Response Variation following Trauma: A Translational Neuroscience Approach to Understanding PTSD

Neuron

Volumn 56, Issue 1, 2007, Pages 19-32

  Yehuda, Rachel ^a   LeDoux, Joseph ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTISONE; GLUCOCORTICOID; GUANFACINE; PROPRANOLOL DERIVATIVE;

AMYGDALOID NUCLEUS; CLINICAL TRIAL; COGNITIVE THERAPY; HIPPOCAMPUS; HUMAN; NONHUMAN; PHENOTYPE; POSTTRAUMATIC STRESS DISORDER; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; STRESS;

ADAPTATION, PSYCHOLOGICAL; AMYGDALA; ANIMALS; EMOTIONS; HIPPOCAMPUS; HUMANS; MODELS, PSYCHOLOGICAL; NEUROSCIENCES; RISK FACTORS; STRESS DISORDERS, POST-TRAUMATIC;

EID: 34748854338     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2007.09.006     Document Type: Review

References (131)

1. Adamec R.E., Blundell J., and Burton P. Relationship of the predatory attack experience to neural plasticity, pCREB expression and neuroendocrine response. Neurosci. Biobehav. Rev. 30 (2006) 356-375
2. Adams R.E., and Boscarino J.A. Predictors of PTSD and delayed PTSD after disaster: the impact of exposure and psychosocial resources. J. Nerv. Ment. Dis. 194 (2006) 485-493
3. Aerni A., Traber R., Hock C., Roozendaal B., Schelling G., Papassotiropoulos A., Nitsch R.M., Schnyder U., and de Quervain D.J. Low-dose cortisol for symptoms of posttraumatic stress disorder. Am. J. Psychiatry 161 (2004) 1488-1490
4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Third Edition (1980), American Psychiatric Association, Washington, D.C
5. Bachmann A.W., Sedgley T.L., Jackson R.V., Gibson J.N., Young R.M., and Torpy D.J. Glucocorticoid receptor polymorphisms and post-traumatic stress disorder. Psychoneuroendocrinology 30 (2005) 297-306
6. Bohus B., and de Kloet E.R. Adrenal steroids and extinction behavior: antagonism by progesterone, deoxycorticosterone and dexamethasone of a specific effect of corticosterone. Life Sci. 28 (1981) 433-440
7. Bolles R.C., and Fanselow M.S. A perceptual-defensive-recuperative model of fear and pain. Behav. Brain Sci. 3 (1980) 291-323
8. Bonne O., Brandes D., Gilboa A., Gomori J.M., Shenton M.E., Pitman R.K., and Shalev A.Y. Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD. Am. J. Psychiatry 158 (2001) 1248-1251
9. Bremner J.D. Functional neuroimaging in post-traumatic stress disorder. Expert Rev. Neurother. 7 (2007) 393-405
10. Bremner J.D., Staib L.H., Kaloupek D., Southwick S.M., Soufer R., and Charney D.S. Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. Biol. Psychiatry 45 (1999) 806-816
11. Bremner J.D., Vermetten E., and Kelley M.E. Cortisol, dehydroepiandrosterone (DHEA), and estradiol measured over 24 hours in women with childhood sexual abuse-related posttraumatic stress disorder (PTSD). J. Nerv. Ment. Dis. (2007) in press
12. Breslau N., and Kessler R.C. The stressor criterion in DSM-IV posttraumatic stress disorder: an empirical investigation. Biol. Psychiatry 50 (2001) 699-704
13. Breslau N., Chilcoat H.D., Kessler R.C., and Davis G.C. Previous exposure to trauma and PTSD effects of subsequent trauma: results from the Detroit Area Survey of Trauma. Am. J. Psychiatry 156 (1999) 902-907
14. Bromet E., Sonnega A., and Kessler R.C. Risk factors for DSM-III-R posttraumatic stress disorder: findings from the National Comorbidity Survey. Am. J. Epidemiol. 147 (1998) 353-361
15. Brunet A., Orr S.P., Tremblay J., Robertson K., Nader K., and Pitman R.K. Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. J. Psychiatr. Res. (2007) 10.1016/j.jpsychires.2007.05.006 in press. Published online June 22, 2007
16. Buchel C., and Dolan R.J. Classical fear conditioning in functional neuroimaging. Curr. Opin. Neurobiol. 10 (2000) 219-223
17. Bush D.E.A., Sortres-Bayon F., and LeDoux J.E. Individual differences in fear: Isolating fear reactivity and fear recovery phenotypes. J. Trauma. Stress 20 (2007) 413-422
18. Charney D.S., and Deutch A. A functional neuroanatomy of anxiety and fear: implications for the pathophysiology and treatment of anxiety disorders. Crit. Rev. Neurobiol. 10 (1996) 419-446
19. Cohen H., and Zohar J. An animal model of posttraumatic stress disorder: the use of cut-off behavioral criteria. Ann. N Y Acad. Sci. 1032 (2004) 167-178
20. Cohen H., Zohar J., Matar M.A., Zeev K., Loewenthal U., and Richter-Levin G. Setting apart the affected: the use of behavioral criteria in animal models of post traumatic stress disorder. Neuropsychopharmacology 29 (2004) 1962-1970
21. Cohen H., Matar M.A., Richter-Levin G., and Zohar J. The contribution of an animal model toward uncovering biological risk factors for PTSD. Ann. N Y Acad. Sci. 1071 (2006) 335-350
22. Cohen H., Zohar J., Gidron Y., Matar M.A., Belkind D., Loewenthal U., Kozlovsky N., and Kaplan Z. Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats. Biol. Psychiatry 59 (2006) 1208-1218
23. Cohen H., Kaplan Z., Matar M.A., Loewenthal U., Kozlovsky N., and Zohar J. Anisomycin, a protein synthesis inhibitor, disrupts traumatic memory consolidation and attenuates posttraumatic stress response in rats. Biol. Psychiatry 60 (2006) 7-76
24. Cohen H., Kaplan Z., Matar M.A., Loewenthal U., Zohar J., and Richter-Levin G. Long-lasting behavioral effects of juvenile trauma in an animal model of PTSD associated with a failure of the autonomic nervous system to recover. Eur. Neuropsychopharmacol. 17 (2007) 464-477
25. Cohen H., Geva A.B., Matar M.A., Zohar J., and Kaplan Z. Post-traumatic stress behavioural responses in inbred mouse strains: can genetic predisposition explain phenotypic vulnerability?. Int. J. Neuropsychopharmacol. (2007) 10.1017/S1461145707007912 in press. Published online July 27, 2007
26. Cools A.R., Brachten R., Heeren D., Willemen A., and Ellenbroek B. Search after neurobiological profile of individual-specific features of Wistar rats. Brain Res. Bull. 24 (1990) 49-69
27. Cure M., and Rolinat J.P. Behavioral heterogeneity in Sprague-Dawley rats. Physiol. Behav. 51 (1992) 771-774
28. de Quervain D.J. Glucocorticoid-induced inhibition of memory retrieval: implications for posttraumatic stress disorder. Ann. N Y Acad. Sci. 1071 (2006) 216-220
29. Debiec J., and LeDoux J.E. Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala. Neuroscience 129 (2004) 267-272
30. Debiec J., and Altemus M. Toward a new treatment for traumatic memories. Cerebrum (2006) 2-11
31. Debiec J., and LeDoux J.E. Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD. Ann. N Y Acad. Sci. 1071 (2006) 521-524
32. Delahanty D.L., Raimonde A.J., Spoonster E., and Cullado M. Injury severity, prior trauma history, urinary cortisol levels, and acute PTSD in motor vehicle accident victims. J. Anxiety Disord. 17 (2003) 149-164
33. Dolan R.J., and Vuilleumier P. Amygdala automaticity in emotional processing. Ann. N Y Acad. Sci. 985 (2003) 348-355
34. Francis D.D., Champagne F.A., Liu D., and Meaney M.J. Maternal care, gene expression, and development of individual differencesin stress reactivity. Ann. N Y Acad. Sci. 896 (1999) 66-84
35. Freeman T., Kimbrell T., Booe L., Myers M., Cardwell D., Lindquist D.M., Hart J., and Komoroski R.A. Evidence of resilience: neuroimaging in former prisoners of war. Psychiatry Res. 146 (2006) 59-64
36. Garcia A., and Armario A. Individual differences in the recovery of the hypothalamic-pituitary-adrenal axis after termination of exposure to a severe stressor in outbred male Sprague-Dawley rats. Psychoneuroendocrinology 26 (2001) 363-374
37. Gilbertson M.W., Gurvits T.V., Lasko N.B., Orr S.P., and Pitman R.K. Multivariate assessment of explicit memory function in combat veterans with posttraumatic stress disorder. J. Trauma. Stress 14 (2001) 413-432
38. Gilbertson M.W., Shenton M.E., Ciszewski A., Kasai K., Lasko N.B., Orr S.P., and Pitman R.K. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat. Neurosci. 5 (2002) 1242-1247
39. Golier J.A., Yehuda R., De Santi S., Segal S., Dolan S., and de Leon M.J. Absence of hippocampal volume differences in survivors of the Nazi Holocaust with and without PTSD. Psychiatry Res. 139 (2005) 53-64
40. Golier J.A., Harvey P.D., Legge J., and Yehuda R. Memory performance in older trauma survivors: implications for the longitudinal course of PTSD. Ann. N Y Acad. Sci. 1071 (2006) 54-66
41. Gray J.A. The Psychology of Fear and Stress (1987), Cambridge University Press, New York
42. Gurvits T.V., Shenton M.E., Hokama H., Ohta H., Lasko N.B., Gilbertson M.W., Orr S.P., Kikinis R., Jolesz F.A., McCarley R.W., and Pitman R.K. Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biol. Psychiatry 40 (1996) 1091-1099
43. Hariri A.R., Mattay V.S., Tessitore A., Fera F., and Weinberger D.R. Neocortical modulation of the amygdala response to fearful stimuli. Biol. Psychiatry 53 (2003) 494-501
44. Heresco-Levy U., Kremer I., Javitt D.C., Goichman R., Reshef A., Blanaru M., and Cohen T. Pilot-controlled trial of D-cycloserine for the treatment of post-traumatic stress disorder. Int. J. Neuropsychopharmacol. 5 (2002) 301-307
45. Holsboer F. Corticotropin-releasing hormone modulators and depression. Curr. Opin. Investig. Drugs 4 (2003) 46-50
46. Kagan J. Galen's Prophecy: Temperament in Human Nature (1994), Basic Books, New York
47. Kardiner A. The Traumatic Neuroses of War (1941), Hoeber, New York
48. Kessler R.C., Sonnega A., Bromet E., Hughes M., and Nelson C.B. Posttraumatic stress disorder in the National Comorbidity Survey. Arch. Gen. Psychiatry 52 (1995) 1048-1060
49. Kessler R.C., Chiu W.T., Demler O., and Walters E.E. Prevalence, severity, and comorbidity of twelve-month DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R). Arch. Gen. Psychiatry 62 (2005) 617-627
50. Koenen K.C., Harley R., Lyons M.J., Wolfe J., Simpson J.C., Goldberg J., Eisen S.A., and Tsuang M. A twin registry study of familial and individual risk factors for trauma exposure and posttraumatic stress disorder. J. Nerv. Ment. Dis. 190 (2002) 209-218
51. Koenen K.C., Moffitt T.E., Poulton R., Martin J., and Caspi A. Early childhood factors associated with the development of post-traumatic stress disorder: results from a longitudinal birth cohort. Psychol. Med. 37 (2007) 181-192
52. Kohda K., Harada K., Kato K., Hoshino A., Motohashi J., Yamaji T., Morinobu S., Matsuoka N., and Kato N. Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: A putative post-traumatic stress disorder model. Neuroscience 148 (2007) 22-33
53. Lanius R.A., Williamson P.C., Hopper J., Densmore M., Boksman K., Gupta M.A., Neufeld R.W., Gati J.S., and Menon R.S. Recall of emotional states in posttraumatic stress disorder: an fMRI investigation. Biol. Psychiatry 53 (2003) 204-210
54. LeDoux J.E. The Emotional Brain (1996), Simon and Schuster, New York
55. Levy A., Kadar T., and Dachir S. An animal model for studying therapeutic drugs against post-traumatic stress disorder. Mil. Med. 166 12, Suppl (2001) 74-75
56. Macklin M.L., Metzger L.J., Litz B.T., McNally R.J., Lasko N.B., Orr S.P., and Pitman R.K. Lower precombat intelligence is a risk factor for posttraumatic stress disorder. J. Consult. Clin. Psychol. 66 (1998) 323-326
57. Manion S.T., Gamble E.H., and Li H. Prazosin administered prior to inescapable stressor blocks subsequent exaggeration of acoustic startle response in rats. Pharmacol. Biochem. Behav. 86 (2007) 559-565
58. Maren S. Neurobiology of Pavlovian fear conditioning. Annu. Rev. Neurosci. 24 (2001) 897-931
59. Mason J.W., Giller E.L., Kosten T.R., Ostroff R.B., and Podd L. Urinary free-cortisol levels in posttraumatic stress disorder patients. J. Nerv. Ment. Dis. 174 (1986) 145-149
60. Matar M.A., Cohen H., Kaplan Z., and Zohar J. The effect of early poststressor intervention with sertraline on behavioral responses in an animal model of post-traumatic stress disorder. Neuropsychopharmacology 31 (2006) 2610-2618
61. McEwen B.S., Gould E.A., and Sakai R.R. The vulnerability of the hippocampus to protective and destructive effects of glucocorticoids in relation to stress. Br. J. Psychiatry Suppl. 15 (1992) 18-23
62. McFarlane A.C. Posttraumatic stress disorder: a model of the longitudinal courseand the role of risk factors. J. Clin. Psychiatry 61 Suppl 5 (2000) 15-20
63. McGaugh J.L., and Roozendaal B. Role of adrenal stress hormones in forming lasting memories in the brain. Curr. Opin. Neurobiol. 12 (2002) 205-210
64. Mechiel Korte S., and De Boer S.F. A robust animal model of state anxiety: fear-potentiated behaviour in the elevated plus-maze. Eur. J. Pharmacol. 463 (2003) 163-175
65. Milad M.R., Quinn B.T., Pitman R.K., Orr S.P., Fischl B., and Rauch S.L. Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory. Proc. Natl. Acad. Sci. USA 102 (2005) 10706-10711
66. Miller M.M., and McEwen B.S. Establishing an agenda for translational research on PTSD. Ann. N Y Acad. Sci. 1071 (2006) 294-312
67. Morgan M.A., and LeDoux J.E. Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Behav. Neurosci. 109 (1995) 681-688
68. Morgan M.A., Romanski L.M., and LeDoux J.E. Extinction of emotional learning: contribution of medial prefrontal cortex. Neurosci. Lett. 163 (1993) 109-113
69. Munck A., Guyre P.M., and Holbrook N.J. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr. Rev. 5 (1984) 25-44
70. Myers K.M., and Davis M. Mechanisms of fear extinction. Mol. Psychiatry 12 (2007) 120-150
71. Nader K., and Wang S.H. Fading in. Learn. Mem. 13 (2006) 530-535
72. Nader K., Schafe G.E., and LeDoux J.E. The labile nature of consolidation theory. Nat. Rev. Neurosci. 1 (2000) 216-219
73. Neylan T.C., Schuff N., Lenoci M., Yehuda R., Weiner M.W., and Marmar C.R. Cortisol levels are positively correlated with hippocampal N-acetylaspartate. Biol. Psychiatry 54 (2003) 1118-1121
74. Neylan T.C., Lenoci M., Samuelson K.W., Metzler T.J., Henn-Haase C., Hierholzer R.W., Lindley S.E., Otte C., Schoenfeld F.B., Yesavage J.A., and Marmar C.R. No improvement of posttraumatic stress disorder symptoms with guanfacine treatment. Am. J. Psychiatry 163 (2006) 2186-2188
75. Nishith P., Mechanic M.B., and Resick P.A. Prior interpersonal trauma: The contribution to current PTSD symptoms in female rape victims. J. Abnorm. Psychol. 109 (2000) 20-25
76. Novik K.L., Nimmrich I., Genc B., Maier S., Piepenbrock C., Olek A., and Beck S. Epigenomics: genome-wide study of methylation phenomena. Curr. Issues Mol. Biol. 4 (2002) 111-128
77. Ochsner K.N., and Gross J.J. The cognitive control of emotion. Trends Cogn. Sci. 9 (2005) 242-249
78. O'Donnell T., Hegadoren K.M., and Coupland N.C. Noradrenergic mechanisms in the pathophysiology of post-traumatic stress disorder. Neuropsychobiology 50 (2004) 273-283
79. Parker K.J., Buckmaster C.L., Justus K.R., Schatzberg A.F., and Lyons D.M. Mild early life stress enhances prefrontal-dependent response inhibition in monkeys. Biol. Psychiatry 57 (2005) 848-855
80. Phelps E.A. Emotion and cognition: insights from studies of the human amygdala. Annu. Rev. Psychol. 57 (2006) 27-53
81. Phelps E.A., and LeDoux J.E. Contributions of the amygdala to emotion processing: from animal models to human behavior. Neuron 48 (2005) 175-187
82. Pitman R.K. Post-traumatic stress disorder, hormones, and memory. Biol. Psychiatry 26 (1989) 221-223
83. Pitman R.K., Sanders K.M., Zusman R.M., Healy A.R., Cheema F., Lasko N.B., Cahill L., and Orr S.P. Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol. Psychiatry 51 (2002) 189-192
84. Pitman R.K., Gilbertson M.W., Gurvits T.V., May F.S., Lasko N.B., Metzger L.J., Shenton M.E., Yehuda R., Orr S.P., and Harvard/VA PTSD Twin Study Investigators. Clarifying the origin of biological abnormalities in PTSD through the study of identical twins discordant for combat exposure. Ann. N Y Acad. Sci. 1071 (2006) 242-254
85. Protopopescu X., Pan H., Altemus M., Tuescher O., Polanecsky M., McEwen B., Silbersweig D., and Stern E. Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle. Proc. Natl. Acad. Sci. USA 102 (2005) 16060-16065
86. Quirk G.J., and Beer J.S. Prefrontal involvement in the regulation of emotion: convergence of rat and human studies. Curr. Opin. Neurobiol. 16 (2006) 723-727
87. Radley J.J., Sisti H.M., Hao J., Rocher A.B., McCall T., Hof P.R., McEwen B.S., and Morrison J.H. Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex. Neuroscience 125 (2004) 1-6
88. Raskind M.A., Peskind E.R., Kanter E.D., Petrie E.C., Radant A., Thompson C.E., Dobie D.J., Hoff D., Rein R.J., Straits-Troster K., et al. Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study. Am. J. Psychiatry 160 (2003) 371-373
89. Rau V., DeCola J.P., and Fanselow M.S. Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder. Neurosci. Biobehav. Rev. 29 (2005) 1207-1223
90. Rauch S.L., Shin L.M., and Wright C.I. Neuroimaging studies of amygdala function in anxiety disorders. Ann. N Y Acad. Sci. 985 (2003) 389-410
91. Rauch S.L., Shin L.M., and Phelps E.A. Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research-past, present, and future. Biol. Psychiatry 60 (2006) 376-382
92. Resnick H.S., Yehuda R., Pitman R.K., and Foy D.W. Effect of previous trauma on acute plasma cortisol level following rape. Am. J. Psychiatry 152 (1995) 1675-1677
93. Ressler K.J., Rothbaum B.O., Tannenbaum L., Anderson P., Graap K., Zimand E., Hodges L., and Davis M. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch. Gen. Psychiatry 61 (2004) 1136-1144
94. Richter-Levin G. Acute and long-term behavioral correlates of underwater trauma-potential relevance to stress and post-stress syndromes. Psychiatry Res. 79 (1998) 73-83
95. Rittenhouse P.A., Bakkum E.A., O'Connor P.A., Carnes M., Bethea C.L., and van de Kar L.D. Comparison of neuroendocrine and behavioral effects of ipsapirone, a 5-HT1A agonist, in three stress paradigms: immobilization, forced swim and conditioned fear. Brain Res. 580 (1992) 205-214
96. Schelling G., Roozendaal B., Krauseneck T., Schmoelz M., de Quervain D., and Briegel J. Efficacy of hydrocortisone in preventing posttraumatic stress disorder following critical illness and major surgery. Ann. N Y Acad. Sci. 1071 (2006) 46-53
97. Segman R.H., and Shalev A.Y. Genetics of posttraumatic stress disorder. CNS Spectr. 8 (2003) 693-698
98. Shin L.M., McNally R.J., Kosslyn S.M., Thompson W.L., Rauch S.L., Alpert N.M., Metzger L.J., Lasko N.B., Orr S.P., and Pitman R.K. Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation. Am. J. Psychiatry 156 (1999) 575-584
99. Shin L.M., Wright C.I., Cannistraro P.A., Wedig M.M., McMullin K., Martis B., Macklin M.L., Lasko N.B., Cavanagh S.R., Krangel T.S., et al. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch. Gen. Psychiatry 62 (2005) 273-281
100. Shinba T., Shinozaki T., and Mugishima G. Clonidine immediately after immobilization stress prevents long-lasting locomotion reduction in the rat. Prog. Neuropsychopharmacol. Biol. Psychiatry 25 (2001) 1629-1640
101. Siegmund A., and Wotjak C.T. Toward an animal model of posttraumatic stress disorder. Ann. N. Y. Acad. Sci. 1071 (2006) 324-334
102. Siegmund A., and Wotjak C.T. Hyperarousal does not depend on trauma-related contextual memory in an animal model of Posttraumatic Stress Disorder. Physiol. Behav. 90 (2007) 103-107
103. Sotres-Bayon F., Bush D.E., and LeDoux J.E. Emotional perseveration: an update on prefrontal-amygdala interactions in fear extinction. Learn. Mem. 11 (2004) 525-535
104. Sotres-Bayon F., Bush D.E., and LeDoux J.E. Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. Neuropsychopharmacology 32 (2007) 1929-1940
105. Stein M.B., Jang K.L., Taylor S., Vernon P.A., and Livesley W.J. Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study. Am. J. Psychiatry 159 (2002) 1675-1681
106. Sutherland J.E., and Costa M. Epigenetics and the environment. Ann. N Y Acad. Sci. 983 (2003) 151-160
107. Tronel S., and Alberini C.M. Persistent disruption of a traumatic memory by postretrieval inactivation of glucocorticoid receptors in the amygdala. Biol. Psychiatry 62 (2007) 33-39
108. True W.R., Rice J., Eisen S.A., Heath A.C., Goldberg J., Lyons M.J., and Nowak J. A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Arch. Gen. Psychiatry 50 (1993) 257-264
109. Urry H.L., van Reekum C.M., Johnstone T., Kalin N.H., Thurow M.E., Schaefer H.S., Jackson C.A., Frye C.J., Greischar L.L., Alexander A.L., and Davidson R.J. Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults. J. Neurosci. 26 (2006) 4415-4425
110. Vaiva G., Ducrocq F., Jezequel K., Averland B., Lestavel P., Brunet A., and Marmar C.R. Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Biol. Psychiatry 54 (2003) 947-949
111. Vasterling J.J., Duke L.M., Brailey K., Constans J.I., Allain Jr. A.N., and Sutker P.B. Attention, learning, and memory performances and intellectual resources in Vietnam veterans: PTSD and no disorder comparisons. Neuropsychology 16 (2001) 5-14
112. Vyas A., Mitra R., Shankaranarayana Rao B.S., and Chattarji S. Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. J. Neurosci. 22 (2002) 6810-6818
113. Weaver I.C., Cervoni N., Champagne F.A., D'Alessio A.C., Sharma S., Seckl J.R., Dymov S., Szyf M., and Meaney M.J. Epigenetic programming by maternal behavior. Nat. Neurosci. 7 (2004) 847-854
114. Yehuda R. Post-traumatic stress disorder. N. Engl. J. Med. 346 (2002) 108-114
115. Yehuda R. Current status of cortisol findings in post-traumatic stress disorder. Psychiatr. Clin. North Am. 25 (2002) 341-368
116. Yehuda R. Risk and resilience in posttraumatic stress disorder. J. Clin. Psychiatry 65 Suppl 1 (2004) 29-36
117. Yehuda R. Neuroendocrine aspects of PTSD. Handb. Exp. Pharmacol. 169 (2005) 371-403
118. Yehuda R., and Antelman S.M. Criteria for rationally evaluating animal models of posttraumatic stress disorder. Biol. Psychiatry 33 (1993) 479-486
119. Yehuda R., and McFarlane A.C. Conflict between current knowledge about posttraumatic stress disorder and its original conceptual basis. Am. J. Psychiatry 152 (1995) 1705-1713
120. Yehuda R., and Flory J.D. Differentiating biological correlates of risk, PTSD, and resilience following trauma exposure. J. Trauma. Stress 20 (2007) 435-447
121. Yehuda R., Levengood R.A., Schmeidler J., Wilson S., Guo L.S., and Gerber D. Increased pituitary activation following metyrapone administration in post-traumatic stress disorder. Psychoneuroendocrinology 21 (1996) 1-16
122. Yehuda R., Teicher M.H., Trestman R.L., Levengood R.A., and Siever L.J. Cortisol regulation in posttraumatic stress disorder and major depression: a chronobiological analysis. Biol. Psychiatry 40 (1996) 79-88
123. Yehuda R., Siever L.J., Teicher M.H., Levengood R.A., Gerber D.K., Schmeidler J., and Yang R.K. Plasma norepinephrine and 3-methoxy-4-hydroxyphenylglycol concentrations and severity of depression in combat posttraumatic stress disorder and major depressive disorder. Biol. Psychiatry 44 (1998) 56-63
124. Yehuda R., Resnick H.S., Schmeidler J., Yang R.K., and Pitman R.K. Predictors of cortisol and 3-methoxy-4-hydroxyphenylglycol responses in the acute aftermath of rape. Biol. Psychiatry 43 (1998) 855-859
125. Yehuda R., McFarlane A.C., and Shalev A.Y. Predicting the development of posttraumatic stress disorder from the acute response to a traumatic event. Biol. Psychiatry 44 (1998) 1305-1313
126. Yehuda R., Halligan S.L., and Bierer L.M. Relationship of parental trauma exposure and PTSD to PTSD, depressive and anxiety disorders in offspring. J. Psychiatr. Res. 35 (2001) 261-270
127. Yehuda R., Engel S.M., Brand S.R., Seckl J., Marcus S.M., and Berkowitz G.S. Transgenerational effects of PTSD in babies of mothers exposed the WTC attacks during pregnancy. J. Clin. Endocrinol. Metab. 90 (2005) 4115-4118
128. Yehuda R., Golier J.A., Tischler L., Harvey P.D., Newmark R., Yang R.K., and Buchsbaum M.S. Hippocampal volume in aging combat veterans with and without post-traumatic stress disorder: Relation to risk and resilience factors. J. Psychiatr. Res. 41 (2006) 435-445
129. Yehuda R., Blair W., Labinsky E., and Bierer L.M. Effects of parental PTSD on the cortisol response to dexamethasone administration in their adult offspring. Am. J. Psychiatry 164 (2007) 163-166
130. Yehuda R., Teicher M.H., Seckl J.R., Grossman R.A., Morris A., and Bierer L.M. Parental posttraumatic stress disorder as a vulnerability factor for low cortisol trait in offspring of holocaust survivors. Arch. Gen. Psychiatry 64 (2007) 1040-1048
131. Yehuda R., Morris A., Labinsky E., Zemelman S., and Schmeidler J. Ten year follow-up study of cortisol levels in aging Holocaust survivors with and without PTSD. J. Trauma. Stress (2007) in press