Antimalarial screening via large-scale purification of Plasmodium falciparum Ca2+-ATPase 6 and in vitro studies

FEBS Journal

Volumn 280, Issue 21, 2013, Pages 5419-5429

  David Bosne, Stéphanie ^a   Florent, Isabelle ^b   Lund Winther, Anne Marie ^c,d   Hansen, John B ^c   Buch Pedersen, Morten ^c   Machillot, Paul ^a   Le Maire, Marc ^a   Jaxel, Christine ^a  

^a INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c Pcovery   (Denmark)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

antiplasmodial activity; Ca2+ ATPase activity; PfATP6; recombinant protein; Saccharomyces cerevisiae

Indexed keywords

2,5 DI TERT BUTYLHYDROQUINONE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (CALCIUM) 6; ANTIMALARIAL AGENT; CHLOROQUINE; CYCLOPIAZONIC ACID; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PURIFICATION; ERYTHROCYTE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MICROBIAL GROWTH; NONHUMAN; PLASMODIUM FALCIPARUM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; WESTERN BLOTTING; YEAST CELL;

ANTIPLASMODIAL ACTIVITY; CA2+-ATPASE ACTIVITY; PFATP6; RECOMBINANT PROTEIN; SACCHAROMYCES CEREVISIAE;

ANIMALS; ANTIMALARIALS; BLOTTING, WESTERN; CALCIUM-TRANSPORTING ATPASES; HUMANS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; RABBITS; SACCHAROMYCES CEREVISIAE; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SMALL MOLECULE LIBRARIES;

MAMMALIA; PLASMODIUM FALCIPARUM; SACCHAROMYCES CEREVISIAE;

EID: 84886102323     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12244     Document Type: Conference Paper

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