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Volumn 3 SEP, Issue , 2013, Pages

Ways to enhance lymphocyte trafficking into tumors and fitness of tumor infiltrating lymphocytes

Author keywords

Adoptive T cell therapy; Combination therapy; Cytotoxic T lymphocyte; NGR TNF; PH; Proton pump inhibitor; Redox; Vaccine

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; DOXORUBICIN; ESOMEPRAZOLE; FIBROBLAST GROWTH FACTOR; FLUOROURACIL; FOLINIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 2; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCLONAL ANTIBODY DC101; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; OXALIPLATIN; PADGEM PROTEIN; PANITUMUMAB; REACTIVE OXYGEN METABOLITE; SUNITINIB; THIOREDOXIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

EID: 84891094512     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00231     Document Type: Review
Times cited : (133)

References (182)
  • 1
    • 2542430341 scopus 로고    scopus 로고
    • The three Es of cancer immunoediting
    • doi:10.1146/annurev.immunol.22.012703.104803
    • Dunn GP, Old LJ, Schreiber RD. The three Es of cancer immunoediting. Annu Rev Immunol (2004) 22:329-60. doi:10.1146/annurev.immunol.22.012703.104803
    • (2004) Annu Rev Immunol , vol.22 , pp. 329-360
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 2
    • 79953087601 scopus 로고    scopus 로고
    • Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment
    • doi:10.1016/j.coi.2010.11.013
    • Gajewski TF, Fuertes M, Spaapen R, Zheng Y, Kline J. Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment. Curr Opin Immunol (2011) 23:286-92. doi:10.1016/j.coi.2010.11.013
    • (2011) Curr Opin Immunol , vol.23 , pp. 286-292
    • Gajewski, T.F.1    Fuertes, M.2    Spaapen, R.3    Zheng, Y.4    Kline, J.5
  • 3
    • 82555191051 scopus 로고    scopus 로고
    • Cancer immunology-analysis of host and tumor factors for personalized medicine
    • doi:10.1038/nrclinonc.2011.122
    • Ogino S, Galon J, Fuchs CS, Dranoff G. Cancer immunology-analysis of host and tumor factors for personalized medicine. Nat Rev Clin Oncol (2011) 8:711-9. doi:10.1038/nrclinonc.2011.122
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 711-719
    • Ogino, S.1    Galon, J.2    Fuchs, C.S.3    Dranoff, G.4
  • 4
    • 84871433609 scopus 로고    scopus 로고
    • Global profiling strategies for mapping dysregulated metabolic pathways in cancer
    • doi:10.1016/j.cmet.2012.09.013
    • Benjamin DI, Cravatt BF, Nomura DK. Global profiling strategies for mapping dysregulated metabolic pathways in cancer. Cell Metab (2012) 16:565-77. doi:10.1016/j.cmet.2012.09.013
    • (2012) Cell Metab , vol.16 , pp. 565-577
    • Benjamin, D.I.1    Cravatt, B.F.2    Nomura, D.K.3
  • 6
    • 84855225492 scopus 로고    scopus 로고
    • The immune score as a new possible approach for the classification of cancer
    • doi:10.1186/1479-5876-10-1
    • Galon J, Pages F, Marincola FM, Thurin M, Trinchieri G, Fox BA, et al. The immune score as a new possible approach for the classification of cancer. J Transl Med (2012) 10:1. doi:10.1186/1479-5876-10-1
    • (2012) J Transl Med , vol.10 , pp. 1
    • Galon, J.1    Pages, F.2    Marincola, F.M.3    Thurin, M.4    Trinchieri, G.5    Fox, B.A.6
  • 7
    • 84887022513 scopus 로고    scopus 로고
    • An evolutionary perspective on anti-tumor immunity
    • doi:10.3389/fonc.2012.00202
    • Klinke DJ II. An evolutionary perspective on anti-tumor immunity. Front Oncol (2012) 2:202. doi:10.3389/fonc.2012.00202
    • (2012) Front Oncol , vol.2 , pp. 202
    • Klinke I.I, D.J.1
  • 9
    • 84880276438 scopus 로고    scopus 로고
    • Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
    • doi:10.1038/nm.3161
    • Robbins PF, Lu YC, El-Gamil M, Li YF, Gross C, Gartner J, et al. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat Med (2013) 19:747-52. doi:10.1038/nm.3161
    • (2013) Nat Med , vol.19 , pp. 747-752
    • Robbins, P.F.1    Lu, Y.C.2    El-Gamil, M.3    Li, Y.F.4    Gross, C.5    Gartner, J.6
  • 10
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • doi:10.1056/NEJMoa1001294
    • Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med (2010) 363:411-22. doi:10.1056/NEJMoa1001294
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3    Berger, E.R.4    Small, E.J.5    Penson, D.F.6
  • 11
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: harnessing the T cell response
    • doi:10.1038/nri3191
    • Restifo NP, Dudley ME, Rosenberg SA. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol (2012) 12:269-81. doi:10.1038/nri3191
    • (2012) Nat Rev Immunol , vol.12 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 12
    • 84860718270 scopus 로고    scopus 로고
    • Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells
    • 132ra153. doi:10.1126/scitranslmed.3003761
    • Scholler J, Brady TL, Binder-Scholl G, Hwang WT, Plesa G, Hege KM, et al. Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells. Sci Transl Med (2012) 4:132ra153. doi:10.1126/scitranslmed.3003761
    • (2012) Sci Transl Med , vol.4
    • Scholler, J.1    Brady, T.L.2    Binder-Scholl, G.3    Hwang, W.T.4    Plesa, G.5    Hege, K.M.6
  • 13
    • 77953988924 scopus 로고    scopus 로고
    • Targeting the tumour vasculature: insights from physiological angiogenesis
    • doi:10.1038/nrc2868
    • Chung AS, Lee J, Ferrara N. Targeting the tumour vasculature: insights from physiological angiogenesis. Nat Rev Cancer (2010) 10:505-14. doi:10.1038/nrc2868
    • (2010) Nat Rev Cancer , vol.10 , pp. 505-514
    • Chung, A.S.1    Lee, J.2    Ferrara, N.3
  • 14
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • doi:10.1038/nrc2981
    • Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 11:85-95. doi:10.1038/nrc2981
    • (2011) Nat Rev Cancer , vol.11 , pp. 85-95
    • Cairns, R.A.1    Harris, I.S.2    Mak, T.W.3
  • 15
    • 37549061827 scopus 로고    scopus 로고
    • Creating immune privilege: active local suppression that benefits friends, but protects foes
    • doi:10.1038/nri2233
    • Mellor AL, Munn DH. Creating immune privilege: active local suppression that benefits friends, but protects foes. Nat Rev Immunol (2008) 8:74-80. doi:10.1038/nri2233
    • (2008) Nat Rev Immunol , vol.8 , pp. 74-80
    • Mellor, A.L.1    Munn, D.H.2
  • 16
    • 0034609968 scopus 로고    scopus 로고
    • T-cell function and migration. Two sides of the same coin
    • von Andrian UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med (2000) 343:1020-34.
    • (2000) N Engl J Med , vol.343 , pp. 1020-1034
    • von Andrian, U.H.1    Mackay, C.R.2
  • 17
    • 2442519018 scopus 로고    scopus 로고
    • Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation
    • doi:10.1038/nri1351
    • Ley K, Kansas GS. Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation. Nat Rev Immunol (2004) 4:325-35. doi:10.1038/nri1351
    • (2004) Nat Rev Immunol , vol.4 , pp. 325-335
    • Ley, K.1    Kansas, G.S.2
  • 18
    • 4544296118 scopus 로고    scopus 로고
    • T-cell trafficking in asthma: lipid mediators grease the way
    • doi:10.1038/nri1438
    • Luster AD, Tager AM. T-cell trafficking in asthma: lipid mediators grease the way. Nat Rev Immunol (2004) 4:711-24. doi:10.1038/nri1438
    • (2004) Nat Rev Immunol , vol.4 , pp. 711-724
    • Luster, A.D.1    Tager, A.M.2
  • 19
    • 33846246384 scopus 로고    scopus 로고
    • Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells
    • doi:10.1016/j.immuni.2007.01.002
    • Alon R, Dustin ML. Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. Immunity (2007) 26:17-27. doi:10.1016/j.immuni.2007.01.002
    • (2007) Immunity , vol.26 , pp. 17-27
    • Alon, R.1    Dustin, M.L.2
  • 20
    • 84876910443 scopus 로고    scopus 로고
    • The integration of T cell migration, differentiation and function
    • doi:10.1038/nri3442
    • Masopust D, Schenkel JM. The integration of T cell migration, differentiation and function. Nat Rev Immunol (2013) 13:309-20. doi:10.1038/nri3442
    • (2013) Nat Rev Immunol , vol.13 , pp. 309-320
    • Masopust, D.1    Schenkel, J.M.2
  • 21
    • 0026776328 scopus 로고
    • An endothelial ligand for l-selectin is a novel mucin-like molecule
    • doi:10.1016/0092-8674(92)90612-G
    • Lasky LA, Singer MS, Dowbenko D, Imai Y, Henzel WJ, Grimley C, et al. An endothelial ligand for l-selectin is a novel mucin-like molecule. Cell (1992) 69:927-38. doi:10.1016/0092-8674(92)90612-G
    • (1992) Cell , vol.69 , pp. 927-938
    • Lasky, L.A.1    Singer, M.S.2    Dowbenko, D.3    Imai, Y.4    Henzel, W.J.5    Grimley, C.6
  • 22
    • 0027407109 scopus 로고
    • Endothelial-leukocyte adhesion molecules
    • doi:10.1146/annurev.iy.11.040193.004003
    • Bevilacqua MP. Endothelial-leukocyte adhesion molecules. Annu Rev Immunol (1993) 11:767-804. doi:10.1146/annurev.iy.11.040193.004003
    • (1993) Annu Rev Immunol , vol.11 , pp. 767-804
    • Bevilacqua, M.P.1
  • 23
    • 0034812434 scopus 로고    scopus 로고
    • Human endothelial cell presentation of antigen and the homing of memory/effector T cells to skin
    • doi:10.1111/j.1749-6632.2001.tb03706.x
    • Pober JS, Kluger MS, Schechner JS. Human endothelial cell presentation of antigen and the homing of memory/effector T cells to skin. Ann N Y Acad Sci (2001) 941:12-25. doi:10.1111/j.1749-6632.2001.tb03706.x
    • (2001) Ann N Y Acad Sci , vol.941 , pp. 12-25
    • Pober, J.S.1    Kluger, M.S.2    Schechner, J.S.3
  • 24
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • doi:10.1038/nature07201
    • Medzhitov R. Origin and physiological roles of inflammation. Nature (2008) 454:428-35. doi:10.1038/nature07201
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 25
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • doi:10.1016/j.cell.2011.02.013
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell (2011) 144:646-74. doi:10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 26
    • 77649193013 scopus 로고    scopus 로고
    • Immune infiltration in human tumors: a prognostic factor that should not be ignored
    • doi:10.1038/onc.2009.416
    • Pages F, Galon J, Dieu-Nosjean MC, Tartour E, Sautes-Fridman C, Fridman WH. Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene (2010) 29:1093-102. doi:10.1038/onc.2009.416
    • (2010) Oncogene , vol.29 , pp. 1093-1102
    • Pages, F.1    Galon, J.2    Dieu-Nosjean, M.C.3    Tartour, E.4    Sautes-Fridman, C.5    Fridman, W.H.6
  • 27
    • 77954890371 scopus 로고    scopus 로고
    • Targeting the ANGPT-TIE2 pathway in malignancy
    • doi:10.1038/nrc2894
    • Huang H, Bhat A, Woodnutt G, Lappe R. Targeting the ANGPT-TIE2 pathway in malignancy. Nat Rev Cancer (2010) 10:575-85. doi:10.1038/nrc2894
    • (2010) Nat Rev Cancer , vol.10 , pp. 575-585
    • Huang, H.1    Bhat, A.2    Woodnutt, G.3    Lappe, R.4
  • 28
    • 58649124493 scopus 로고    scopus 로고
    • A dialogue between the hypoxia-inducible factor and the tumor microenvironment
    • doi:10.1007/s12307-008-0006-3
    • Dayan F, Mazure NM, Brahimi-Horn MC, Pouyssegur J. A dialogue between the hypoxia-inducible factor and the tumor microenvironment. Cancer Microenviron (2008) 1:53-68. doi:10.1007/s12307-008-0006-3
    • (2008) Cancer Microenviron , vol.1 , pp. 53-68
    • Dayan, F.1    Mazure, N.M.2    Brahimi-Horn, M.C.3    Pouyssegur, J.4
  • 29
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • doi:10.1126/science.1104819
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science (2005) 307:58-62. doi:10.1126/science.1104819
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 30
    • 0038143145 scopus 로고    scopus 로고
    • Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma
    • doi:10.1038/nrc1092
    • Hendrix MJ, Seftor EA, Hess AR, Seftor RE. Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma. Nat Rev Cancer (2003) 3:411-21. doi:10.1038/nrc1092
    • (2003) Nat Rev Cancer , vol.3 , pp. 411-421
    • Hendrix, M.J.1    Seftor, E.A.2    Hess, A.R.3    Seftor, R.E.4
  • 31
    • 0028924988 scopus 로고
    • Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma
    • doi:10.1084/jem.181.2.811
    • Piali L, Fichtel A, Terpe HJ, Imhof BA, Gisler RH. Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma. J Exp Med (1995) 181:811-6. doi:10.1084/jem.181.2.811
    • (1995) J Exp Med , vol.181 , pp. 811-816
    • Piali, L.1    Fichtel, A.2    Terpe, H.J.3    Imhof, B.A.4    Gisler, R.H.5
  • 32
    • 0030044629 scopus 로고    scopus 로고
    • Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors
    • Griffioen AW, Damen CA, Martinotti S, Blijham GH, Groenewegen G. Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors. Cancer Res (1996) 56:1111-7.
    • (1996) Cancer Res , vol.56 , pp. 1111-1117
    • Griffioen, A.W.1    Damen, C.A.2    Martinotti, S.3    Blijham, G.H.4    Groenewegen, G.5
  • 33
    • 0030700761 scopus 로고    scopus 로고
    • Endothelial CD34 is suppressed in human malignancies: role of angiogenic factors
    • doi:10.1016/S0304-3835(97)00310-8
    • Hellwig SM, Damen CA, Van Adrichem NP, Blijham GH, Groenewegen G, Griffioen AW. Endothelial CD34 is suppressed in human malignancies: role of angiogenic factors. Cancer Lett (1997) 120:203-11. doi:10.1016/S0304-3835(97)00310-8
    • (1997) Cancer Lett , vol.120 , pp. 203-211
    • Hellwig, S.M.1    Damen, C.A.2    Van Adrichem, N.P.3    Blijham, G.H.4    Groenewegen, G.5    Griffioen, A.W.6
  • 34
    • 41149097574 scopus 로고    scopus 로고
    • Adoptive cell transfer: a clinical path to effective cancer immunotherapy
    • doi:10.1038/nrc2355
    • Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME. Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer (2008) 8:299-308. doi:10.1038/nrc2355
    • (2008) Nat Rev Cancer , vol.8 , pp. 299-308
    • Rosenberg, S.A.1    Restifo, N.P.2    Yang, J.C.3    Morgan, R.A.4    Dudley, M.E.5
  • 35
    • 67650744372 scopus 로고    scopus 로고
    • Immune therapy for cancer
    • doi:10.1146/annurev.immunol.021908.132544
    • Dougan M, Dranoff G. Immune therapy for cancer. Annu Rev Immunol (2009) 27:83-117. doi:10.1146/annurev.immunol.021908.132544
    • (2009) Annu Rev Immunol , vol.27 , pp. 83-117
    • Dougan, M.1    Dranoff, G.2
  • 36
    • 80052206084 scopus 로고    scopus 로고
    • Prognostic and predictive impact of intra-and peritumoral immune infiltrates
    • doi:10.1158/0008-5472.CAN-11-1316
    • Fridman WH, Galon J, Pages F, Tartour E, Sautes-Fridman C, Kroemer G. Prognostic and predictive impact of intra-and peritumoral immune infiltrates. Cancer Res (2011) 71:5601-5. doi:10.1158/0008-5472.CAN-11-1316
    • (2011) Cancer Res , vol.71 , pp. 5601-5605
    • Fridman, W.H.1    Galon, J.2    Pages, F.3    Tartour, E.4    Sautes-Fridman, C.5    Kroemer, G.6
  • 37
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • doi:10.1126/science.1129139
    • Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science (2006) 313:1960-4. doi:10.1126/science.1129139
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3    Kirilovsky, A.4    Mlecnik, B.5    Lagorce-Pages, C.6
  • 38
    • 42749085280 scopus 로고    scopus 로고
    • Vascular targeting, chemotherapy and active immunotherapy: teaming up to attack cancer
    • doi:10.1016/j.it.2008.02.003
    • Bellone M, Mondino A, Corti A. Vascular targeting, chemotherapy and active immunotherapy: teaming up to attack cancer. Trends Immunol (2008) 29:235-41. doi:10.1016/j.it.2008.02.003
    • (2008) Trends Immunol , vol.29 , pp. 235-241
    • Bellone, M.1    Mondino, A.2    Corti, A.3
  • 39
    • 0029894219 scopus 로고    scopus 로고
    • Tumor necrosis factor: function, release and clearance
    • doi:10.1615/CritRevImmunol.v16.i1.10
    • Bemelmans MH, Van Tits LJ, Buurman WA. Tumor necrosis factor: function, release and clearance. Crit Rev Immunol (1996) 16:1-11. doi:10.1615/CritRevImmunol.v16.i1.10
    • (1996) Crit Rev Immunol , vol.16 , pp. 1-11
    • Bemelmans, M.H.1    Van Tits, L.J.2    Buurman, W.A.3
  • 40
    • 0023191197 scopus 로고
    • Recombinant human tumor necrosis factor-alpha: evidence of an indirect mode of antitumor activity
    • Manda T, Shimomura K, Mukumoto S, Kobayashi K, Mizota T, Hirai O, et al. Recombinant human tumor necrosis factor-alpha: evidence of an indirect mode of antitumor activity. Cancer Res (1987) 47:3707-11.
    • (1987) Cancer Res , vol.47 , pp. 3707-3711
    • Manda, T.1    Shimomura, K.2    Mukumoto, S.3    Kobayashi, K.4    Mizota, T.5    Hirai, O.6
  • 41
    • 0025212179 scopus 로고
    • Studies of effects of recombinant human tumor necrosis factor on autochthonous tumor and transplanted normal tissue in mice
    • McIntosh JK, Mule JJ, Travis WD, Rosenberg SA. Studies of effects of recombinant human tumor necrosis factor on autochthonous tumor and transplanted normal tissue in mice. Cancer Res (1990) 50:2463-9.
    • (1990) Cancer Res , vol.50 , pp. 2463-2469
    • McIntosh, J.K.1    Mule, J.J.2    Travis, W.D.3    Rosenberg, S.A.4
  • 42
    • 41149083660 scopus 로고    scopus 로고
    • Tumor necrosis factor-mediated interactions between inflammatory response and tumor vascular bed
    • doi:10.1111/j.1600-065X.2008.00619.x
    • ten Hagen TLM, Seynhaeve ALB, Eggermont AMM. Tumor necrosis factor-mediated interactions between inflammatory response and tumor vascular bed. Immunol Rev (2008) 222:299-315. doi:10.1111/j.1600-065X.2008.00619.x
    • (2008) Immunol Rev , vol.222 , pp. 299-315
    • ten Hagen, T.L.M.1    Seynhaeve, A.L.B.2    Eggermont, A.M.M.3
  • 43
    • 0033950895 scopus 로고    scopus 로고
    • Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis
    • Pasqualini R, Koivunen E, Kain R, Lahdenranta J, Sakamoto M, Stryhn A, et al. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res (2000) 60:722-7.
    • (2000) Cancer Res , vol.60 , pp. 722-727
    • Pasqualini, R.1    Koivunen, E.2    Kain, R.3    Lahdenranta, J.4    Sakamoto, M.5    Stryhn, A.6
  • 44
    • 0036468937 scopus 로고    scopus 로고
    • Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells
    • Curnis F, Arrigoni G, Sacchi A, Fischetti L, Arap W, Pasqualini R, et al. Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells. Cancer Res (2002) 62:867-74.
    • (2002) Cancer Res , vol.62 , pp. 867-874
    • Curnis, F.1    Arrigoni, G.2    Sacchi, A.3    Fischetti, L.4    Arap, W.5    Pasqualini, R.6
  • 45
    • 0033764170 scopus 로고    scopus 로고
    • Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13)
    • doi:10.1038/81183
    • Curnis F, Sacchi A, Borgna L, Magni F, Gasparri A, Corti A. Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13). Nat Biotechnol (2000) 18:1185-90. doi:10.1038/81183
    • (2000) Nat Biotechnol , vol.18 , pp. 1185-1190
    • Curnis, F.1    Sacchi, A.2    Borgna, L.3    Magni, F.4    Gasparri, A.5    Corti, A.6
  • 46
    • 0036678474 scopus 로고    scopus 로고
    • Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration
    • doi:10.1172/JCI200215223
    • Curnis F, Sacchi A, Corti A. Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration. J Clin Invest (2002) 110:475-82. doi:10.1172/JCI200215223
    • (2002) J Clin Invest , vol.110 , pp. 475-482
    • Curnis, F.1    Sacchi, A.2    Corti, A.3
  • 47
    • 45749129790 scopus 로고    scopus 로고
    • Vasculature-targeted tumor necrosis factor-alpha increases the therapeutic index of doxorubicin against prostate cancer
    • doi:10.1002/pros.20775
    • Bertilaccio MT, Grioni M, Sutherland BW, Degl'Innocenti E, Freschi M, Jachetti E, et al. Vasculature-targeted tumor necrosis factor-alpha increases the therapeutic index of doxorubicin against prostate cancer. Prostate (2008) 68:1105-15. doi:10.1002/pros.20775
    • (2008) Prostate , vol.68 , pp. 1105-1115
    • Bertilaccio, M.T.1    Grioni, M.2    Sutherland, B.W.3    Degl'Innocenti, E.4    Freschi, M.5    Jachetti, E.6
  • 48
    • 84872867897 scopus 로고    scopus 로고
    • Approaches to improve tumor accumulation and interactions between monoclonal antibodies and immune cells
    • doi:10.4161/mabs.22775
    • Marcucci F, Bellone M, Rumio C, Corti A. Approaches to improve tumor accumulation and interactions between monoclonal antibodies and immune cells. MAbs (2013) 5:34-46. doi:10.4161/mabs.22775
    • (2013) MAbs , vol.5 , pp. 34-46
    • Marcucci, F.1    Bellone, M.2    Rumio, C.3    Corti, A.4
  • 49
    • 84857829255 scopus 로고    scopus 로고
    • Targeting TNF-alpha to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy
    • doi:10.4049/jimmunol.1101877
    • Calcinotto A, Grioni M, Jachetti E, Curnis F, Mondino A, Parmiani G, et al. Targeting TNF-alpha to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy. J Immunol (2012) 188:2687-94. doi:10.4049/jimmunol.1101877
    • (2012) J Immunol , vol.188 , pp. 2687-2694
    • Calcinotto, A.1    Grioni, M.2    Jachetti, E.3    Curnis, F.4    Mondino, A.5    Parmiani, G.6
  • 50
    • 84872834025 scopus 로고    scopus 로고
    • Won't you come on in? How to favor lymphocyte infiltration in tumors
    • doi:10.4161/onci.20213
    • Bellone M, Calcinotto A, Corti A. Won't you come on in? How to favor lymphocyte infiltration in tumors. Oncoimmunology (2012) 1:986-8. doi:10.4161/onci.20213
    • (2012) Oncoimmunology , vol.1 , pp. 986-988
    • Bellone, M.1    Calcinotto, A.2    Corti, A.3
  • 51
    • 80052203877 scopus 로고    scopus 로고
    • Chromogranin A restricts drug penetration and limits the ability of NGR-TNF to enhance chemotherapeutic efficacy
    • doi:10.1158/0008-5472.CAN-11-1273
    • Dondossola E, Gasparri AM, Colombo B, Sacchi A, Curnis F, Corti A. Chromogranin A restricts drug penetration and limits the ability of NGR-TNF to enhance chemotherapeutic efficacy. Cancer Res (2011) 71:5881-90. doi:10.1158/0008-5472.CAN-11-1273
    • (2011) Cancer Res , vol.71 , pp. 5881-5890
    • Dondossola, E.1    Gasparri, A.M.2    Colombo, B.3    Sacchi, A.4    Curnis, F.5    Corti, A.6
  • 52
    • 31544479807 scopus 로고    scopus 로고
    • Effects of the tumor vasculature targeting agent NGR-TNF on the tumor microenvironment in murine lymphomas
    • doi:10.1007/s10637-005-4540-2
    • van Laarhoven HW, Gambarota G, Heerschap A, Lok J, Verhagen I, Corti A, et al. Effects of the tumor vasculature targeting agent NGR-TNF on the tumor microenvironment in murine lymphomas. Invest New Drugs (2006) 24:27-36. doi:10.1007/s10637-005-4540-2
    • (2006) Invest New Drugs , vol.24 , pp. 27-36
    • van Laarhoven, H.W.1    Gambarota, G.2    Heerschap, A.3    Lok, J.4    Verhagen, I.5    Corti, A.6
  • 53
    • 84863007720 scopus 로고    scopus 로고
    • Phase II study of NGR-hTNF in combination with doxorubicin in relapsed ovarian cancer patients
    • doi:10.1038/bjc.2012.233
    • Lorusso D, Scambia G, Amadio G, Di Legge A, Pietragalla A, De Vincenzo R, et al. Phase II study of NGR-hTNF in combination with doxorubicin in relapsed ovarian cancer patients. Br J Cancer (2012) 107:37-42. doi:10.1038/bjc.2012.233
    • (2012) Br J Cancer , vol.107 , pp. 37-42
    • Lorusso, D.1    Scambia, G.2    Amadio, G.3    Di Legge, A.4    Pietragalla, A.5    De Vincenzo, R.6
  • 54
    • 10744221996 scopus 로고    scopus 로고
    • Selective targeted delivery of TNFalpha to tumor blood vessels
    • doi:10.1182/blood-2003-04-1039
    • Borsi L, Balza E, Carnemolla B, Sassi F, Castellani P, Berndt A, et al. Selective targeted delivery of TNFalpha to tumor blood vessels. Blood (2003) 102:4384-92. doi:10.1182/blood-2003-04-1039
    • (2003) Blood , vol.102 , pp. 4384-4392
    • Borsi, L.1    Balza, E.2    Carnemolla, B.3    Sassi, F.4    Castellani, P.5    Berndt, A.6
  • 55
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • doi:10.1038/nrd1381
    • Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov (2004) 3:391-400. doi:10.1038/nrd1381
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 56
    • 0037448353 scopus 로고    scopus 로고
    • Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    • doi:10.1056/NEJMoa020177
    • Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G, et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med (2003) 348:203-13. doi:10.1056/NEJMoa020177
    • (2003) N Engl J Med , vol.348 , pp. 203-213
    • Zhang, L.1    Conejo-Garcia, J.R.2    Katsaros, D.3    Gimotty, P.A.4    Massobrio, M.5    Regnani, G.6
  • 57
    • 84858785703 scopus 로고    scopus 로고
    • Coordinated regulation of myeloid cells by tumours
    • doi:10.1038/nri3175
    • Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol (2012) 12:253-68. doi:10.1038/nri3175
    • (2012) Nat Rev Immunol , vol.12 , pp. 253-268
    • Gabrilovich, D.I.1    Ostrand-Rosenberg, S.2    Bronte, V.3
  • 58
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • doi:10.1038/nri1806
    • Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol (2006) 6:295-307. doi:10.1038/nri1806
    • (2006) Nat Rev Immunol , vol.6 , pp. 295-307
    • Zou, W.1
  • 59
    • 33947259319 scopus 로고    scopus 로고
    • Immunosuppressive strategies that are mediated by tumor cells
    • doi:10.1146/annurev.immunol.25.022106.141609
    • Rabinovich GA, Gabrilovich D, Sotomayor EM. Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol (2007) 25:267-96. doi:10.1146/annurev.immunol.25.022106.141609
    • (2007) Annu Rev Immunol , vol.25 , pp. 267-296
    • Rabinovich, G.A.1    Gabrilovich, D.2    Sotomayor, E.M.3
  • 60
    • 33646231504 scopus 로고    scopus 로고
    • Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors
    • doi:10.1096/fj.05-4493com
    • Dirkx AEM, Oude Egbrink MGA, Castermans K, Van Der Schaft DWJ, Thijssen VLJL, Dings RPM, et al. Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors. FASEB J (2006) 20:621-30. doi:10.1096/fj.05-4493com
    • (2006) FASEB J , vol.20 , pp. 621-630
    • Dirkx, A.E.M.1    Oude Egbrink, M.G.A.2    Castermans, K.3    Van Der Schaft, D.W.J.4    Thijssen, V.L.J.L.5    Dings, R.P.M.6
  • 61
    • 33845343558 scopus 로고    scopus 로고
    • Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy
    • doi:10.1158/1078-0432.CCR-06-1558
    • Li B, Lalani AS, Harding TC, Luan B, Koprivnikar K, Huan Tu G, et al. Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy. Clin Cancer Res (2006) 12:6808-16. doi:10.1158/1078-0432.CCR-06-1558
    • (2006) Clin Cancer Res , vol.12 , pp. 6808-6816
    • Li, B.1    Lalani, A.S.2    Harding, T.C.3    Luan, B.4    Koprivnikar, K.5    Huan Tu, G.6
  • 62
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • doi:10.1158/0008-5472.CAN-10-0153
    • Shrimali RK, Yu Z, Theoret MR, Chinnasamy D, Restifo NP, Rosenberg SA. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res (2010) 70:6171-80. doi:10.1158/0008-5472.CAN-10-0153
    • (2010) Cancer Res , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3    Chinnasamy, D.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 63
    • 84867902940 scopus 로고    scopus 로고
    • Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
    • doi:10.1073/pnas.1215397109
    • Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, et al. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A (2012) 109:17561-6. doi:10.1073/pnas.1215397109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 17561-17566
    • Huang, Y.1    Yuan, J.2    Righi, E.3    Kamoun, W.S.4    Ancukiewicz, M.5    Nezivar, J.6
  • 64
    • 0033782775 scopus 로고    scopus 로고
    • Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine
    • doi:10.1038/80506
    • Wei YQ, Wang QR, Zhao X, Yang L, Tian L, Lu Y, et al. Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine. Nat Med (2000) 6:1160-6. doi:10.1038/80506
    • (2000) Nat Med , vol.6 , pp. 1160-1166
    • Wei, Y.Q.1    Wang, Q.R.2    Zhao, X.3    Yang, L.4    Tian, L.5    Lu, Y.6
  • 65
    • 78049436238 scopus 로고    scopus 로고
    • Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice
    • doi:10.1172/JCI43490
    • Chinnasamy D, Yu Z, Theoret MR, Zhao Y, Shrimali RK, Morgan RA, et al. Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice. J Clin Invest (2010) 120:3953-68. doi:10.1172/JCI43490
    • (2010) J Clin Invest , vol.120 , pp. 3953-3968
    • Chinnasamy, D.1    Yu, Z.2    Theoret, M.R.3    Zhao, Y.4    Shrimali, R.K.5    Morgan, R.A.6
  • 66
    • 84878588973 scopus 로고    scopus 로고
    • Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice
    • doi:10.1158/0008-5472.CAN-12-3913
    • Chinnasamy D, Tran E, Yu Z, Morgan RA, Restifo NP, Rosenberg SA. Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice. Cancer Res (2013) 73:3371-80. doi:10.1158/0008-5472.CAN-12-3913
    • (2013) Cancer Res , vol.73 , pp. 3371-3380
    • Chinnasamy, D.1    Tran, E.2    Yu, Z.3    Morgan, R.A.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 67
    • 5444225991 scopus 로고    scopus 로고
    • Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    • doi:10.1016/j.ccr.2004.08.031
    • Yang L, Debusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, et al. Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell (2004) 6:409-21. doi:10.1016/j.ccr.2004.08.031
    • (2004) Cancer Cell , vol.6 , pp. 409-421
    • Yang, L.1    Debusk, L.M.2    Fukuda, K.3    Fingleton, B.4    Green-Jarvis, B.5    Shyr, Y.6
  • 68
    • 74249123434 scopus 로고    scopus 로고
    • VEGFR2 is selectively expressed by FOXP3high CD4+ Treg
    • doi:10.1002/eji.200939887
    • Suzuki H, Onishi H, Wada J, Yamasaki A, Tanaka H, Nakano K, et al. VEGFR2 is selectively expressed by FOXP3high CD4+ Treg. Eur J Immunol (2010) 40:197-203. doi:10.1002/eji.200939887
    • (2010) Eur J Immunol , vol.40 , pp. 197-203
    • Suzuki, H.1    Onishi, H.2    Wada, J.3    Yamasaki, A.4    Tanaka, H.5    Nakano, K.6
  • 69
    • 77952310126 scopus 로고    scopus 로고
    • Risk of arterial thromboembolic events with sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials
    • doi:10.1200/JCO.2009.27.2757
    • Choueiri TK, Schutz FA, Je Y, Rosenberg JE, Bellmunt J. Risk of arterial thromboembolic events with sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials. J Clin Oncol (2010) 28:2280-5. doi:10.1200/JCO.2009.27.2757
    • (2010) J Clin Oncol , vol.28 , pp. 2280-2285
    • Choueiri, T.K.1    Schutz, F.A.2    Je, Y.3    Rosenberg, J.E.4    Bellmunt, J.5
  • 70
    • 77951764520 scopus 로고    scopus 로고
    • Concomitant tumor and minor histocompatibility antigen-specific immunity initiate rejection and maintain remission from established spontaneous solid tumors
    • doi:10.1158/0008-5472.CAN-09-4253
    • Hess Michelini R, Freschi M, Manzo T, Jachetti E, Degl'Innocenti E, Grioni M, et al. Concomitant tumor and minor histocompatibility antigen-specific immunity initiate rejection and maintain remission from established spontaneous solid tumors. Cancer Res (2010) 70:3505-14. doi:10.1158/0008-5472.CAN-09-4253
    • (2010) Cancer Res , vol.70 , pp. 3505-3514
    • Hess Michelini, R.1    Freschi, M.2    Manzo, T.3    Jachetti, E.4    Degl'Innocenti, E.5    Grioni, M.6
  • 71
    • 84881420066 scopus 로고    scopus 로고
    • Vaccine-instructed intratumoral IFN-gamma enables regression of autochthonous mouse prostate cancer in allogeneic T cell transplantation
    • doi:10.1158/0008-5472.CAN-12-3464
    • Hess Michelini R, Manzo T, Sturmheit T, Basso V, Rocchi M, Freschi M, et al. Vaccine-instructed intratumoral IFN-gamma enables regression of autochthonous mouse prostate cancer in allogeneic T cell transplantation. Cancer Res (2013) 73(15):4641-52. doi:10.1158/0008-5472.CAN-12-3464
    • (2013) Cancer Res , vol.73 , Issue.15 , pp. 4641-4652
    • Hess Michelini, R.1    Manzo, T.2    Sturmheit, T.3    Basso, V.4    Rocchi, M.5    Freschi, M.6
  • 72
    • 18344375283 scopus 로고    scopus 로고
    • Immunotherapy and chemotherapy-a practical partnership
    • doi:10.1038/nrc1613
    • Lake RA, Robinson BW. Immunotherapy and chemotherapy-a practical partnership. Nat Rev Cancer (2005) 5:397-405. doi:10.1038/nrc1613
    • (2005) Nat Rev Cancer , vol.5 , pp. 397-405
    • Lake, R.A.1    Robinson, B.W.2
  • 74
    • 84860521444 scopus 로고    scopus 로고
    • The next challenge in cancer immunotherapy: controlling T-cell traffic to the tumor
    • doi:10.1158/0008-5472.CAN-11-3538
    • Abastado JP. The next challenge in cancer immunotherapy: controlling T-cell traffic to the tumor. Cancer Res (2012) 72:2159-61. doi:10.1158/0008-5472.CAN-11-3538
    • (2012) Cancer Res , vol.72 , pp. 2159-2161
    • Abastado, J.P.1
  • 75
    • 85006768050 scopus 로고
    • The metabolism of tumors in the body
    • doi:10.1085/jgp.8.6.519
    • Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. J Gen Physiol (1927) 8:519-30. doi:10.1085/jgp.8.6.519
    • (1927) J Gen Physiol , vol.8 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 76
    • 0038269105 scopus 로고    scopus 로고
    • Gene array and protein expression profiles suggest post-transcriptional regulation during CD8+ T cell differentiation
    • doi:10.1074/jbc.M212741200
    • Cham CM, Xu H, O'Keefe JP, Rivas FV, Zagouras P, Gajewski TF. Gene array and protein expression profiles suggest post-transcriptional regulation during CD8+ T cell differentiation. J Biol Chem (2003) 278:17044-52. doi:10.1074/jbc.M212741200
    • (2003) J Biol Chem , vol.278 , pp. 17044-17052
    • Cham, C.M.1    Xu, H.2    O'Keefe, J.P.3    Rivas, F.V.4    Zagouras, P.5    Gajewski, T.F.6
  • 77
    • 18244395827 scopus 로고    scopus 로고
    • Metabolic mechanisms of tumor resistance to T cell effector function
    • doi:10.1385/IR:31:2:107
    • Cham CM, Gajewski TF. Metabolic mechanisms of tumor resistance to T cell effector function. Immunol Res (2005) 31:107-18. doi:10.1385/IR:31:2:107
    • (2005) Immunol Res , vol.31 , pp. 107-118
    • Cham, C.M.1    Gajewski, T.F.2
  • 78
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • doi:10.1038/nrc1478
    • Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 4:891-9. doi:10.1038/nrc1478
    • (2004) Nat Rev Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 79
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
    • doi:10.1038/nrd2467
    • Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov (2008) 7:168-81. doi:10.1038/nrd2467
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 168-181
    • Supuran, C.T.1
  • 80
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • doi:10.1158/0008-5472.CAN-08-2470
    • Chiche J, Ilc K, Laferriere J, Trottier E, Dayan F, Mazure NM, et al. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res (2009) 69:358-68. doi:10.1158/0008-5472.CAN-08-2470
    • (2009) Cancer Res , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferriere, J.3    Trottier, E.4    Dayan, F.5    Mazure, N.M.6
  • 81
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation
    • doi:10.1038/nm0297-177
    • Helmlinger G, Yuan F, Dellian M, Jain RK. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med (1997) 3:177-82. doi:10.1038/nm0297-177
    • (1997) Nat Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 82
    • 36349001899 scopus 로고    scopus 로고
    • Targeting vacuolar H+-ATPases as a new strategy against cancer
    • doi:10.1158/0008-5472.CAN-07-1805
    • Fais S, De Milito A, You H, Qin W. Targeting vacuolar H+-ATPases as a new strategy against cancer. Cancer Res (2007) 67:10627-30. doi:10.1158/0008-5472.CAN-07-1805
    • (2007) Cancer Res , vol.67 , pp. 10627-10630
    • Fais, S.1    De Milito, A.2    You, H.3    Qin, W.4
  • 83
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • doi:10.1038/nrc2397
    • Dewhirst MW, Cao Y, Moeller B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer (2008) 8:425-37. doi:10.1038/nrc2397
    • (2008) Nat Rev Cancer , vol.8 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 84
    • 73449121970 scopus 로고    scopus 로고
    • Redox-based escape mechanism from death: the cancer lesson
    • doi:10.1089/ars.2009.2739
    • Pani G, Giannoni E, Galeotti T, Chiarugi P. Redox-based escape mechanism from death: the cancer lesson. Antioxid Redox Signal (2009) 11:2791-806. doi:10.1089/ars.2009.2739
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2791-2806
    • Pani, G.1    Giannoni, E.2    Galeotti, T.3    Chiarugi, P.4
  • 85
    • 33751178410 scopus 로고    scopus 로고
    • The thioredoxin system in cancer
    • doi:10.1016/j.semcancer.2006.10.009
    • Arner ES, Holmgren A. The thioredoxin system in cancer. Semin Cancer Biol (2006) 16:420-6. doi:10.1016/j.semcancer.2006.10.009
    • (2006) Semin Cancer Biol , vol.16 , pp. 420-426
    • Arner, E.S.1    Holmgren, A.2
  • 86
    • 51949087589 scopus 로고    scopus 로고
    • The redox state of the lung cancer microenvironment depends on the levels of thioredoxin expressed by tumor cells and affects tumor progression and response to prooxidants
    • doi:10.1002/ijc.23709
    • Ceccarelli J, Delfino L, Zappia E, Castellani P, Borghi M, Ferrini S, et al. The redox state of the lung cancer microenvironment depends on the levels of thioredoxin expressed by tumor cells and affects tumor progression and response to prooxidants. Int J Cancer (2008) 123:1770-8. doi:10.1002/ijc.23709
    • (2008) Int J Cancer , vol.123 , pp. 1770-1778
    • Ceccarelli, J.1    Delfino, L.2    Zappia, E.3    Castellani, P.4    Borghi, M.5    Ferrini, S.6
  • 87
    • 31544467810 scopus 로고    scopus 로고
    • Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer
    • doi:10.1158/0008-5472.CAN-05-1357
    • Csiki I, Yanagisawa K, Haruki N, Nadaf S, Morrow JD, Johnson DH, et al. Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer. Cancer Res (2006) 66:143-50. doi:10.1158/0008-5472.CAN-05-1357
    • (2006) Cancer Res , vol.66 , pp. 143-150
    • Csiki, I.1    Yanagisawa, K.2    Haruki, N.3    Nadaf, S.4    Morrow, J.D.5    Johnson, D.H.6
  • 88
    • 34347207246 scopus 로고    scopus 로고
    • Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species
    • doi:10.1158/0008-5472.CAN-06-4095
    • De Milito A, Iessi E, Logozzi M, Lozupone F, Spada M, Marino ML, et al. Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species. Cancer Res (2007) 67:5408-17. doi:10.1158/0008-5472.CAN-06-4095
    • (2007) Cancer Res , vol.67 , pp. 5408-5417
    • De Milito, A.1    Iessi, E.2    Logozzi, M.3    Lozupone, F.4    Spada, M.5    Marino, M.L.6
  • 89
    • 84876771596 scopus 로고    scopus 로고
    • The immune system as a sensor of the metabolic state
    • doi:10.1016/j.immuni.2013.04.001
    • Odegaard JI, Chawla A. The immune system as a sensor of the metabolic state. Immunity (2013) 38:644-54. doi:10.1016/j.immuni.2013.04.001
    • (2013) Immunity , vol.38 , pp. 644-654
    • Odegaard, J.I.1    Chawla, A.2
  • 90
    • 84875261622 scopus 로고    scopus 로고
    • Indoleamine 2,3 dioxygenase and metabolic control of immune responses
    • doi:10.1016/j.it.2012.10.001
    • Munn DH, Mellor AL. Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol (2013) 34:137-43. doi:10.1016/j.it.2012.10.001
    • (2013) Trends Immunol , vol.34 , pp. 137-143
    • Munn, D.H.1    Mellor, A.L.2
  • 91
    • 84880664259 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
    • doi:10.1084/jem.20130066
    • Holmgaard RB, Zamarin D, Munn DH, Wolchok JD, Allison JP. Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J Exp Med (2013) 210:1389-402. doi:10.1084/jem.20130066
    • (2013) J Exp Med , vol.210 , pp. 1389-1402
    • Holmgaard, R.B.1    Zamarin, D.2    Munn, D.H.3    Wolchok, J.D.4    Allison, J.P.5
  • 92
    • 0035575975 scopus 로고    scopus 로고
    • Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions
    • Caldwell CC, Kojima H, Lukashev D, Armstrong J, Farber M, Apasov SG, et al. Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. J Immunol (2001) 167:6140-9.
    • (2001) J Immunol , vol.167 , pp. 6140-6149
    • Caldwell, C.C.1    Kojima, H.2    Lukashev, D.3    Armstrong, J.4    Farber, M.5    Apasov, S.G.6
  • 93
    • 0037438642 scopus 로고    scopus 로고
    • Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation
    • Conforti L, Petrovic M, Mohammad D, Lee S, Ma Q, Barone S, et al. Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation. J Immunol (2003) 170:695-702.
    • (2003) J Immunol , vol.170 , pp. 695-702
    • Conforti, L.1    Petrovic, M.2    Mohammad, D.3    Lee, S.4    Ma, Q.5    Barone, S.6
  • 94
    • 33749512970 scopus 로고    scopus 로고
    • Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes
    • Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, et al. Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. J Immunol (2006) 177:4962-5.
    • (2006) J Immunol , vol.177 , pp. 4962-4965
    • Lukashev, D.1    Klebanov, B.2    Kojima, H.3    Grinberg, A.4    Ohta, A.5    Berenfeld, L.6
  • 95
    • 36849008476 scopus 로고    scopus 로고
    • Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival
    • doi:10.1371/journal.pone.0000853
    • Thiel M, Caldwell CC, Kreth S, Kuboki S, Chen P, Smith P, et al. Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival. PLoS ONE (2007) 2:e853. doi:10.1371/journal.pone.0000853
    • (2007) PLoS ONE , vol.2
    • Thiel, M.1    Caldwell, C.C.2    Kreth, S.3    Kuboki, S.4    Chen, P.5    Smith, P.6
  • 96
    • 58149147369 scopus 로고    scopus 로고
    • Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia
    • doi:10.1158/1078-0432.CCR-08-0229
    • Sitkovsky MV, Kjaergaard J, Lukashev D, Ohta A. Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia. Clin Cancer Res (2008) 14:5947-52. doi:10.1158/1078-0432.CCR-08-0229
    • (2008) Clin Cancer Res , vol.14 , pp. 5947-5952
    • Sitkovsky, M.V.1    Kjaergaard, J.2    Lukashev, D.3    Ohta, A.4
  • 97
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • doi:10.1038/nature10169
    • Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature (2011) 475:226-30. doi:10.1038/nature10169
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1    Peng, X.2    Hagemann, I.S.3    Balint, K.4    Barchetti, A.5    Wang, L.P.6
  • 98
    • 80052277906 scopus 로고    scopus 로고
    • Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
    • doi:10.1016/j.cell.2011.07.033
    • Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell (2011) 146:772-84. doi:10.1016/j.cell.2011.07.033
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1    Barbi, J.2    Yang, H.Y.3    Jinasena, D.4    Yu, H.5    Zheng, Y.6
  • 99
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • doi:10.1084/jem.20110278
    • Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med (2011) 208:1367-76. doi:10.1084/jem.20110278
    • (2011) J Exp Med , vol.208 , pp. 1367-1376
    • Shi, L.Z.1    Wang, R.2    Huang, G.3    Vogel, P.4    Neale, G.5    Green, D.R.6
  • 100
    • 79955040909 scopus 로고    scopus 로고
    • IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer
    • doi:10.4049/jimmunol.1003251
    • Kryczek I, Wu K, Zhao E, Wei S, Vatan L, Szeliga W, et al. IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer. J Immunol (2011) 186:4388-95. doi:10.4049/jimmunol.1003251
    • (2011) J Immunol , vol.186 , pp. 4388-4395
    • Kryczek, I.1    Wu, K.2    Zhao, E.3    Wei, S.4    Vatan, L.5    Szeliga, W.6
  • 101
    • 84873691650 scopus 로고    scopus 로고
    • The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin
    • doi:10.1146/annurev-pathol-011110-130318
    • Weaver CT, Elson CO, Fouser LA, Kolls JK. The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin. Annu Rev Pathol (2013) 8:477-512. doi:10.1146/annurev-pathol-011110-130318
    • (2013) Annu Rev Pathol , vol.8 , pp. 477-512
    • Weaver, C.T.1    Elson, C.O.2    Fouser, L.A.3    Kolls, J.K.4
  • 102
    • 70449530422 scopus 로고    scopus 로고
    • T helper 17 cells promote cytotoxic T cell activation in tumor immunity
    • doi:10.1016/j.immuni.2009.09.014
    • Martin-Orozco N, Muranski P, Chung Y, Yang XO, Yamazaki T, Lu S, et al. T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity (2009) 31:787-98. doi:10.1016/j.immuni.2009.09.014
    • (2009) Immunity , vol.31 , pp. 787-798
    • Martin-Orozco, N.1    Muranski, P.2    Chung, Y.3    Yang, X.O.4    Yamazaki, T.5    Lu, S.6
  • 103
    • 77950196277 scopus 로고    scopus 로고
    • T(H)17 cells in tumour immunity and immunotherapy
    • doi:10.1038/nri2742
    • Zou W, Restifo NP. T(H)17 cells in tumour immunity and immunotherapy. Nat Rev Immunol (2010) 10:248-56. doi:10.1038/nri2742
    • (2010) Nat Rev Immunol , vol.10 , pp. 248-256
    • Zou, W.1    Restifo, N.P.2
  • 104
    • 84866361046 scopus 로고    scopus 로고
    • Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells
    • doi:10.1158/0008-5472.CAN-12-1383
    • Noman MZ, Buart S, Romero P, Ketari S, Janji B, Mari B, et al. Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells. Cancer Res (2012) 72:4629-41. doi:10.1158/0008-5472.CAN-12-1383
    • (2012) Cancer Res , vol.72 , pp. 4629-4641
    • Noman, M.Z.1    Buart, S.2    Romero, P.3    Ketari, S.4    Janji, B.5    Mari, B.6
  • 105
    • 0017384820 scopus 로고
    • Energy metabolism and T-cell-mediated cytolysis. II. Selective inhibition of cytolysis by 2-deoxy-d-glucose
    • doi:10.1084/jem.146.3.710
    • MacDonald HR. Energy metabolism and T-cell-mediated cytolysis. II. Selective inhibition of cytolysis by 2-deoxy-d-glucose. J Exp Med (1977) 146:710-9. doi:10.1084/jem.146.3.710
    • (1977) J Exp Med , vol.146 , pp. 710-719
    • MacDonald, H.R.1
  • 106
    • 0035071662 scopus 로고    scopus 로고
    • The effects of extracellular pH on immune function
    • Lardner A. The effects of extracellular pH on immune function. J Leukoc Biol (2001) 69:522-30.
    • (2001) J Leukoc Biol , vol.69 , pp. 522-530
    • Lardner, A.1
  • 107
    • 39149122935 scopus 로고    scopus 로고
    • Metabolic acidosis in patients with sepsis: epiphenomenon or part of the pathophysiology?
    • Kellum JA. Metabolic acidosis in patients with sepsis: epiphenomenon or part of the pathophysiology? Crit Care Resusc (2004) 6:197-203.
    • (2004) Crit Care Resusc , vol.6 , pp. 197-203
    • Kellum, J.A.1
  • 108
    • 33645750798 scopus 로고    scopus 로고
    • Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells
    • doi:10.1158/0008-5472.CAN-05-3204
    • Lugini L, Matarrese P, Tinari A, Lozupone F, Federici C, Iessi E, et al. Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells. Cancer Res (2006) 66:3629-38. doi:10.1158/0008-5472.CAN-05-3204
    • (2006) Cancer Res , vol.66 , pp. 3629-3638
    • Lugini, L.1    Matarrese, P.2    Tinari, A.3    Lozupone, F.4    Federici, C.5    Iessi, E.6
  • 109
    • 0023245199 scopus 로고
    • Regulation of T-cell functions by l-lactate
    • doi:10.1016/0008-8749(87)90223-1
    • Droge W, Roth S, Altmann A, Mihm S. Regulation of T-cell functions by l-lactate. Cell Immunol (1987) 108:405-16. doi:10.1016/0008-8749(87)90223-1
    • (1987) Cell Immunol , vol.108 , pp. 405-416
    • Droge, W.1    Roth, S.2    Altmann, A.3    Mihm, S.4
  • 110
    • 0025261897 scopus 로고
    • Lymphocytes stimulated with recombinant human interleukin-2: relationship between motility into protein matrix and in vivo localization in normal and neoplastic tissues of mice
    • doi:10.1093/jnci/82.7.612
    • Ratner S. Lymphocytes stimulated with recombinant human interleukin-2: relationship between motility into protein matrix and in vivo localization in normal and neoplastic tissues of mice. J Natl Cancer Inst (1990) 82:612-6. doi:10.1093/jnci/82.7.612
    • (1990) J Natl Cancer Inst , vol.82 , pp. 612-616
    • Ratner, S.1
  • 111
    • 0025721115 scopus 로고
    • Comparative studies of the cytotoxic T lymphocyte-mediated cytotoxicity and of extracellular ATP-induced cell lysis. Different requirements in extracellular Mg2+ and pH
    • Redegeld F, Filippini A, Sitkovsky M. Comparative studies of the cytotoxic T lymphocyte-mediated cytotoxicity and of extracellular ATP-induced cell lysis. Different requirements in extracellular Mg2+ and pH. J Immunol (1991) 147:3638-45.
    • (1991) J Immunol , vol.147 , pp. 3638-3645
    • Redegeld, F.1    Filippini, A.2    Sitkovsky, M.3
  • 112
    • 34247352844 scopus 로고    scopus 로고
    • Inhibitory effect of tumor cell-derived lactic acid on human T cells
    • doi:10.1182/blood-2006-07-035972
    • Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M, et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood (2007) 109:3812-9. doi:10.1182/blood-2006-07-035972
    • (2007) Blood , vol.109 , pp. 3812-3819
    • Fischer, K.1    Hoffmann, P.2    Voelkl, S.3    Meidenbauer, N.4    Ammer, J.5    Edinger, M.6
  • 113
    • 84861861104 scopus 로고    scopus 로고
    • Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes
    • doi:10.1158/0008-5472.CAN-11-1272
    • Calcinotto A, Filipazzi P, Grioni M, Iero M, De Milito A, Ricupito A, et al. Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes. Cancer Res (2012) 72:2746-56. doi:10.1158/0008-5472.CAN-11-1272
    • (2012) Cancer Res , vol.72 , pp. 2746-2756
    • Calcinotto, A.1    Filipazzi, P.2    Grioni, M.3    Iero, M.4    De Milito, A.5    Ricupito, A.6
  • 114
    • 0034142187 scopus 로고    scopus 로고
    • IL-2 unresponsiveness in anergic CD4+ T cells is due to defective signaling through the common gamma-chain of the IL-2 receptor
    • Grundstrom S, Dohlsten M, Sundstedt A. IL-2 unresponsiveness in anergic CD4+ T cells is due to defective signaling through the common gamma-chain of the IL-2 receptor. J Immunol (2000) 164:1175-84.
    • (2000) J Immunol , vol.164 , pp. 1175-1184
    • Grundstrom, S.1    Dohlsten, M.2    Sundstedt, A.3
  • 115
    • 0034283927 scopus 로고    scopus 로고
    • T cell effector function and anergy avoidance are quantitatively linked to cell division
    • Wells AD, Walsh MC, Sankaran D, Turka LA. T cell effector function and anergy avoidance are quantitatively linked to cell division. J Immunol (2000) 165:2432-43.
    • (2000) J Immunol , vol.165 , pp. 2432-2443
    • Wells, A.D.1    Walsh, M.C.2    Sankaran, D.3    Turka, L.A.4
  • 116
    • 84886945702 scopus 로고    scopus 로고
    • The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
    • doi:10.4161/onci.22058
    • Bellone M, Calcinotto A, Filipazzi P, De Milito A, Fais S, Rivoltini L. The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors. Oncoimmunology (2013) 2:e22058. doi:10.4161/onci.22058
    • (2013) Oncoimmunology , vol.2
    • Bellone, M.1    Calcinotto, A.2    Filipazzi, P.3    De Milito, A.4    Fais, S.5    Rivoltini, L.6
  • 117
    • 0015596284 scopus 로고
    • Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent
    • doi:10.1172/JCI107236
    • Babior BM, Kipnes RS, Curnutte JT. Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest (1973) 52:741-4. doi:10.1172/JCI107236
    • (1973) J Clin Invest , vol.52 , pp. 741-744
    • Babior, B.M.1    Kipnes, R.S.2    Curnutte, J.T.3
  • 118
    • 84868314921 scopus 로고    scopus 로고
    • Redox control of NLRP3 inflammasome activation in health and disease
    • doi:10.1189/jlb.0512265
    • Rubartelli A. Redox control of NLRP3 inflammasome activation in health and disease. J Leukoc Biol (2012) 92:951-8. doi:10.1189/jlb.0512265
    • (2012) J Leukoc Biol , vol.92 , pp. 951-958
    • Rubartelli, A.1
  • 119
    • 4444240314 scopus 로고    scopus 로고
    • T cell receptor stimulation, reactive oxygen species, and cell signaling
    • doi:10.1016/j.freeradbiomed.2004.05.029
    • Williams MS, Kwon J. T cell receptor stimulation, reactive oxygen species, and cell signaling. Free Radic Biol Med (2004) 37:1144-51. doi:10.1016/j.freeradbiomed.2004.05.029
    • (2004) Free Radic Biol Med , vol.37 , pp. 1144-1151
    • Williams, M.S.1    Kwon, J.2
  • 120
    • 0032533159 scopus 로고    scopus 로고
    • Arginine metabolism: nitric oxide and beyond
    • Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. Biochem J (1998) 336(Pt 1):1-17.
    • (1998) Biochem J , vol.336 , Issue.PART 1 , pp. 1-17
    • Wu, G.1    Morris Jr., S.M.2
  • 121
    • 0034769118 scopus 로고    scopus 로고
    • Nitric oxide and the immune response
    • doi:10.1038/35098532
    • Bogdan C. Nitric oxide and the immune response. Nat Immunol (2001) 2:907-16. doi:10.1038/35098532
    • (2001) Nat Immunol , vol.2 , pp. 907-916
    • Bogdan, C.1
  • 122
    • 0037077192 scopus 로고    scopus 로고
    • Regulation of T cell receptor CD3zeta chain expression by l-arginine
    • doi:10.1074/jbc.M110675200
    • Rodriguez PC, Zea AH, Culotta KS, Zabaleta J, Ochoa JB, Ochoa AC. Regulation of T cell receptor CD3zeta chain expression by l-arginine. J Biol Chem (2002) 277:21123-9. doi:10.1074/jbc.M110675200
    • (2002) J Biol Chem , vol.277 , pp. 21123-21129
    • Rodriguez, P.C.1    Zea, A.H.2    Culotta, K.S.3    Zabaleta, J.4    Ochoa, J.B.5    Ochoa, A.C.6
  • 123
    • 4143130091 scopus 로고    scopus 로고
    • Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
    • doi:10.1158/0008-5472.CAN-04-0465
    • Rodriguez PC, Quiceno DG, Zabaleta J, Ortiz B, Zea AH, Piazuelo MB, et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res (2004) 64:5839-49. doi:10.1158/0008-5472.CAN-04-0465
    • (2004) Cancer Res , vol.64 , pp. 5839-5849
    • Rodriguez, P.C.1    Quiceno, D.G.2    Zabaleta, J.3    Ortiz, B.4    Zea, A.H.5    Piazuelo, M.B.6
  • 124
    • 33846933459 scopus 로고    scopus 로고
    • l-arginine availability regulates T-lymphocyte cell-cycle progression
    • doi:10.1182/blood-2006-06-031856
    • Rodriguez PC, Quiceno DG, Ochoa AC. l-arginine availability regulates T-lymphocyte cell-cycle progression. Blood (2007) 109:1568-73. doi:10.1182/blood-2006-06-031856
    • (2007) Blood , vol.109 , pp. 1568-1573
    • Rodriguez, P.C.1    Quiceno, D.G.2    Ochoa, A.C.3
  • 125
    • 0032526629 scopus 로고    scopus 로고
    • Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway
    • Bingisser RM, Tilbrook PA, Holt PG, Kees UR. Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway. J Immunol (1998) 160:5729-34.
    • (1998) J Immunol , vol.160 , pp. 5729-5734
    • Bingisser, R.M.1    Tilbrook, P.A.2    Holt, P.G.3    Kees, U.R.4
  • 128
    • 0033179327 scopus 로고    scopus 로고
    • Nitric oxide mediation of active immunosuppression associated with graft-versus-host reaction
    • Bobe P, Benihoud K, Grandjon D, Opolon P, Pritchard LL, Huchet R. Nitric oxide mediation of active immunosuppression associated with graft-versus-host reaction. Blood (1999) 94:1028-37.
    • (1999) Blood , vol.94 , pp. 1028-1037
    • Bobe, P.1    Benihoud, K.2    Grandjon, D.3    Opolon, P.4    Pritchard, L.L.5    Huchet, R.6
  • 129
    • 33846006154 scopus 로고    scopus 로고
    • Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells
    • doi:10.1182/blood-2006-02-002246
    • Sato K, Ozaki K, Oh I, Meguro A, Hatanaka K, Nagai T, et al. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood (2007) 109:228-34. doi:10.1182/blood-2006-02-002246
    • (2007) Blood , vol.109 , pp. 228-234
    • Sato, K.1    Ozaki, K.2    Oh, I.3    Meguro, A.4    Hatanaka, K.5    Nagai, T.6
  • 130
    • 0032475865 scopus 로고    scopus 로고
    • Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process
    • doi:10.1074/jbc.273.40.25804
    • Xia Y, Tsai AL, Berka V, Zweier JL. Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. J Biol Chem (1998) 273:25804-8. doi:10.1074/jbc.273.40.25804
    • (1998) J Biol Chem , vol.273 , pp. 25804-25808
    • Xia, Y.1    Tsai, A.L.2    Berka, V.3    Zweier, J.L.4
  • 131
    • 0037223170 scopus 로고    scopus 로고
    • IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice
    • Bronte V, Serafini P, De Santo C, Marigo I, Tosello V, Mazzoni A, et al. IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice. J Immunol (2003) 170:270-8.
    • (2003) J Immunol , vol.170 , pp. 270-278
    • Bronte, V.1    Serafini, P.2    De Santo, C.3    Marigo, I.4    Tosello, V.5    Mazzoni, A.6
  • 132
    • 28044445899 scopus 로고    scopus 로고
    • Role of immature myeloid cells in mechanisms of immune evasion in cancer
    • doi:10.1007/s00262-005-0048-z
    • Kusmartsev S, Gabrilovich DI. Role of immature myeloid cells in mechanisms of immune evasion in cancer. Cancer Immunol Immunother (2006) 55:237-45. doi:10.1007/s00262-005-0048-z
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 237-245
    • Kusmartsev, S.1    Gabrilovich, D.I.2
  • 133
    • 0028947405 scopus 로고
    • The formation of peroxynitrite in vivo from nitric oxide and superoxide
    • doi:10.1016/0009-2797(94)03591-U
    • Squadrito GL, Pryor WA. The formation of peroxynitrite in vivo from nitric oxide and superoxide. Chem Biol Interact (1995) 96:203-6. doi:10.1016/0009-2797(94)03591-U
    • (1995) Chem Biol Interact , vol.96 , pp. 203-206
    • Squadrito, G.L.1    Pryor, W.A.2
  • 134
    • 34447118098 scopus 로고    scopus 로고
    • Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
    • doi:10.1038/nm1609
    • Nagaraj S, Gupta K, Pisarev V, Kinarsky L, Sherman S, Kang L, et al. Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat Med (2007) 13:828-35. doi:10.1038/nm1609
    • (2007) Nat Med , vol.13 , pp. 828-835
    • Nagaraj, S.1    Gupta, K.2    Pisarev, V.3    Kinarsky, L.4    Sherman, S.5    Kang, L.6
  • 135
    • 80054694464 scopus 로고    scopus 로고
    • Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
    • doi:10.1084/jem.20101956
    • Molon B, Ugel S, Del Pozzo F, Soldani C, Zilio S, Avella D, et al. Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J Exp Med (2011) 208:1949-62. doi:10.1084/jem.20101956
    • (2011) J Exp Med , vol.208 , pp. 1949-1962
    • Molon, B.1    Ugel, S.2    Del Pozzo, F.3    Soldani, C.4    Zilio, S.5    Avella, D.6
  • 136
    • 70349314830 scopus 로고    scopus 로고
    • Extracellular redox modulation by regulatory T cells
    • doi:10.1038/nchembio.212
    • Yan Z, Garg SK, Kipnis J, Banerjee R. Extracellular redox modulation by regulatory T cells. Nat Chem Biol (2009) 5:721-3. doi:10.1038/nchembio.212
    • (2009) Nat Chem Biol , vol.5 , pp. 721-723
    • Yan, Z.1    Garg, S.K.2    Kipnis, J.3    Banerjee, R.4
  • 137
    • 0037022345 scopus 로고    scopus 로고
    • Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation
    • doi:10.1073/pnas.022630299
    • Angelini G, Gardella S, Ardy M, Ciriolo MR, Filomeni G, Di Trapani G, et al. Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc Natl Acad Sci U S A (2002) 99:1491-6. doi:10.1073/pnas.022630299
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 1491-1496
    • Angelini, G.1    Gardella, S.2    Ardy, M.3    Ciriolo, M.R.4    Filomeni, G.5    Di Trapani, G.6
  • 138
    • 78650651362 scopus 로고    scopus 로고
    • Regulatory T cells interfere with glutathione metabolism in dendritic cells and T cells
    • doi:10.1074/jbc.M110.189944
    • Yan Z, Garg SK, Banerjee R. Regulatory T cells interfere with glutathione metabolism in dendritic cells and T cells. J Biol Chem (2010) 285:41525-32. doi:10.1074/jbc.M110.189944
    • (2010) J Biol Chem , vol.285 , pp. 41525-41532
    • Yan, Z.1    Garg, S.K.2    Banerjee, R.3
  • 139
    • 33750832563 scopus 로고    scopus 로고
    • T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine
    • Kobie JJ, Shah PR, Yang L, Rebhahn JA, Fowell DJ, Mosmann TR. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J Immunol (2006) 177:6780-6.
    • (2006) J Immunol , vol.177 , pp. 6780-6786
    • Kobie, J.J.1    Shah, P.R.2    Yang, L.3    Rebhahn, J.A.4    Fowell, D.J.5    Mosmann, T.R.6
  • 140
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • doi:10.1084/jem.20062512
    • Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 204:1257-65. doi:10.1084/jem.20062512
    • (2007) J Exp Med , vol.204 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3    Friedman, D.4    Usheva, A.5    Erat, A.6
  • 141
    • 67650096912 scopus 로고    scopus 로고
    • Enhancing CD8 T-cell memory by modulating fatty acid metabolism
    • doi:10.1038/nature08097
    • Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS, et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature (2009) 460:103-7. doi:10.1038/nature08097
    • (2009) Nature , vol.460 , pp. 103-107
    • Pearce, E.L.1    Walsh, M.C.2    Cejas, P.J.3    Harms, G.M.4    Shen, H.5    Wang, L.S.6
  • 142
    • 79952740612 scopus 로고    scopus 로고
    • Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma
    • doi:10.1073/pnas.1014480108
    • Keunen O, Johansson M, Oudin A, Sanzey M, Rahim SA, Fack F, et al. Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci U S A (2011) 108:3749-54. doi:10.1073/pnas.1014480108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3749-3754
    • Keunen, O.1    Johansson, M.2    Oudin, A.3    Sanzey, M.4    Rahim, S.A.5    Fack, F.6
  • 143
    • 84857407549 scopus 로고    scopus 로고
    • Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
    • doi:10.1073/pnas.1018866109
    • Conley SJ, Gheordunescu E, Kakarala P, Newman B, Korkaya H, Heath AN, et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci U S A (2012) 109:2784-9. doi:10.1073/pnas.1018866109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 2784-2789
    • Conley, S.J.1    Gheordunescu, E.2    Kakarala, P.3    Newman, B.4    Korkaya, H.5    Heath, A.N.6
  • 144
    • 80052453669 scopus 로고    scopus 로고
    • Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype
    • doi:10.1158/1078-0432.CCR-11-1185
    • Carbone C, Moccia T, Zhu C, Paradiso G, Budillon A, Chiao PJ, et al. Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype. Clin Cancer Res (2011) 17:5822-32. doi:10.1158/1078-0432.CCR-11-1185
    • (2011) Clin Cancer Res , vol.17 , pp. 5822-5832
    • Carbone, C.1    Moccia, T.2    Zhu, C.3    Paradiso, G.4    Budillon, A.5    Chiao, P.J.6
  • 145
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • doi:10.1016/j.ccr.2009.01.027
    • Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell (2009) 15:220-31. doi:10.1016/j.ccr.2009.01.027
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3    Takeda, T.4    Okuyama, H.5    Vinals, F.6
  • 146
    • 34547820876 scopus 로고    scopus 로고
    • Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
    • doi:10.1038/nbt1323
    • Shojaei F, Wu X, Malik AK, Zhong C, Baldwin ME, Schanz S, et al. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat Biotechnol (2007) 25:911-20. doi:10.1038/nbt1323
    • (2007) Nat Biotechnol , vol.25 , pp. 911-920
    • Shojaei, F.1    Wu, X.2    Malik, A.K.3    Zhong, C.4    Baldwin, M.E.5    Schanz, S.6
  • 147
    • 44849093414 scopus 로고    scopus 로고
    • A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumour activities
    • doi:10.1093/annonc/mdm408
    • Christensen JG. A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumour activities. Ann Oncol (2007) 18(Suppl 10):x3-10. doi:10.1093/annonc/mdm408
    • (2007) Ann Oncol , vol.18 , Issue.SUPPL. 10
    • Christensen, J.G.1
  • 148
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • doi:10.1200/JCO.2008.20.1293
    • Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol (2009) 27:3584-90. doi:10.1200/JCO.2008.20.1293
    • (2009) J Clin Oncol , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3    Michaelson, M.D.4    Bukowski, R.M.5    Oudard, S.6
  • 149
    • 84860591982 scopus 로고    scopus 로고
    • Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice
    • doi:10.1172/JCI58976
    • Maione F, Capano S, Regano D, Zentilin L, Giacca M, Casanovas O, et al. Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice. J Clin Invest (2012) 122:1832-48. doi:10.1172/JCI58976
    • (2012) J Clin Invest , vol.122 , pp. 1832-1848
    • Maione, F.1    Capano, S.2    Regano, D.3    Zentilin, L.4    Giacca, M.5    Casanovas, O.6
  • 150
    • 58149179532 scopus 로고    scopus 로고
    • Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients
    • doi:10.1158/1078-0432.CCR-07-5212
    • Finke JH, Rini B, Ireland J, Rayman P, Richmond A, Golshayan A, et al. Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients. Clin Cancer Res (2008) 14:6674-82. doi:10.1158/1078-0432.CCR-07-5212
    • (2008) Clin Cancer Res , vol.14 , pp. 6674-6682
    • Finke, J.H.1    Rini, B.2    Ireland, J.3    Rayman, P.4    Richmond, A.5    Golshayan, A.6
  • 151
    • 53249111806 scopus 로고    scopus 로고
    • Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival
    • doi:10.1158/1078-0432.CCR-08-0656
    • van Cruijsen H, Van Der Veldt AA, Vroling L, Oosterhoff D, Broxterman HJ, Scheper RJ, et al. Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival. Clin Cancer Res (2008) 14:5884-92. doi:10.1158/1078-0432.CCR-08-0656
    • (2008) Clin Cancer Res , vol.14 , pp. 5884-5892
    • van Cruijsen, H.1    Van Der Veldt, A.A.2    Vroling, L.3    Oosterhoff, D.4    Broxterman, H.J.5    Scheper, R.J.6
  • 152
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
    • doi:10.1158/1078-0432.CCR-08-1332
    • Ko JS, Zea AH, Rini BI, Ireland JL, Elson P, Cohen P, et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin Cancer Res (2009) 15:2148-57. doi:10.1158/1078-0432.CCR-08-1332
    • (2009) Clin Cancer Res , vol.15 , pp. 2148-2157
    • Ko, J.S.1    Zea, A.H.2    Rini, B.I.3    Ireland, J.L.4    Elson, P.5    Cohen, P.6
  • 153
    • 80054098093 scopus 로고    scopus 로고
    • Sunitinib facilitates the activation and recruitment of therapeutic anti-tumor immunity in concert with specific vaccination
    • doi:10.1002/ijc.25863
    • Bose A, Taylor JL, Alber S, Watkins SC, Garcia JA, Rini BI, et al. Sunitinib facilitates the activation and recruitment of therapeutic anti-tumor immunity in concert with specific vaccination. Int J Cancer (2011) 129:2158-70. doi:10.1002/ijc.25863
    • (2011) Int J Cancer , vol.129 , pp. 2158-2170
    • Bose, A.1    Taylor, J.L.2    Alber, S.3    Watkins, S.C.4    Garcia, J.A.5    Rini, B.I.6
  • 154
    • 84878999668 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: A link between metabolism and T cell differentiation and a potential therapeutic target
    • doi:10.4161/onci.19457
    • Pan F, Barbi J, Pardoll DM. Hypoxia-inducible factor 1: A link between metabolism and T cell differentiation and a potential therapeutic target. Oncoimmunology (2012) 1:510-5. doi:10.4161/onci.19457
    • (2012) Oncoimmunology , vol.1 , pp. 510-515
    • Pan, F.1    Barbi, J.2    Pardoll, D.M.3
  • 155
    • 80054033683 scopus 로고    scopus 로고
    • Human TH17 cells are long-lived effector memory cells
    • 104ra100. doi:10.1126/scitranslmed.3002949
    • Kryczek I, Zhao E, Liu Y, Wang Y, Vatan L, Szeliga W, et al. Human TH17 cells are long-lived effector memory cells. Sci Transl Med (2011) 3:104ra100. doi:10.1126/scitranslmed.3002949
    • (2011) Sci Transl Med , vol.3
    • Kryczek, I.1    Zhao, E.2    Liu, Y.3    Wang, Y.4    Vatan, L.5    Szeliga, W.6
  • 156
    • 84866335513 scopus 로고    scopus 로고
    • The HIF-1alpha hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy
    • doi:10.1158/2159-8290.CD-11-0314
    • Palazon A, Martinez-Forero I, Teijeira A, Morales-Kastresana A, Alfaro C, Sanmamed MF, et al. The HIF-1alpha hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy. Cancer Discov (2012) 2:608-23. doi:10.1158/2159-8290.CD-11-0314
    • (2012) Cancer Discov , vol.2 , pp. 608-623
    • Palazon, A.1    Martinez-Forero, I.2    Teijeira, A.3    Morales-Kastresana, A.4    Alfaro, C.5    Sanmamed, M.F.6
  • 157
    • 65549166946 scopus 로고    scopus 로고
    • Bicarbonate increases tumor pH and inhibits spontaneous metastases
    • doi:10.1158/0008-5472.CAN-07-5575
    • Robey IF, Baggett BK, Kirkpatrick ND, Roe DJ, Dosescu J, Sloane BF, et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res (2009) 69:2260-8. doi:10.1158/0008-5472.CAN-07-5575
    • (2009) Cancer Res , vol.69 , pp. 2260-2268
    • Robey, I.F.1    Baggett, B.K.2    Kirkpatrick, N.D.3    Roe, D.J.4    Dosescu, J.5    Sloane, B.F.6
  • 159
    • 77953463274 scopus 로고    scopus 로고
    • pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity
    • doi:10.1002/ijc.25009
    • De Milito A, Canese R, Marino ML, Borghi M, Iero M, Villa A, et al. pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity. Int J Cancer (2010) 127:207-19. doi:10.1002/ijc.25009
    • (2010) Int J Cancer , vol.127 , pp. 207-219
    • De Milito, A.1    Canese, R.2    Marino, M.L.3    Borghi, M.4    Iero, M.5    Villa, A.6
  • 160
    • 70350212812 scopus 로고    scopus 로고
    • Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications
    • doi:10.1007/s10620-009-0951-9
    • Kedika RR, Souza RF, Spechler SJ. Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications. Dig Dis Sci (2009) 54:2312-7. doi:10.1007/s10620-009-0951-9
    • (2009) Dig Dis Sci , vol.54 , pp. 2312-2317
    • Kedika, R.R.1    Souza, R.F.2    Spechler, S.J.3
  • 161
    • 84865147552 scopus 로고    scopus 로고
    • Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments
    • doi:10.1158/0008-5472.CAN-11-3881
    • Wojtkowiak JW, Rothberg JM, Kumar V, Schramm KJ, Haller E, Proemsey JB, et al. Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Res (2012) 72:3938-47. doi:10.1158/0008-5472.CAN-11-3881
    • (2012) Cancer Res , vol.72 , pp. 3938-3947
    • Wojtkowiak, J.W.1    Rothberg, J.M.2    Kumar, V.3    Schramm, K.J.4    Haller, E.5    Proemsey, J.B.6
  • 162
    • 79958759965 scopus 로고    scopus 로고
    • Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells
    • doi:10.1038/cddis.2010.67
    • Marino ML, Fais S, Djavaheri-Mergny M, Villa A, Meschini S, Lozupone F, et al. Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells. Cell Death Dis (2010) 1:e87. doi:10.1038/cddis.2010.67
    • (2010) Cell Death Dis , vol.1
    • Marino, M.L.1    Fais, S.2    Djavaheri-Mergny, M.3    Villa, A.4    Meschini, S.5    Lozupone, F.6
  • 163
    • 84865293299 scopus 로고    scopus 로고
    • Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity
    • doi:10.1111/j.1600-065X.2012.01141.x
    • Townsend KN, Hughson LR, Schlie K, Poon VI, Westerback A, Lum JJ. Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity. Immunol Rev (2012) 249:176-94. doi:10.1111/j.1600-065X.2012.01141.x
    • (2012) Immunol Rev , vol.249 , pp. 176-194
    • Townsend, K.N.1    Hughson, L.R.2    Schlie, K.3    Poon, V.I.4    Westerback, A.5    Lum, J.J.6
  • 164
    • 79954623272 scopus 로고    scopus 로고
    • A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity
    • doi:10.1016/j.immuni.2011.04.006
    • Li Q, Rao RR, Araki K, Pollizzi K, Odunsi K, Powell JD, et al. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity (2011) 34:541-53. doi:10.1016/j.immuni.2011.04.006
    • (2011) Immunity , vol.34 , pp. 541-553
    • Li, Q.1    Rao, R.R.2    Araki, K.3    Pollizzi, K.4    Odunsi, K.5    Powell, J.D.6
  • 165
    • 84859400580 scopus 로고    scopus 로고
    • Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity
    • doi:10.4049/jimmunol.1103365
    • Li Q, Rao R, Vazzana J, Goedegebuure P, Odunsi K, Gillanders W, et al. Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity. J Immunol (2012) 188:3080-7. doi:10.4049/jimmunol.1103365
    • (2012) J Immunol , vol.188 , pp. 3080-3087
    • Li, Q.1    Rao, R.2    Vazzana, J.3    Goedegebuure, P.4    Odunsi, K.5    Gillanders, W.6
  • 167
    • 0028142291 scopus 로고
    • Coffee and cancer: a prospective study of 43,000 Norwegian men and women
    • doi:10.1007/BF01694753
    • Stensvold I, Jacobsen BK. Coffee and cancer: a prospective study of 43,000 Norwegian men and women. Cancer Causes Control (1994) 5:401-8. doi:10.1007/BF01694753
    • (1994) Cancer Causes Control , vol.5 , pp. 401-408
    • Stensvold, I.1    Jacobsen, B.K.2
  • 168
    • 0030998210 scopus 로고    scopus 로고
    • Diet and risk of cutaneous malignant melanoma: a prospective study of 50,757 Norwegian men and women
    • doi:10.1002/(SICI)1097-0215(19970516)71:4<600::AID-IJC15>3.3.CO;2-C
    • Veierod MB, Thelle DS, Laake P. Diet and risk of cutaneous malignant melanoma: a prospective study of 50,757 Norwegian men and women. Int J Cancer (1997) 71:600-4. doi:10.1002/(SICI)1097-0215(19970516)71:4<600::AID-IJC15>3.3.CO;2-C
    • (1997) Int J Cancer , vol.71 , pp. 600-604
    • Veierod, M.B.1    Thelle, D.S.2    Laake, P.3
  • 169
    • 35548950221 scopus 로고    scopus 로고
    • Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy
    • doi:10.1038/nrc2250
    • Colombo MP, Piconese S. Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy. Nat Rev Cancer (2007) 7:880-7. doi:10.1038/nrc2250
    • (2007) Nat Rev Cancer , vol.7 , pp. 880-887
    • Colombo, M.P.1    Piconese, S.2
  • 170
    • 84874608992 scopus 로고    scopus 로고
    • Control of inflammation by integration of environmental cues by regulatory T cells
    • doi:10.1172/JCI57175
    • Chaudhry A, Rudensky AY. Control of inflammation by integration of environmental cues by regulatory T cells. J Clin Invest (2013) 123:939-44. doi:10.1172/JCI57175
    • (2013) J Clin Invest , vol.123 , pp. 939-944
    • Chaudhry, A.1    Rudensky, A.Y.2
  • 171
  • 172
    • 84856706929 scopus 로고    scopus 로고
    • Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients
    • doi:10.1007/s00262-011-1161-9
    • Filipazzi P, Huber V, Rivoltini L. Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients. Cancer Immunol Immunother (2012) 61:255-63. doi:10.1007/s00262-011-1161-9
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 255-263
    • Filipazzi, P.1    Huber, V.2    Rivoltini, L.3
  • 173
    • 41149148269 scopus 로고    scopus 로고
    • Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives
    • doi:10.1111/j.1600-065X.2008.00608.x
    • Rodriguez PC, Ochoa AC. Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives. Immunol Rev (2008) 222:180-91. doi:10.1111/j.1600-065X.2008.00608.x
    • (2008) Immunol Rev , vol.222 , pp. 180-191
    • Rodriguez, P.C.1    Ochoa, A.C.2
  • 174
    • 77957991455 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in human cancer
    • doi:10.1097/PPO.0b013e3181eb3358
    • Nagaraj S, Gabrilovich DI. Myeloid-derived suppressor cells in human cancer. Cancer J (2010) 16:348-53. doi:10.1097/PPO.0b013e3181eb3358
    • (2010) Cancer J , vol.16 , pp. 348-353
    • Nagaraj, S.1    Gabrilovich, D.I.2
  • 175
    • 70249140303 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells down-regulate l-selectin expression on CD4+ and CD8+ T cells
    • doi:10.4049/jimmunol.0804253
    • Hanson EM, Clements VK, Sinha P, Ilkovitch D, Ostrand-Rosenberg S. Myeloid-derived suppressor cells down-regulate l-selectin expression on CD4+ and CD8+ T cells. J Immunol (2009) 183:937-44. doi:10.4049/jimmunol.0804253
    • (2009) J Immunol , vol.183 , pp. 937-944
    • Hanson, E.M.1    Clements, V.K.2    Sinha, P.3    Ilkovitch, D.4    Ostrand-Rosenberg, S.5
  • 176
    • 42449123606 scopus 로고    scopus 로고
    • Natural killer cell-directed therapies: moving from unexpected results to successful strategies
    • doi:10.1038/ni1580
    • Terme M, Ullrich E, Delahaye NF, Chaput N, Zitvogel L. Natural killer cell-directed therapies: moving from unexpected results to successful strategies. Nat Immunol (2008) 9:486-94. doi:10.1038/ni1580
    • (2008) Nat Immunol , vol.9 , pp. 486-494
    • Terme, M.1    Ullrich, E.2    Delahaye, N.F.3    Chaput, N.4    Zitvogel, L.5
  • 177
    • 84862506395 scopus 로고    scopus 로고
    • Prostate cancer, tumor immunity and a renewed sense of optimism in immunotherapy
    • doi:10.1007/s00262-012-1216-6
    • Rigamonti N, Bellone M. Prostate cancer, tumor immunity and a renewed sense of optimism in immunotherapy. Cancer Immunol Immunother (2012) 61:453-68. doi:10.1007/s00262-012-1216-6
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 453-468
    • Rigamonti, N.1    Bellone, M.2
  • 178
    • 84891053440 scopus 로고    scopus 로고
    • The tumor microenvironment and strategies to improve drug distribution
    • doi:10.3389/fonc.2013.00154
    • Saggar JK, Yu M, Tan Q, Tannock IF. The tumor microenvironment and strategies to improve drug distribution. Front Oncol (2013) 3:154. doi:10.3389/fonc.2013.00154
    • (2013) Front Oncol , vol.3 , pp. 154
    • Saggar, J.K.1    Yu, M.2    Tan, Q.3    Tannock, I.F.4
  • 179
    • 84886943622 scopus 로고    scopus 로고
    • Re-orienting the immune system: durable tumor regression and successful re-induction therapy using anti-PD1 antibodies
    • doi:10.4161/onci.23661
    • Lipson EJ. Re-orienting the immune system: durable tumor regression and successful re-induction therapy using anti-PD1 antibodies. Oncoimmunology (2013) 2:e23661. doi:10.4161/onci.23661
    • (2013) Oncoimmunology , vol.2
    • Lipson, E.J.1
  • 180
    • 59749089432 scopus 로고    scopus 로고
    • Targeted therapy for advanced colorectal cancer-more is not always better
    • doi:10.1056/NEJMe0809343
    • Mayer RJ. Targeted therapy for advanced colorectal cancer-more is not always better. N Engl J Med (2009) 360:623-5. doi:10.1056/NEJMe0809343
    • (2009) N Engl J Med , vol.360 , pp. 623-625
    • Mayer, R.J.1
  • 181
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • doi:10.1056/NEJMoa0808268
    • Tol J, Koopman M, Cats A, Rodenburg CJ, Creemers GJ, Schrama JG, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med (2009) 360:563-72. doi:10.1056/NEJMoa0808268
    • (2009) N Engl J Med , vol.360 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3    Rodenburg, C.J.4    Creemers, G.J.5    Schrama, J.G.6
  • 182
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • doi:10.1200/JCO.2008.19.8135
    • Hecht JR, Mitchell E, Chidiac T, Scroggin C, Hagenstad C, Spigel D, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol (2009) 27:672-80. doi:10.1200/JCO.2008.19.8135
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3    Scroggin, C.4    Hagenstad, C.5    Spigel, D.6


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