguyen A, Rauch TA, Pfeifer GP, Hu VW. 2010. Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. FASEB J 24: 3036-3051.
44. Nikolov R, Jonker J, Scahill L. 2006. Autistic disorder: Current psychopharmacological treatments and areas of interest for future developments. Rev Bras Psiquiatr 28: S39-S46.
45. Perez-Cadahia B, Drobic B, Davie JR. 2011. Activation and function of immediate-early genes in the nervous system. Biochem Cell Biol 89: 61-73.
46. Phillips RG, LeDoux JE. 1992. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106: 274-285.
47. Pidsley R, Mill J. 2011. Epigenetic studies of psychosis: Current findings, methodological approaches, and implications for postmortem research. Biol Psychiatry 69: 146-156.
48. Ploski JE, Newton SS, Duman RS. 2006. Electroconvulsive seizure-induced gene expression profile of the hippocampus dentate gyrus granule cell layer. J Neurochem 99: 1122-1132.
49. Rai K, Huggins IJ, James SR, Karpf AR, Jones DA, Cairns BR. 2008. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell 135: 1201-1212.
50. Sheng M, Greenberg ME. 1990. The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4: 477-485.
51. Soule J, Messaoudi E, Bramham CR. 2006. Brain-derived neurotrophic factor and control of synaptic consolidation in the adult brain. Biochem Soc Trans 34: 600-604.
52. Stranahan AM, Khalil D, Gould E. 2007. Running induces widespread structural alterations in the hippocampus and entorhinal cortex. Hippocampus 17: 1017-1022.
53. VecseyCG,HawkJD, LattalKM,Stein JM, Fabian SA, AttnerMA,CabreraSM, McDonough CB, Brindle PK, Abel T, et al. 2007. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB: CBP-dependent transcriptional activation. J Neurosci 27: 6128-6140.
54. Wu H, Sun YE. 2009. Reversing DNA methylation: New insights from neuronal activity-induced Gadd45b in adult neurogenesis. Sci Signal 2: pe17. doi: 10.1126/scisignal.264pe17.
55. Yu NK, Baek SH, Kaang BK. 2011. DNA methylation-mediated control of learning and memory. Mol Brain 4: 5. doi: 10.1186 /1756-6606-4-5.