APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 7, 2000, Pages 3352-3357

  Rowan, A J ^a   Lamlum, H ^a   Ilyas, M ^b   Wheeler, J ^b   Straub, J ^b   Papadopoulou, A ^a   Bicknell, D ^b   Bodmer, W F ^b   Tomlinson, I P M ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; ONCOPROTEIN;

ADENOMATOUS POLYP; ADULT; AGED; ALLELE; AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CODON; COLORECTAL TUMOR; FAMILIAL POLYPOSIS; FEMALE; GENE CLUSTER; GENE LOCUS; GENE LOSS; GENE MUTATION; GERM LINE; HUMAN; HUMAN CELL; MALE; MUTATION RATE; PRIORITY JOURNAL; PROTEIN STABILITY; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; BETA CATENIN; COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; DNA PRIMERS; GENES, APC; HUMANS; LOSS OF HETEROZYGOSITY; MUTATION; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0034724186     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.7.3352     Document Type: Article

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