Enhanced Stem Cell Survival in Familial Adenomatous Polyposis

American Journal of Pathology

Volumn 164, Issue 4, 2004, Pages 1369-1377

  Kim, Kyoung Mee ^a   Calabrese, Peter ^b   Tavaré, Simon ^b   Shibata, Darryl ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN;

ADENOMATOUS POLYP; ADOLESCENT; ADULT; ALLELE; ARTICLE; CELL LINEAGE; CELL SURVIVAL; CLINICAL ARTICLE; CLONE; COLORECTAL CANCER; CONTROLLED STUDY; DNA METHYLATION; FAMILIAL POLYPOSIS; FEMALE; GENE MUTATION; HETEROZYGOTE; HUMAN; HUMAN TISSUE; INTESTINE CRYPT; MALE; PRIORITY JOURNAL; STEM CELL; TUMOR GROWTH;

EID: 1642396519     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63223-3     Document Type: Article

References (47)

1. Kinzler KW, Vogelstein B: Lessons from hereditary colorectal cancer. Cell 1996, 87:159-170
2. Fearnhead NS, Britton MP, Bodmer WF: The ABC of APC. Hum Mol Genet 2001, 10:721-733
3. Lamlum H, Papadopoulou A, Ilyas M, Rowan A, Gillet C, Hanby A, Talbot I, Bodmer W, Tomlinson I: APC mutations are sufficient for the growth of early colorectal adenomas. Proc Natl Acad Sci USA 2000, 97:2225-2228
4. Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, Nakatsuru S, Aoki T, Miki Y, Mori T, Nakamura Y: Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1992, 1:229-233
5. Lamlum H, Ilyas M, Rowan A, Clark S, Johnson V, Bell J, Frayling I, Efstathiou J, Pack K, Payne S, Roylance R, Gorman P, Sheer D, Neale K, Phillips R, Talbot I, Bodmer W, Tomlinson I: The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis. Nat Med 1999, 5:1071-1075
6. Rowan AJ, Lamlum H, Ilyas M, Wheeler J, Straub J, Papadopoulou A, Bicknell D, Bodmer WF, Tomlinson IP: APC mutations in sporadic colorectal tumors: a mutational "hotspot" and interdependence of the "two hits." Proc Natl Acad Sci USA 2000, 97:3352-3357
7. Smits R, Holland N, Edelmann W, Geugien M, Jagmohan-Changur S, Albuquerque C, Breukel C, Kucherlapati R, Kielman MF, Fodde R: Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity. Genes Chromosom Cancer 2000, 29:229-239
8. Crabtree M, Sieber OM, Lipton L, Hodgson SV, Lamlum H, Thomas HJ, Neale K, Phillips RK, Heinimann K, Tomlinson IP: Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients. Oncogene 2003, 22:4257-4265
9. Yatabe Y, Tavaré S, Shibata D: Investigating stem cells in human colon by using methylation patterns. Proc Natl Acad Sci USA 2001, 98:10839-10844
10. Kim KM, Shibata D: Methylation reveals a niche: stem cell succession in human colon crypts. Oncogene 2002, 21:5441-5449
11. Potten CS, Loeffler M: Stem cells: attributes, cycles, spirals, pitfalls, and uncertainties. Lessons for and from the crypt. Development 1990, 110:1001-1020
12. Marshman E, Booth C, Potten CS: The intestinal epithelial stem cell. Bioessays 2002, 24:91-98
13. Williams ED, Lowes AP, Williams D, Williams GT: A stem cell niche theory of intestinal crypt maintenance based on a study of somatic mutation in colonic mucosa. Am J Pathol 1992, 141:773-776
14. Watt FM, Hogan BL: Out of Eden: stem cells and their niches. Science 2000, 287:1427-1430
15. Spradling A, Drummond-Barbosa D, Kai T: Stem cells find their niche. Nature 2001, 414:98-104
16. Calabrese P, Tavaré S, Shibata D: Pre-tumor progression: clonal evolution of human stem cell populations. Am J Pathol 2004, 164: 1337-1346
17. Nowell PC: The clonal evolution of tumor cell populations. Science 1976, 194:23-28
18. Su LK, Johnson KA, Smith KJ, Hill DE, Vogelstein B, Kinzler KW: Association between wild type and mutant APC gene products. Cancer Res 1993, 53:2728-2731
19. Song X, Zhu CH, Doan C, Xie T: Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science 2002, 296:1855-1857
20. Chenn A, Walsh CA: Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 2002, 297:365-369
21. Nakamura S, Kino I, Baba S: Nuclear DNA content of isolated crypts of background colonic mucosa from patients with familial adenomatous polyposis and sporadic colorectal cancer. Gut 1993, 34:1240-1244
22. Potten CS, Kellett M, Rew DA, Roberts SA: Proliferation in human gastrointestinal epithelium using bromodeoxyuridine in vivo: data for different sites, proximity to a tumour, and polyposis coli. Gut 1992, 33:524-529
23. Wasan HS, Park HS, Liu KC, Mandir NK, Winnett A, Sasieni P, Bodmer WF, Goodlad RA, Wright NA: APC in the regulation of intestinal crypt fission. J Pathol 1998, 185:246-255
24. Olek A, Oswald J, Walter J: A modified and improved method for bisulphite based cytosine methylation analysis. Nucleic Acids Res 1996, 24:5064-5066
25. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP: CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999, 96:8681-8686
26. Ashley DJ: Colonic cancer arising in polyposis coli. J Med Genet 1969, 6:376-378
27. Knudson AG: Two genetic hits (more or less) to cancer. Nat Rev Cancer 2001, 1:157-162
28. Cairns J: Mutation selection and the natural history of cancer. Nature 1975, 255:197-200
29. Pearson H: Surviving a knockout blow. Nature 2002, 415:8-9
30. Fuchs E, Merrill BJ, Jamora C, DasGupta R: At the roots of a neverending cycle. Dev Cell 2001, 1:13-25
31. Korinek V, Barker N, Moerer P, van Donselaar E, Huls G, Peters PJ, Clevers H: Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 1998, 19:379-383
32. Smith KJ, Johnson KA, Bryan TM, Hill DE, Markowitz S, Willson JK, Paraskeva C, Petersen GM, Hamilton SR, Vogelstein B, Kinzler KW: The APC gene product in normal and tumor cells. Proc Natl Acad Sci USA 1993, 90:2846-2850
33. Dihlmann S, Gebert J, Siermann A, Herfarth C, von Knebel Doeberitz M: Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis. Cancer Res 1999, 59:1857-1860
34. Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P: Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci USA 1995, 92: 3046-3050
35. Hinck L, Nelson WJ, Papkoff J: Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin. J Cell Biol 1994, 124:729-741
36. Campbell F, Geraghty JM, Appleton MA, Williams ED, Williams GT: Increased stem cell somatic mutation in the non-neoplastic colorectal mucosa of patients with familial adenomatous polyposis. Hum Pathol 1998, 29:1531-1535
37. Boman BM, Fields JZ, Bonham-Carter O, Runquist OA: Computer modeling implicates stem cell overproduction in colon cancer initiation. Cancer Res 2001, 61:8408-8411
38. Spirio LN, Samowitz W, Robertson J, Robertson M, Burt RW, Leppert M, White R: Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps. Nat Genet 1998, 20:385-388
39. Moser AR, Dove WF, Roth KA, Gordon JI: The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J Cell Biol 1992, 116:1517-1526
40. Tsao JL, Zhang J, Salovaara R, Li ZH, Jarvinen HJ, Mecklin JP, Aaltonen LA, Shibata D: Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture. Am J Pathol 1998, 153:1189-1200
41. Nowak MA, Komarova NL, Sengupta A, Jallepalli PV, Shih IEM, Vogelstein B, Lengauer C: The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci USA 2002, 99:16226-16231
42. Armitage P, Doll R: A two-stage theory of carcinogenesis in relation to the age distribution of human cancer. Br J Cancer 1957, 11:161-169
43. Moolgavkar SH, Luebeck EG: Multistage carcinogenesis: population-based model for colon cancer. J Nat) Cancer Inst 1992, 84:610-618
44. Hernegger GS, Moore HG, Guillem JG: Attenuated familial adenomatous polyposis: an evolving and poorly understood entity. Dis Colon Rectum 2002, 45:127-134
45. Houlston R, Crabtree M, Phillips R, Crabtree M, Tomlinson I: Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes. Gut 2001, 48:1-5
46. Kinzler KW, Vogelstein B: Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 1997, 386:761-763
47. Calabrese P, Tsao JL, Yatabe Y, Salovaara R, Mecklin JP, Järvinen HJ, Aaltonen LA, Tavaré S, Shibata D: Colorectal pretumor progression before and after loss of DNA mismatch repair. Am J Pathol 2004, 164:1447-1453