Refining the relation between 'first hits' and 'second hits' at the APC locus: The 'loose fit' model and evidence for differences in somatic mutation spectra among patients

Oncogene

Volumn 22, Issue 27, 2003, Pages 4257-4265

  Crabtree, Michael ^a,b   Sieber, Oliver M ^a   Lipton, Lara ^a,b,c   Hodgson, Shirley V ^c   Lamlum, Hanan ^a   Thomas, Hunu J W ^b   Neale, Kay ^b   Phillips, Robin K S ^b   Heinimann, Karl ^a,d   Tomlinson, Ian P M ^a,b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b ST MARK S HOSPITAL   (United Kingdom)

^c GUY S HOSPITAL   (United Kingdom)

^d University Clinics   (Switzerland)

Author keywords

APC; Colorectal tumours; Polyposis; Two hit hypothesis

Indexed keywords

APC PROTEIN;

ADENOMATOUS POLYP; ALLELE; APC GENE; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CODON; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE SEVERITY; FAMILIAL CANCER; FRAMESHIFT MUTATION; GENE LOCUS; GENE MUTATION; GENETIC CODE; GENETIC RECOMBINATION; GENOTYPE; GERM LINE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; SOMATIC MUTATION; SPECTROSCOPY; TUMOR SUPPRESSOR GENE;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; ALLELES; BETA CATENIN; CODON; COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; EXONS; GENE DELETION; GERM-LINE MUTATION; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MODELS, GENETIC; MUTATION; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 0037699438     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206471     Document Type: Article

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