Natural products, stylissadines A and B, specific antagonists of the P2X7 receptor, an important inflammatory target

Journal of Organic Chemistry

Volumn 72, Issue 7, 2007, Pages 2309-2317

  Buchanan, Malcolm S ^a   Carroll, Anthony R ^a   Addepalli, Rama ^a   Avery, Vicky M ^a   Hooper, John N A ^b   Quinn, Ronald J ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b QUEENSLAND MUSEUM   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOIDS; BIOACTIVE CONSTITUENTS; RECEPTOR INHIBITORS;

BIOACTIVITY; DISEASES; NONMETALS; SCREENING; STEREOCHEMISTRY;

ORGANIC COMPOUNDS;

ADENOSINE TRIPHOSPHATE; ALKALOID; ETHER DERIVATIVE; GUANIDINE DERIVATIVE; IMIDAZOLE DERIVATIVE; NATURAL PRODUCT; PURINE P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRROLE DERIVATIVE; STYLISSADINE A; STYLISSADINE B; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN; DRUG ISOLATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INFLAMMATION; SPONGE (PORIFERA); STEREOCHEMISTRY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL PRODUCTS; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PORIFERA; PYRROLES; RECEPTORS, PURINERGIC P2;

EID: 34047195642     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo062007q     Document Type: Article

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1. After submission of this manuscript and presentation in part at the International Conference on Biodiversity and Natural Products, ICOB-5 & ISCNP-25 IUPAC, Kyoto, Japan, July 23-28, 2006, we learned of the publication by Grube and Köck published on the web September 23, 2006 (Grube, A.; Köck, M. Org. Lett. 2006, 8, 4675-4678). Our flabellazoles A and B were identical to stylissadines B and A, respectively. We acknowledge the precedence of stylissadines A and B.
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