Spontaneous cell fusion in macrophage cultures expressing high levels of the P2Z/P2X7 receptor

Journal of Cell Biology

Volumn 138, Issue 3, 1997, Pages 697-706

  Chiozzi, Paola ^a   Sanz, Juana M ^a   Ferrari, Davide ^a   Falzoni, Simonetta ^a   Aleotti, Arrigo ^a   Buell, Gary N ^b   Collo, Ginetta ^b   Di Virgilio, Francesco ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; MEMBRANE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL FUSION; CELL MEMBRANE; GENE EXPRESSION; GIANT CELL; GRANULOMATOUS INFLAMMATION; IMMUNOBLOTTING; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL AGGREGATION; CELL FUSION; CELL LINE; GIANT CELLS; HEXOKINASE; HUMANS; MACROPHAGES; MICE; PHENOTYPE; RECEPTORS, PURINERGIC P2;

ANIMALIA;

EID: 0030757928     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.138.3.697     Document Type: Article

References (51)

1. Abraham, E.H., A.G. Prat, L. Gerweck, T. Seneveratne, R.J. Arceci, R. Kramer, G. Guidotti, and H.F. Cantiello. 1993. The multidrug resistance (mdr1) gene product functions as an ATP channel. Proc. Natl. Acad. Sci. USA. 90:312-316.
2. Baricordi, O., D. Ferrari, L. Melchiorri, P. Chiozzi, S. Hanau, E. Chiari, M. Ruhini, and F. Di Virgilio. 1996. An ATP-activated channel is involved in mitogenic stimulation of human T lymphocytes. Blood, 87:682-690.
3. Blanchard, D.K., S. McMillen, and J.Y. Djeu. 1991. IFN-γ enhances sensitivity of human macrophages to extracellular ATP-mediated lysis. J. Immunol. 147:2579-2585.
4. Blanchard, D.K., S. Wei, C. Duan, F. Pericle, J.I. Diaz, and J.Y. Djeu. 1995. Role of extracellular adenosine triphosphate in the cytotoxic T-lymphocyte-mediated lysis of antigen presenting cells. Blood. 11:3173-3182.
5. Born, G.V.R., and M.A.A. Kratzer. 1984. Source and concentration of extracellular adenosine triphosphate during haemostasis in rats, rabbits, and man. J. Physiol. 354:419-429.
6. Brake, A.J., M.J. Wagenbach, and D. Julius. 1994. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature (Lond.). 371:519-523.
7. 1 receptor activation in HL60 cells. Blood, 87:2659-2664.
8. Burnstock, G. 1972. Purinergic nerves. Pharmacol. Rev. 24:509-560.
9. Burnstock, G. 1996. P2 purinoceptors: historical perspective and classification. Ciba Found. Symp. 198:1-34.
10. Chiozzi, P., M. Murgia, S. Falzoni, D. Ferrari, and F. Di Virgilio. 1996. Role of the purinergic P2Z receptor in spontaneous cell death in J774 macrophage cultures. Biochem. Biophys. Res. Commun. 218:176-181.
11. Cockcroft, S., and B.D. Gomperts. 1979. ATP induces nucleotide permeability in rat mast cells. Nature. (Lond.). 279:541-542.
12. 4- receptor of rat mast cells. Biochem. J. 188:789-798.
13. Corey, D.P., and J. Garcia-Anoveros. 1996. Mechanosensation and the DEG/ENaC ion channels. Science (Wash. DC). 273:323-324.
14. Di Virgilio, F. 1995. The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death. Immunol. Today. 16:524-528.
15. Di Virgilio, F., and T.H. Steinberg. 1993. ATP permeabilization. In Cell and Tissue Culture: Laboratory Procedures. Wiley & Sons Inc., New York. 5B:4.1-4.5.
16. Di Virgilio, F., V. Bronte, D. Collavo, and P. Zanovello. 1989. Responses of mouse lymphocytes to extracellular adenosine 5′-triphosphate (ATP). Lymphocytes with cytotoxic activity are resistant to the permeabilizing effects of ATP. J. Immunol. 143:1955-1960.
17. Di Virgilio, F., P. Pizzo, P. Zanovello, V. Bronte, and D. Collavo. 1990. Extracellular ATP as a possible mediator of cell-mediated cytotoxicity. Immunol. Today. 11:274-277.
18. Di Virgilio, F., D. Ferrari, M. Munerati, S. Falzoni, M. Villalba, V. Bronte, A. Zamhon, P. Zanovello, and T.H. Steinberg. 1995. The P2Z receptor and its regulation of macrophage function. In Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology. L. Belardinelli and A. Pelleg, editors Kluver Academic Publisher, Boston, MA. 329-335.
19. Di Virgilio, P., D. Ferrari, S. Falzoni, P. Chiozzi, M. Munerati, T.H. Steinberg, and O.R. Baricordi. 1996. P2 purinoceptors in the immune system. Ciba Found. Symp. 198:290-305.
20. Evans, R.J., C. Lewis, G. Buell, R.A. North, and A. Surprenant. 1995. Pharmacological characterization of heterologously expressed ATP-galed cation channels (P2X-purinoceptors). Mol. Pharmacol. 48:178-183.
21. Falzoni, S., M. Munerati, D. Ferrari, S. Spisani, S. Moretti, and F. Di Virgilio. 1995. The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role. J. Clin. Invest. 95:1207-1216.
22. Ferrari, D., P. Chiozzi, S. Falzoni, S. Hanau, and F. Di Virgilio. 1997. Purinergic modulation of interleukin-1β release from microglial cells stimulated with bacterial endotoxin. J. Exp. Med. 185:579-582.
23. Filippini, A., R.E. Taffs, T. Agui, and M.V. Sitkovsky. 1990. Ecto-ATPase activity in cytolytic lymphocytes. Protection from the cytolytic effects of extracellular ATP. J. Biol. Chem. 265:334-340.
24. Gordon, J.L. 1990. The effects of ATP on endothelium. Ann. N.Y. Acad. Sci. 603:46-52.
25. 2+ fluxes in J774 macrophages by two distinct mechanisms. J. Biol. Chem. 263:10337-10343.
26. Hickman, S.E., J. El Khoury, S. Greenberg, I. Schieren, and S.C. Silverstein. 1994. P2Z adenosine triphosphate receptor activity in cultured human monocyte-derived macrophages. Blood. 84:2452-2456.
27. Hoyle, C.H.V., and G. Burnstock. 1996. Purines. In Principles of Medical Biology. E.E. Bittar and N. Bittar, editors JAI Press Inc., Greenwich, CT. 49-75.
28. McInnes, A., and D.M. Rennick. 1988. Interleukin 4 induces cultured monocyte/macrophages to form giant multinucleated cells. J. Exp. Med. 167:598-605.
29. Modderman, W.E., T. Vrijheid-Lammers, C.W.G.M. Lowik, and P.J. Nijweide. 1994. Removal of hematopoietic cells and macrophages from mouse bone marrow cultures: isolation of fibroblastlike stromal cells. Exp. Hematol. (NY). 22:194-201.
30. Molloy, A., P. Loachumroonvorapong, and G. Kaplan. 1994. Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guerin. J. Exp. Med. 180:1499-1509.
31. Most, J., H.P. Neumayer, and M.P. Dierich. 1990. Cytokine-induced generation of multinucleated giant cells in vitro requires interferon-γ and expression of LFA-1. Eur. J. Immunol. 20:1661-1667.
32. Murgia, M., P. Pizzo, T.H. Steinberg, and F. Di Virgilio. 1992. Characterization of the cytotoxie effect of extracellular ATP in J774 mouse macrophages. Biochem. J. 288:897-901.
33. Murgia, M., S. Hanau, P. Pizzo, M. Rippa, and F. Di Virgilio. 1993. Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor. J. Biol. Chem. 268:8199-8203.
34. Nichols, C.G., S-L. Shyng, A. Nestorowicz, B. Glaser, J.P. Clement IV, G. Gonzales, L. Aguilar-Bryan, M.A. Permutt, and J. Bryan. 1996. Adenosine diphosphate as an intracellular regulator of insulin secretion. Science (Wash. DC). 272:1785-1787.
35. North, R.A. 1996. Families of ion channels with two hydrophobic segments. Curr. Opin. Cell Biol. 8:474-483.
36. Nuttle, L.C., and G.R. Dubyak. 1994. Differential activation of cation channels and non-selective pores by macrophages P2Z purinergic receptors expressed in Xenopous oocyles. J. Biol. Chem. 269:13988-13996.
37. Pearson, J.D., and J.L. Gordon. 1979. Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides. Nature (Lond.). 281:384-386.
38. Reddy, M.M., P.M. Quinton, C. Haws, J.J. Wine, R. Grygorczyk, J.A. Tabcharani, J.W. Hanrahan, K.L. Gunderson, R.R. Kopito. 1996. Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP. Science (Wash. DC). 271:1876-1879.
39. Reisin, I.L., A.G. Prat, E.H. Abraham, J.F. Amara, R.J. Gregory, D.A. Ausiello, and H.F. Cantiello. 1994. The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel. J. Biol. Chem. 32:20584-20591.
40. Rozengurt, E., L.A. Heppel, and I. Friedberg. 1977. Effect of exogenous ATP on the permeability properties of transformed cultures of mouse cell lines. J. Biol. Chem. 252:4584-4590.
41. Schaeren-Wiemers, N., and A. Gerfin-Moser. 1993. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultures cells: in situ hybridization using digoxigenin-labeled cRNA probes. Hystochemisrry. 100:431-440.
42. Schwiebert, E.M., M.E. Egan, T-H. Hwang, S.B. Fulmer, S.S. Allen, G.R. Cutting, and W.B. Guggino. 1995. CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell. 81:1063-1073.
43. 4- promotes cation fluxes in the J774 mouse macrophage cell line. J. Biol. Chem. 262:3118-3122.
44. 4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes. J. Biol. Chem. 262:8884-8888.
45. Steinberg, T.H., H.P. Buisman, S. Greenherg, F. Di Virgilio, and S.C. Silverstein. 1990. Effects of extracellular ATP on mononuclear phagocytes. Ann. N.Y. Acad. Sci. 603:120-129.
46. Surprenant, A., G. Buell, R.A. North. 1995. P2X receptors bring new structure to ligand-gated ion channels. Trends Neurosci. 18:224-229.
47. 7). Science (Wash. DC). 272:735-738.
48. Takashima, T., K. Ohnishi, I. Tsuyuguchi, and S. Kishimoto. 1993. Differential regulation of formation of multinucleated giant cells from concanavalin A-stimulated human blood monocytes by IFN-γ and IL-4. J. Immunol. 150:3002-3007.
49. Valera, S., N. Hussy, R.J. Evans, N. Adami, R.A. North, A. Surprenant, and G. Buell. 1994. A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP. Nature (Lond.). 371:516-519.
50. Weinberg, J.B., M.M. Hobbs, and M.A. Misukonis. 1984. Recombinant human γ-inteferon induces human monocyte polykarion formation. Proc. Natl. Acad. Sci. USA. 81:4554-4560.
51. Zimmermann, H. 1994. Signalling via ATP in the nervous system. Trends Neurosci. 17:420-426.