Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanaian children with moderate malaria

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 2, 2001, Pages 509-516

  Krishna, S ^a   Planche, T ^a   Agbenyega, T ^a   Woodrow, C ^a   Agranoff, D ^a   Bedu Addo, G ^a   Owusu Ofori, A K ^a   Appiah, J A ^a   Ramanathan, S ^a   Mansor, S M ^a   Navaratnam, V ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE; DIAZEPAM; DIHYDROARTEMISININ; PARACETAMOL; PHENOBARBITAL; QUININE SULFATE;

ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; FEMALE; FEVER; GHANA; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SEIZURE; SIDE EFFECT;

ADMINISTRATION, RECTAL; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; CHLOROQUINE; FEMALE; FOLLOW-UP STUDIES; GHANA; HUMANS; INFANT; INJECTIONS, INTRAVENOUS; MALARIA; MALARIA, CEREBRAL; MALE; SESQUITERPENES;

EID: 0035143173     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.2.509-516.2001     Document Type: Article

References (21)

1. Glucose and lactate kinetics in children with severe malaria
2. Artesunate. A review of its pharmacology and therapeutic efficacy in the treatment of malaria
3. A pharmacokinetic and pharmacodynamic study of intravenous vs oral artesunate in uncomplicated falciparum malaria
4. A pharmacokinetic and pharmacodynamic study of artesunate for vivax malaria
5. Pharmacokinetics of artemisinin and artesunate after oral administration in healthy volunteers
6. Pharmacokinetics of oral artesunate in children with moderately severe Plasmodium falciparum malaria
7. Pharmacokinetic/pharmacodynamic data analysis: Concepts and applications, 2nd ed.
8. Plasma levels of artesunate and dihydroartemisinin in children with Plasmodium falciparum malaria in Gabon after administration of 50-milligram artesunate suppositories
9. An overview of the clinical use of artemisinin and its derivatives in the treatment of falciparum malaria in Viet Nam
10. Comparison of artemisinin suppositories with intravenous artesunate and intravenous quinine in the treatment of cerebral malaria
11. An open randomized comparison of intravenous and intramuscular artesunate in severe falciparum malaria
12. Comparative effectiveness of artemisinin suppositories and oral quinine in children with acute falciparum malaria
13. Qinghaosu
14. Metabolism of antimalarial sesquiterpene lactones
15. Simultaneous determination of artesunate and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies
16. Severe falciparum malaria in children: Current understanding of its pathophysiology and supportive treatment
17. Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria
18. pfmdr1 gene amplification and multidrug-resistant Plasmodium falciparum on the northwest border of Thailand
19. Comparative clinical trial of artesunate suppositories and oral artesunate in combination with mefloquine in the treatment of children with acute falciparum malaria
20. Treatment of malaria: Some considerations and limitations of current methods of assessment