Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis

Oncogene

Volumn 32, Issue 39, 2013, Pages 4675-4682

  Christie, M ^a,b   Jorissen, R N ^a   Mouradov, D ^a   Sakthianandeswaren, A ^a   Li, S ^a   Day, F ^a,b   Tsui, C ^a   Lipton, L ^a,b   Desai, J ^a   Jones, I T ^a   McLaughlin, S ^c   Ward, R L ^d   Hawkins, N J ^e   Ruszkiewicz, A R ^f   Moore, J ^g   Burgess, A W ^a   Busam, D ^h   Zhao, Q ^h   Strausberg, R L ^i,j   Simpson, A J ^i,j   Tomlinson, I P M ^k   Gibbs, P ^a,b   Sieber, O M ^a,b   more..

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c WESTERN HOSPITAL   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

^f INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^g ROYAL ADELAIDE HOSPITAL   (Australia)

^h J CRAIG VENTER INSTITUTE   (United States)

ⁱ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^k UNIVERSITY OF OXFORD   (United Kingdom)

more..

Author keywords

APC; colorectal cancer; just right signalling; mutation

Indexed keywords

AMINO ACID; APC PROTEIN; ARMADILLO DOMAIN PROTEIN; BETA CATENIN; WNT PROTEIN;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CODON; COLORECTAL CANCER; DINUCLEOTIDE REPEAT; EXON; FEMALE; GENE MUTATION; GENOTYPE; HETEROZYGOSITY LOSS; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADENOMATOUS POLYPOSIS COLI; ADULT; AGED; AGED, 80 AND OVER; CELL TRANSFORMATION, NEOPLASTIC; CODON; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS; FEMALE; GENES, APC; GENOTYPE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTATION; ORGAN SPECIFICITY; RECTAL NEOPLASMS; SEQUENCE DELETION; SIGMOID NEOPLASMS; WNT SIGNALING PATHWAY;

ARMADILLO;

EID: 84884900384     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.486     Document Type: Article

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