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From the list in ref 1, there are an additional 8 oral drugs approved for the first time in the U.S. in 2003 that are not included in this study (miglustat, epinastine, tadalafil, gefitinib, rosuvastatin, vardenafil, aprepitant, and atazanavir). The mean (median) physical property values for these 8 drugs show increases in physical properties relative to 1983-2002 oral drugs: Mol Wt 440 (464); cLogP 3.12 (2.85); O + N 7.75 (7) and OH + NH 2.38 (2). Their inclusion in the analysis does not alter the conclusions reached in this paper.
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