-
1
-
-
42949160050
-
Natural products as leads to potential drugs: an old process or the new hope for drug discovery?
-
Newman, D.J. (2008) Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J. Med. Chem., 51, 2589-2599.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 2589-2599
-
-
Newman, D.J.1
-
2
-
-
1542268206
-
Selective optimization of side activities: another way for drug discovery
-
Wermuth, C.G. (2004) Selective optimization of side activities: another way for drug discovery. J. Med. Chem., 47, 1303-1314.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 1303-1314
-
-
Wermuth, C.G.1
-
3
-
-
0037124196
-
Drugs, leads, and drug-likeness: an analysis of some recently launched drugs
-
Proudfoot, J.R. (2002) Drugs, leads, and drug-likeness: an analysis of some recently launched drugs. Bioorg. Med. Chem. Lett., 12, 1647-1650.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 1647-1650
-
-
Proudfoot, J.R.1
-
4
-
-
0028303820
-
Plasma protein binding displacement interactions - why are they still regarded as clinically important?
-
Rolan, P.E. (1994) Plasma protein binding displacement interactions - why are they still regarded as clinically important? Br. J. Clin. Pharmacol., 37, 125-128.
-
(1994)
Br J. Clin. Pharmacol.
, vol.37
, pp. 125-128
-
-
Rolan, P.E.1
-
5
-
-
33845370513
-
Estimation of volume of distribution in humans from high throughput HPLC-based measurements of human serum albumin binding and immobilized artificial membrane partitioning
-
Hollósy, F., Valkó, K., Hersey, A., Nunhuck, S., Kéri, G., and Bevan, C. (2006) Estimation of volume of distribution in humans from high throughput HPLC-based measurements of human serum albumin binding and immobilized artificial membrane partitioning. J. Med. Chem., 49, 6958-6971
-
(2006)
J. Med. Chem.
, vol.49
, pp. 6958-6971
-
-
Hollósy, F.1
Valkó, K.2
Hersey, A.3
Nunhuck, S.4
Kéri, G.5
Bevan, C.6
-
6
-
-
33645675081
-
A hybrid mixture discriminant analysis-random forest computational model for the prediction of volume of distribution of drugs in human
-
Lombardo, F., Obach, R.S., DiCapua, F.M., Bakken, G.A., Lu, J., Potter, D.M., Gao, F., Miller, M.D., and Zhang, Y. (2006) A hybrid mixture discriminant analysis-random forest computational model for the prediction of volume of distribution of drugs in human. J. Med. Chem., 49, 2262-2267
-
(2006)
J. Med. Chem.
, vol.49
, pp. 2262-2267
-
-
Lombardo, F.1
Obach, R.S.2
DiCapua, F.M.3
Bakken, G.A.4
Lu, J.5
Potter, D.M.6
Gao, F.7
Miller, M.D.8
Zhang, Y.9
-
7
-
-
33645404135
-
In silico human and rat Vss quantitative structure - activity relationship models
-
Gleeson, M.P., Water, N.J., Paine, S.W., and Davis, A.M. (2006) In silico human and rat Vss quantitative structure - activity relationship models. J. Med. Chem., 49, 1953-1963
-
(2006)
J. Med. Chem.
, vol.49
, pp. 1953-1963
-
-
Gleeson, M.P.1
Water, N.J.2
Paine, S.W.3
Davis, A.M.4
-
8
-
-
1242273811
-
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding dat
-
Lombardo, F., Obach, R.S., Shalaeva, M.Y., and Gao, F. (2002) Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding dat. J. Med. Chem., 45, 2867-2876; (2004) J. Med. Chem., 47, 1242-1250.
-
(2002)
J. Med. Chem., 45, 2867-2876; (2004) J. Med. Chem.
, vol.47
, pp. 1242-1250
-
-
Lombardo, F.1
Obach, R.S.2
Shalaeva, M.Y.3
Gao, F.4
-
9
-
-
46849089254
-
Recent developments in fragment-based drug discovery
-
Congreve, M., Chessari, G., Tisi, D., and Woodhead, A.J. (2008) Recent developments in fragment-based drug discovery. J. Med. Chem., 51, 3661-3680
-
(2008)
J. Med. Chem.
, vol.51
, pp. 3661-3680
-
-
Congreve, M.1
Chessari, G.2
Tisi, D.3
Woodhead, A.J.4
-
10
-
-
33845364148
-
Fragment-based drug design: how big is too big?
-
Hajduk, P.J. (2006) Fragment-based drug design: how big is too big? J. Med. Chem., 49, 6972-6976
-
(2006)
J. Med. Chem.
, vol.49
, pp. 6972-6976
-
-
Hajduk, P.J.1
-
11
-
-
1642288258
-
Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization
-
Boehm, H. et al. (2000) Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening. J. Med. Chem., 43, 2664-2674
-
(2000)
A promising alternative to random screening. J. Med. Chem.
, vol.43
, pp. 2664-2674
-
-
Boehm, H.1
-
12
-
-
0034646370
-
Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors
-
Maly, D.J., Choong, I.C., and Ellman, J.A. (2000) Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors. Proc. Natl. Acad. Sci. U.S.A., 97, 2419-2424
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 2419-2424
-
-
Maly, D.J.1
Choong, I.C.2
Ellman, J.A.3
-
13
-
-
0030708525
-
Discovering high-affinity ligands for proteins
-
Hajduk, P.J., Meadows, R.P., and Fesik, S.W. (1997) Discovering high-affinity ligands for proteins. Science, 278, 497-499
-
(1997)
Science
, vol.278
, pp. 497-499
-
-
Hajduk, P.J.1
Meadows, R.P.2
Fesik, S.W.3
-
14
-
-
0035324944
-
Molecular complexity and its impact on the probability of finding leads for drug discovery
-
Hann, M.M., Leach, A.R., and Harper, G. (2001) Molecular complexity and its impact on the probability of finding leads for drug discovery. J. Chem. Inf. Comput. Sci., 41, 856-864
-
(2001)
J. Chem. Inf. Comput. Sci.
, vol.41
, pp. 856-864
-
-
Hann, M.M.1
Leach, A.R.2
Harper, G.3
-
15
-
-
0035438391
-
Is there a difference between leads and drugs? A historical perspective
-
Oprea, T.I., Davis, A.M., Teague, S.J., and Leeson, P.D. (2001) Is there a difference between leads and drugs? A historical perspective. J. Chem. Inf. Comput. Sci., 41, 1308-1315.
-
(2001)
J. Chem. Inf. Comput. Sci.
, vol.41
, pp. 1308-1315
-
-
Oprea, T.I.1
Davis, A.M.2
Teague, S.J.3
Leeson, P.D.4
-
16
-
-
79955794782
-
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of Heat Shock Protein 90
-
Zehnder, L. et al. (2011) Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of Heat Shock Protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2- difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide. J. Med. Chem., 54(9), 3368-3385
-
(2011)
Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2- difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide. J. Med. Chem.
, vol.54
, Issue.9
, pp. 3368-3385
-
-
Zehnder, L.1
-
17
-
-
37349073397
-
8-(3-(R)-Aminopiperidin-1-yl)-7-but-3-ynyl- 3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes
-
Eckhardt, M. et al. (2007) 8-(3-(R)-Aminopiperidin-1-yl)-7-but-3-ynyl- 3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes. J. Med. Chem., 50, 6450-6453.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 6450-6453
-
-
Eckhardt, M.1
-
18
-
-
33749260698
-
A critical assessment of docking programs and scoring functions
-
Warren, G.L. et al. (2006) A critical assessment of docking programs and scoring functions. J. Med. Chem., 49, 5912-5931.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 5912-5931
-
-
Warren, G.L.1
-
19
-
-
54549098184
-
Target flexibility: an emerging consideration in drug discovery and design
-
Cozzini, P. et al. (2008) Target flexibility: an emerging consideration in drug discovery and design. J. Med. Chem., 51, 6237-6255.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 6237-6255
-
-
Cozzini, P.1
-
20
-
-
33845493850
-
Protein-ligand binding affinity predictions by implicit solvent simulations: a tool for lead optimization?
-
Michel, J., Verdonk, M.L., and Essex, J.W. (2006) Protein-ligand binding affinity predictions by implicit solvent simulations: a tool for lead optimization? J. Med. Chem., 49, 7427-7439.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 7427-7439
-
-
Michel, J.1
Verdonk, M.L.2
Essex, J.W.3
-
21
-
-
0037082199
-
The emerging importance of predictive ADME simulation in drug discovery
-
Selick, H.E., Beresford, A.P., and Tarbit, M.H. (2002) The emerging importance of predictive ADME simulation in drug discovery. Drug Discov. Today, 7, 109-116.
-
(2002)
Drug Discov. Today
, vol.7
, pp. 109-116
-
-
Selick, H.E.1
Beresford, A.P.2
Tarbit, M.H.3
-
22
-
-
26044482076
-
The discovery of fluoxetine hydrochloride (prozac)
-
Wong, D.T., Perry, K.W., and Bymaster, F.P. (2005) The discovery of fluoxetine hydrochloride (prozac). Nat. Rev. Drug Discov., 4, 764-774.
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 764-774
-
-
Wong, D.T.1
Perry, K.W.2
Bymaster, F.P.3
-
23
-
-
0043069489
-
Drug research: myths, hype and reality
-
Kubinyi, H. (2003) Drug research: myths, hype and reality. Nat. Rev. Drug Discov., 2, 665-668.
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 665-668
-
-
Kubinyi, H.1
-
24
-
-
6444234760
-
The role of the medicinal chemist in drug discovery - then and now
-
Lombardino, J.G. and Lowe, J.A. III (2004) The role of the medicinal chemist in drug discovery - then and now. Nat. Rev., 3, 853-862.
-
(2004)
Nat. Rev.
, vol.3
, pp. 853-862
-
-
Lombardino, J.G.1
Lowe III, J.A.2
-
25
-
-
84858298708
-
The Rational Optimist
-
How Prosperity Evolves, Fourth Estate, London
-
Ridley, M. (2010) The Rational Optimist. How Prosperity Evolves, Fourth Estate, London
-
(2010)
-
-
Ridley, M.1
-
26
-
-
84882198128
-
The physiology of plunder, Economic Sophisms, Irvington-on-Hudson, The Foundation for Economic Education
-
first publishing date: 1845, Inc., New York, Ch.1
-
Bastiat, F. (1996, first publishing date: 1845) The physiology of plunder, Economic Sophisms, Irvington-on-Hudson, The Foundation for Economic Education, Inc., New York http://www.econlib.org/library/Bastiat/basSoph5.html#S.2, Ch.1.
-
(1996)
-
-
Bastiat, F.1
-
27
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski, C.A., Lombardo, F., Dominy, B.W., and Feeney, P.J. (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev., 23, 3-25.
-
(1997)
Adv. Drug Deliv. Rev.
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
28
-
-
39749181550
-
Generation of a set of simple, interpretable ADMET rules of thumb
-
Gleeson, M.P. (2008) Generation of a set of simple, interpretable ADMET rules of thumb. J. Med. Chem., 51, 817-834.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 817-834
-
-
Gleeson, M.P.1
-
29
-
-
9744232909
-
Time-related differences in the physical property profiles of oral drugs
-
Leeson, P.D. and Davis, A.M. (2004) Time-related differences in the physical property profiles of oral drugs. J. Med. Chem., 47, 6338-6348.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 6338-6348
-
-
Leeson, P.D.1
Davis, A.M.2
-
30
-
-
71049126548
-
Escape from flatland: increasing saturation as an approach to improving clinical success
-
Lovering, F., Bikker, J., and Humblet, C. (2009) Escape from flatland: increasing saturation as an approach to improving clinical success. J. Med. Chem., 52, 6752-6756
-
(2009)
J. Med. Chem.
, vol.52
, pp. 6752-6756
-
-
Lovering, F.1
Bikker, J.2
Humblet, C.3
-
31
-
-
43949104093
-
Molecular characteristics for solid-state limited solubility
-
Wassvik, C.M., Holmén, A.G., Draheim, R., Artursson, P., and Bergström, C.A.S. (2008) Molecular characteristics for solid-state limited solubility. J. Med. Chem., 51, 3035-3039.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 3035-3039
-
-
Wassvik, C.M.1
Holmén, A.G.2
Draheim, R.3
Artursson, P.4
Bergström, C.A.S.5
-
32
-
-
43949129098
-
Physicochemical properties of antibacterial compounds: implications for drug discovery
-
O'Shea, R. and Moser, H.E. (2008) Physicochemical properties of antibacterial compounds: implications for drug discovery. J. Med. Chem., 51, 2871-2878.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 2871-2878
-
-
O'Shea, R.1
Moser, H.E.2
-
33
-
-
77249122159
-
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorbtion and first-pass elimination
-
Varma, M.V.S. et al. (2010) Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorbtion and first-pass elimination. J. Med. Chem., 53, 1098-1108
-
(2010)
J. Med. Chem.
, vol.53
, pp. 1098-1108
-
-
Varma, M.V.S.1
-
34
-
-
33745149302
-
Computational prediction of oral drug absorbtion based on absorbtion rate constants in humans
-
Linnankoski, J., Mäkelä, J.M., Ranta, V.-P., Urtti, A., and Yliperttula, M. (2006) Computational prediction of oral drug absorbtion based on absorbtion rate constants in humans. J. Med. Chem., 49, 3674-3681
-
(2006)
J. Med. Chem.
, vol.49
, pp. 3674-3681
-
-
Linnankoski, J.1
Mäkelä, J.M.2
Ranta, V.-P.3
Urtti, A.4
Yliperttula, M.5
-
35
-
-
0034729673
-
QSAR model for drug human oral bioavailability
-
Yoshida, F. and Topliss, J.G. (2000) QSAR model for drug human oral bioavailability. J. Med. Chem., 43, 2575-2785
-
(2000)
J. Med. Chem.
, vol.43
, pp. 2575-2785
-
-
Yoshida, F.1
Topliss, J.G.2
-
36
-
-
0033199346
-
Absorbtion prediction from physicochemical parameters
-
Krämer, S.D. (1999) Absorbtion prediction from physicochemical parameters. Pharm. Sci. Technol. Today, 2, 373-380
-
(1999)
Pharm. Sci. Technol. Today
, vol.2
, pp. 373-380
-
-
Krämer, S.D.1
-
37
-
-
0032585545
-
Evaluation of dynamic polar molecular surface area as predictor of drug absorbtion: comparison with other computational and experimental predictors
-
Palm, K., Luthman, K., Ungell, A.-L., Strandlund, G., Beigi, F., Lundahl, P., and Artursson, P. (1998) Evaluation of dynamic polar molecular surface area as predictor of drug absorbtion: comparison with other computational and experimental predictors. J. Med. Chem., 41, 5382-5392
-
(1998)
J. Med. Chem.
, vol.41
, pp. 5382-5392
-
-
Palm, K.1
Luthman, K.2
Ungell, A.-L.3
Strandlund, G.4
Beigi, F.5
Lundahl, P.6
Artursson, P.7
-
38
-
-
0032480901
-
Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters
-
Winiwarter, S., Bonham, N.M., Ax, F., Hallberg, A., Lennernäs, H., and Karlén, A. (1998) Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. J. Med. Chem., 41, 4939-4949
-
(1998)
A multivariate data analysis approach. J. Med. Chem.
, vol.41
, pp. 4939-4949
-
-
Winiwarter, S.1
Bonham, N.M.2
Ax, F.3
Hallberg, A.4
Lennernäs, H.5
Karlén, A.6
-
40
-
-
0037030653
-
Molecular properties that influence the oral bioavailability of drug candidates
-
Veber, D.F., Johnson, S.R., Cheng, H., Smith, B.R., Ward, K.W., and Kopple, K.D. (2002) Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem., 45, 2615-2623
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2615-2623
-
-
Veber, D.F.1
Johnson, S.R.2
Cheng, H.3
Smith, B.R.4
Ward, K.W.5
Kopple, K.D.6
-
41
-
-
0037468884
-
A comparison of physicochemical property profiles of development and marketed oral drugs
-
Wenlock, M.C., Austin, R.P., Barton, P., Davis, A.M., and Leeson, P.D. (2003) A comparison of physicochemical property profiles of development and marketed oral drugs. J. Med. Chem., 46, 1250-1256
-
(2003)
J. Med. Chem.
, vol.46
, pp. 1250-1256
-
-
Wenlock, M.C.1
Austin, R.P.2
Barton, P.3
Davis, A.M.4
Leeson, P.D.5
-
42
-
-
8644219619
-
Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat
-
See also (c)
-
See also (c) Lu, J.J. et al. (2004) Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat. J. Med. Chem., 47, 6104-6107.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 6104-6107
-
-
Lu, J.J.1
-
43
-
-
79952779478
-
A novel approach for predicting p-glycoprotein (ABCB1) inhibition using molecular interaction fields
-
Broccatelli, F., Carosati, E., Neri, A., Frosini, M., Goracci, L., Oprea, T.I., and Cruciani, G. (2011) A novel approach for predicting p-glycoprotein (ABCB1) inhibition using molecular interaction fields. J. Med. Chem., 54, 1740-1751
-
(2011)
J. Med. Chem.
, vol.54
, pp. 1740-1751
-
-
Broccatelli, F.1
Carosati, E.2
Neri, A.3
Frosini, M.4
Goracci, L.5
Oprea, T.I.6
Cruciani, G.7
-
44
-
-
25844495011
-
Medicinal chemical properties of successful central nervous system drugs
-
Pajouhesh, H., and Lenz, G.R. (2005) Medicinal chemical properties of successful central nervous system drugs. J. Am. Soc. Exp. Neurotherapeutics, 2, 541-553
-
(2005)
J. Am. Soc. Exp. Neurotherapeutics
, vol.2
, pp. 541-553
-
-
Pajouhesh, H.1
Lenz, G.R.2
-
46
-
-
0029871091
-
The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system
-
Begley, D.J. (1996) The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system. J. Pharm. Pharmacol., 48, 136-146.
-
(1996)
J. Pharm. Pharmacol.
, vol.48
, pp. 136-146
-
-
Begley, D.J.1
-
47
-
-
33845937770
-
Structure-brain exposure relationships
-
Hitchcock, S.A. and Pennington, L.D. (2006) Structure-brain exposure relationships. J. Med. Chem., 49, 7559-7583
-
(2006)
J. Med. Chem.
, vol.49
, pp. 7559-7583
-
-
Hitchcock, S.A.1
Pennington, L.D.2
-
48
-
-
0032714220
-
Polar molecular surface as a dominating determinant for oral absorbtion and brain penetration of drugs
-
Kelder, J. et al. (1999) Polar molecular surface as a dominating determinant for oral absorbtion and brain penetration of drugs. Pharm. Res., 16, 1514-1519.
-
(1999)
Pharm. Res.
, vol.16
, pp. 1514-1519
-
-
Kelder, J.1
-
49
-
-
15644370083
-
Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists
-
Rowley, M. et al. (1997) Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists. J. Med. Chem., 40, 4053-4068.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 4053-4068
-
-
Rowley, M.1
-
50
-
-
77349115125
-
P450 enzymes: their structure, reactivity, and selectivity-modeled by QM/MM calculations
-
Shaik, S., Cohen, S., Wang, Y., Chen, H., Kumar, D., and Thiel, W. (2010) P450 enzymes: their structure, reactivity, and selectivity-modeled by QM/MM calculations. Chem. Rev., 110, 949-1017
-
(2010)
Chem. Rev.
, vol.110
, pp. 949-1017
-
-
Shaik, S.1
Cohen, S.2
Wang, Y.3
Chen, H.4
Kumar, D.5
Thiel, W.6
-
51
-
-
33845358503
-
Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization
-
Yano, J.K., Denton, T.T., Cerny, M.A., Zhang, X., Johnson, E.F., and Cashman, J.R. (2006) Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J. Med. Chem., 49, 6987-7001
-
(2006)
J. Med. Chem.
, vol.49
, pp. 6987-7001
-
-
Yano, J.K.1
Denton, T.T.2
Cerny, M.A.3
Zhang, X.4
Johnson, E.F.5
Cashman, J.R.6
-
52
-
-
33750118328
-
Recursive partitioning for the prediction of cytochromes P450 2D6 and 1A2 inhibition: importance of the quality of the dataset
-
Burton, J., Ijjaali, I., Barberan, O., Petitet, F., Vercauteren, D.P., and Michel, A. (2006) Recursive partitioning for the prediction of cytochromes P450 2D6 and 1A2 inhibition: importance of the quality of the dataset. J. Med. Chem., 49, 6231-6240
-
(2006)
J. Med. Chem.
, vol.49
, pp. 6231-6240
-
-
Burton, J.1
Ijjaali, I.2
Barberan, O.3
Petitet, F.4
Vercauteren, D.P.5
Michel, A.6
-
53
-
-
33745866245
-
Line-walking method for predicting the inhibition of P450 drug metabolism
-
Hudelson, M.G. and Jones, J.P. (2006) Line-walking method for predicting the inhibition of P450 drug metabolism. J. Med. Chem., 49, 4367-4373
-
(2006)
J. Med. Chem.
, vol.49
, pp. 4367-4373
-
-
Hudelson, M.G.1
Jones, J.P.2
-
54
-
-
0033533750
-
A novel approach to predicting P450 mediated drug metabolism
-
de Groot, M., Ackland, M.J., Horne, V.A., Alex, A.A., and Jones, B.C. (1999) A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6. J. Med. Chem., 42, 4062-4070
-
(1999)
CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6. J. Med. Chem.
, vol.42
, pp. 4062-4070
-
-
de Groot, M.1
Ackland, M.J.2
Horne, V.A.3
Alex, A.A.4
Jones, B.C.5
-
55
-
-
0030924503
-
Properties of cytochrome P450 isoenzymes and their substrates Part 1: active site characteristics, and Part 2: properties of cytochrome P450 substrates
-
Smith, D.A., Ackland, M.J., and Jones, B.C. (1997) Properties of cytochrome P450 isoenzymes and their substrates Part 1: active site characteristics, and Part 2: properties of cytochrome P450 substrates. Drug Discov. Today, 2, 406-414, 479-486.
-
(1997)
Drug Discov. Today
, vol.2
-
-
Smith, D.A.1
Ackland, M.J.2
Jones, B.C.3
-
56
-
-
0035154850
-
The potential pharmacological and toxicological impact of P450 screening
-
Riley, R.J. (2001) The potential pharmacological and toxicological impact of P450 screening. Curr. Opin. Drug Discov. Dev., 4, 45-54.
-
(2001)
Curr. Opin. Drug Discov. Dev.
, vol.4
, pp. 45-54
-
-
Riley, R.J.1
-
57
-
-
19444376971
-
Drug metabolism and variability among patients in drug response
-
Wilkinson, G.R. (2005) Drug metabolism and variability among patients in drug response. New Engl. J. Med., 352, 2211-2221
-
(2005)
New Engl. J. Med.
, vol.352
, pp. 2211-2221
-
-
Wilkinson, G.R.1
-
58
-
-
1542346411
-
Orange juice substantially reduces the bioavailability of the β-adrenergic blocking agent celiprolol
-
Lilja, J.J., Juntti-Patinen, L., and Neuvonen, P.J. (2004) Orange juice substantially reduces the bioavailability of the β-adrenergic blocking agent celiprolol. Clin. Pharmacol. Ther., 75, 184-190
-
(2004)
Clin. Pharmacol. Ther.
, vol.75
, pp. 184-190
-
-
Lilja, J.J.1
Juntti-patinen, L.2
Neuvonen, P.J.3
-
59
-
-
0036159433
-
Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
-
Dresser, G.K., Bailey, D.G., Leake, B.F., Schwarz, U.I., Dawson, P.A., Freeman, D.J., and Kim, R.B. (2002) Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin. Pharmacol. Ther., 71, 11-20.
-
(2002)
Clin. Pharmacol. Ther.
, vol.71
, pp. 11-20
-
-
Dresser, G.K.1
Bailey, D.G.2
Leake, B.F.3
Schwarz, U.I.4
Dawson, P.A.5
Freeman, D.J.6
Kim, R.B.7
-
60
-
-
29444432234
-
Clemastine, a conventional antihistamine, is a high potency inhibitor of the hERG K+ channel
-
Ridley, J.M., Milnes, J.T., Hancox, J.C., and Witchel, H.J. (2006) Clemastine, a conventional antihistamine, is a high potency inhibitor of the hERG K+ channel. J. Mol. Cell. Cardiol., 40, 107-118.
-
(2006)
J. Mol. Cell. Cardiol.
, vol.40
, pp. 107-118
-
-
Ridley, J.M.1
Milnes, J.T.2
Hancox, J.C.3
Witchel, H.J.4
-
61
-
-
0034693179
-
Effects of fluoroquinolones on hERG currents
-
Bischoff, U., Schmidt, C., Netzer, R., and Pongs, O. (2000) Effects of fluoroquinolones on hERG currents. Eur. J. Pharmacol., 406, 341-343.
-
(2000)
Eur. J. Pharmacol.
, vol.406
, pp. 341-343
-
-
Bischoff, U.1
Schmidt, C.2
Netzer, R.3
Pongs, O.4
-
62
-
-
33750998518
-
Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers
-
Aronov, A.M. (2006) Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers. J. Med. Chem, 49, 6917-6921
-
(2006)
J. Med. Chem
, vol.49
, pp. 6917-6921
-
-
Aronov, A.M.1
-
63
-
-
33747505446
-
Medicinal chemistry of hERG optimizations: highlights and hang-ups
-
Jamieson, C., Moir, E.M., Rankovic, Z., and Wishart, G. (2006) Medicinal chemistry of hERG optimizations: highlights and hang-ups. J. Med. Chem., 49, 5029-5046
-
(2006)
J. Med. Chem.
, vol.49
, pp. 5029-5046
-
-
Jamieson, C.1
Moir, E.M.2
Rankovic, Z.3
Wishart, G.4
-
64
-
-
0037194634
-
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K+ channel blockers
-
Cavalli, A., Poluzzi, E., De Ponti, F., and Recanatini, M. (2002) Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K+ channel blockers. J. Med. Chem., 45, 3844-3853.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 3844-3853
-
-
Cavalli, A.1
Poluzzi, E.2
De Ponti, F.3
Recanatini, M.4
-
66
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola, I. and Landis, J. (2004) Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov., 3, 711-716
-
(2004)
Nat Rev. Drug Discov.
, vol.3
, pp. 711-716
-
-
Kola, I.1
Landis, J.2
-
67
-
-
0037277752
-
Drug metabolism and pharmacokinetics in drug discovery
-
Roberts, S.A. (2003) Drug metabolism and pharmacokinetics in drug discovery. Curr. Opin. Drug Discov. Dev., 6, 66-80.
-
(2003)
Curr. Opin. Drug Discov. Dev.
, vol.6
, pp. 66-80
-
-
Roberts, S.A.1
-
68
-
-
53549107196
-
In vitro metabolism and covalent binding of enol-carboxamide derivatives and anti-inflammatory agents sudoxicam and meloxicam: insights into the hepatotoxicity of sudoxicam
-
Obach, R.S., Kalgutkar, A.S., Ryder, T.F., and Walker, G.S. (2008) In vitro metabolism and covalent binding of enol-carboxamide derivatives and anti-inflammatory agents sudoxicam and meloxicam: insights into the hepatotoxicity of sudoxicam. Chem. Res. Toxicol., 21, 1890-1899.
-
(2008)
Chem. Res. Toxicol.
, vol.21
, pp. 1890-1899
-
-
Obach, R.S.1
Kalgutkar, A.S.2
Ryder, T.F.3
Walker, G.S.4
-
69
-
-
0030913557
-
Structural features associated with reactive metabolite formation in clozapine analogues
-
Uetrecht, J., Zahid, N., Tehim, A., Fu, J.M., and Rakhit, S. (1997) Structural features associated with reactive metabolite formation in clozapine analogues. Chem. Biol. Interact., 104, 117-129
-
(1997)
Chem. Biol. Interact.
, vol.104
, pp. 117-129
-
-
Uetrecht, J.1
Zahid, N.2
Tehim, A.3
Fu, J.M.4
Rakhit, S.5
-
70
-
-
0029555342
-
Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells
-
Liu, Z.C. and Uetrecht, J.P. (1995) Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells. J. Pharmacol. Exp. Ther., 275, 1476-1483.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.275
, pp. 1476-1483
-
-
Liu, Z.C.1
Uetrecht, J.P.2
-
71
-
-
34248562343
-
Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression
-
Leone, A.M., Kao, L.M., McMillan, M.K., Nie, A.Y., Parker, J.B., Kelley, M.F., Usuki, E., Parkinson, A., Lord, P.G., and Johnson, M.D. (2007) Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression. Chem. Res. Toxicol., 20, 600-608
-
(2007)
Chem. Res. Toxicol.
, vol.20
, pp. 600-608
-
-
Leone, A.M.1
Kao, L.M.2
McMillan, M.K.3
Nie, A.Y.4
Parker, J.B.5
Kelley, M.F.6
Usuki, E.7
Parkinson, A.8
Lord, P.G.9
Johnson, M.D.10
-
72
-
-
0037058251
-
Mechanisms of idiosyncratic drug reactions: the case of felbamate
-
Dieckhaus, C.M., Thompson, C.D., Roller, S.G., and Macdonald, T.L. (2002) Mechanisms of idiosyncratic drug reactions: the case of felbamate. Chem. Biol. Interact., 142, 99-117
-
(2002)
Chem. Biol. Interact.
, vol.142
, pp. 99-117
-
-
Dieckhaus, C.M.1
Thompson, C.D.2
Roller, S.G.3
Macdonald, T.L.4
-
73
-
-
0033012622
-
Quantification of patient urine samples of felbamate and three metabolites: acid carbamate and two mercapturic acids
-
Thompson, C.D. et al. (1999) Quantification of patient urine samples of felbamate and three metabolites: acid carbamate and two mercapturic acids. Epilepsia, 40, 769-776.
-
(1999)
Epilepsia
, vol.40
, pp. 769-776
-
-
Thompson, C.D.1
-
74
-
-
62249155473
-
Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction
-
Bauman, J.N., Kelly, J.M., Tripathy, S., Zhao, S.X., Lam, W.W., Kalgutkar, A.S., and Obach, R.S. (2009) Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction. Chem. Res. Toxicol., 22, 332-340
-
(2009)
Chem. Res. Toxicol.
, vol.22
, pp. 332-340
-
-
Bauman, J.N.1
Kelly, J.M.2
Tripathy, S.3
Zhao, S.X.4
Lam, W.W.5
Kalgutkar, A.S.6
Obach, R.S.7
-
75
-
-
53549100467
-
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose
-
Obach, R.S., Kalgutkar, A.S., Soglia, J.R., and Zhao, S.X. (2008) Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose. Chem. Res. Toxicol., 21, 1814-1822.
-
(2008)
Chem. Res. Toxicol.
, vol.21
, pp. 1814-1822
-
-
Obach, R.S.1
Kalgutkar, A.S.2
Soglia, J.R.3
Zhao, S.X.4
-
76
-
-
79954452584
-
Measurement and estimation of electrophilic reactivity for predictive toxicology
-
Schwöbel, J.A.H., Koleva, Y.K., Enoch, S.J., Bajot, F., Hewitt, M., Madden, J.C., Roberts, D.W., Schultz, T.W., and Cronin, M.T.D. (2011) Measurement and estimation of electrophilic reactivity for predictive toxicology. Chem. Rev., 111, 2562-2596
-
(2011)
Chem. Rev.
, vol.111
, pp. 2562-2596
-
-
Schwöbel, J.A.H.1
Koleva, Y.K.2
Enoch, S.J.3
Bajot, F.4
Hewitt, M.5
Madden, J.C.6
Roberts, D.W.7
Schultz, T.W.8
Cronin, M.T.D.9
-
77
-
-
79954550877
-
Mechanisms of chemical carcinogenicity and mutagenicity: a review with implications for predictive toxicology
-
Benigni, R. and Bossa, C. (2011) Mechanisms of chemical carcinogenicity and mutagenicity: a review with implications for predictive toxicology. Chem. Rev., 111, 2507-2536
-
(2011)
Chem. Rev.
, vol.111
, pp. 2507-2536
-
-
Benigni, R.1
Bossa, C.2
-
78
-
-
20044383057
-
Structure-activity relationship studies of chemical mutagens and carcinogens: mechanistic investigations and prediction approaches
-
Benigni, R. (2005) Structure-activity relationship studies of chemical mutagens and carcinogens: mechanistic investigations and prediction approaches. Chem. Rev., 105, 1767-1800.
-
(2005)
Chem. Rev.
, vol.105
, pp. 1767-1800
-
-
Benigni, R.1
-
79
-
-
79952804851
-
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry
-
Ishikawa, M. and Hashimoto, Y. (2011) Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry. J. Med. Chem., 54, 1539-1554
-
(2011)
J. Med. Chem.
, vol.54
, pp. 1539-1554
-
-
Ishikawa, M.1
Hashimoto, Y.2
-
80
-
-
0343002338
-
Aqueous solubilities of the isomeric pentanols
-
Ginnings, P.M. and Baum, R. (1937) Aqueous solubilities of the isomeric pentanols. J. Am. Chem. Soc., 59, 1111-1113
-
(1937)
J. Am. Chem. Soc.
, vol.59
, pp. 1111-1113
-
-
Ginnings, P.M.1
Baum, R.2
-
81
-
-
0022465471
-
Mutual binary solubilities: water-alcohols and water-esters
-
Stephenson, R. and Stuart, J. (1986) Mutual binary solubilities: water-alcohols and water-esters. J. Chem. Ing., 31, 56-70.
-
(1986)
J. Chem. Ing.
, vol.31
, pp. 56-70
-
-
Stephenson, R.1
Stuart, J.2
-
82
-
-
0021997028
-
A revision of the metabolic disposition of amantadine
-
Köppel, C. and Tenczer, J. (1984) A revision of the metabolic disposition of amantadine. Biol. Mass Spectrom., 12, 499-501.
-
(1984)
Biol. Mass Spectrom.
, vol.12
, pp. 499-501
-
-
Köppel, C.1
Tenczer, J.2
-
83
-
-
0035064201
-
Pharmacokinetics and metabolism of nateglinide in humans
-
Weaver, M.L. et al. (2001) Pharmacokinetics and metabolism of nateglinide in humans. Drug Metab. Dispos., 29, 415-421.
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 415-421
-
-
Weaver, M.L.1
-
85
-
-
0001364392
-
Polar effects on the formation of imines from isobutyraldehyde and primary aliphatic amines
-
Hine, J., Yeh, C.Y., and Schmalstieg, F.C. (1970) Polar effects on the formation of imines from isobutyraldehyde and primary aliphatic amines. J. Org. Chem., 35, 340-344.
-
(1970)
J. Org. Chem.
, vol.35
, pp. 340-344
-
-
Hine, J.1
Yeh, C.Y.2
Schmalstieg, F.C.3
-
86
-
-
72849175695
-
Über den Stoffwechsel des 2-Methoxy- 4-allylphenoxyessigsäure-N, N-diäthylamid
-
Pulver, R. and Litvan, F. (1960) Über den Stoffwechsel des 2-Methoxy- 4-allylphenoxyessigsäure-N, N-diäthylamid. Arzneimittel-Forsch., 10, 111-113.
-
(1960)
Arzneimittel-Forsch.
, vol.10
, pp. 111-113
-
-
Pulver, R.1
Litvan, F.2
-
87
-
-
0028146445
-
Novel carbamate metabolites of mofegiline, a primary amine monoamine oxidase B inhibitor, in dogs and humans
-
Dow, J., Piriou, F., Wolf, E., Dulery, B.D., and Haegele, K.D. (1994) Novel carbamate metabolites of mofegiline, a primary amine monoamine oxidase B inhibitor, in dogs and humans. Drug Metab. Dispos., 22, 738-749.
-
(1994)
Drug Metab. Dispos.
, vol.22
, pp. 738-749
-
-
Dow, J.1
Piriou, F.2
Wolf, E.3
Dulery, B.D.4
Haegele, K.D.5
-
88
-
-
49449097238
-
The many roles for fluorine in medicinal chemistry
-
Hagmann, W.K. (2008) The many roles for fluorine in medicinal chemistry. J. Med. Chem., 51, 4359-4369
-
(2008)
J. Med. Chem.
, vol.51
, pp. 4359-4369
-
-
Hagmann, W.K.1
-
89
-
-
0035038661
-
Metabolism of fluorine-containing drugs
-
Park, B.K., Kitteringham, N.R., and O'Neill, P.M. (2001) Metabolism of fluorine-containing drugs. Annu. Rev. Pharmacol. Toxicol., 41, 443-470
-
(2001)
Annu. Rev. Pharmacol. Toxicol.
, vol.41
, pp. 443-470
-
-
Park, B.K.1
Kitteringham, N.R.2
O'Neill, P.M.3
-
90
-
-
7744243992
-
Bioisosterism: a rational approach in drug design
-
Patani, G.A. and LaVoie, E.J. (1996) Bioisosterism: a rational approach in drug design. Chem. Rev., 96, 3147-3176
-
(1996)
Chem. Rev.
, vol.96
, pp. 3147-3176
-
-
Patani, G.A.1
LaVoie, E.J.2
-
91
-
-
0028074997
-
Effects of fluorine substitution on drug metabolism: pharmacological and toxicological implication
-
Park, B.K. and Kitteringham, N.R. (1994) Effects of fluorine substitution on drug metabolism: pharmacological and toxicological implication. Drug Metabol. Rev., 26, 605-64
-
(1994)
Drug Metabol. Rev.
, vol.26
, pp. 605-664
-
-
Park, B.K.1
Kitteringham, N.R.2
-
92
-
-
0032989064
-
Organic nitrates
-
Sneader, W. (1999) Organic nitrates. Drug News Perspect., 12, 58-63.
-
(1999)
Drug News Perspect.
, vol.12
, pp. 58-63
-
-
Sneader, W.1
-
93
-
-
0017645407
-
Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine
-
Durant, G.J., Emmett, J.C., Ganellin, C.R., Miles, P.D., Parsons, M.E., Prain, H.D., and White, G.R. (1977) Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine. J. Med. Chem., 20, 901-906.
-
(1977)
J. Med. Chem.
, vol.20
, pp. 901-906
-
-
Durant, G.J.1
Emmett, J.C.2
Ganellin, C.R.3
Miles, P.D.4
Parsons, M.E.5
Prain, H.D.6
White, G.R.7
-
95
-
-
0030965263
-
Synthetic muscle relaxants
-
Sneader, W. (1997) Synthetic muscle relaxants. Drug News Perspect., 10, 113-117.
-
(1997)
Drug News Perspect.
, vol.10
, pp. 113-117
-
-
Sneader, W.1
-
96
-
-
37349033211
-
N, Ń-Dihydroxyamidines: a new prodrug principle to improve the oral bioavailability of amidines
-
Reeh, C., Wundt, J., and Clement, B. (2007) N, Ń-Dihydroxyamidines: a new prodrug principle to improve the oral bioavailability of amidines. J. Med. Chem., 50, 6730-6734.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 6730-6734
-
-
Reeh, C.1
Wundt, J.2
Clement, B.3
-
97
-
-
0033576649
-
Quantitative structure-metabolism relationships: steric and nonsteric effects in the enzymatic hydrolysis of noncongener carboxylic esters
-
Buchwald, P. and Bodor, N. (1999) Quantitative structure-metabolism relationships: steric and nonsteric effects in the enzymatic hydrolysis of noncongener carboxylic esters. J. Med. Chem., 42, 5160-5168.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 5160-5168
-
-
Buchwald, P.1
Bodor, N.2
-
98
-
-
78649496901
-
Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore
-
Fleming, F.F., Yao, L., Ravikumar, P.C., Funk, L., and Shook, B.C. (2010) Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore. J. Med. Chem., 53, 7902-7917.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 7902-7917
-
-
Fleming, F.F.1
Yao, L.2
Ravikumar, P.C.3
Funk, L.4
Shook, B.C.5
-
99
-
-
0019962638
-
Structural considerations in the metabolism of nitriles to cyanide in vivo
-
Silver, E.H., Kuttab, S.H., Hasan, T., and Hassan, M. (1982) Structural considerations in the metabolism of nitriles to cyanide in vivo. Drug Metabol. Dispos., 10, 495-498;
-
(1982)
Drug Metabol. Dispos.
, vol.10
, pp. 495-498
-
-
Silver, E.H.1
Kuttab, S.H.2
Hasan, T.3
Hassan, M.4
-
100
-
-
0024397981
-
Metabolism of organonitriles to cyanide by rat nasal tissue enzymes
-
Dahl, A.R. and Waruszewski, B.A. (1989) Metabolism of organonitriles to cyanide by rat nasal tissue enzymes. Xenobiotica, 19, 1201-1205.
-
(1989)
Xenobiotica
, vol.19
, pp. 1201-1205
-
-
Dahl, A.R.1
Waruszewski, B.A.2
-
101
-
-
43649084815
-
Opioid pharmacology
-
Trescot, A.M., Datta, S., Lee, M., and Hansen, H. (2008) Opioid pharmacology. Pain Physician, 11, S133-S153;
-
(2008)
Pain Physician
, vol.11
-
-
Trescot, A.M.1
Datta, S.2
Lee, M.3
Hansen, H.4
-
102
-
-
0032556425
-
The discovery of heroin
-
Sneader, W. (1998) The discovery of heroin. Lancet, 352, 1697-1699.
-
(1998)
Lancet
, vol.352
, pp. 1697-1699
-
-
Sneader, W.1
-
103
-
-
0034704836
-
Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent
-
Bromidge, S.M. et al. (2000) Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J. Med. Chem., 43, 1123-1134.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 1123-1134
-
-
Bromidge, S.M.1
-
104
-
-
0036572486
-
Two of a kind
-
May
-
Carlsson, E., Lindberg, P., and von Unge, S. (May 2002) Two of a kind. Chem. Br., 42-45.
-
(2002)
Chem. Br.
, pp. 42-45
-
-
Carlsson, E.1
Lindberg, P.2
Von Unge, S.3
-
105
-
-
77649202344
-
Highlights in the discovery of antiviral drugs: a personal retrospective
-
De Clercq, E. (2010) Highlights in the discovery of antiviral drugs: a personal retrospective. J. Med. Chem., 53, 1438-1450;
-
(2010)
J. Med. Chem.
, vol.53
, pp. 1438-1450
-
-
De Clercq, E.1
-
106
-
-
67650685040
-
Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer
-
Parker, W.B. (2009) Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer. Chem. Rev., 109, 2880-2893.
-
(2009)
Chem. Rev.
, vol.109
, pp. 2880-2893
-
-
Parker, W.B.1
-
108
-
-
0018329376
-
The benzodiazepine story
-
Sternbach, L.H. (1979) The benzodiazepine story. J. Med. Chem., 22, 1-7.
-
(1979)
J. Med. Chem.
, vol.22
, pp. 1-7
-
-
Sternbach, L.H.1
-
109
-
-
77951097617
-
Evolving carbapenemases: can medicinal chemists advance one step ahead of the coming storm?
-
Oelschlaeger, P., Ai, N., DuPrez, K.T., Welsh, W.J., and Toney, J.H. (2010) Evolving carbapenemases: can medicinal chemists advance one step ahead of the coming storm? 524 70 β-Lactams J. Med. Chem., 53, 3013-3027;
-
(2010)
β-Lactams J. Med. Chem.
, vol.524
-
-
Oelschlaeger, P.1
Ai, N.2
DuPrez, K.T.3
Welsh, W.J.4
Toney, J.H.5
-
110
-
-
47749093130
-
The bacteria fight back
-
Taubes, G. (2008) The bacteria fight back. Science, 321, 356-361;
-
(2008)
Science
, vol.321
, pp. 356-361
-
-
Taubes, G.1
-
111
-
-
14844366787
-
Antibiotic resistance
-
Walsh, C. and Wright, G. (2005) Antibiotic resistance. Chem. Rev., 105, 391-393;
-
(2005)
Chem. Rev.
, vol.105
, pp. 391-393
-
-
Walsh, C.1
Wright, G.2
-
112
-
-
14844362964
-
Bacterial resistance to β-lactam antibiotics: compelling opportunism, compelling opportunity
-
Fisher, J.F., Meroueh, S.O., and Mobashery, S. (2005) Bacterial resistance to β-lactam antibiotics: compelling opportunism, compelling opportunity. Chem. Rev., 105, 395-424.
-
(2005)
Chem. Rev.
, vol.105
, pp. 395-424
-
-
Fisher, J.F.1
Meroueh, S.O.2
Mobashery, S.3
-
113
-
-
58249118173
-
How the anti-hypertensive losartan was discovered
-
Bhardwaj, G. (2006) How the anti-hypertensive losartan was discovered. Expert Opin. Drug Discov., 1, 609-618;
-
(2006)
Expert Opin. Drug Discov.
, vol.1
, pp. 609-618
-
-
Bhardwaj, G.1
-
114
-
-
0027208070
-
Angiotensin II receptors and angiotensin II receptor antagonists
-
Timmermans, P.B., Wong, P.C., Chiu, A.T., Herblin, W.F., Benfield, P., Carini, D.J., Lee, R.J., Wexler, R.R., Saye, J.A.M., and Smith, R.D. (1993) Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol. Rev., 45, 205-251.
-
(1993)
Pharmacol. Rev.
, vol.45
, pp. 205-251
-
-
Timmermans, P.B.1
Wong, P.C.2
Chiu, A.T.3
Herblin, W.F.4
Benfield, P.5
Carini, D.J.6
Lee, R.J.7
Wexler, R.R.8
Saye, J.A.M.9
Smith, R.D.10
-
115
-
-
33845508580
-
Paclitaxel prodrugs: toward smarter delivery of anticancer agents
-
Skwarczynski, M., Hayashi, Y., and Kiso, Y. (2006) Paclitaxel prodrugs: toward smarter delivery of anticancer agents. J. Med. Chem., 49, 7253-7269.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 7253-7269
-
-
Skwarczynski, M.1
Hayashi, Y.2
Kiso, Y.3
-
116
-
-
79953777824
-
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery
-
Marsault, E. and Peterson, M.L. (2011) Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. J. Med. Chem., 54, 1961-2004.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 1961-2004
-
-
Marsault, E.1
Peterson, M.L.2
|