DNA methylation signatures within the human brain

American Journal of Human Genetics

Volumn 81, Issue 6, 2007, Pages 1304-1315

  Ladd Acosta, Christine ^a   Pevsner, Jonathan ^b   Sabunciyan, Sarven ^a   Yolken, Robert H ^a   Webster, Maree J ^c   Dinkins, Tiffany ^a   Callinan, Pauline A ^a   Fan, Jian Bing ^d   Potash, James B ^a,e   Feinberg, Andrew P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^d Illumina   (United States)

^e JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; ARTICLE; BRAIN CORTEX; BRAIN REGION; CEREBELLUM; CPG ISLAND; DNA DETERMINATION; DNA METHYLATION; EPIGENETICS; FEMALE; GENE CLUSTER; GENE LOCUS; GENE REPLICATION; GENETIC LINKAGE; GENETIC MARKER; HUMAN; HUMAN TISSUE; LIVER; MALE; MICROARRAY ANALYSIS; PONS; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

EPICOCCUM;

EID: 36749052947     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/524110     Document Type: Article

References (26)

1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/ Omim/ (for Rett syndrome, EN2, autism, HDAC7A, HTR2A, SLC22A3, IGF1, FGF1, FGFR2, and MAFD1)
2. Feinberg AP (2007) Phenotypic plasticity and the epigenetics of human disease. Nature 447:433-440
3. Razin A, Riggs AD (1980) DNA methylation and gene function. Science 210:604-610
4. Feinberg AP, Tycko B (2004) The history of cancer epigenetics. Nat Rev Cancer 4:143-153
5. Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23:185-188
6. Callinan PA, Feinberg AP (2006) The emerging science of epigenomics. Hum Mol Genet 15:R95-R101
7. Sandberg R, Yasuda R, Pankratz DG, Carter TA, Del Rio JA, Wodicka L, Mayford M, Lockhart DJ, Barlow C (2000) Regional and strain-specific gene expression mapping in the adult mouse brain. Proc Natl Acad Sci USA 97:11038-11043
8. Letwin NE, Kafkafi N, Benjamini Y, Mayo C, Frank BC, Luu T, Lee NH, Elmer GI (2006) Combined application of behavior genetics and microarray analysis to identify regional expression themes and gene-behavior associations. J Neurosci 26:5277-5287
9. Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, Boe AF, Boguski MS, Brockway KS, Byrnes EJ, et al (2007) Genome-wide atlas of gene expression in the adult mouse brain. Nature 445:168-176
10. Khaitovich P, Muetzel B, She X, Lachmann M, Hellmann I, Dietzsch J, Steigele S, Do HH, Weiss G, Enard W, et al (2004) Regional patterns of gene expression in human and chimpanzee brains. Genome Res 14:1462-1473
11. Roth RB, Hevezi P, Lee J, Willhite D, Lechner SM, Foster AC, Zlotnik A (2006) Gene expression analyses reveal molecular relationships among 20 regions of the human CNS. Neurogenetics 7:67-80
12. Bibikova M, Lin Z, Zhou L, Chudin E, Garcia EW, Wu B, Doucet D, Thomas NJ, Wang Y, Vollmer E, et al (2006) High-throughput DNA methylation profiling using universal bead arrays. Genome Res 16:383-393
13. Reich M, Liefeld T, Gould J, Lerner J, Tamayo P, Mesirov JP (2006) GenePattern 2.0. Nat Genet 38:500-501
14. Strichman-Almashanu LZ, Lee RS, Onyango PO, Perlman E, Flam F, Frieman MB, Feinberg AP (2002) A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Res 12:543-554
15. Gius D, Cui H, Bradbury CM, Cook J, Smart DK, Zhao S, Young L, Brandenburg SA, Hu Y, Bisht KS, et al (2004) Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell 6:361-371
16. Millen KJ, Wurst W, Herrup K, Joyner AL (1994) Abnormal embryonic cerebellar development and patterning of post-natal foliation in two mouse Engrailed-2 mutants. Development 120:695-706
17. Benayed R, Gharani N, Rossman I, Mancuso V, Lazar G, Kamdar S, Bruse SE, Tischfield S, Smith BJ, Zimmerman RA, et al (2005) Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus. Am J Hum Genet 77:851-868
18. Kato MV, Shimizu T, Nagayoshi M, Kaneko A, Sasaki MS, Ikawa Y (1996) Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma. Am J Hum Genet 59:1084-1090
19. Norton N, Owen MJ (2005) HTR2A: association and expression studies in neuropsychiatric genetics. Ann Med 37:121-129
20. Lazar A, Walitza S, Jetter A, Gerlach M, Warnke A, Herpertz-Dahlmann B, Grundemann D, Grimberg G, Schulz E, Remschmidt H, et al (2007) Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharmacol (http://journals. cambridge.org/action/displayAbstract?fromPage=online&aid=1009648) (electronically published May 4, 2007; accessed October 31, 2007)
21. Zwart R, Sleutels F, Wutz A, Schinkel AH, Barlow DP (2001) Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes. Genes Dev 15:2361-2366
22. Bach MA, Shen-Orr Z, Lowe WL Jr, Roberts CT Jr, LeRoith D (1991) Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain. Brain Res Mol Brain Res 10:43-48
23. Vaccarino FM, Schwartz ML, Raballo R, Rhee J, Lyn-Cook R (1999) Fibroblast growth factor signaling regulates growth and morphogenesis at multiple steps during brain development. Curr Top Dev Biol 46:179-200
24. Colella S, Shen L, Baggerly KA, Issa JP, Krahe R (2003) Sensitive and quantitative universal pyrosequencing methylation analysis of CpG sites. Biotechniques 35:146-150
25. Tudor M, Akbarian S, Chen RZ, Jaenisch R (2002) Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci USA 99:15536-15541
26. Mountcastle VB (1957) Modality and topographic properties of single neurons of cat's somatic sensory cortex. J Neurophysiol 20:408-434