Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs

Pharmaceutical Research

Volumn 16, Issue 10, 1999, Pages 1514-1519

  Kelder, Jan ^a   Grootenhuis, Peter D J ^a,b   Bayada, Denis M ^a   Delbressine, Leon P C ^c   Ploemen, Jan Peter ^c  

^a NV ORGANON   (Netherlands)

^b Formerly CombiChem Inc   (United States)

^c NONE   (Netherlands)

Author keywords

Brain penetration; Oral absorption; Polar molecular surface area

Indexed keywords

2,3,3A,12B TETRAHYDRO 3 METHYL 1H DIBENZO[B,F]OXEPINO[10,11 C]PYRROLE; 7 CHLORO 5,6 DIHYDRO 3 (5 ISOPROPYL 1,2,4 OXADIAZOL 3 YL) 5 METHYL 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPIN 6 ONE; AMITRIPTYLINE; CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; CENTRAL NERVOUS SYSTEM AGENTS; CIMETIDINE; CLONIDINE; DESIPRAMINE; DOMPERIDONE; ICOTIDINE; IMIPRAMINE; LUPITIDINE; MEPYRAMINE; MIANSERIN; MIRTAZAPINE; RANITIDINE; RISPERIDONE; TEMELASTINE; TIBOLONE; ZOLANTIDINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; DRUG ABSORPTION; DRUG BRAIN LEVEL; DRUG FORMULATION; DRUG PENETRATION; GASTROINTESTINAL ABSORPTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CENTRAL NERVOUS SYSTEM AGENTS; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INTESTINAL ABSORPTION; MALE; MOLECULAR CONFORMATION; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

EID: 0032714220     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015040217741     Document Type: Article

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