Pumped up: Reflections on PfATP6 as the target for artemisinins

Trends in Pharmacological Sciences

Volumn 35, Issue 1, 2014, Pages 4-11

  Krishna, Sanjeev ^a   Pulcini, Serena ^a   Moore, Catherine M ^a   Teo, Beatrix Huei Yi ^a   Staines, Henry M ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

antimalarial; artemisinin resistance; calcium homeostasis; endoperoxides; SERCA; yeast expression

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ; ARTEMISININ DERIVATIVE; ARTESUNATE; CHLOROQUINE; CYCLOPIAZONIC ACID; DIHYDROARTEMISININ; HYDROXYQUINONE DERIVATIVE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SPIROINDOLONE DERIVATIVE; THAPEROXIDE DERIVATIVE; THAPSIGARGIN; TRIOXOLANE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; DRUG MECHANISM; DRUG SENSITIVITY; DRUG SPECIFICITY; DRUG TARGETING; GENE MUTATION; HETEROLOGOUS EXPRESSION; HUMAN; IC 50; MALARIA; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PARASITE SURVIVAL; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REVIEW; TOXOPLASMA GONDII; XENOPUS;

EID: 84891615637     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2013.10.007     Document Type: Review

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