Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents

Journal of Medicinal Chemistry

Volumn 53, Issue 21, 2010, Pages 7864-7868

  Sun, Lingzhi ^a   Shah, Falgun ^b   Helal, Mohamed A ^b,d   Wu, Yunshan ^b   Pedduri, Yakambram ^b   Chittiboyina, Amar G ^b   Gut, Jiri ^c   Rosenthal, Philip J ^c   Avery, Mitchell A ^a,b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SUEZ CANAL UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; ENDOPEROXIDE; GUAIANOLIDE DERIVATIVE; THAPEROXIDE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; IC 50; PARASITE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CERCOPITHECUS AETHIOPS; DRUG DESIGN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; PARASITIC SENSITIVITY TESTS; PEROXIDES; PLASMODIUM FALCIPARUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SESQUITERPENES, GUAIANE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THAPSIGARGIN; VERO CELLS;

EID: 78149241541     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1006462     Document Type: Article

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