Mitogen-Activated Protein Kinase and Caspase Signaling Pathways Are Required for P2X7 Receptor (P2X7R)-Induced Pore Formation in Human THP-1 Cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 3, 2004, Pages 1053-1061

  Donnelly Roberts, Diana L ^a   Namovic, Marian T ^a   Faltynek, Connie R ^a   Jarvis, Michael F ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 2,3 O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; CASPASE; CASPASE 3; CASPASE INHIBITOR; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; MAITOTOXIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PURINE P2X2 RECEPTOR; PURINE P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL MEMBRANE; CHANNEL GATING; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; MACROPHAGE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASES; CELL MEMBRANE; CELLS, CULTURED; HUMANS; INTERLEUKIN-1; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION;

EID: 1342323323     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.059600     Document Type: Article

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