ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site

FASEB Journal

Volumn 22, Issue 3, 2008, Pages 861-869

  Adriouch, Sahil ^a,b   Bannas, Peter ^a   Schwarz, Nicole ^a   Fliegert, Ralf ^a   Guse, Andreas H ^a   Seman, Michel ^b   Haag, Friedrich ^a   Koch Nolte, Friedrich ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITÉ DE ROUEN   (France)

Author keywords

ADP ribosyltransferases; Leukocyte ecto enzymes; Post translational modification; Purinoceptors

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE TRIPHOSPHATE; ION CHANNEL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PURINERGIC P2X7 RECEPTOR;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; COVALENT BOND; GENE; HUMAN; HUMAN CELL; MOLECULAR MODEL; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN FUNCTION; R125 GENE; STRUCTURE ANALYSIS;

ADP RIBOSE TRANSFERASES; AMINO ACID SUBSTITUTION; ARGININE; BINDING SITES; CELL LINE, TUMOR; HUMANS; ION CHANNEL GATING; LEUKOCYTES; LIGANDS; MODELS, MOLECULAR; NUCLEOTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, PURINERGIC P2;

EID: 40449130117     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-9294com     Document Type: Article

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