An APC: WNT counter-current-like mechanism regulates cell division along the human colonic crypt axis: A mechanism that explains how APC mutations induce proliferative abnormalities that drive colon cancer development

Frontiers in Oncology

Volumn 3 NOV, Issue , 2013, Pages

  Boman, Bruce M ^a,b   Fields, Jeremy Z ^c  

^a UNIVERSITY OF DELAWARE   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c CATX Inc   (United States)

Author keywords

Adenoma morphogenesis; Adenomatous polyposis coli; Colon cancer stem cells; Colonic stem cells; Crypt cycle; Crypt fission; Survivin; WNT signaling

Indexed keywords

AURORA B KINASE; EB1; INCENP; SURVIVIN; UNCLASSIFIED DRUG;

ADENOMA; ARTICLE; CELL DIVISION; CELL PROLIFERATION; COLON CANCER; COLON CARCINOGENESIS; COLON POLYPOSIS; GENE EXPRESSION; HISTOLOGY; HUMAN; INTESTINE CRYPT; MITOSIS SPINDLE; MUTATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STEM CELL NICHE; WNT SIGNALING PATHWAY;

EID: 84891110207     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00244     Document Type: Article

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