Substrate distortion contributes to the catalysis of orotidine 5′-monophosphate decarboxylase

Journal of the American Chemical Society

Volumn 135, Issue 46, 2013, Pages 17432-17443

  Fujihashi, Masahiro ^a   Ishida, Toyokazu ^b   Kuroda, Shingo ^a   Kotra, Lakshmi P ^c,d   Pai, Emil F ^c,e   Miki, Kunio ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; CARBOXYLATION; CATALYSIS; ENZYMES; INDIUM COMPOUNDS; LIGANDS; MOLECULAR DYNAMICS; MOLECULAR MODELING; QUANTUM THEORY; REACTION INTERMEDIATES; REACTION KINETICS;

COMPUTATIONAL ANALYSIS; DECARBOXYLATION REACTIONS; ENZYME-SUBSTRATE COMPLEXES; INTRINSIC ELECTRONICS; ORDERS OF MAGNITUDE; QUANTUM MECHANICS/MOLECULAR MECHANICS; REACTION MECHANISM; TRANSITION STATE STABILIZATION;

SUBSTRATES;

6 AMINO URIDINE 5' MONOPHOSPHATE; 6 METHYL URIDINE 5' MONOPHOSPHATE; CARBOXYLIC ACID; METHYL GROUP; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; URIDINE PHOSPHATE;

ARTICLE; BINDING COMPETITION; CATALYSIS; COVALENT BOND; CRYSTALLIZATION; DECARBOXYLATION; DENSITY FUNCTIONAL THEORY; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NONHUMAN; QUANTUM MECHANICS; REACTION ANALYSIS; ROTATION; STATIC ELECTRICITY; WILD TYPE;

BIOCATALYSIS; DECARBOXYLATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; QUANTUM THEORY; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 84888355894     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja408197k     Document Type: Article

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