Theoretical studies of the effect of thio substitution on orotidine monophosphate decarboxylase substrates

Journal of Organic Chemistry

Volumn 70, Issue 4, 2005, Pages 1211-1221

  Phillips, Linda M ^a   Lee, Jeehiun K ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLATION; CATALYSIS; COMPUTATIONAL METHODS; CONFORMATIONS; PROBABILITY; SUBSTITUTION REACTIONS;

CATALYTIC PATHWAY; PROTON TRANSFER; THIOCARBONYL;

ENZYMES;

2 THIO 1 METHYL OROTATE; 2 THIO OROTIDINE 5' MONOPHOSPHATE; 4 THIO 1 METHYL OROTATE; 4 THIO OROTIDINE 5' MONOPHOSPHATE; CARBONYL DERIVATIVE; NUCLEOSIDE; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; OXYGEN; THIOCARBONYL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BOLTZMANN PROBABILITY; CALCULATION; CATALYSIS; CHEMICAL MODEL; CONFORMATION; CONFORMATIONAL TRANSITION; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; DECARBOXYLATION; ENERGY TRANSFER; ENZYME BINDING; ENZYME KINETICS; MOLECULAR MECHANICS; OPTICAL ROTATION; PROBABILITY; PROTON TRANSPORT; THEORETICAL STUDY;

ELECTROSTATICS; MOLECULAR STRUCTURE; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; PROBABILITY; ROTATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS; THERMODYNAMICS;

EID: 13844306906     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo040279s     Document Type: Article

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