Genomewide scan reveals amplification of mdr1 as a common denominator of resistance to mefloquine, lumefantrine, and artemisinin in Plasmodium chabaudi malaria parasites

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 10, 2011, Pages 4858-4865

  Borges, Sofia ^a   Cravo, Pedro ^c   Creasey, Alison ^b   Fawcett, Richard ^b   Modrzynska, Katarzyna ^b   Rodrigues, Louise ^a   Martinelli, Axel ^a   Hunt, Paul ^b  

^a INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; BENFLUMETOL; MEFLOQUINE; MULTIDRUG RESISTANCE PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOPHELES STEPHENSI; ARTICLE; BACKCROSSING; CHROMOSOME 12; CHROMOSOME 4; CHROMOSOME DUPLICATION; CONTROLLED STUDY; DRUG CONTROL; FEMALE; GENE AMPLIFICATION; GENE MUTATION; GENETIC ASSOCIATION; MALARIA; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; OOCYTE; PARASITE SURVIVAL; PARASITEMIA; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROGENY; SINGLE NUCLEOTIDE POLYMORPHISM; SPOROZOITE;

ANTIMALARIALS; ARTEMISININS; BASE SEQUENCE; CHROMOSOME MAPPING; DRUG RESISTANCE, MULTIPLE; ETHANOLAMINES; FLUORENES; GENETIC LINKAGE; GENOME, PROTOZOAN; MALARIA; MEFLOQUINE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PLASMODIUM CHABAUDI; SEQUENCE ANALYSIS, DNA;

EID: 80052823947     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01748-10     Document Type: Article

References (41)

1. Reference deleted.
2. Carter, R., and D. Walliker. 1975. New observations on the malaria parasites of rodents of the Central African Republic Plasmodium vinckei petteri subsp. nov. and Plasmodium chabaudi Landau, 1965. Ann. Trop. Med. Parasitol. 69:187-196.
3. Chavchich, M., et al. 2010. Induction of resistance to artemisinin derivatives in Plasmodium falciparum: role of Pfmdr1 amplification and expression. Antimicrob. Agents Chemother. 54:2455-2464.
4. Cheesman, S., et al. 2007. Validation of pyrosequencing for accurate and high throughput estimation of allele frequencies in malaria parasites. Mol. Biochem. Parasitol. 152:213-219.
5. Cowman, A. F., D. Galatis, and J. K. Thompson. 1994. Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr 1 gene and cross-resistance to halofantrine and quinine. Proc. Natl. Acad. Sci. U. S. A. 91:1143-1147.
6. Cravo, P. V., et al. 2003. Genetics of mefloquine resistance in the rodent malaria parasite Plasmodium chabaudi. Antimicrob. Agents Chemother. 47: 709-718. (Pubitemid 36158105)
7. Culleton, R., A. Martinelli, P. Hunt, and R. Carter. 2005. Linkage group selection: rapid gene discovery in malaria parasites. Genome Res. 15:92-97.
8. Dondorp, A. M., et al. 2009. Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 361:455-467.
9. Duraisingh, M. T., and P. Refour. 2005. Multiple drug resistance genes in malaria-from epistasis to epidemiology. Mol. Microbiol. 57:874-877.
10. Duraisingh, M. T., and A. F. Cowman. 2005. Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop. 94:181-190.
11. Reference deleted.
12. Hunt, P., et al. 2007. Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites. Mol. Microbiol. 65:27-40.
13. Hunt, P., et al. 2010. Experimental evolution, genetic analysis and genome resequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites. BMC Genomics 11:499.
14. Jacobs, R. L. 1964. Role of p-aminobenzoic acid in Plasmodium berghei infection in the mouse. Exp. Parasitol. 15:213-225.
15. Lim, P., et al. 2009. Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia. Malar. J. 8:11.
16. MacPherson, S., M. Larochelle, and B. Turcotte. 2006. A fungal family of transcriptional regulators: the zinc cluster proteins. Microbiol. Mol. Biol. Rev. 70:583-604.
17. Nair, S., et al. 2007. Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites. Mol. Biol. Evol. 24:562-573.
18. Reference deleted.
19. Noedl, H., et al. 2008. Evidence of artemisinin-resistant malaria in Western Cambodia. N. Engl. J. Med. 359:2619-2620.
20. Padua, R. A. 1981. Plasmodium chabaudi: genetics of resistance to chloroquine. Exp. Parasitol. 52:419-426.
21. Peel, S. A., P. Bright, B. Yount, J. Handy, and R. S. Baric. 1994. A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P glycoprotein gene homolog (pfmdr) of Plasmodium falciparum in vitro. Am. J. Trop. Med. Hyg. 51:648-658.
22. Reference deleted.
23. Preechapornkul, P., et al. 2009. Plasmodium falciparum Pfmdr1 amplification, mefloquine resistance, and parasite fitness. Antimicrob. Agents Chemother. 53:1509-1515.
24. Price, R. N., et al. 1999. The pfmdr1 gene is associated with a multidrugresistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob. Agents Chemother. 43:2943-2949.
25. Price, R. N., et al. 2004. Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet 364:438-447. (Pubitemid 39036891)
26. Price, R. N., et al. 2006. Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria. Clin. Infect. Dis. 42:1570-1577.
27. Reed, M. B., K. J. Saliba, S. R. Caruana, K. Kirk, and A. F. Cowman. 2000. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403:906-909.
28. Ribacke, U., et al. 2007. Genome wide gene amplifications and deletions in Plasmodium falciparum. Mol. Biochem. Parasitol. 155:33-44. (Pubitemid 47042215)
29. Riordan, J. R., K. Deuchars, N. Kartner, N. Alon, and J. Trent. 1985. Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 316:817-819. (Pubitemid 15003740)
30. Rodrigues, L. A., et al. 2010. Experimental evolution of resistance to artemisinin combination therapy results in amplification of the mdr1 gene in a rodent malaria parasite. PLoS One 5:7.
31. Rogers, W. O., et al. 2009. Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. Malar. J. 12:8-10.
32. Rohrbach, P., et al. 2006. Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum. EMBO J. 25:3000-3011. (Pubitemid 44106753)
33. Rosario, V. E. 1976. Genetics of chloroquine resistance in malaria parasites. Nature 262:585-586.
34. Sidhu, A. B., et al. 2006. Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. J. Infect. Dis. 194:528-535.
35. Torigoe, T., et al. 2005. Cisplatin resistance and transcription factors. Curr. Med. Chem. Anticancer Agents 5:15-27.
36. Uhlemann, A. C., et al. 2007. Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand. J. Infect. Dis. 195:134-141.
37. Valderramos, S. G., and D. A. Fidock. 2006. Transporters involved in resistance to antimalarial drugs. Trends Pharmacol. Sci. 27:594-601.
38. Walliker, D., R. Carter, and A. Sanderson. 1975. Genetic studies on Plasmodium chabaudi: recombination between enzyme markers. Parasitology 70:19-24.
39. Wilson, C. M., et al. 1993. Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. Mol. Biochem. Parasitol. 57:151-160.
40. Woodrow, C. J., and S. Krishna. 2006. Antimalarial drugs: recent advances in molecular determinants of resistance and their clinical significance. Cell. Mol. Life Sci. 63:1586-1596.
41. World Health Organization. 1996. Guidelines for the treatment of malaria. WHO, Geneva, Switzerland.