Differential genetic and epigenetic regulation of catechol-O-methyl-transferase (COMT) is associated with impaired fear inhibition in posttraumatic stress disorder

Frontiers in Behavioral Neuroscience

Volumn , Issue MAR, 2013, Pages

  Norrholm, Seth Davin ^a,b   Jovanovic, Tanja ^b   Smith, Alicia K ^b   Binder, Elisabeth ^b,c   Klengel, Torsten ^c   Conneely, Karen ^b   Mercer, Kristina B ^d   Davis, Jennifer S ^b   Kerley, Kimberly ^b   Winkler, Jennifer ^b   Gillespie, Charles F ^b   Bradley, Bekh ^a,b   Ressler, Kerry J ^b,d  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Catechol O methyltransferase; Epigenetic; Fear potentiated startle; Methylation; Posttraumatic stress disorder; Trauma

Indexed keywords

CATECHOL METHYLTRANSFERASE; GENOMIC DNA;

AFRICAN AMERICAN; ARTICLE; COMT GENE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA METHYLATION; EPIGENETICS; FEAR; FEMALE; GENE; GENE FREQUENCY; GENE FUNCTION; GENETIC REGULATION; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; POSTTRAUMATIC STRESS DISORDER; PROMOTER REGION; UNITED STATES;

EID: 84875943910     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2013.00030     Document Type: Article

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