메뉴 건너뛰기




Volumn 27, Issue 2, 2011, Pages 73-81

Plasmodium sensitivity to artemisinins: Magic bullets hit elusive targets

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ARTEMETHER PLUS BENFLUMETOL; ARTEMISININ; ARTESUNATE PLUS MEFLOQUINE; BENFLUMETOL; CHLOROQUINE; THAPSIGARGIN; TUMOR PROTEIN;

EID: 79251599335     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2010.11.006     Document Type: Review
Times cited : (57)

References (92)
  • 1
    • 0442307497 scopus 로고    scopus 로고
    • Antimalarial drug toxicity: a review
    • Taylor W.R., White N.J. Antimalarial drug toxicity: a review. Drug Saf. 2004, 27:25-61.
    • (2004) Drug Saf. , vol.27 , pp. 25-61
    • Taylor, W.R.1    White, N.J.2
  • 2
    • 77951436519 scopus 로고    scopus 로고
    • Toxicity of the antimalarial artemisinin and its dervatives
    • Efferth T., Kaina B. Toxicity of the antimalarial artemisinin and its dervatives. Crit. Rev. Toxicol. 2010, 40:405-421.
    • (2010) Crit. Rev. Toxicol. , vol.40 , pp. 405-421
    • Efferth, T.1    Kaina, B.2
  • 3
    • 77949568358 scopus 로고    scopus 로고
    • Artemisinin resistance: current status and scenarios for containment
    • Dondorp A.M., et al. Artemisinin resistance: current status and scenarios for containment. Nat. Rev. Microbiol. 2010, 8:272-280.
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 272-280
    • Dondorp, A.M.1
  • 4
    • 33646582624 scopus 로고    scopus 로고
    • Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance
    • Krishna S., et al. Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance. Trends Mol. Med. 2006, 12:200-205.
    • (2006) Trends Mol. Med. , vol.12 , pp. 200-205
    • Krishna, S.1
  • 5
    • 77950362820 scopus 로고    scopus 로고
    • Biological actions of artemisinin: insights from medicinal chemistry studies
    • Li J., Zhou B. Biological actions of artemisinin: insights from medicinal chemistry studies. Molecules 2010, 15:1378-1397.
    • (2010) Molecules , vol.15 , pp. 1378-1397
    • Li, J.1    Zhou, B.2
  • 6
    • 0037021405 scopus 로고    scopus 로고
    • Artemisinin: mechanisms of action, resistance and toxicity
    • Meshnick S.R. Artemisinin: mechanisms of action, resistance and toxicity. Int. J. Parasitol. 2002, 32:1655-1660.
    • (2002) Int. J. Parasitol. , vol.32 , pp. 1655-1660
    • Meshnick, S.R.1
  • 7
    • 33751006146 scopus 로고    scopus 로고
    • Current perspectives on the mechanism of action of artemisinins
    • Golenser J., et al. Current perspectives on the mechanism of action of artemisinins. Int. J. Parasitol. 2006, 36:1427-1441.
    • (2006) Int. J. Parasitol. , vol.36 , pp. 1427-1441
    • Golenser, J.1
  • 8
    • 77950362015 scopus 로고    scopus 로고
    • The molecular mechanism of action of artemisinin--the debate continues
    • O'Neill P.M., et al. The molecular mechanism of action of artemisinin--the debate continues. Molecules 2010, 15:1705-1721.
    • (2010) Molecules , vol.15 , pp. 1705-1721
    • O'Neill, P.M.1
  • 9
    • 0035005885 scopus 로고    scopus 로고
    • Possible modes of action of the artemisinin-type compounds
    • Olliaro P.L., et al. Possible modes of action of the artemisinin-type compounds. Trends Parasitol. 2001, 17:122-126.
    • (2001) Trends Parasitol. , vol.17 , pp. 122-126
    • Olliaro, P.L.1
  • 10
    • 78649251920 scopus 로고    scopus 로고
    • Heme as Trigger and Target for Trioxane-Containing Antimalarial Drugs (dagger)
    • Meunier B., Robert A. Heme as Trigger and Target for Trioxane-Containing Antimalarial Drugs (dagger). Acc. Chem. Res. 2010, 43:1444-1451. 10.1021/ar100070k.
    • (2010) Acc. Chem. Res. , vol.43 , pp. 1444-1451
    • Meunier, B.1    Robert, A.2
  • 11
    • 2942666622 scopus 로고    scopus 로고
    • Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivity
    • Haynes R.K., et al. Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivity. Angew. Chem. Int. Ed. Engl. 2004, 43:1381-1385.
    • (2004) Angew. Chem. Int. Ed. Engl. , vol.43 , pp. 1381-1385
    • Haynes, R.K.1
  • 12
    • 0042860063 scopus 로고    scopus 로고
    • Artemisinins target the SERCA of Plasmodium falciparum
    • Eckstein-Ludwig U., et al. Artemisinins target the SERCA of Plasmodium falciparum. Nature 2003, 424:957-961.
    • (2003) Nature , vol.424 , pp. 957-961
    • Eckstein-Ludwig, U.1
  • 13
    • 0028109346 scopus 로고
    • Reaction of antimalarial endoperoxides with specific parasite proteins
    • Asawamahasakda W., et al. Reaction of antimalarial endoperoxides with specific parasite proteins. Antimicrob. Agents Chemother. 1994, 38:1854-1858.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 1854-1858
    • Asawamahasakda, W.1
  • 14
    • 0032568952 scopus 로고    scopus 로고
    • The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin
    • Bhisutthibhan J., et al. The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin. J. Biol. Chem. 1998, 273:16192-16198.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16192-16198
    • Bhisutthibhan, J.1
  • 15
    • 0034913428 scopus 로고    scopus 로고
    • Immunoprecipitation of [(3)H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodies
    • Bhisutthibhan J., Meshnick S.R. Immunoprecipitation of [(3)H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodies. Antimicrob. Agents Chemother. 2001, 45:2397-2399.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 2397-2399
    • Bhisutthibhan, J.1    Meshnick, S.R.2
  • 16
    • 0033970883 scopus 로고    scopus 로고
    • Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoelii
    • Walker D.J., et al. Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoelii. Antimicrob. Agents Chemother. 2000, 44:344-347.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 344-347
    • Walker, D.J.1
  • 17
    • 22144461405 scopus 로고    scopus 로고
    • A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
    • Uhlemann A.C., et al. A single amino acid residue can determine the sensitivity of SERCAs to artemisinins. Nat. Struct. Mol. Biol. 2005, 12:628-629.
    • (2005) Nat. Struct. Mol. Biol. , vol.12 , pp. 628-629
    • Uhlemann, A.C.1
  • 18
    • 77956108989 scopus 로고    scopus 로고
    • Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance
    • Valderramos S.G., et al. Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrob. Agents Chemother. 2010, 54:3842-3852.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 3842-3852
    • Valderramos, S.G.1
  • 19
    • 27744592680 scopus 로고    scopus 로고
    • Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins
    • O'Neill P.M., et al. Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins. Chembiochem 2005, 6:2048-2054.
    • (2005) Chembiochem , vol.6 , pp. 2048-2054
    • O'Neill, P.M.1
  • 20
    • 0029142546 scopus 로고
    • Synthesis, structure, and antimalarial activity of some enantiomerically pure, cis-fused cyclopenteno-1,2,4-trioxanes
    • Jefford C.W., et al. Synthesis, structure, and antimalarial activity of some enantiomerically pure, cis-fused cyclopenteno-1,2,4-trioxanes. Helvetica Chimica Acta 1995, 78:647-662.
    • (1995) Helvetica Chimica Acta , vol.78 , pp. 647-662
    • Jefford, C.W.1
  • 21
    • 55449124885 scopus 로고    scopus 로고
    • Yeast model uncovers dual roles of mitochondria in action of artemisinin
    • Li W., et al. Yeast model uncovers dual roles of mitochondria in action of artemisinin. PLoS Genet. 2005, 1:e36.
    • (2005) PLoS Genet. , vol.1
    • Li, W.1
  • 22
    • 77949661216 scopus 로고    scopus 로고
    • Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation
    • Wang J., et al. Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. PLoS ONE 2010, 5:e9582.
    • (2010) PLoS ONE , vol.5
    • Wang, J.1
  • 23
    • 52049121086 scopus 로고    scopus 로고
    • Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate
    • Natalang O., et al. Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate. BMC Genomics 2008, 9:388.
    • (2008) BMC Genomics , vol.9 , pp. 388
    • Natalang, O.1
  • 24
    • 77951220629 scopus 로고    scopus 로고
    • Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism
    • Witkowski B., et al. Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism. Antimicrob. Agents Chemother. 2010, 54:1872-1877.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 1872-1877
    • Witkowski, B.1
  • 25
    • 33749989605 scopus 로고    scopus 로고
    • Transporters involved in resistance to antimalarial drugs
    • Valderramos S.G., Fidock D.A. Transporters involved in resistance to antimalarial drugs. Trends Pharmacol. Sci. 2006, 27:594-601.
    • (2006) Trends Pharmacol. Sci. , vol.27 , pp. 594-601
    • Valderramos, S.G.1    Fidock, D.A.2
  • 26
    • 19544366088 scopus 로고    scopus 로고
    • Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?
    • Anderson T.J.C., et al. Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?. Antimicrob. Agents Chemother. 2005, 49:2180-2188.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 2180-2188
    • Anderson, T.J.C.1
  • 27
    • 34250662528 scopus 로고    scopus 로고
    • Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites
    • Hunt P., et al. Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites. Mol. Microbiol. 2007, 65:27-40.
    • (2007) Mol. Microbiol. , vol.65 , pp. 27-40
    • Hunt, P.1
  • 28
    • 0035021982 scopus 로고    scopus 로고
    • Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models
    • Carlton J.M., et al. Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models. Trends Parasitol. 2001, 17:236-242.
    • (2001) Trends Parasitol. , vol.17 , pp. 236-242
    • Carlton, J.M.1
  • 29
    • 68049123592 scopus 로고    scopus 로고
    • Artemisinin resistance in Plasmodium falciparum malaria
    • Dondorp A.M., et al. Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 2009, 361:455-467.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 455-467
    • Dondorp, A.M.1
  • 30
    • 57749099137 scopus 로고    scopus 로고
    • Evidence of artemisinin-resistant malaria in western Cambodia
    • Noedl H., et al. Evidence of artemisinin-resistant malaria in western Cambodia. N. Engl. J. Med. 2008, 359:2619-2620.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 2619-2620
    • Noedl, H.1
  • 31
    • 68049146050 scopus 로고    scopus 로고
    • Artemisinin-resistant malaria in Asia
    • Noedl H., et al. Artemisinin-resistant malaria in Asia. N. Engl. J. Med. 2009, 361:540-541.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 540-541
    • Noedl, H.1
  • 32
    • 77954324867 scopus 로고    scopus 로고
    • Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009
    • Malaria Journal. 2010. 9:181 9, 181
    • Thanh, N.V. et al. (2010) Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009. Malaria Journal 2010 9:181 9, 181.
    • (2010)
    • Thanh, N.V.1
  • 33
    • 77953731111 scopus 로고    scopus 로고
    • Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum
    • Imwong M., et al. Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum. Antimicrob. Agents Chemother. 2010, 54:2886-2892.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 2886-2892
    • Imwong, M.1
  • 34
    • 0037015614 scopus 로고    scopus 로고
    • Genome sequence of the human malaria parasite Plasmodium falciparum
    • Gardner M.J., et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 2002, 419:498-511.
    • (2002) Nature , vol.419 , pp. 498-511
    • Gardner, M.J.1
  • 35
    • 28244477359 scopus 로고    scopus 로고
    • Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6
    • Jambou R., et al. Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet 2005, 366:1960-1963.
    • (2005) Lancet , vol.366 , pp. 1960-1963
    • Jambou, R.1
  • 36
    • 77949703350 scopus 로고    scopus 로고
    • Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversity
    • Jambou R., et al. Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversity. PLoS ONE 2010, 5:e9424.
    • (2010) PLoS ONE , vol.5
    • Jambou, R.1
  • 37
    • 33846600057 scopus 로고    scopus 로고
    • Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania
    • Malaria Journal 2009 8:31 5, 126
    • Mugittu, K. et al. (2006) Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania. Malaria Journal 2009 8:31 5, 126.
    • (2006)
    • Mugittu, K.1
  • 38
    • 33847115335 scopus 로고    scopus 로고
    • In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance-associated mutations of Plasmodium falciparum from São Tomé and Príncipe
    • Ferreira I.D., et al. In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance-associated mutations of Plasmodium falciparum from São Tomé and Príncipe. Trop. Med. Int. Health 2007, 12:353-362.
    • (2007) Trop. Med. Int. Health , vol.12 , pp. 353-362
    • Ferreira, I.D.1
  • 39
    • 33750563820 scopus 로고    scopus 로고
    • Resistance to dihydroartemisinin
    • Cojean S., et al. Resistance to dihydroartemisinin. Emerging. Infect. Dis. 2006, 12:1798-1799.
    • (2006) Emerging. Infect. Dis. , vol.12 , pp. 1798-1799
    • Cojean, S.1
  • 40
    • 77955182470 scopus 로고    scopus 로고
    • Different mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia
    • Eshetu T., et al. Different mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia. Malar. J. 2010, 9:226.
    • (2010) Malar. J. , vol.9 , pp. 226
    • Eshetu, T.1
  • 41
    • 34247871354 scopus 로고    scopus 로고
    • Resistance to dihydroartemisinin
    • author reply 809
    • Legrand E., et al. Resistance to dihydroartemisinin. Emerging. Infect. Dis. 2007, 13:808-809. author reply 809.
    • (2007) Emerging. Infect. Dis. , vol.13 , pp. 808-809
    • Legrand, E.1
  • 42
    • 2142769136 scopus 로고    scopus 로고
    • Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    • Price R.N., et al. Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet 2004, 364:438-447.
    • (2004) Lancet , vol.364 , pp. 438-447
    • Price, R.N.1
  • 43
    • 0032804039 scopus 로고    scopus 로고
    • The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand
    • Price R.N., et al. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob. Agents Chemother. 1999, 43:2943-2949.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 2943-2949
    • Price, R.N.1
  • 44
    • 0042769406 scopus 로고    scopus 로고
    • Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1
    • Pickard A.L., et al. Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1. Antimicrob. Agents and Chemother. 2003, 47:2418-2423.
    • (2003) Antimicrob. Agents and Chemother. , vol.47 , pp. 2418-2423
    • Pickard, A.L.1
  • 45
    • 58449119995 scopus 로고    scopus 로고
    • Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia. Malaria Journal 2009 8:31 8, 11
    • Lim, P. et al. (2009) Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia. Malaria Journal 2009 8:31 8, 11.
    • (2009)
    • Lim, P.1
  • 46
    • 34249707784 scopus 로고    scopus 로고
    • Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border
    • Alker A.P., et al. Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border. Am. J. Trop. Med. Hyg. 2007, 76:641-647.
    • (2007) Am. J. Trop. Med. Hyg. , vol.76 , pp. 641-647
    • Alker, A.P.1
  • 47
    • 33646736568 scopus 로고    scopus 로고
    • Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria
    • Price R.N., et al. Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria. Clin. Infect. Dis. 2006, 42:1570-1577.
    • (2006) Clin. Infect. Dis. , vol.42 , pp. 1570-1577
    • Price, R.N.1
  • 48
    • 78650640147 scopus 로고    scopus 로고
    • Genetic predisposition favors the acquisition of stable artemisinin resistance in malaria parasites
    • published online ahead of print on 1 November 2010, DOI: 10.1128/AAC.00916-10
    • Beez D., et al. Genetic predisposition favors the acquisition of stable artemisinin resistance in malaria parasites. Antimicrob. Agents Chemother. 2010, published online ahead of print on 1 November 2010, DOI: 10.1128/AAC.00916-10.
    • (2010) Antimicrob. Agents Chemother.
    • Beez, D.1
  • 49
    • 70350267053 scopus 로고    scopus 로고
    • Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility
    • Andriantsoanirina V., et al. Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility. Antimicrob. Agents Chemother. 2009, 53:4588-4597.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 4588-4597
    • Andriantsoanirina, V.1
  • 50
    • 0034995810 scopus 로고    scopus 로고
    • Madagascan isolates of Plasmodium falciparum showing low sensitivity to artemether in vitro
    • Randrianarivelojosia M., et al. Madagascan isolates of Plasmodium falciparum showing low sensitivity to artemether in vitro. Ann. Trop. Med. Parasitol. 2001, 95:237-243.
    • (2001) Ann. Trop. Med. Parasitol. , vol.95 , pp. 237-243
    • Randrianarivelojosia, M.1
  • 51
    • 0037502801 scopus 로고    scopus 로고
    • Analysis of pfcrt, pfmdr1, dhfr, and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin
    • Ngo T., et al. Analysis of pfcrt, pfmdr1, dhfr, and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin. Am. J. Trop. Med. Hyg. 2003, 68:350-356.
    • (2003) Am. J. Trop. Med. Hyg. , vol.68 , pp. 350-356
    • Ngo, T.1
  • 52
    • 0037020024 scopus 로고    scopus 로고
    • Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
    • Sidhu A.B., et al. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science 2002, 298:210-213.
    • (2002) Science , vol.298 , pp. 210-213
    • Sidhu, A.B.1
  • 53
    • 18244396971 scopus 로고    scopus 로고
    • Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum
    • Cooper R.A., et al. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Mol. Pharmacol. 2002, 61:35-42.
    • (2002) Mol. Pharmacol. , vol.61 , pp. 35-42
    • Cooper, R.A.1
  • 54
    • 77954048493 scopus 로고    scopus 로고
    • Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum
    • Valderramos S.G., et al. Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum. PLoS Pathog. 2010, 6:e1000887.
    • (2010) PLoS Pathog. , vol.6
    • Valderramos, S.G.1
  • 55
    • 0034708162 scopus 로고    scopus 로고
    • Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
    • Reed M.B., et al. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 2000, 403:906-909.
    • (2000) Nature , vol.403 , pp. 906-909
    • Reed, M.B.1
  • 56
    • 0034112601 scopus 로고    scopus 로고
    • Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum
    • Duraisingh M.T., et al. Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. Mol. Microbiol. 2000, 36:955-961.
    • (2000) Mol. Microbiol. , vol.36 , pp. 955-961
    • Duraisingh, M.T.1
  • 57
    • 33746302565 scopus 로고    scopus 로고
    • Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
    • Sidhu A.B., et al. Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. J. Infect. Dis. 2006, 194:528-535.
    • (2006) J. Infect. Dis. , vol.194 , pp. 528-535
    • Sidhu, A.B.1
  • 58
    • 77952664258 scopus 로고    scopus 로고
    • Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum
    • Chavchich M., et al. Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum. Antimicrob. Agents Chemother. 2010, 54:2455-2464.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 2455-2464
    • Chavchich, M.1
  • 59
    • 77952663685 scopus 로고    scopus 로고
    • De-amplification of pfmdr1-containing amplicon on chromosome 5 in Plasmodium falciparum is associated with reduced resistance to artelinic acid in vitro. Antimicrobial Agents and Chemotherapy, 10.1128/AAC.01421-01409
    • Chen, N. et al. (2010) De-amplification of pfmdr1-containing amplicon on chromosome 5 in Plasmodium falciparum is associated with reduced resistance to artelinic acid in vitro. Antimicrobial Agents and Chemotherapy, 10.1128/AAC.01421-01409.
    • (2010)
    • Chen, N.1
  • 60
    • 0842341149 scopus 로고    scopus 로고
    • Plasmodium yoelii: identification and partial characterization of an MDR1 gene in an artemisinin-resistant line
    • Ferrer-Rodríguez I., et al. Plasmodium yoelii: identification and partial characterization of an MDR1 gene in an artemisinin-resistant line. J. Parasitol. 2004, 90:152-160.
    • (2004) J. Parasitol. , vol.90 , pp. 152-160
    • Ferrer-Rodríguez, I.1
  • 61
    • 31944444061 scopus 로고    scopus 로고
    • Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10
    • Afonso A., et al. Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10. Antimicrob. Agents Chemother. 2006, 50:480-489.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 480-489
    • Afonso, A.1
  • 62
    • 77956563692 scopus 로고    scopus 로고
    • Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites
    • Hunt P., et al. Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites. BMC Genomics 2010, 11:499.
    • (2010) BMC Genomics , vol.11 , pp. 499
    • Hunt, P.1
  • 63
    • 77955451229 scopus 로고    scopus 로고
    • Experimental Evolution of Resistance to Artemisinin Combination Therapy Results in Amplification of the mdr1 Gene in a Rodent Malaria Parasite
    • Rodrigues L.A., et al. Experimental Evolution of Resistance to Artemisinin Combination Therapy Results in Amplification of the mdr1 Gene in a Rodent Malaria Parasite. PLoS ONE 2010, 5:e11593.
    • (2010) PLoS ONE , vol.5
    • Rodrigues, L.A.1
  • 64
    • 77950943615 scopus 로고    scopus 로고
    • High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia
    • Anderson T.J., et al. High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia. J. Infect. Dis. 2010, 201:1326-1330.
    • (2010) J. Infect. Dis. , vol.201 , pp. 1326-1330
    • Anderson, T.J.1
  • 65
    • 0033844213 scopus 로고    scopus 로고
    • Mathematical modelling of the chemotherapy of Plasmodium falciparum malaria with artesunate: postulation of 'dormancy', a partial cytostatic effect of the drug, and its implication for treatment regimens
    • Hoshen M.B., et al. Mathematical modelling of the chemotherapy of Plasmodium falciparum malaria with artesunate: postulation of 'dormancy', a partial cytostatic effect of the drug, and its implication for treatment regimens. Parasitology 2000, 121(Pt 3):237-246.
    • (2000) Parasitology , vol.121 , Issue.PART 3 , pp. 237-246
    • Hoshen, M.B.1
  • 66
    • 35848943438 scopus 로고    scopus 로고
    • Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis
    • Nagamune K., et al. Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis. Antimicrob. Agents Chemother. 2007, 51:3816-3823.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 3816-3823
    • Nagamune, K.1
  • 67
    • 73849093637 scopus 로고    scopus 로고
    • Discovery of artemisinin (Qinghaosu)
    • Liao F. Discovery of artemisinin (Qinghaosu). Molecules 2009, 14:5362-5366.
    • (2009) Molecules , vol.14 , pp. 5362-5366
    • Liao, F.1
  • 68
    • 33646942669 scopus 로고    scopus 로고
    • Reflections on the 'discovery' of the antimalarial qinghao
    • Hsu E., Hsu E. Reflections on the 'discovery' of the antimalarial qinghao. Br. J. Clin. Pharmacol. 2006, 61:666-670.
    • (2006) Br. J. Clin. Pharmacol. , vol.61 , pp. 666-670
    • Hsu, E.1    Hsu, E.2
  • 69
    • 0021948029 scopus 로고
    • Qinghaosu (artemisinin): an antimalarial drug from China
    • Klayman D.L. Qinghaosu (artemisinin): an antimalarial drug from China. Science 1985, 228:1049-1055.
    • (1985) Science , vol.228 , pp. 1049-1055
    • Klayman, D.L.1
  • 70
    • 35248815969 scopus 로고    scopus 로고
    • Ensuring sustained ACT production and reliable artemisinin supply
    • Kindermans J.M., et al. Ensuring sustained ACT production and reliable artemisinin supply. Malar. J. 2007, 6:125.
    • (2007) Malar. J. , vol.6 , pp. 125
    • Kindermans, J.M.1
  • 71
    • 33747138408 scopus 로고    scopus 로고
    • Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug
    • Liu C., et al. Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug. Appl. Microbiol. Biotechnol. 2006, 72:11-20.
    • (2006) Appl. Microbiol. Biotechnol. , vol.72 , pp. 11-20
    • Liu, C.1
  • 72
    • 4344630762 scopus 로고    scopus 로고
    • Identification of an antimalarial synthetic trioxolane drug development candidate
    • Vennerstrom J.L., et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 2004, 430:900-904.
    • (2004) Nature , vol.430 , pp. 900-904
    • Vennerstrom, J.L.1
  • 73
    • 70449732094 scopus 로고    scopus 로고
    • Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
    • Eastman R.T., Fidock D.A. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nat. Rev. Microbiol. 2009, 7:864-874.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 864-874
    • Eastman, R.T.1    Fidock, D.A.2
  • 74
    • 67650397861 scopus 로고    scopus 로고
    • Spread and evolution of Plasmodium falciparum drug resistance
    • Mita T., et al. Spread and evolution of Plasmodium falciparum drug resistance. Parasitol. Int. 2009, 58:201-209.
    • (2009) Parasitol. Int. , vol.58 , pp. 201-209
    • Mita, T.1
  • 75
    • 0014964375 scopus 로고
    • Altered dihydrofolate reductase associated with drug-resistance transfer between rodent plasmodia
    • Ferone R., et al. Altered dihydrofolate reductase associated with drug-resistance transfer between rodent plasmodia. Science 1970, 167:1263-1264.
    • (1970) Science , vol.167 , pp. 1263-1264
    • Ferone, R.1
  • 76
    • 0027339057 scopus 로고
    • Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand
    • Wilson C.M., et al. Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. Mol. Biochem. Parasitol. 1993, 57:151-160.
    • (1993) Mol. Biochem. Parasitol. , vol.57 , pp. 151-160
    • Wilson, C.M.1
  • 77
    • 0018577246 scopus 로고
    • Comparative studies on dihydrofolate reductases from Plasmodium falciparum and Aotus trivirgatus
    • Kan S.C., Siddiqui W.A. Comparative studies on dihydrofolate reductases from Plasmodium falciparum and Aotus trivirgatus. J. Protozool. 1979, 26:660-664.
    • (1979) J. Protozool. , vol.26 , pp. 660-664
    • Kan, S.C.1    Siddiqui, W.A.2
  • 78
    • 0344666075 scopus 로고
    • Drug resitance In Plasmodium falciparum from Thailand
    • Young M., et al. Drug resitance In Plasmodium falciparum from Thailand. Am. J. Trop. Med. Hyg. 1963, 12:305-314.
    • (1963) Am. J. Trop. Med. Hyg. , vol.12 , pp. 305-314
    • Young, M.1
  • 79
    • 0000063469 scopus 로고
    • Plasmodium falciparum resistant to chloroquine in Cambodia
    • Eyles D., et al. Plasmodium falciparum resistant to chloroquine in Cambodia. Am. J. Trop. Med. Hyg. 1963, 12:840-843.
    • (1963) Am. J. Trop. Med. Hyg. , vol.12 , pp. 840-843
    • Eyles, D.1
  • 80
    • 0025350150 scopus 로고
    • Drug-resistant malaria: mechanisms of development and inferences for malaria control
    • Björkman A., Phillips-Howard P.A. Drug-resistant malaria: mechanisms of development and inferences for malaria control. Trans. R. Soc. Trop. Med. Hyg. 1990, 84:323-324.
    • (1990) Trans. R. Soc. Trop. Med. Hyg. , vol.84 , pp. 323-324
    • Björkman, A.1    Phillips-Howard, P.A.2
  • 81
    • 79251594566 scopus 로고    scopus 로고
    • Guidelines for the Treatment of Malaria
    • WHO (2006) Guidelines for the Treatment of Malaria.
    • (2006) WHO
  • 82
    • 0034732666 scopus 로고    scopus 로고
    • The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin
    • Duraisingh M.T., et al. The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol. Biochem. Parasitol. 2000, 108:13-23.
    • (2000) Mol. Biochem. Parasitol. , vol.108 , pp. 13-23
    • Duraisingh, M.T.1
  • 83
    • 23744435838 scopus 로고    scopus 로고
    • Pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum
    • Sidhu A.B., Fidock D.A. pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Mol. Microbiol. 2005, 57:913-926.
    • (2005) Mol. Microbiol. , vol.57 , pp. 913-926
    • Sidhu, A.B.1    Fidock, D.A.2
  • 84
    • 78649891852 scopus 로고    scopus 로고
    • Artemisinin resistance in cambodia: a clinical trial designed to address an emerging problem in southeast Asia
    • Noedl H., et al. Artemisinin resistance in cambodia: a clinical trial designed to address an emerging problem in southeast Asia. Clin. Infect. Dis. 2010, 51:e82-89.
    • (2010) Clin. Infect. Dis. , vol.51
    • Noedl, H.1
  • 85
    • 67650327631 scopus 로고    scopus 로고
    • Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene
    • Tahar R., et al. Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene. Am. J. Trop. Med. Hyg. 2009, 81:13-18.
    • (2009) Am. J. Trop. Med. Hyg. , vol.81 , pp. 13-18
    • Tahar, R.1
  • 86
    • 65649153380 scopus 로고    scopus 로고
    • Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro
    • Muangnoicharoen S., et al. Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro. Antimicrob. Agents Chemother. 2009, 53:1362-1366.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 1362-1366
    • Muangnoicharoen, S.1
  • 87
    • 0036592772 scopus 로고    scopus 로고
    • Molecular epidemiology of malaria in Cameroon. X. Evaluation of PFMDR1 mutations as genetic markers for resistance to amino alcohols and artemisinin derivatives
    • Basco L.K., Ringwald P. Molecular epidemiology of malaria in Cameroon. X. Evaluation of PFMDR1 mutations as genetic markers for resistance to amino alcohols and artemisinin derivatives. Am. J. Trop. Med. Hyg. 2002, 66:667-671.
    • (2002) Am. J. Trop. Med. Hyg. , vol.66 , pp. 667-671
    • Basco, L.K.1    Ringwald, P.2
  • 88
    • 34547626439 scopus 로고    scopus 로고
    • Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda
    • Nsobya S.L., et al. Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Antimicrob. Agents Chemother. 2007, 51:3023-3025.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 3023-3025
    • Nsobya, S.L.1
  • 89
    • 34249883577 scopus 로고    scopus 로고
    • The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa
    • Sisowath C., et al. The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa. Trop. Med. Int. Health 2007, 12:736-742.
    • (2007) Trop. Med. Int. Health , vol.12 , pp. 736-742
    • Sisowath, C.1
  • 90
    • 33646450674 scopus 로고    scopus 로고
    • Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic
    • Dokomajilar C., et al. Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrob. Agents Chemother. 2006, 50:1893-1895.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 1893-1895
    • Dokomajilar, C.1
  • 91
    • 33847655633 scopus 로고    scopus 로고
    • Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria
    • Humphreys G.S., et al. Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria. Antimicrob. Agents Chemother. 2007, 51:991-997.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 991-997
    • Humphreys, G.S.1
  • 92
    • 33846837894 scopus 로고    scopus 로고
    • Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial
    • Zongo I., et al. Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial. Lancet 2007, 369:491-498.
    • (2007) Lancet , vol.369 , pp. 491-498
    • Zongo, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.