Spontaneous mutations in the plasmodium falciparum sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (PfATP6) gene among geographically widespread parasite populations unexposed to artemisinin-based combination therapies

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 1, 2011, Pages 94-100

  Tanabe, Kazuyuki ^a   Zakeri, Sedigheh ^b   Palacpac, Nirianne Marie Q ^a   Afsharpad, Manada ^b   Randrianarivelojosia, Milijaona ^c   Kaneko, Akira ^d   Marma, Aung Swi Prue ^e   Horii, Toshihiro ^a   Mita, Toshihiro ^f  

^a OSAKA UNIVERSITY   (Japan)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

^c INSTITUT PASTEUR DE MADAGASCAR   (Madagascar)

^d KAROLINSKA INSTITUTE   (Sweden)

^e Directorate General of Health Services   (Bangladesh)

^f TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; GENE FREQUENCY; GEOGRAPHIC DISTRIBUTION; HAPLOTYPE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SPONTANEOUS MUTATION;

ANIMALS; ANTI-INFECTIVE AGENTS; ARTEMISININS; GENE FREQUENCY; HAPLOTYPES; MUTATION; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTOZOAN PROTEINS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 78650639910     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01156-10     Document Type: Article

References (35)

1. Anderson, T. J., B. Haubold, J. T. Williams, J. G. Estrada-Franco, L. Richardson, R. Mollinedo, M. Bockarie, J. Mokili, S. Mharakurwa, N. French, J. Whitworth, I. D. Velez, A. H. Brockman, F. Nosten, M. U. Ferreira, and K. P. Day. 2000. Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Mol. Biol. Evol. 17:1467-1482.
2. Bacon, D. J., A. M. McCollum, S. M. Griffing, C. Salas, V. Soberon, M. Santolalla, R. Haley, P. Tsukayama, C. Lucas, A. A. Escalante, and V. Udhayakumar. 2009. Dynamics of malaria drug resistance patterns in the Amazon Basin region following changes in Peruvian national treatment policy for uncomplicated malaria. Antimicrob. Agents Chemother. 53:2042-2051.
3. Bertaux, L., L. H. Quang, V. Sinou, N. X. Thanh, and D. Parzy. 2009. New PfATP6 mutations found in Plasmodium falciparum isolates from Vietnam. Antimocrob. Agents Chemother. 53:4570-4571.
4. Bwijo, B., A. Kaneko, M. Takechi, I. L. Zungu, Y. Moriyama, J. K. Lum, T. Tsukahara, T. Mita, N. Takahashi, Y. Bergqvist, A. Bjorkman, and T. Kobayakawa. 2003. High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi. Acta Trop. 85:363-373.
5. Cojean, S., V. Hubert, J. Le Bras, and R. Durand. 2006. Resistance to dihydroartemisinin. Emerg. Infect. Dis. 12:1798-1799.
6. 2+-ATPase orthologue of Plasmodium falciparum (PfATP6). Infect. Genet. Evol. 8:340-345.
7. Dondorp, A. M., F. Nosten, P. Yi, D. Das, A. P. Phyo, J. Tarning, K. M. Lwin, F. Ariey, W. Hanpithakpong, S. J. Lee, P. Ringwald, K. Silamut, M. Imwong, K. Chotivanich, P. Lim, T. Herdman, S. S. An, S. Yeung, P. Singhasivanon, N. P. Day, N. Lindegardh, D. Socheat, and N. J. White. 2009. Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 361:455-467.
8. Eastman, R. T., and D. A. Fidock. 2009. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nat. Rev. Microbiol. 7:864-874.
9. Eckstein-Ludwig, U., R. J. Webb, I. D. Van Goethem, J. M. East, A. G. Lee, M. Kimura, P. M. O'Neill, P. G. Bray, S. A. Ward, and S. Krishna. 2003. Artemisinins target the SERCA of Plasmodium falciparum. Nature 424:957-961.
10. Excoffier, L., G. Laval, and S. Schneider. 2005. Arlequin (version 3.0): an integrated software package for population genetics data analysis. Evol. Bioinform. 1:47-50.
11. Ferreira, I. D., A. Martinelli, L. A. Rodrigues, E. L. do Carmo, V. E. do Rosário, M. M. Póvoa, and P. Cravo. 2008. Plasmodium falciparum from Pará state (Brazil) shows satisfactory in vitro response to artemisinin derivatives and absence of the S769N mutation in the SERCA-type PfATPase6. Trop. Med. Int. Health 13:199-207.
12. Ibrahim, M. L., N. Khim, H. H. Adam, F. Ariey, and J.-B. Duchemin. 2009. Polymorphism of PfATPase in Niger: detection of three new point mutations. Malar. J. 8:28.
13. Jambou, R., E. Legrand, M. Niang, N. Khim, P. Lim, B. Volney, M. T. Ekala, C. Bouchier, P. Esterre, T. Fandeur, and O. Mercereau-Puijalon. 2005. Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet 366:1960-1963.
14. 2+ATPase (PfSERCA) gene diversity. PLoS One 5:e9424.
15. Krishna, S. 2006. Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance. Trend Mol. Med. 12:200-205.
16. Legrand, E., B. Volney, J. B. Meynard, P. Esterr, and O. Mercereau-Puijalon. 2007. Resistance to dihydroartemisinin. Emerg. Infect. Dis. 13:808-809.
17. Marma, A. S., T. Mita, H. Eto, T. Tsukahara, S. Sarker, and H. Endo. 2010. High prevalence of sulfadoxine/pyrimethamine resistance alleles in Plasmodium falciparum parasites from Bangladesh. Parasitol. Int. 59:178-182.
18. Menegon, M., A. R. Sannella, G. Majori, and C. Severini. 2008. Detection of novel point mutations in the Plasmodium falciparum ATPase6 candidate gene for resistance to artemisinins. Parasitol. Int. 57:233-235.
19. Mu, J., P. Awadalla, J. Duan, K. M. McGee, J. Keebler, K. Seydel, G. A. T. McVean, and X.-Z. Su. 2007. Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome. Nat. Genet. 39:126-130.
20. Mugittu, K., B. Genton, H. Mshindal, and H. P. Beck. 2006. Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania. Malar. J. 5:126.
21. Nei, M. 1987. Molecular evolutionary genetics. Columbia University Press, New York, NY.
22. Noedl, H., Y. Se, K. Schaecher, B. L. Smith, D. Socheat, and M. M. Fukuda. 2008. Evidence of artemisinin-resistant malaria in western Cambodia. N. Engl. J. Med. 359:2619-2620.
23. Nosten, F., and N. J. White. 2007. Artemisinin-based combination treatment of falciparum malaria. Am. J. Trop. Med. Hyg. 77(Suppl. 6):181-192.
24. Randrianarivelojosia, M., J. L. Harisoa, L. P. Rabarijaona, L. A. Raharimalala, L. Ranaivo, V. Pietra, J. B. Duchemin, F. Rakotomanana, V. Robert, P. Mauclere, and F. Ariey. 2002. In vitro sensitivity of Plasmodium falciparum to amodiaquine compared with other major antimalarials in Madagascar. Parassitologia 44:141-147.
25. Rozas, J., J. C. Sánchez-DelBarrio, X. Messeguer, and R. Rozas. 2003. DnaSP, DNA polymorphism analyses by the coalescent and other methods. Bioinformatics 19:2496-2497.
26. Tahar, R., P. Ringwald, and L. K. Basco. 2009. Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene. Am. J. Trop. Med. Hyg. 81:13-18.
27. Tamura, K., J. Dudley, M. Nei, and S. Kumar. 2007. MEGA 4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol. Biol. Evol. 24:1596-1599.
28. Tanabe, K., N. Sakihama, T. Hattori, L. Ranford-Cartwright, I. Goldman, A. A. Escalante, and A. A. Lal. 2004. Genetic distance in housekeeping genes between Plasmodium falciparum and Plasmodium reichenowi and within P. falciparum. J. Mol. Evol. 59:687-694.
29. Tanabe, K., N. Sakihama, D. Walliker, H. Babiker, A. A. Abdel-Muhsin, B. Bakote'e, H. Ohmae, N. Arisue, T. Horii, I. Rooth, A. Färnert, A. Björkman, and L. Ranford-Cartwright. 2007. Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum msp1. Gene 397:153-160.
30. Tanabe, K., T. Mita, T. Jombart, A. Eriksson, S. Horibe, N. Palacpac, L. Ranford-Cartwright, H. Sawai, N. Sakihama, H. Ohmae, M. Nakamura, M. U. Ferreira, A. A. Escalante, F. Prugnolle, A. Björkman, A. Färnert, A. Kaneko, T. Horii, A. Manica, H. Kishino, and F. Balloux. 2010. Plasmodium falciparum accompanied the human expansion out of Africa. Curr. Biol. 70:1-7.
31. Thompson, J. D., T. J. Gibson, F. Plewniak, F. Jeanmougin, and D. G. Higgins. 1997. The CLUSTAL X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 24:4876-4882.
32. Uhlemann, A. C., A. Cameron, U. Eckstein-Ludwig, J. Fischbarg, P. Iserovich, F. A. Zuniga, M. East, A. Lee, L. Brady, R. K. Haynes, and S. A. Krishna. 2005. A single amino acid residue can determine the sensitivity of SERCAs to artemisinins. Nat. Struct. Mol. Biol. 12:628-629.
33. Valderramos, S. G., D. Scanfeld, A. C. Uhlemann, D. A. Fidock, and S. Krishna. 2010. Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrob. Agents Chemother. 54:3842-3852.
34. World Health Organization. 2006. WHO guidelines for the treatment of malaria. World Health Organization, Geneva, Switzerland.
35. Zhang, G., Y. Guan, B. Zheng, S. Wu, and L. Tang. 2008. No PfATPase6 S769N mutation found in Plasmodium falciparum isolates from China. Malar. J. 7:122.