Intramuscular bioavailability and clinical efficacy of artesunate in Gabonese children with severe malaria

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 12, 2002, Pages 3933-3939

  Nealon, Claire ^a   Dzeing, Arnaud ^b   Müller Römer, Ulrich ^a,b,c   Planche, Timothy ^a   Sinou, Veronique ^c   Kombila, Maryvonne ^b   Kremsner, Peter G ^c,d   Parzy, Daniel ^e   Krishna, Sanjeev ^a,b  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b University of Libreville   (Gabon)

^c ALBERT SCHWEITZER HOSPITAL   (Gabon)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e SERVICE DE SANTÉ DES ARMÉES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ DERIVATIVE; ARTESUNATE; DIHYDROARTEMISININ; FANSIDAR; QUININE; ANTIMALARIAL AGENT; SESQUITERPENE;

AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; FEMALE; GABON; HEMOGLOBINURIA; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALARIA; MALE; OLIGURIA; OUTCOMES RESEARCH; PARASITEMIA; PATIENT MONITORING; PHARMACODYNAMICS; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STEADY STATE; BIOAVAILABILITY; BLOOD; HALF LIFE TIME; INFANT; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALARIA FALCIPARUM; METABOLIC CLEARANCE RATE; METABOLISM; TREATMENT OUTCOME;

ANTIMALARIALS; AREA UNDER CURVE; ARTEMISININS; BIOLOGICAL AVAILABILITY; CHILD, PRESCHOOL; CROSS-OVER STUDIES; FEMALE; GABON; HALF-LIFE; HUMANS; INFANT; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; MALARIA, FALCIPARUM; MALE; METABOLIC CLEARANCE RATE; SESQUITERPENES; TREATMENT OUTCOME;

EID: 0036896785     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.12.3933-3939.2002     Document Type: Article

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