Evolving carbapenemases: Can medicinal chemists advance one step ahead of the coming storm?

Journal of Medicinal Chemistry

Volumn 53, Issue 8, 2010, Pages 3013-3027

  Oelschlaeger, Peter ^a   Ai, Ni ^b   Duprez, Kevin T ^a   Welsh, William J ^b   Toney, Jeffrey H ^c  

^a CALIFORNIA STATE POLYTECHNIC UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c KEAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BETA LACTAMASE INHIBITOR; BIPHENYL DERIVATIVE; BIPHENYL TETRAZOLE DERIVATIVE; CARBAPENEMASE; CARBOXYLIC ACID DERIVATIVE; CYSTEINYL PEPTIDE DERIVATIVE; DORIPENEM; ERTAPENEM; HYDRAZONE DERIVATIVE; IMIPENEM; IMIPENEMASE; KETONE DERIVATIVE; KLEBSIELLA PNEUMONIAE CARBAPENEMASE; MERCAPTOCARBOXYLATE; MEROPENEM; METALLO BETA LACTAMASE; METALLO BETA LACTAMASE INHIBITOR; OXACILLINASE; PEPTIDE DERIVATIVE; PHTHALIC ACID DERIVATIVE; PYRIDINE DERIVATIVE; PYRIDINE DICARBOXYLATE DERIVATIVE; SUCCINIC ACID DERIVATIVE; SULFONYLHYDRAZONE DERIVATIVE; TETRAZOLE DERIVATIVE; THIOESTER; THIOL DERIVATIVE; TRIFLUOROMETHYL KETONE DERIVATIVE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; BACTEROIDES FRAGILIS; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENTEROBACTER; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; GEOGRAPHIC DISTRIBUTION; KLEBSIELLA PNEUMONIAE; NONHUMAN; PHYLOGENY; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; REVIEW; SERRATIA MARCESCENS;

ALGORITHMS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; CRYSTALLOGRAPHY, X-RAY; DATABASES, FACTUAL; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; KLEBSIELLA PNEUMONIAE; METALLOPROTEINS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 77951097617     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9012938     Document Type: Review

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