A simplified intravenous artesunate regimen for severe malaria

Journal of Infectious Diseases

Volumn 205, Issue 2, 2012, Pages 312-319

  Kremsner, Peter Gottfried ^a,b   Taylor, Terrie ^d,g   Issifou, Saadou ^a,b   Kombila, Maryvonne ^c   Chimalizeni, Yamikani ^e   Kawaza, Kondwana ^f   Bouyou Akotet, Marielle K ^c   Duscha, Mattias ^a,b   Mordmüller, Benjamin ^a,b   Kösters, Katrin ^a   Humberg, Alexander ^a   Miller, R Scott ^h   Weina, Peter ^h   Duparc, Stephan ⁱ   Möhrle, Jörg ⁱ   Kun, Jürgen F J ^a   Planche, Tim ^b,j   Teja Isavadharm, Paktiya ^k   Simpson, Julie Anne ^l   Köhler, Carsten ^a   Krishna, Sanjeev ^b,j   more..

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b ALBERT SCHWEITZER HOSPITAL   (Gabon)

^c UNIVERSITÉ DES SCIENCES DE LA SANTÉ   (Gabon)

^d Blantyre Malaria Project   (Malawi)

^e UNIVERSITY OF MALAWI   (Malawi)

^f QUEEN ELIZABETH CENTRAL HOSPITAL   (Malawi)

^g MICHIGAN STATE UNIVERSITY   (United States)

^h WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

ⁱ International Centre Contrin   (Switzerland)

^j ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^k ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

^l UNIVERSITY OF MELBOURNE   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ARTESUNATE; DIHYDROARTEMISININ; PLACEBO; PYRIMETHAMINE PLUS SULFADOXINE;

AFRICA; ARTICLE; BIOCHEMISTRY; CHILD; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; FEMALE; HEMATOLOGICAL PARAMETERS; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; PARASITE CLEARANCE; PARASITEMIA; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; UNSPECIFIED SIDE EFFECT;

ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALARIA, FALCIPARUM; MALE; PARASITE LOAD; PARASITEMIA; TIME FACTORS; TREATMENT OUTCOME;

EID: 84555195609     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir724     Document Type: Article

References (17)

1. Newton CW, Krishna S. Severe falciparum malaria in children: current understanding of its pathophysiology and supportive treatment. Pharmacol Ther 1998; 79:1-53. (Pubitemid 28318261)
2. van Hensbroek MB, Onyiorah E, Jaffar S, et al. A trial of artemether or quinine in children with cerebralmalaria. New Engl JMed 1996; 335:69-75. (Pubitemid 26240107)
3. Fargier JJ, Louis FJ, Duparc S, Hounsinou C, Ringwald P, Danis M. Comparative study of artemether and quinine in severe Plasmodium falciparum malaria in adults and older children in Cameroon. Med Trop (Mars) 1999; 59:151-6.
4. Krudsood S, Wilairatana P, Vannaphan S, et al. Clinical experience with intravenous quinine, intramuscular artemether and intravenous artesunate for the treatment of severe malaria in Thailand. Southeast Asian J Trop Med Public Health 2003; 34:54-61. (Pubitemid 36959615)
5. Woodrow CJ, Haynes RK, Krishna S. Artemisinins. Postgrad Med J 2005; 81:71-8. (Pubitemid 40282867)
6. Li Q, Xie LH, Johnson TO, Si Y, Haeberle AS, Weina PJ. Toxicity evaluation of artesunate and artelinate in Plasmodium berghei-infected and uninfected rats. Trans R Soc Trop Med Hyg 2007; 101:104-12. (Pubitemid 44835337)
7. Dondorp A, Nosten F, Stepniewska K, Day N, White N. Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial. Lancet 2005; 366:717-25. (Pubitemid 41207233)
8. Dondorp AM, Fanello CI, Hendriksen IC, et al. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet 2010; 376:1647-57.
9. Nealon C, Dzeing A, Muller-Romer U, et al. Intramuscular bioavailability and clinical efficacy of artesunate in Gabonese children with severe malaria. Antimicrob Agents Chemother 2002; 46:3933-9. (Pubitemid 35403271)
10. Planche T, Krishna S, Kombila M, et al. Comparison of methods for the rapid laboratory assessment of children with malaria. Am J Trop Med Hyg 2001; 65:599-602. (Pubitemid 33134599)
11. Kun JF, Schmidt-Ott RJ, Lehman LG, et al. Merozoite surface antigen 1 and 2 genotypes and rosetting of Plasmodium falciparum in severe and mild malaria in Lambarene, Gabon. Trans R Soc Trop Med Hyg 1998; 92:110-4. (Pubitemid 28073749)
12. Teja-Isavadharm P, Siriyanonda D, Siripokasupkul R, et al. A simplified liquid chromatography-mass spectrometry assay for artesunate and dihydroartemisinin, its metabolite, in human plasma. Molecules 2010; 15:8747-68.
13. World Health Organization. Guidelines for the treatment of malaria. http://whqlibdoc.who.int/publications/2010/9789241547925-eng.pdf. Accessed 27 October 2011.
14. Bethell D, Se Y, Lon C, et al. Dose-dependent risk of neutropenia after 7-day courses of artesunate monotherapy in Cambodian patients with acute Plasmodium falciparum malaria. Clin Infect Dis 2010; 51:e105-114.
15. Simpson JA, Agbenyega T, Barnes KI, et al. Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients. PLoS Med 2006; 3:e444.
16. Gomes MF, Faiz MA, Gyapong JO, et al. Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial. Lancet 2009; 373:557-66.
17. Saralamba S, Pan-Ngum W, Maude RJ, et al. Intrahost modeling of artemisinin resistance in Plasmodium falciparum. Proc Natl Acad Sci USA 2010; 108:397-402.