T-cell function and migration: Two sides of the same coin

New England Journal of Medicine

Volumn 343, Issue 14, 2000, Pages 1020-1034

  Von Andrian, Ulrich H ^a,c   Mackay, Charles R ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c CENTER FOR BLOOD RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDRESSIN; CD11B ANTIGEN; CD15 ANTIGEN; CHEMOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOPROTEIN P 15095; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 2; L SELECTIN; LYMPHOCYTE ANTIGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

B LYMPHOCYTE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; DENDRITIC CELL; EFFECTOR CELL; IMMUNOSURVEILLANCE; MEMORY CELL; PEYER PATCH; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

B-LYMPHOCYTES; CELL ADHESION MOLECULES; CELL MOVEMENT; CHEMOKINES; DENDRITIC CELLS; HUMANS; LYMPHOID TISSUE; RECEPTORS, CHEMOKINE; T-LYMPHOCYTES;

EID: 0034609968     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200010053431407     Document Type: Review

References (116)

1. The route of re-circulation of lymphocytes in the rat
2. The migration of lymphocytes through the endothelium of venules in lymph nodes: An electron microscope study
3. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
4. The dynamics oft cell receptor signaling: Complex orchestration and the key roles of tempo and cooperation
5. The CD1 system: Antigen-presenting molecules for T cell recognition of lipids and glycolipids
6. A direct estimate of the human αβ T cell receptor diversity
7. Perturbation of the T cell repertoire in rheumatoid arthritis
8. Dendritic cells and the control of immunity
9. Lymphocyte homing and homeostasis
10. Determinants of endothelial cell phenotype in venules
11. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
12. Leukocyte-endothelial adhesion molecules
13. L-selectin-mediated leukocyte adhesion in vivo: Microvillous distribution determines tethering efficiency, but not roiling velocity
14. Selectins and their ligands: Current concepts and controversies
15. Mechanisms that regulate the function of the selectins and their ligands
16. Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins
17. 2 integrins in vivo
18. 4 Integrins mediate lymphocyte attachment and roiling under physiologic flow
19. The integrin VLA-4 supports tethering and roiling in flow on VCAM-1
20. Chemokines: Signals lamps for trafficking of T and B cells for development and effector function
21. Chemokines and cell migration in secondary lymphoid organs
22. Chemokines: A new classification system and their role in immunity
23. Chemokines and the arrest of lymphocytes rolling under flow conditions
24. Th1/Th2 subsets: Distinct differences in homing and chemokine receptor expression?
25. The role of chemokine receptors in directing traffic of naive, type 1 and type 2 T cells
26. The chemokine system: Redundancy for robust outputs
27. Multistep navigation the combinatorial control of leukocyte chemotaxis
28. Chemokine receptors in lymphoid organ homeostasis
29. Leukocyte rolling and extravasation are severely compromised in P selectin deficient mice
30. Infectious susceptibility and severe deficiency of leukocyte roiling and recruitment in E-selectin and P-selectin double mutant mice
31. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins
32. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
33. Multiple targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment
34. Critical role for β7 integrins in formation of the gut-associated lymphoid tissue
35. Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice
36. Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice
37. CCR7 coordinates the primary immune responses by establishing functional microenvironments in secondary lymphoid organs
38. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules
39. The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules
40. Leukocyte adhesion deficiency: An inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins
41. Recurrent severe infections caused by a novel leukocyte adhesion deficiency
42. Virulence factors of Bordetella pertussis
43. Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules
44. Molecular mechanisms of lymphocyte homing to peripheral lymph nodes
45. Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
46. Inflammatory skin diseases, T cells, and immune surveillance
47. 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined
48. High endothelial venules (HEVs): Specialized endothelium for lymphocyte migration
49. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
50. L-selectinmediated lymphocyte rolling on MAdCAM-1
51. The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches
52. The α(1,3) fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis
53. A putative chemokine receptor, BLRI, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
54. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
55. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
56. Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal Langerhans cells
57. Mobilizing dendritic cells for tolerance, priming, and chronic inflammation
58. Visualization of specific B and T lymphocyte interactions in the lymph node
59. The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo
60. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
61. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
62. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
63. Chemokine receptor allelic polymorphisms: Relationships to HIV resistance and disease progression
64. Association of rheumatoid arthritis with a functional chemokine receptor, CCR5
65. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
66. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin
67. Acquisition of selectin binding and peripheral homing properties by CD4(+) and CD8(+) T cells
68. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4
69. Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on alpha1, 3-fucosyltransferase VII gene expression
70. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
71. Eotaxin: A potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation
72. Cloning of the human eosinophil chemoattractant, eotaxin: Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils
73. Eotaxin: From an eosinophilic chemokine to a major regulator of allergic reactions
74. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
75. Migration kinetics and final destination of type I and type 2 CD8 effector cells predict protection against pulmonary virus infection
76. β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans
77. Cytotoxic T lymphocytes, chemokines and antiviral immunity
78. Differential homing commitments of antigen-specific T cells after oral or parenteral immunization in humans
79. Selective endothelial binding of interleukin-2-dependent human T-cell lines derived from different tissues
80. Naive and memory T cells show distinct pathways of lymphocyte recirculation
81. A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses
82. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
83. Regions in β-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity
84. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
85. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
86. CC CKRS: A RANTES, MIP-1α MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1
87. HIV-1 entry cofactor: Functional eDNA cloning of a seven-transmembrane, G protein-coupled receptor
88. The HIV coreceptors CXCR4 and CCK5 are differentially expressed and regulated on human T lymphocytes
89. Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
90. Chemokines and their receptors in lymphocyte traffic and HIV infection
91. Modulating chemokines: More lessons from viruses
92. A broad-spectrum chemokine antagonist by Kaposi's sarcoma-associated herpesvirus
93. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines
94. 'The good, the bad, and the ugly': The role of chemokines in models of human disease
95. Adhesion molecules in rheumatoid arthritis
96. Cell adhesion molecules in clinical renal transplantation
97. Mechanisms of inflammation in MS tissue: Adhesion molecules and chemokines
98. Roles of leukocyte/endothelial cell adhesion molecules in the pathogenesis of vasculitis
99. Chemokines and atherosclerosis
100. Chemokines and asthma: Redundancy of function or a coordinated effort?
101. Cytokine/chemokine cascades in immunity to tuberculosis
102. Chemokines in the inflammatory bowel diseases
103. Chemokines in allergy
104. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness
105. Selective, tight-binding inhibitots of integrin alpha4betal that inhibit allergic airway responses
106. 1 integrin
107. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity
108. Blocking chemokine receptors
109. Cutting edge: A small molecule antagonist of LFA-1-mediated cell adhesion
110. In vivo migration and function of transferred HIV-1-specific cytotoxic T cells
111. T cell therapy of human CMV and EBV infection in immunocompromised hosts
112. Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells
113. Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
114. Regression of human metastatic renal cell carcinoma after vaccination with tumor cell-dendritic cell hybrids
115. Negative regulation oft cell homing by CD43
116. Active movement of T cells away from a chemokine